![[logo] US EPA](https://webarchive.library.unt.edu/eot2008/20081105221906im_/http://www.epa.gov/epafiles/images/logo_epaseal.gif){kind=logo}
Center for Child Environmental Health Risks Research
EPA Grant Number: R831709Center: University of Washington Center for Child Environmental Health Risks Research
Center Director: Faustman, Elaine
Title: Center for Child Environmental Health Risks Research
Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2003 through October 31, 2008
Project Amount: $3,651,710
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Health Effects , Children's Health
Description:
Objective:The University of Washington Center for Child Environmental Health Risks Research (CHC) was established in 1998. The theme of the Center is understanding the biochemical, molecular and exposure mechanisms that define children's susceptibility to pesticides and the implications for assessing pesticide risks to normal development and learning. The CHC is a multi-disciplinary research program that conducts basic and applied mechanistic research aimed at reducing the adverse effects of environmental pesticide exposures in children. The Center’s research program includes basic mechanistic studies of toxicity, exposure assessment, risk assessment, and community based participatory research. Researchers from the University of Washington and the Fred Hutchinson Cancer Research Center work in the lab, in the field and in the community to bring a unique and successful approach to the study of children’s environmental health. It is administratively housed within the Institute for Risk Analysis and Risk Communication that is in the UW's School of Public Health and Community Medicine.
To facilitate both basic and applied research on reducing the adverse effects of environmental pesticide exposures, center participants include members from multiple institutions, schools, and varied departments and clinics. To achieve tangible effects on the community, the CHC includes a partnership with an eastern Washington community within the Yakima Valley agricultural center of our state, to jointly accomplish pesticide intervention with reduced childhood pesticide exposures.
The six specific objectives of our Center are:
- To identify cellular, biochemical and molecular mechanisms for the adverse developmental neurotoxicity of pesticides.
- To identify susceptibility factors for developmental neurotoxicity of pesticides, including genetic polymorphisms.
- To improve our understanding of critical pathways of pesticide exposure for children.
- To intervene to reduce children’s exposure to pesticides, including the development of a culturally-appropriate intervention to break the take-home pathway.
- To provide core support for the development and application of risk assessment methods. This will enable basic research on pesticide toxicity and exposure to be translated for improved child health by informing risk decisions to protect children’s health from pesticides.
- To foster partnerships between academic researchers and the community in which information requested by the community and basic research deficiencies/gaps are translated into studies that address the health needs of both.
The CHC is comprised of two laboratory based research projects, two field based projects, and four facility cores. The four facility cores (Neurobehavioral Assessment, Exposure Assessment, Risk Characterization and Risk Communication) are designed to support the research agenda and to put the research into a child specific risk assessment context. Thus the scientific findings on pesticide toxicity and exposure can be directly incorporated into risk assessment models that are designed to protect child health.
Highlights of Research Projects:
Molecular Mechanisms of Pesticide Induced Developmental Neurotoxicity
The Molecular Mechanisms Research Project specifically evaluates the molecular and cellular mechanisms of toxicity through which pesticides can exert their neurodevelopmental toxicity. Alterations in the regulatory dynamics of neural cell proliferation, differentiation, and cell death are examined.
We are investigating two of the most commonly used organophosphate pesticides - chlorpyrifos and diazinon, as well as persistent pesticides that were used historically. We focus on the molecular and cellular mechanisms of toxicity during “windows of susceptibility,” the periods during which these pesticides can cause neurodevelopmental toxicity and disease. A systems biology based assessment integrates in vitro and in vivo studies (as well as toxicogenomic assessments) across endpoints and functional outcomes using Physiologically Based Toxicokinetic (PBTK) and Biologically Based Dose Response (BBDR) models. This approach allows for evaluation of the mechanisms of action including gene environment interactions on cell cycle regulation, oxidative stress and apoptosis. Neurodevelopmental models for normal as well as toxicant perturbed neocortical development (including neurogenesis and synaptogenesis) have been created. The systems biology approach that our center employs, and links with neurobehavioral function, leads to an integrated understanding of the critical pesticide exposures associated with neurodevelopmental toxicity.
Genetic Susceptibility to Pesticides
The Genetic Susceptibility Research Project examines gene/environment interactions important for children’s health by evaluating differences in genetics that affect metabolism and define susceptibility. The overall aim of this research project is to investigate the developmental neurotoxicity of the organophosphates chlorpyrifos oxon and diazoxon, and to determine the role of genetic variability in the polymorphic serum enzyme paraoxonase (PON1) in protecting against developmental neurotoxicity.
Recent studies in humans (run in collaboration with the UC-Berkeley CHAMACOS) have shown that developmental onset of PON1 is highly variable among children. It can appear at ages as early as four months and as late as two years. Inter-individual variability in PON1192 genotype, PON-1 levels and development time course means that children can have different susceptibilities to adverse effects of pesticides. The contribution of PON1 to pesticide toxicity has had profound effects for understanding human health and now its role in defining children’s susceptibility is under investigation.
Community-Based Participatory Research Project
The overall goal of the Community Based Participatory Research Project (CBPR) is to investigate multiple pathways that may contribute to pesticide exposure in adults and children living in agricultural communities.
The community-based research project has evaluated the impacts of the occupational take home pathway on pesticide exposure in children of farmworkers. Concentrations of OP pesticide metabolites in the urine of farmworkers and their children were correlated with concentrations of OP pesticide residues in vehicle and house dust. Concentrations were higher in households with an adult who worked in apple and/or pear orchards. Consistent with our findings, these fruit crops had the highest amounts of OP pesticides applied per acre. In addition, the Center is collecting longitudinal data to gain an understanding of the effects of within person variability versus between person variability to better identify an exposed cohort within a population by using a limited number of bioassays.
Pesticide Spray Drift Study
The overall objective of this project is to understand the underlying physical and behavioral mechanisms by which non-occupational exposure occurs following pesticide applications.
One study measured airborne concentrations of pesticides in a community during and after a spray event. The study investigated assumptions that are made to ensure the safe application of pesticides. Results revealed that the existing volatilization model under-predicted (by about 4 fold) the measured pesticide concentration after the spray event when temperatures rose significantly. This indicates a need to re-examine inhalation exposures for pesticides when the temperature is high. Further, when linked with our study examining children’s activity profiles, the spray drift study suggests a need to re-evaluate transport modeling and exposure factors.
Important research findings from the UW Center:
Contributions of occupational factors to home contamination -- Evidence of Take-home Pathway
- Higher concentrations of OP pesticide dimethyl metabolites in the urine of farmworkers and their children were correlated with higher concentrations of azinphos-methyl pesticide residue in vehicle and house dust.
- Children of orchard workers have an additional source of pesticide exposure through pesticides that are transported on the clothing, boots and skin of their farmworker parents.
Contributions of occupational factors to home contamination -- Evidence of Crop-associated Exposure
- Concentrations of OP pesticide dimethyl metabolites in the urine of farmworkers and their children and concentrations of azinphos-methyl pesticide residue in vehicle and house dust were higher among farmworker households employed in the pome fruit crops.
- Consistent with these findings, the pome fruit crops of apples and pears had the highest amounts of OP pesticides applied per acre, in particular azinphos-methyl.
- After controlling for crop, we did not detect differences in exposure between farmworkers performing varying job tasks.
Exposure Assessment Study
- Analyzed three longitudinal studies of OP metabolites (WA, MN, and MD) and estimated within and between person variability.
- Within child variation larger than between child variations.
- Large within child variability for OP pesticide biomarkers limits ability to identify exposed populations.
PON1 Status of farmworker mothers and children
(Study conducted in collaboration with UC-Berkeley CHAMACOS)
- 8 – 10-fold variability in sensitivity to CPO between groups of mothers and their newborns.
Production of ‘Humanized’ Transgenic Mouse Lines Carrying hPON1Q192 or hPON1R192 in Place of Mouse PON1
- PON1Q192 mice were twice as sensitive as PON1R192 mice to brain ChE inhibition by chlorpyrifos oxon (CPO).
- PON1Q192 mice were more sensitive than PON1R192 mice to neocortical histopathology resulting from chronic developmental exposure to low doses (0.18-0.25 mg/kg/d) of CPO.
Washington Pesticide Spray Drift Study
- A new method of using small backpacks equipped with GPS for tracking children’s movements was developed to better understand children’s movements throughout the day.
- An innovative laser-based system (LIDAR) of real-time measurement of drift during pesticide-spraying was developed. Observations made with this system have resulted in a reassessment of methods to estimate exposures from pesticide drift currently used at the EPA.
Journal Articles: 168 Displayed | Download in RIS Format
| Other center views: | All 219 publications | 197 publications in selected types | All 168 journal articles |
| Type | Citation | ||
|---|---|---|---|
|
|
Andersen ME, Conolly RB, Faustman EM, Kavlock RJ, Portier CJ, Sheehan DM, Wier PJ, Ziese L. Quantitative mechanistically based dose-response modeling with endocrine-active compounds. Environmental Health Perspectives 1999;107(4):631-8. |
R831709 (2005) |
not available |
|
|
Bartell SM, Ponce RA, Sanga RN, Faustman EM. Human variability in mercury toxicokinetics and steady state biomarker ratios. Environmental Research 2000;84(2):127-32. |
R831709 (2005) |
not available |
|
|
Bartell SM, Ponce RA, Takaro TK, Zerbe RO, Omenn GS, Faustman EM. Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention. Risk Analysis 2000;20(1):87-99. |
R831709 (2005) R825173 (1999) |
not available |
|
|
Bekris LM, Shephard C, Janer M, Graham J, McNeney B, Shin J, Zarghami M, Griffith W, Farin F, Kavanagh TJ, Lernmark A. Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels. Experimental and Clinical Endocrinology & Diabetes 2007;115(4):221-228. |
R831709 (2005) R832733 (2007) |
|
|
|
Bogdanffy MS, Daston G, Faustman EM, Kimmel CA, Kimmel GL, Seed J, Vu V. Harmonization of cancer and non-cancer risk assessment: proceedings of a consensus-building workshop. Toxicological Sciences 2001;61(1):18-31. |
R831709 (2005) |
not available |
|
|
Brophy VH, Jarvik GP, Richter RJ, Rozek LS, Schellenberg GD, Furlong CE. Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 2000;10:453-60. |
R831709 (2005) |
not available |
|
|
Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE. Effects of 5’ regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. American Journal of Human Genetics 2001;68(6):1428-1436. |
R831709 (2005) R826886C002 (2001) |
|
|
|
Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE.Paraoxonase (PON1) regulatory region polymorphisms affect activity level. Toxicological Sciences 2001;60(Supp):51. |
R831709 (2005) |
not available |
|
|
Brophy V H, Hastings MD, Clendenning JB, Richter RJ, Jarvik GP, Furlong CE. Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics 2001;11(1):77-84. |
R831709 (2005) R826886C002 (2001) |
|
|
|
Burbacher TM, Grant KS, Gilbert SG, Rice DC. The effects of methylmercury exposure on visual and auditory functions in nonhuman primates. The Toxicologist 1999;19:243. |
R831709 (2005) |
not available |
|
|
Burbacher TM, Grant KS. Methods for studying nonhuman primates in neurobehavioral toxicology and teratology. Neurotoxicology and Teratology 2000;22(4):475-86. |
R831709 (2005) |
not available |
|
|
Burry M, Guizzetti M, Oberdoerster J, Costa LG. Developmental neurotoxicity of toluene: in vivo and in vitro effects on astroglial cells. Developmental Neuroscience 2003;25(1):14-9. |
R831709 (2005) |
not available |
|
|
Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Zhengui X. Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. The Journal of Neuroscience 2001;21(2):434-443. |
R831709 (2005) |
not available |
|
|
CE Furlong CE, Li WF, Costa LG, Richter RJ, Shih DM, Lusis AJ. Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse modelfor the human PON1 polymorphism. Neurotoxicology 1998;19(4-5):645-50. |
R831709 (2005) |
not available |
|
|
Chan GCK, Lernmark U, Xia Z, Storm DR. DNA elements of the type 1 adenylyl cyclase gene locus enhance reporter gene expression in neurons and pinealocytes. European Journal of Neuroscience 2001;13(11):2054-2066. |
R831709 (2005) |
not available |
|
|
Chen P, Eggleston PA. Allergenic proteins are fragmented in low concentrations of sodium hypochlorite. Clinical and Experimental Allergy 2001;31:1086-93. |
R831709 (2005) |
not available |
|
|
Cole TB, Li WF, Richter RJ, Furlong CE, Costa LG. Inhibition of paraoxonase (PON1) by heavy metals. Toxicological Sciences 2002;66(Suppl 1):312. |
R831709 (2005) |
not available |
|
|
Cole, TB, Walter, BJ. Contribution of paraoxonase (PON1) levels and Q192R genotype to organophosphate detoxication: evidence from humans and "humanized" transgenic mice. Toxicological Sciences 2003;72(Suppl 1):100. |
R831709 (2005) |
not available |
|
|
Cole TB, Jampsa RL, Walter BJ, Arndt TL, Richter RJ, Shih DM, Tward A, Lusis AJ, Jack RM, Costa LG, Furlong CE. Expression of human paraoxonase (PON1) during development. Pharmacogenetics 2003;13:357-64. |
R831709 (2005) |
not available |
|
|
Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenetics and Genomics 2005;15(8):589-598. |
R831709 (2005) R831709C002 (2005) |
not available |
|
|
Coronado GD, Thompson B, Strong L, Griffith WC, Islas I. Activities and organophosphate exposures: response. Environmental Health Perspectives 2004;112(13):A725-A726. |
R831709 (2005) R831709C003 (2005) |
not available |
|
|
Coronado GD, Thompson B, Strong L, Griffith WC, Islas I. Agricultural task and exposure to organophosphate pesticides among farmworkers. Environmental Health Perspectives 2004;112:142-7. |
R831709 (2005) R831709C003 (2004) |
not available |
|
|
Coronado GD, Thompson B, Griffith WC. Children’s exposure to OP pesticides: response to Fenske et al. Environmental Health Perspectives 2004;112(15):A866. |
R831709C003 (2005) |
not available |
|
|
Coronado GD, Vigoren EM, Thompson B, Griffith WC, Faustman EM. Organophosphate pesticide exposure and work in pome fruit: evidence for the take-home pesticide pathway. Environmental Health Perspectives 2006;114(7):999-1006. |
R831709 (2005) R831709C003 (2006) |
|
|
|
Coronado G, Thompson B. Children's Exposure to OP Pesticides: Response to Fenske et al. Environmental Health Perspectives 2004;112(15): A866. |
R831709 (2005) |
not available |
|
|
Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chemico-Biological Interactions 1999;119-120:429-438. |
R831709 (2005) R826886C002 (2000) |
|
|
|
Costa LG. The emerging field of ecogenetics. NeuroToxicology 2000;21(1-2):85-89. |
R831709 (2005) R826886C002 (2000) |
|
|
|
Costa LG, Guizzetti M, Lu H, Bordi F, Vitalone A, Tita B, Palmery P, Silvestrini B. Intracellular signal transduction pathways as targets for neurotoxicants. Toxicology 2001;160(1-3):19-26. |
R831709 (2005) |
not available |
|
|
Costa LG. Pesticide exposure: differential risk for neurotoxic outcomes due to enzyme polymorphisms. Clinics in Occupational and Environmental Medicine 2001;1:511-523. |
R831709 (2005) |
not available |
|
|
Costa LG, Guizzetti M, Burry M, Oberdoerster J. Developmental neurotoxicity: do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria. Toxicology Letters 2002;127(1-3):197-205. |
R831709 (2005) |
not available |
|
|
Costa LG, Cole TB, Jarvik GP, Furlong CE. Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annual Review of Medicine 2003;54:371-92. |
R831709 (2005) R831709C002 (2004) |
not available |
|
|
Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003;8(1):1-12. |
R831709 (2005) R831709C002 (2004) R826886C002 (2002) |
|
|
|
Costa LG, Cole TB, Furlong CE. Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. Journal of Toxicology-Clinical Toxicology 2003;41:37-45. |
R831709 (2005) R831709C002 (2004) |
not available |
|
|
Costa LG, Aschner M. Developmental neuropathology of environmental agents. Annual Review of Pharmacology and Toxicology 2004;44:87-110. |
R831709 (2005) |
not available |
|
|
Costa LG, Cole TB, Vitalone A, Furlong CE. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clinica Chimica Acta 2005;352(1-2):37-47. |
R831709 (2005) R831709C002 (2004) |
not available |
|
|
Costa LG, Vitalone A, Cole TB, Furlong CE. Modulation of paraoxonase (PON1) activity. Biochemical Pharmacology 2005;69(4):541-550. |
R831709 (2005) R831709C002 (2004) |
not available |
|
|
Costa LG, Cole TB, Furlong CE. Paraoxonase (PON1): from toxicology to cardiovascular medicine. Acta Biomed Ateneo Parmense 2005;76(Suppl 2):50-7. |
R831709 (2005) |
not available |
|
|
Costa LG. Current issues in organophosphate toxicology. Clinica Chimica Acta 2006;366(1-2):1-13. |
R831709 (2005) R831709 (2006) R831709C001 (2006) |
|
|
|
Costa LG, Cole TB, Furlong CE. Gene-environment interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity. Lab Medicine 2006;37(2):109-113. |
R831709 (2005) R831709C001 (2007) R831709C002 (2007) |
not available |
|
|
Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Frontiers in Bioscience 2008;13(4):1240-1249. |
R831709 (2005) R831709 (2007) R831709C001 (2007) R831709C002 (2007) |
|
|
|
Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TW, Griffith W, Coronado G, Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environmental Health Perspectives 2002;110(12):A787-A792. |
R831709 (2005) R826886C003 (2001) R826886C003 (2002) R826886C004 (2001) R826886C004 (2002) |
|
|
|
Curl CL, Fenske RA, Elgethun K. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environmental Health Perspectives 2003;111:377-82. |
R831709 (2005) |
not available |
|
|
Drew CH, Grace DA, Silbernagel SM, Hemmings ES, Smith A, Griffith WC, Takaro TK, Faustman EM. Nuclear waste transportation: case studies of identifying stakeholder risk information needs. Environmental Health Perspectives 2003;111:263-72. |
R831709 (2005) |
not available |
|
|
Eggleston PA. Clinical trials of allergen avoidance in established asthma. Journal of Allergy and Clinical Immunology 2001;108(5):685-687. |
R831709 (2005) |
not available |
|
|
Eggleston PA. Methods and effectiveness of indoor environmental control. Annals of Allergy Asthma & Immunology 2001;87(6 Suppl 3):44-47. |
R831709 (2005) |
not available |
|
|
Elgethun K, Fenske RA, Yost MG, Palcisko GJ. Time-location analysis for exposure assessment studies of children using a novel global positioning system instrument. Environmental Health Perspectives 2003;111(1):115-122. |
R831709 (2005) R826886C004 (2002) |
|
|
|
Elgethun K, Yost MG, Fitzpatrick CT, Nyerges TL, Fenske RA. Comparison of GPS tracking to the NHEXAS diary timeline for time-location measurement of children. Journal of Exposure Analysis and Environmental Epidemiology 2007;17:196-206. |
R831709 (2005) |
not available |
|
|
Elgethun K, Yost MG, Fitzpatrick CTE, NyergesTL, Fenske RA. Comparison of global positioning system (GPS) tracking and parent-report diaries to characterize children's time–location patterns. Journal of Exposure Science and Environmental Epidemiology 2007;17(2):196-206. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709C004 (2006) R831709C004 (2007) |
|
|
|
Eskenazi B, Harley K, Bradman A, Weltzien E, Jewell NP, Barr DB, Furlong CE, Holland NT. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environmental Health Perspectives 2004;112(10):1116-1124. |
R831709C002 (2004) R831710 (2004) R831710 (2005) R831710C001 (2004) |
|
|
|
Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R831709 (2005) R831709C001 (2004) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829390 (2005) R831710 (2005) R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) R832141 (2005) |
|
|
|
Faustman EM, Lewandowski TA, Ponce RA, Bartell SM. Biologically based dose-response models for developmental toxicants: lessons from methylmercury. Inhalation Toxicology 1999;11(6-7):559-572. |
R831709 (2005) R825173 (1999) R825358 (Final) |
not available |
|
|
Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA. Mechanisms underlying children’s susceptibility to environmental toxicants. Environmental Health Perspectives 2000;108(Suppl 1):13-21. |
R831709 (2005) R825173 (1999) R825173 (2000) R826886 (2000) |
|
|
|
Faustman EM, Ponce RA, Ou YC, Mendoza MA, Lewandowski T, Kavanagh T. Investigations of methylmercury-induced alterations in neurogenesis. Environmental Health Perspectives 2002;110(Suppl 5):859-64. |
R831709 (2005) |
not available |
|
|
Faustman EM, Gohlke, JM, Judd NL, Lewandowski TA, Bartell SA, Griffith WC. Modeling developmental processes in animals: Applications in neurodevelopmental toxicology. Environmental Toxicology and Pharmacology 2005;19(3):615-624. |
R831709 (2005) R831709 (2006) R831709C001 (2004) R831709C001 (2005) R831709C001 (2006) |
|
|
|
Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH, Keifer MC. Biologically based pesticide dose estimates for children in an agricultural community. Environmental Health Perspectives 2000;108(6):515-520. |
R831709 (2005) R826886C004 (2001) |
|
|
|
Fenske RA, Lu C, Simcox NJ, Loewenherz C, Touchstone J, Moate TF, Allen EH, Kissel JC. Strategies for assessing children’s organophosphorus pesticide exposures in agricultural communities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Suppl 2):662-671. |
R831709 (2005) R825171 (2000) R826886C004 (2001) |
|
|
|
Fenske RA, Kedan G, Lu C, Fisker-Andersen JA, Curl CL. Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State. Journal of Exposure Analysis and Environmental Epidemiology 2002;12(1):21-8. |
R831709 (2005) |
not available |
|
|
Fenske RA, Lu C, Barr D, Needham L. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington state. Environmental Health Perspectives 2002;110(5):549-553. |
R831709 (2005) |
not available |
|
|
Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children’s pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. |
R831709 (2005) R827027 (2002) R828609 (Final) R831710 (2004) R831710 (2005) R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R832141 (2006) |
|
|
|
Fenske RA, Lu C, Curl CL, Shirai JH, Kissel JC. Biologic monitoring to characterize organophosphorus pesticide exposure among children and workers: an analysis of recent studies in Washington State. Environmental Health Perspectives 2005;113:1651-7. |
R831709 (2005) |
not available |
|
|
Figueroa-Masot XA, Hetman M, Higgins MJ, Kokot N, Xia Z. Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation. The Journal of Neuroscience 2001;21(13):4657-4667. |
R831709 (2005) |
not available |
|
|
Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). NeuroToxicology 2000;21(1-2):91-100. |
R831709 (2005) R826886C002 (2000) R826886C002 (2001) |
|
|
|
Furlong CE. PON1 status and neurologic symptom complexes in Gulf War veterans. Genome Research 2000;10(2):153-5. |
R831709 (2005) |
not available |
|
|
Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG. The PON1 gene and detoxication. NeuroToxicology 2000;21(4):581-587. |
R831709 (2005) R826886C002 (2001) |
|
|
|
Furlong CE, Li W-F, Shih DM, Lusis AJ, Richter RJ, Costa LG. Genetic factors in susceptibility:serum PON1 variation between individuals and species. Human and Ecological Risk Assessment 2002;8(1):31-43. |
R831709 (2005) R826886C002 (2002) |
|
|
|
Furlong CE, Cole TB, Arndt T, Shih D, Tward A, Lusis A, Costa L. Organophosphate toxicity in mice expressing the human 192R or 192Q isoforms of paraoxonase (PON1). Toxicological Sciences 2002;66:35. |
R831709 (2005) |
not available |
|
|
Furlong CE, Cole TB, Jarvik GP, Costa LG. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenomics 2002;3(3):341-348. |
R831709 (2005) R826886C002 (2002) |
|
|
|
Furlong CE, Rieder MJ. New polymorphisms in the human paraoxonase (PON1) gene. Toxicology Science 2003;72(Suppl 1):100. |
R831709 (2005) |
not available |
|
|
Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG. Paraoxonase 1 (PON1) status and risk of insecticide exposure. Journal of Biochemical and Molecular Toxicology 2005;19(3):182-183. |
R831709 (2005) R831709C002 (2005) |
not available |
|
|
Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward DA, Lusis JA, Costa LG. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology 2005;26(4):651-659. |
R831709 (2005) R831709C002 (2004) |
not available |
|
|
Furlong CE, Holland N, Richter RJ, Bradman A, Ho A, Eskenazi B. PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity. Pharmacogenetics and Genomics 2006;16(3):183-190. |
R831709 (2005) R831709 (2006) R831709C002 (2006) R831710 (2004) R831710 (2005) |
|
|
|
Furlong C. Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds. Journal of Biochemical and Molecular Toxicology 2007;21(4):197-205. |
R831709 (2005) |
not available |
|
|
Garlock TJ, Shirai JH, Kissel JC. Adult responses to a survey of soil contact-related behaviors. Journal of Exposure Analysis and Environmental Epidemiology 1999;9(2):134-42. |
R831709 (2005) |
not available |
|
|
Garry MR, Sidhu JS. Differential modulation of stress and ubiquitination signaling pathways by Cadmium, H202, and serum withdrawal in cultrued mouse fibroblasts. Toxicologist 2003;72:311. |
R831709 (2005) |
not available |
|
|
Garry MR, Kavanagh TJ, Faustman EM, Sidhu JS, Liao R, Ware C, Vlieta PA, Deeb SS. Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stress. Free Radical Biology & Medicine 2008;44(6):1075-87. |
R831709 (2005) |
not available |
|
|
Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. Journal of Celluar Biology 2000;150(2):335-47. |
R831709 (2005) |
not available |
|
|
Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology 2007;219(2-3):181-189. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709C001 (2006) R831709C001 (2007) R831709C002 (2007) |
|
|
|
Gohlke JM, Griffith WC, Bartell SM, Lewandowski TA, Faustman EM. A computational model for neocortical neuronogenesis predicts ethanol-induced neocortical neuron number deficits. Developments in Neuroscience 2002;24:467-77. |
R831709 (2005) |
not available |
|
|
Gohlke JM, Griffith WC, Faustman EM. The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse. Developmental Brain Research 2004;151(1-2):43-54. |
R831709 (2005) R831709C001 (2004) |
not available |
|
|
Gohlke JM, Griffith WC, Faustman EM. A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. Toxicology Science 2005;86:470-84. |
R831709 (2004) R831709 (2005) R831709C001 (2005) |
not available |
|
|
Gohlke JM, Griffith WC, Faustman EM. Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human. Cerebral Cortex 2007;17(10):2433-2442. |
R831709 (2005) R831709 (2007) |
|
|
|
Gohlke J, Griffith W. Evaluation of interspecies variability during neocortical neurogenesis using biologically based computational models. Toxicologist 2003;72: 179. |
R831709 (2005) |
not available |
|
|
Goldstein BD, Erdal S, Burger J, Faustman E. Stakeholder participation: Experience from the CRESP program. Environmental Epidemiology and Toxicology2000; 2: 103-111. |
R831709 (2005) |
not available |
|
|
Gribble E, Mendoza A. Evaluation of cell cycle kinetics in p53 mouse embryonal fibroblasts: Effects of methylmercury. Toxicologist 2003; 72(322). |
R831709 (2005) |
not available |
|
|
Gribble E, Hong S. Kinetic and dynamic characterization of a mouse embryonal mesencephalon neuronal precursor cell culture. Birth Defects Research. Part A, Clinical Molecular Teratology 2005;73(5): 301. |
R831709 (2005) |
not available |
|
|
Griffith W, Gohlke J. Building BBDR models for cell signaling pathways using transgenic animal models. Toxicologist 2003;72: 182. |
R831709 (2005) |
not available |
|
|
Griffith W, DeFrank N. Systems biology models for integration of diverse studies of the developing neocortex after exposure to low dose radiation from external and internal sources. Toxicologist 2006;90: 336. |
R831709 (2005) |
not available |
|
|
Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 2005;215(3):182-190. |
R831709 (2005) R831709 (2006) R831709C001 (2005) R831709C001 (2006) R831709C002 (2006) |
|
|
|
Hetman M, Kanning K, Cavanaugh JE, Xia Z . Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular-signal-regulated kinase and phosphatidylinositol-3 kinase. Journal of Biological Chemistry1999; (274): 22569-22580. |
R831709 (2005) |
not available |
|
|
Hetman M, Cavanaugh JE, Kimelman D, Xia Z. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. The Journal of Neuroscience2000; 20(7):2567-2574. |
R831709 (2005) |
not available |
|
|
Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. Journal of Biological Chemistry 277(51):49577-84. |
R831709 (2005) |
not available |
|
|
Holland N, Furlong C, Bastaki M, Richter R, Bradman A, Huen K, Beckman K, Eskenazi B. Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns. Environmental Health Perspectives 2006;114(7):985-991. |
R831709 (2005) R831709 (2006) R831709C002 (2006) R831710 (2004) R831710 (2005) R832734 (2006) |
|
|
|
Hong S, Sidhu J. Refinement of high-throughput 2D-Page technique for the evaluation of ubiquitin-conjugated protein status induced by developmental toxicants. Toxicologist 2003;72: 732. |
R831709 (2005) |
not available |
|
|
Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R831709 (2005) R831709C003 (2005) R831709C003 (2006) R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) R831710 (2004) R831710 (2005) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
|
|
|
Jarvik GP, Rozek LS, Brophy VH, Hatsukami TS , Richter RJ, Schellenberg GD, Furlong CE. Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arteriosclerosis, Thrombosis, and Vascular Biology2000; 20(11): 2441-7. |
R831709 (2005) |
not available |
|
|
Jarvik GP, Jampsa R, Richter RJ, Carlson CS, Rieder MJ, Nickerson DA, Furlong CE. Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status. Pharmacogenetics 2003;13(5):291-295. |
R831709 (2005) R831709C002 (2004) |
not available |
|
|
Judd NL, Griffith WC, Kalman DA, Faustman EM. A value of information assessment for congener specific analytical techniques for PCBs: do they meet risk assessment needs?Toxicologist2001; 60(1): 256. |
R831709 (2005) |
not available |
|
|
Judd NL, Griffith WC, Ylitalo GM, Faustman EM. Alternative strategies for PCB risk reduction from contaminated seafood: options for children as susceptible populations. Bulletin of Environmental Contaminantion and Toxicology 2002;69:847-54. |
R831709 (2005) |
not available |
|
|
Judd NL, Griffith WC. Evaluation of TEQ Exposure from Fish Consumption Relative to Average Population Total Exposure: Implications for PCB, PCDF, and PCDD Risk Management. Toxicologist 2002; 66(1-5): 105. |
R831709 (2005) |
not available |
|
|
Judd NL, Griffith WC, Takaro T, Faustman EM. A model for optimization of biomarker testing frequency to minimize disease and cost: example of beryllium sensitization testing. Risk Analysis2003; 23(6): 1211-20. |
R831709 (2005) |
not available |
|
|
Judd NL, Griffith WC, Kalman DA, Faustman EM. Assessment of PCB congener analytical methods: do they meet risk assessment needs? Archives of Environmental Contamination and Toxicology2003; 44(1):132-9. |
R831709 (2005) |
not available |
|
|
Judd NL, Karr JR, Griffith WC, Faustman EM. Challenges in defining background levels for human and ecological risk assessments.Human and Ecological Risk Assessment2003; 9(7): 1623-1632. |
R831709 (2005) |
not available |
|
|
Judd NL, Griffith WC, Faustman EM. Consideration of cultural and lifestyle factors in defining susceptible populations for environmental disease. Toxicology2004; 198(1-3): 121-133. |
R831709 (2005) |
not available |
|
|
Judd N, Griffith WC, Faustman EM. Contribution of PCB exposure from fish consumption to total dioxin-like dietary exposure. Regulatory Toxicology and Pharmacology 2004;40:125-35. |
R831709 (2005) |
not available |
|
|
Kelada SN, Stapleton PL, Farin FM, Bammler TK, Eaton DL, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT Jr, Checkoway H. Glutathione S-transferase M1, T1, and P1 polymorphisms and Parkinson's disease. Neuroscience Letters 2003;337:5-8. |
R831709 (2005) |
not available |
|
|
Kissel JC, Curl CL, Kedan G, Lu C, Griffith W, Barr DB, Needham LL, Fenske RA. Comparison of organophosphorus pesticide metabolite levels in single and multiple daily urine samples collected from preschool children in Washington State. Journal of Exposure Analysis and Environmental Epidemiology 2005;15:164-71. |
R831709 (2005) |
not available |
|
|
Kissel J, Kedan G. Attempted reconcilliation of predicted children's exposures to organophosphate pesticides with measured metabolite levels in urine.Epidemiology1999;10(4). |
R831709 (2005) |
not available |
|
|
Koch D, Lu CS, Fisker-Andersen J, Jolley L, Fenske RA. Temporal association of children's pesticide exposure and agricultural spraying: Report of a longitudinal biological monitoring study. Environmental Health Perspectives 2002;110(8):829-833. |
R831709 (2005) R825171 (2000) |
not available |
|
|
Koo B, Gaydos TM, Pandis SN. Evaluation of the equilibrium, dynamic, and hybrid aerosol modeling approaches. Aerosol Science And Technology. 2003;37:53-64. |
R831709C003 (2004) R826371 (Final) R826371C005 (Final) |
not available |
|
|
Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch R, Griffith E, Hu L, Haddad C, Xia Z, Greenberg M. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events.Nueron2002; 34: 221-233. |
R831709 (2005) |
not available |
|
|
Latowsky G. Report: Community-based, participatory research in Lawrence, Massachusetts, flags environmental health hazards and fuels education and action. Science Communication 2003;25(2):204-208. |
R831709 (2006) |
|
|
|
Lewandowski TA, Pierce CH, Pingree SD, Hong S, Faustman EM. Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis.Teratology2002; 66(5): 235-41. |
R831709 (2005) |
not available |
|
|
Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis. Developmental Brain Research 2003;141(1-2):117-128. |
R831709 (2005) R831709C001 (2004) |
not available |
|
|
Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis: potential cross-species differences and implications for risk assessment. Toxicological Sciences 2003;75(1):124-133. |
R831709 (2005) R831709C001 (2004) |
not available |
|
|
Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. Catalytic efficiency determines the in- vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics 2000;10(9):767-779. |
R831709 (2005) R826886C002 (2000) R826886C002 (2001) |
|
|
|
Little SA, Mirkes PE. Teratogen-induced activation of caspase-9 and the mitochondrial apoptotic pathway in early postimplantation mouse embryos. Toxicology and Applied Pharmacology2002; 181(2): 142-51. |
R831709 (2005) |
not available |
|
|
Lu CS, Knutson DE, Fisker-Andersen J, Fenske RA. Biological monitoring survey of organophosphorus pesticide exposure among preschool children in the Seattle metropolitan area. Environmental Health Perspectives 2001;109(3):299-303. |
R831709 (2005) R825171 (2000) |
not available |
|
|
Lu C, Fenske RA. Dermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications. Environmental Health Perspectives 1999;107(6):463-467. |
R831709 (2005) R826886C004 (2001) |
|
|
|
Lu C, Fenske RA, Simcox NJ, Kalman D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environmental Research 2000;84(3):290-302. |
R831709 (2005) R826886C004 (2001) |
|
|
|
Luderer U, Diaz D, Faustman EM, Kavanagh TJ. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Molecular Reproduction and Development2003;65(3): 254-61. |
R831709 (2005) |
not available |
|
|
Mendoza MAC, Ponce RA, Ou YC, Faustman EM. p21(WAF1/CIP1) inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. Toxicology and Applied Pharmacology2002; 178(2): 117-25. |
R831709 (2005) |
not available |
|
|
Mirkes PE, Little SA. Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. Cell Death & Differentiation1998; 5(7): 592-600. |
R831709 (2005) |
not available |
|
|
Mirkes PE, Cornel LM, Wilson KL, Dilmann WH. Heat shock protein 70 (Hsp70) protects postimplantation murine embryos from the embryolethal effects of hyperthermia. Development Dynamics1999; 214(2): 159-70. |
R831709 (2005) |
not available |
|
|
Mirkes PE, Little SA. Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicology and Applied Pharmacology 2000;162(3):197-206. |
R831709 (2005) R826886C001 (2001) |
|
|
|
Mirkes PE, Wilson KL, Cornel LM. Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos. Teratology 2000;62(1):14-25. |
R831709 (2005) R826886C001 (2001) |
|
|
|
Mirkes PE. 2001 Warkany lecture: to die or not to die, the role of apoptosis in normal and abnormal mammalian development. Teratology2002; 65(5): 228-39. |
R831709 (2005) |
not available |
|
|
Moate TF, Lu C, Fenske RA, Hahne RMA, Kalman DA. Improved cleanup and determination of dialkyl phosphates in the urine of children exposed to organophosphorus insecticides. Journal of Analytical Toxicology 1999;23(4):230-236. |
R831709 (2005) R825171 (1999) R825171 (2000) R826886C004 (2001) |
|
|
|
Moate TF, Furia M, Curl C, Muniz JF, Yu J, Fenske RA. Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust. Journal of AOAC International 2002;85(1):36-43. |
R831709 (2005) R826886C004 (2001) R826886C004 (2002) |
|
|
|
Namgung U, Xia Z. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. The Journal of Neuroscience2000; 20(17): 6442-6451. |
R831709 (2005) |
not available |
|
|
Namgung U, Xia Z. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicology and Applied Pharmacology 2001;174(2):130-138. |
R831709 (2005) R826886C001 (2002) |
|
|
|
Ou YC, Thompson SA, Ponce RA, Shroeder J, Kavanagh TJ, Faustman EM. Induction of the cell cycle regulatory gene, p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicology and Applied Pharmacology 1999;157:203-212. |
R831709 (2005) R825358 (Final) |
not available |
|
|
Ou YC, White CC, Krejsa, CM, Ponce RA, Kavanagh TJ, Faustman EM. The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. Neurotoxicology, Volume 20, Issue 5, October 1999, Pages 793-804. |
R831709 (2005) R825358 (Final) |
not available |
|
|
Ou Y, Thompson S. The role of glutathione in methylmercury-induced toxicity in primary rodent embryonic cells. Toxicology and Applied Pharmacology 1999;157(3): 203-212. |
R831709 (2005) |
not available |
|
|
Polifka JE, Faustman EM, Neil N. Weighing the risks and the benefits: a call for the empirical assessment of perceived teratogenic risk. Reproductive Toxicology1997;11(4): 633-40. |
R831709 (2005) |
not available |
|
|
Polifka JE, Faustman EM. Developmental toxicity: web resources for evaluating risk in humans. Toxicology 2002;173:35-65. |
R831709 (2005) |
not available |
|
|
Ponce RA, Bartell SM, Wong EY , LaFlamme D , Carrington C , Lee RC , Patrick DL, Faustman EM, Bolger M. Use of quality-adjusted life year weights with dose response models for public health decisions: A case study of the risks and benefits of fish consumption. Risk Analysis2000; 20: 529-542. |
R831709 (2005) |
not available |
|
|
Ponce RA, Wong EY, Faustman EM. Quality adjusted life years (QALYs) and dose response models in environmental health policy analysis-methodological considerations.Science of the Total Environment2001;274(1-3): 79-91. |
R831709 (2005) |
not available |
|
|
Poser S, Impey S, Trinh K, Xia Z, Storm DR. SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation.The EMBO Journal2000; 19(18): 4955-66. |
R831709 (2005) |
not available |
|
|
Ramaprasad J, Tsai M-Y, Elgethun K, Hebert VR, Felsot A, Yost MG, Fenske RA. The Washington aerial spray drift study: assessment of off-target organophosphorus insecticide atmospheric movement by plant surface volatilization. Atmospheric Environment 2004;38(33):5703-5713. |
R831709 (2005) R831709C004 (2004) |
not available |
|
|
Richter RJ, Furlong CE. Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics1999; 9(6): 745-53. |
R831709 (2005) |
not available |
|
|
Sanga RN , Bartell SM, Ponce RA, Boischio A, Joiris CR, Pierce CH, Faustman EM. Effects of uncertainties on exposure estimates to methylmercury: A Monte Carlo analysis of biomarkers of exposure vs. predictive dietary estimation. Risk Analysis 2001;(21): 5. |
R831709 (2005) |
not available |
|
|
Sidhu JS, Ponce RA, Vredevoogd MA, Yu X, Gribble E, Hong S-W, Schneider E, Faustman EM. Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Toxicological Sciences 2006;89(2):475-484. |
R831709 (2005) R831709 (2006) R831709C001 (2005) R831709C001 (2006) |
|
|
|
Sidhu J, Hong S. Methylmercury induces differential ubiquitin conjugated protein levels in p53 variant mouse embryonal biroblasts. Toxicologist 2003;72: 323. |
R831709 (2005) |
not available |
|
|
Snipes SA, Thompson B, O’Connor K, Godina R, Ibarra G. Anthropological and psychological merge: design of a stress measure for Mexican farmworkers. Culture, Medicine and Psychiatry2007; 31(3): 359-88. |
R831709 (2005) |
not available |
|
|
Stevens RC, Soelberg SD, Eberhart BT, Spencer S, Wekell JC, Chinowsky TM, Trainer VL, Furlong CE. Detection of the toxin domoic acid from clam extracts using a portable surface plasmon resonance biosensor. Harmful Algae2007;6(2): 166-174. |
R831709 (2005) |
not available |
|
|
Strong LL, Thompson B, Coronado GD, Griffith WC, Vigoren EM, Islas I. Health symptoms and exposure to organophosphate pesticides in farmworkers. American Journal of Industrial Medecine 2004;46:599-606. |
R831709 (2005) R831709C003 (2004) |
not available |
|
|
Strong LL, Thompson B, Koepsell TD, Meischke H. Factors associated with pesticide safety practices in farmworkers. American Journal of Industrial Medicine 2008;51(1):69-81. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709C003 (2006) |
|
|
|
Strong LL, Thompson B, Koepsell TD, Meischke H. Factors associated with pesticide safety practices in farmworkers. American Journal of Industrial Medicine 2008;51(1):69-81. |
R831709C003 (2007) |
|
|
|
Takaro T, Griffith W. Asbestos and radiation as combined exposures in pulmonary fibrosis. Toxicologist 2003;72: 220. |
R831709 (2005) |
not available |
|
|
Thompson B, Coronado G, Puschel K, Allen E. Identifying constituents to participate in a project to control pesticide exposure in children of farmworkers. Environmental Health Perspectives 2001;109(Suppl 3):443-448. |
R831709 (2005) R826886C003 (2001) R826886C003 (2002) R826886C004 (2001) R826886C004 (2002) |
|
|
|
Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, Curl CL, Shirai JH, Kissel JC, Fenske RA. Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. Journal of Occupational and Environmental Medicine 2003;45(1):42-53. |
R831709 (2005) R831709C003 (2004) R826886C003 (2002) |
|
|
|
Thompson B, Coronado GD, Vigoren EM, Griffith WC, Fenske RA, Kissel JC, Shirai JH, Faustman EM. Para ninos saludables: a community intervention trial to reduce organophosphate pesticide exposure in children of farmworkers.Environmental Health Perspectives 2008;116(5):687-694. |
R831709 (2005) R831709C003 (2007) |
|
|
|
Tiffany-Castiglioni E, Venkratraj V, Qian Y. Genetic polymorphisms and mechanisms of neurotoxicity: overview. Neurotoxicology 2005;26(4):641-649. |
R831709C002 (2004) |
not available |
|
|
Tsai M-Y, Elgethun K, Ramaprasad J, Yost MG, Felsot AS, Hebert VR, Fenske RA. The Washington aerial spray drift study:modeling pesticide spray drift deposition from an aerial application. Atmospheric Environment 2005;39(33):6194-6203. |
R831709 (2005) R831709C004 (2005) R831709C004 (2006) |
|
|
|
Umpierre CC, Little SA, Mirkes PE. Co-localization of active caspase-3 and DNA fragmentation (TUNEL) in normal and hyperthermia-induced abnormal mouse development. Teratology 2001;63(3):134-143. |
R831709 (2005) R826886C001 (2001) R826886C001 (2002) |
|
|
|
Weppner S, Elgethun K, Lu C, Herbert V, Yost MG, Fenske RA. The Washington aerial spray drift study: children's exposure to methamidophos in an agricultural community following fixed-wing aircraft applications. Journal of Exposure Science and Environmental Epidemiology 2006;16(5):387-396. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709C004 (2006) R831709C004 (2007) |
|
|
|
Wong EY, Shirai JH, Garlock TJ, Kissel JC. Adult proxy responses to a survey of children's dermal soil contact activities.Journal of Exposure Analysis and Environmental Epidemiology2000; 10(6 Pt 1):509-17. |
R831709 (2005) |
not available |
|
|
Wong EY, Shirai JH, Garlock TJ, Kissel JC . Survey of selected activities relevant to exposures to soils.Bulletin of Environmental Contamination and Toxicology2000; 65(4): 443-50. |
R831709 (2005) |
not available |
|
|
Wong EY, Farrow S. Examination of health toxicity data with application to benefit-cost analysis of environmental health policy. Toxicologist 2002;66(1-5): 100. |
R831709 (2005) |
not available |
|
|
Wong EY, Ponce RA, Farrow S, Bartell SM, Lee RC, Faustman EM. Comparative risk and policy analysis in environmental health. Risk Analysis 2003;23:1337-49. |
R831709 (2005) |
not available |
|
|
Wong EY, Gohlke J, Griffith WC, Farrow S, Faustman EM. Assessing the health benefits of air pollution reduction for children. Environmental Health Perspectives 2004;112:226-32. |
R831709 (2005) |
not available |
|
|
Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, Holland NT. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. NeuroToxicology 2005;26(2):199-209. |
R831709 (2005) R831709 (2006) R831709C002 (2004) R831709C002 (2006) R831710 (2004) R831710 (2005) |
|
|
|
Yu X, Sidhu JS, Hong S, Faustman EM. Essential role of extracellular matrix (ECM) overlay in establishing the functional integrity of primary neonatal rat Sertoli cell/gonocyte co-cultures: an improved in vitro model for assessment of male reproductive toxicity. Toxicology Science 2005;84:378-93. |
R831709 (2005) |
not available |
|
|
Yu X, Griffith WC, Hanspers K, Dillman III JF, Ong H, Vredevoogd MA, Faustman EM. A system-based approach to interpret dose-and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences 2006;92(2):560-577. |
R831709 (2005) R831709 (2006) R831709C001 (2006) R832733 (2007) |
|
|
|
Yue TL, Ni J, Romanic AM, Gu JL, Keller P, Wang C, Kumar S, Yu GL, Hart TK, Wang X, Xia Z, DeWolf WE, Feuerstein GZ. TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease. Journal of Biological Chemistry 1999;274(3): 1479-1486. |
R831709 (2005) |
not available |
|
|
Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons.Journal of Biological Chemistry2002; 277(25):22909-22914. |
R831709 (2005) |
not available |
|
|
Kelada SN, Costa-Mallen P, Checkoway H, Viernes HA, Farin FM, Smith-Weller T, Franklin GM, Costa LG, Longstreth Jr. WT, Furlong CE, Javrik GP, Swanson PD. Paraoxonase 1 promoter and coding region polymorphisms in Parkinson’s disease. Journal of Neurology Neurosurgery and Psychiatry 2003;74(4):546-547. |
R831709 (2005) R831709C002 (2004) |
not available |
|
|
Gribble EJ, Hong S-W, Faustman EM. The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53 dependent. Birth Defects Research Part A: Clinical and Molecular Teratology 2005;73(1):29-38. |
R831709 (2005) R831709C001 (2004) |
not available |
Geographic Area, Health, RFA, Scientific Discipline, Biochemistry, Children's Health, Environmental Chemistry, Epidemiology, Health Risk Assessment, Risk Assessments, State, Human Health Risk Assessment, Washington (WA), agricultural community, assessment of exposure, children, children's environmental health, children's vulnerablity, developmental disorders, developmental effects, developmental neurotoxicity, developmental neurotoxicology, developmental toxicity, environmental health, environmental health hazard, epidemelogy, epidemeology, exposure, exposure assessment, farm worker, growth & development, harmful environmental agents, health effects, human exposure, human health risk, insecticides, neurotoxicity, organophosphate pesticides, pesticide exposure,
,
ENVIRONMENTAL MANAGEMENT, Scientific Discipline, Health, RFA, Risk Assessment, Health Risk Assessment, Children's Health, Biochemistry, Environmental Chemistry, health effects, children's environmental health, assessment of exposure, developmental neurotoxicity, agricultural community, community-based intervention, pesticide exposure, genetic polymorphisms, biological response, environmental health, environmental risks, children's vulnerablity
Progress and Final Reports:
2004 Progress Report
2005 Progress Report
2006 Progress Report
2007 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831709C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
R831709C002 Genetic Susceptibility to Pesticides
R831709C003 Community-Based Participatory Research Project
R831709C004 Pesticide Exposure Pathways Research Project