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A Community-Based Participatory Research Project: CHAMACOS
EPA Grant Number: R831710C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R831710
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: University of California Berkeley Center for Children’s Environmental Health Research
Center Director: Eskenazi, Brenda
Title: A Community-Based Participatory Research Project: CHAMACOS
Investigators: Eskenazi, Brenda , Alkon, Abbey , Boyce, Thomas , Cuevas, Maximiliano , Johnson, Caroline , Lipsett, Michael , Macher, Janet , Minkler, Meredith , Sedgwick, Jaqueline , Tager, Ira , Tunzi, Mark
Current Investigators: Eskenazi, Brenda
Institution: University of California - Berkeley
EPA Project Officer: Fields, Nigel
Project Period: May 1, 2004 through October 31, 2008
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Health Effects , Children's Health
Description:
Objective:The Community-Based Prevention Research (CBPR) component of the Center is the CHAMACOS birth cohort study of the potential health effects of pesticide and allergen exposures to pregnant women and their children. The specific aims of the project are to determine whether organophosphate pesticide exposure in utero and/or during the postnatal period is associated at preschool and school-age with: 1) poorer neurodevelopment and behavioral performance; 2) slower somatic growth; 3) atopy, active asthma or asthma-like symptoms, and airway reactivity; and, 4) autonomic nervous system dysfunction. We are also investigating the relationship between environmental antigens and respiratory outcomes in our populations.
Approach:OP exposure will be defined by levels of six non-specific OP metabolites measured in urine collected from mothers at enrollment, 26-weeks gestation, and postpartum, and from children at 6-, 12-, 24-, 42-, and 60-months of age. Exposures related to respiratory outcomes will be assessed by home inspection, questionnaire, and, for a subset of children, measurements of allergens and endotoxin in children’s homes. We will assess growth and perform a battery of neuropsychological assessments (e.g., cognition, memory, attention, motor) of the children at 42- and 60-months, and obtain teacher and parent evaluation of behavior and school performance at 84-months. We will assess respiratory health by questionnaire, medical record review, blood analysis of IgE and Th1 and Th2 cytokines, and tests of lung function and airway reactivity at 60-months.
Expected Results:This research will enhance our knowledge of the health and development of these hard-to-reach low-income Latino children living in agricultural areas and provide critical information on the health effects of organophosphate pesticide exposure to children for the U.S. Environmental Protection Agency’s implementation of the Food Quality Protection Act.
Publications and Presentations:Publications have been submitted on this subproject: View all 16 publications for this subproject | View all 114 publications for this center
Journal Articles:Journal Articles have been submitted on this subproject: View all 7 journal articles for this subproject | View all 65 journal articles for this center
Supplemental Keywords:endocrine disruptor, wheeze, neurodevelopment, ANS, FQPA, organophosphate,
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HUMAN HEALTH, ENVIRONMENTAL MANAGEMENT, Scientific Discipline, Health, RFA, PESTICIDES, Health Effects, Risk Assessment, Health Risk Assessment, Children's Health, Pesticide Types, exposure assessment, insecticides, allergen, respiratory problems, children's environmental health, assessment of exposure, childhood respiratory disease, outreach and education, agricultural community, community-based intervention, pesticide exposure, airway disease, environmental risks, environmental health hazard, asthma
Progress and Final Reports:
2004 Progress Report
2005 Progress Report
Main Center Abstract and Reports:
R831710 University of California Berkeley Center for Children’s Environmental Health Research
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831710C001 A Community-Based Participatory Research Project: CHAMACOS
R831710C002 Pesticide Exposure Assessment Project
R831710C003 Mechanisms of Pesticide Neuro and Immunotoxicity in Children Project
R831710C004 Community Outreach and Translation Core