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Inner City Toxicants and Neurodevelopmental Impairment
EPA Grant Number: R827039Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Center Director: Wolff, Mary S.
Title: Inner City Toxicants and Neurodevelopmental Impairment
Investigators: Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Fields, Nigel
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Amount: $3,136,392
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects
Description:
Objective:Environmental Toxicants and Neuro-Developmental Impairment in Inner City Children is the unifying scientific theme of the Mount Sinai Center for Children's Environmental Health and Disease Prevention Research. This Center resides within the Department of Community and Preventive Medicine, in the Division of Environmental Health Science.
Children living in poverty in inner-city communities suffer some of the heaviest exposures to environmental toxicants in the United States. The goals of the Mount Sinai Center for Children's Environmental Health and Disease Prevention Research are (1) to identify linkages between environmental toxicants and neuro-developmental dysfunction in inner-city children; (2) to elucidate the pathogenic mechanisms by which environmental toxicants can cause developmental impairment; and (3) to prevent neuro-developmental dysfunction of environmental origin in urban children.
The research and prevention programs of the Center will focus on a range of neurodevelopmental toxicants encountered in the inner city: (1) pesticides-legal insecticides such as chlorpyrifos, and illegal "street" pesticides such as methyl Darathion. tres pasitos and tiza china; (2) polychlorinated biphenyls (PCBs); and (3) lead. Patterns of exposure to these toxicants will be assessed. Adverse developmental outcomes will be examined through epidemiological studies and will include loss of intelligence, delayed attainment of developmental milestones, alteration of behavior and diminished life achievement; potential linkages of these problems to environmental exposures will be studied and etiologic mechanisms elucidated. New aDDroaches to prevention will be evaluated.
The Center includes five interdisciplinary research projects that link epidemiological and basic biological research at the Mount Sinai Medical Center and the New York Academy of Medicine's Center of Urban Epidemiologic Studies with the Boriken Neighborhood Health Center, with the East Harlem Community Health Committee and with an extensive network of community-based organizations in East Harlem.
Journal Articles: 7 Displayed | Download in RIS Format
| Other center views: | All 13 publications | 8 publications in selected types | All 7 journal articles |
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Berkowitz GS, Wolff MS, Matte T, Susser E, Landrigan PJ. The rationale for a national prospective cohort study of environmental exposure and childhood development. Environmental Research 2001;85(2):59-68. |
R827039 (2002) R827039C004 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, Landrigan PJ, Wolff MS. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environmental Health Perspectives 2003;111(1):79-84. |
R827039 (2002) R827039C004 (2002) R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Chen J, Germer S, Higuchi R, Berkowitz G, Godbold J, Wetmur JG. Kinetic polymerase chain reaction on pooled DNA: a high-throughput, high-efficiency alternative in genetic epidemiological studies. Cancer Epidemiology, Biomarkers & Prevention 2002;11(1):131-136. |
R827039 (2002) R827039C001 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Gore AC. Environmental toxicant effects on neuroendocrine function. Endocrine 2001;14(2):235-246. |
R827039 (2002) R827039C002 (2002) R831711 (2005) R831711 (2007) R831711C001 (2006) R831711C003 (2006) |
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Gore AC, Wu TJ, Oung T, Lee JB, Woller MJ. A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone (GnRH) neurones. Journal of Neuroendocrinology 2002;14(10):814-823. |
R827039 (2002) R827039C002 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Gore AC. Organochlorine pesticides directly regulate gonadotropin-releasing hormone (GnRH) gene expression and biosynthesis in the GT1-7 hypothalamic cell line. Molecular and Cellular Endocrinology 2002;192(1-2):157-170. |
R827039 (2002) R827039C002 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Claudio L, Markowitz SB, Berkowitz GS, Brenner BL, Romero H, Wetmur JG, Matte TD, Gore AC, Godbold JH, Wolff MS. Pesticides and inner-city children: exposures, risks, and prevention. Environmental Health Perspectives 1999;107(Suppl 3):431-437. |
R827039 (2002) R827039C002 (2002) R827039C003 (2000) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2004) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Toxics, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, genetic susceptability, Epidemiology, Children's Health, pesticides, environmentally caused disease, environmental hazard exposures, neurodevelopmental toxicity, respiratory problems, urban air, children's environmental health, lead, assessment of exposure, childhood respiratory disease, human health risk, PCBs, susceptibility, developmental neurotoxicity, childhood lead exposure, pesticide exposure, environmental health, lead exposure, developmental lead exposure, airway disease, children, environmental risks, age dependent response, growth & development, children's vulnerablity, health risks, human exposure, Human Health Risk Assessment
Progress and Final Reports:
2000 Progress Report
2002 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides