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Centers of Excellence in Children's Environmental Health and Disease Prevention Research
EPA Grant Number: R827027Center: CECEHDPR - Columbia University School of Public Health
Center Director: Perera, Frederica P.
Title: Centers of Excellence in Children's Environmental Health and Disease Prevention Research
Investigators: Perera, Frederica P.
Institution: Columbia University
EPA Project Officer: Fields, Nigel
Project Period: August 1, 1998 through July 31, 2003 (Extended to October 31, 2004)
Project Amount: $3,136,357
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects
Description:
Objective:The mission of the Columbia Center for Children's Environmental Health (CCCEH) is to undertake a comprehensive community-based assessment of environmental risks to infants and children, and to develop strategies for reducing, and ultimately preventing, those risks. The Center is responsive to the urgent health needs of the minority communities in Northern Manhattan and the South Bronx, which suffer uniquely high rates of asthma, adverse birth outcomes, impaired development, and other diseases. These communities also have disproportionately heavy exposure to environmental pollutants, which may contribute to these adverse health outcomes. Community participation is an integral component of both the Center's organizational structure and its research projects. We anticipate that research results will aid the development of community-based strategies to reduce and ultimately prevent asthma and developmental impairment in the target population, and will have implications for the control of these health risks in other inner-city, minority communities. Thus, the Center is responsive to the need for environmental justice. The Center utilizes an innovative approach -molecular epidemiology - to answer questions regarding environmental impacts on children's health. Biomarkers will be used in conjunction with questionnaires, individual exposure assessment, clinical evaluations, and quantitative measures of community-level risk factors to evaluate exposure, susceptibility, and risk from the environmental toxicants of concern, and to monitor the efficacy of intervention. The main hypotheses of the Center are that: 1) prenatal and postnatal environmental exposures to airborne particulate matter (PM), polycyclic aromatic hydrocarbons (PAH), environmental tobacco smoke (ETS), and home allergens (cockroach, house dust mite and rodent) increase the risk of asthma and/or developmental impairment in these disadvantaged communities; 2) inadequate nutritional status exacerbates the impact of these environmental toxicants; and 3) a community-based intervention to reduce these toxic exposures and improve nutritional status can reduce the risk of disease. To test these hypotheses and meet its objective, the Center is undertaking three interrelated research studies, all of which build on a prospective cohort of 400 African American and Dominican mothers and their newborn infants living in Washington Heights, Harlem and the South Bronx. The research studies (described in detail below) include projects that investigate the impact of environmental pollutants and allergens on: 1) growth and development; and 2) asthma. The third research study investigates the impact of community and home-based interventions to reduce toxicant and allergen exposure, as well as risk of asthma.
Journal Articles: 42 Displayed | Download in RIS Format
| Other center views: | All 67 publications | 42 publications in selected types | All 42 journal articles |
| Type | Citation | ||
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Adibi J, Whyatt RM, Camann DE, Peki K, Jedrychowski W, Perera FP. Personal air monitoring of phthalate diesters in two urban populations. Indoor Air, 2002. |
R827027 (2002) |
not available |
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Barr DB, Barr JR, Maggio VL, Whitehead RD Jr., Sadowski MA, Whyatt RM, Needham LL. A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high resolution mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2002;778(1-2):99-111. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Bocskay KA, Tang D, Orjuela MA, Liu X, Warburton DP, Perera FP. Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons. Cancer Epidemiology Biomarkers & Prevention 2005;14(2):506-511. |
R827027 (2002) R832141 (2006) R832141C001 (2005) |
not available |
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Bradman A, Whyatt RM. Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children’s Study: a review of monitoring and measurement methodologies. Environmental Health Perspectives 2005;113(8):1092-1099. |
R827027 (2002) R828609 (Final) R831710 (2004) R831710 (2005) R832141 (2006) |
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Carlton EJ, Moats HL, Feinberg M, Shepard P, Garfinkel R, Whyatt RM, Evans D. Pesticide sales in low-income, minority neighborhoods. Journal of Community Health 2004;29(3):231-244. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Chow JC, Watson JG, Chen LW, Ho SS, Koracin D, Zielinska B, Tang D, Perera F, Cao J, Lee SC. Exposure to PM2.5 and PAHs from the Tong Liang, China epidemiological study. Journal of Environmental Science and Health Part A-Toxic/Hazardous Substances & Environmental Engineering 2006;41:517-42. |
R827027 (2002) |
not available |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned from the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R827027 (2002) R826710 (Final) R829389 (2003) R829389 (2004) R829389 (2005) R831710 (2004) R831710 (2005) R831861 (2005) R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) R832141 (2006) |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829390 (2005) R831709 (2005) R831709C001 (2004) R831710 (2005) R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) R832141 (2005) |
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Evans DT, Fullilove MT, Green L, Levison M. Awareness of environmental risks and protective actions among minority women in Northern Manhattan. Environmental Health Perspectives 2002;110(S2):271-275. |
R827027 (2002) R832141 (2005) R832141 (2006) |
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Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children’s pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. |
R827027 (2002) R828609 (Final) R831709 (2005) R831710 (2004) R831710 (2005) R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R832141 (2006) |
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Fullilove MT. Links between the social and physical environments. Pediatric Clinics of North America, Review 2001;48(5):1253-1266. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R827027 (2002) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826710 (Final) R831845 (2005) R831861 (2004) R831861 (2005) R832141 (2006) |
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Goldstein IF, Perzanowski MS, Lendor C, Garfinkel RS, Hoepner LA, Chew GL, Perera FP, Miller RL. Prevalence of allergy symptoms and total IgE in a New York City cohort and their association with birth order. International Archives of Allergy and Immunology 2005;137:249-57. |
R827027 (2002) R832141 (2006) R832141C002 (2005) |
not available |
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Green L, Fullilove M, Evans D, Shepard P. “Hey, Mom, Thanks!”: Use of focus groups in the development of place-specific materials for a community environmental action campaign. Environmental Health Perspectives 2002;110(S2):265-269. |
R827027 (2002) R832141 (2005) R832141 (2006) |
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Kinney PL, Northridge ME, Correa JC, Gronning E, Joseph E, Prakash S, Goldstein I. On the front lines of environmental asthma intervention in NYC. American Journal of Public Health 2002;92(1):24-26. |
R827027 (2002) R832141 (2005) |
not available |
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Meyer IH, Whyatt RM, Perera FP, Ford JG. Risk for asthma in 1-year-old infants residing in New York City high-risk neighborhoods. Journal of Asthma 2003;40(5):545-550. |
R827027 (2002) R832141 (2005) |
not available |
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Miller RL, Chew GL, Bell CA, Biedermann SA, Aggarwal M, Kinney PL, Tsai W-Y, Whyatt RM, Perera FP, Ford JG. Prenatal exposure, maternal sensitization, and sensitization in utero to indoor allergens in an inner-city cohort. American Journal of Respiratory and Critical Care Medicine 2001;164(6):995-1001. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Miller RL, Garfinkel R, Horton M, Camann D, Pereral FP, Whyatt RM, Kinney PL. Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Chest 2004;126(4):1071-1078. |
R827027 (2002) R832141 (2006) R832141C002 (2004) |
not available |
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Perera FP, Whyatt RM, Jedrychowski W, Rauh V, Manchester D, Santella RM, Ottman R. Recent developments in molecular epidemiology: a study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland. American Journal of Epidemiology 1998;147(3):309-314. |
R827027 (2002) R832141 (2005) |
not available |
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Perera FP, Jedrychowski W, Rauh V, Whyatt RM. Molecular epidemiologic research on the effects of environmental pollutants on the fetus. Environmental Health Perspectives 1999;107(S3):451-460. |
R827027 (2002) R832141 (2005) |
not available |
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Perera FP. Molecular epidemiology: on the path to prevention? Journal of the National Cancer Institute 2000;92(8):602-612. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Perera FP, Weinstein IB. Molecular epidemiology: recent advances and future directions. Carcinogenesis 2000;21(3):517-524. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Perera FP, Illman SM, Kinney PL, Whyatt RM, Kelvin EA, Shepard P, Evans D, Fullilove M, Ford JG, Miller RL, Meyer IH, Rauh VA. The challenge of preventing environmentally related disease in young children: community-based research in New York City. Environmental Health Perspectives 2002;110(2):197-204. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Perera FP, Rauh V, Tsai WY, Kinney PL, Camann DE, Barr DB, Garfinkel R, Tu Y-H, Diaz D, Dietrich J, Whyatt RM. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multi-ethnic population. Environmental Health Perspectives 2003;111(2):201-205. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Perera FP, Tang D, Tu YH, Cruz LA, Borjas M, Bernert T, Whyatt RM. Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage. Environmental Health Perspectives 2004;112(10):1133-1136. |
R827027 (2002) R832141C001 (2005) |
not available |
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Perera FP, Rauh V, Whyatt RM, Tang D, Tsai WY, Bernert JT, Tu YH, Andrews H, Barr DB, Camann DE, Diaz D, Dietrich J, Reyes A, Kinney PL. A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures. Neurotoxicology 2005;26:573-587. |
R827027 (2002) R832141 (2006) |
not available |
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Perera FP, Rauh V, Whyatt RM, Tsai WY, Tang D, Diaz D, Hoepner L, Barr D, Tu YH, Camann D, Kinney P. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environmental Health Perspectives 2006;114(8):1287-1292. |
R827027 (2002) R832141 (2006) |
not available |
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Perera F, Tang DL, Whyatt R, Lederman SA, Jedrychowski W. DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center area, Poland, and China. Cancer Epidemiology Biomarkers & Prevention 2005;14(3):709-714. |
R827027 (2002) R832141 (2006) R832141C001 (2005) |
not available |
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Perzanowski MS, Miller RL, Thorne PS, Barr RG, Divjan A, Sheares B, Garfinkel R, Perera F, Goldstein I, Chew G. Endotoxin in inner-city homes: associations with wheeze and eczema in early childhood. Journal of Allergy and Clinical Immunology 2006;117(5):1082-1089. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Rauh VA, Andrews HF, Garfinkel RS. The contribution of maternal age to racial disparities in birthweight: a multi-level perspective. American Journal of Public Health 2001;91(11):1815-1824. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Rauh VA, Chew GL, Garfinkel RS. Deteriorated housing contributes to high cockroach allergen level in inner-city households. Environmental Health Perspectives 2002;110(S2):323-327. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Rauh VA, Whyatt RM, Garfinkel R, Andrews H, Hoepner L, Reyes A, Diaz D, Camaan D, Perera FP. Developmental effects of exposure to environmental tobacco smoke and material hardship among inner-city children. Neurotoxicology and Teratology 2004;26(3):373-385. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Rauh V. Benefits and limitations of common study designs. Reducing disparities in asthma care: Priorities for research. National Heart, Lung and Blood Institute Workshop, Bethesda, Maryland, January 2001. Journal of Allergy and Clinical Immunology. |
R827027 (2002) |
not available |
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Tonne CC, Whyatt RM, Camann DE, Perera FP, Kinney PL. Predictors of personal polycyclic aromatic hydrocarbon exposures among pregnant minority women in New York City. Environmental Health Perspectives 2004;112(6):754-759. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Wallace D, Wallace R, Rauh V. Community stress, demoralization and body mass index: evidence for social signal transduction. Social Science and Medicine 2003;56(12):2467-2478. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Wallace R, Wallace RG. Adaptive chronic infection, structured stress, and medical magic bullets: do reductionist cures select for holistic diseases? Biosystems 2004;77:93-108. |
R827027 (2002) R832141 (2006) |
not available |
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Whyatt RM, Perera FP, Jedrychowski W, Santella RM, Garte SJ, Bell DA. Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and Glutathione S-Transferase P1 and CYP1A1 polymorphisms. Cancer Epidemiology Biomarkers & Prevention 2000;9(2):207-212. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Whyatt RM, Jedrychowski W, Hemminki K, Santella RM, Tsai WY, Yong K, Perera FP. Biomarkers of polycyclic aromatic hydrocarbon-DNA damage and cigarette smoke exposures in paired maternal and newborn blood samples as a measure of differential susceptibility. Cancer Epidemiology Biomarkers and Prevention 2001;10(6):581-588. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Whyatt RM, Barr DB. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environmental Health Perspectives 2001;109(4):417-420. |
R827027 (2002) R832141 (2005) R832141 (2006) |
not available |
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Whyatt RM, Barr DB, Camann DE, Kinney PL, Barr JR, Andrews HF, Hoepner LA, Garfinkel R, Hazi Y, Reyes A, Ramirez J, Cosme Y, Perera FP. Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environmental Health Perspectives 2003;111(5):749-756. |
R827027 (2002) R828609 (2002) R828609 (2004) R828609 (Final) R832141 (2005) R832141 (2006) |
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Whyatt RM, Camann D, Perera FP, Rauh VA, Tang D, Kinney PL, Garfinkel R, Andrews H, Hoepner L, Barr DB. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicology and Applied Pharmacology 2005;206(2):246-254. |
R827027 (2002) R828609 (2004) R828609 (Final) R832141 (2005) R832141 (2006) |
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Perera FP, Tang D, Rauh VA, Lester K, Tsai WY, Tu YH, Weiss L, Hoepner L, King J, Del Priore G, Lederman SA. Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growth. Environmental Health Perspectives 2005;113(8):1062-1067. |
R827027 (2002) R832141 (2005) |
not available |
Economic, Social, & Behavioral Science Research Program, Air, Geographic Area, Scientific Discipline, Health, RFA, environmental justice, Risk Assessments, Disease & Cumulative Effects, Health Risk Assessment, Epidemiology, Ecological Risk Assessment, Children's Health, Biochemistry, particulate matter, Allergens/Asthma, State, inner city toxicants, Acute health effects, ambient air quality, indoor air quality, developmental toxicity, community based intervention, children's environmental health, environmental toxicant, hazardous environmental exposures, indoor environment, second hand smoke, childhood respiratory disease, environmental health effects, aersol particles, age-related differences, harmful environmental agents, human health risk, New York (NY), ambient particulates, epidemeology, risk and vulnerability, air pollutants, air toxics, community-based intervention, human health effects, particulates, sensitive populations, environmental health, air pollution, airborne pollutants, airway disease, children, environmental risks, environmental toxicants, epidemiological studies, tobacco smoke, lung disease, disease, exposure, urban environmental exposure, asthma, human exposure, PM, pulmonary disease, airway inflammation
Progress and Final Reports:
2002 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827027C001 Community-Based Intervention: Reducing Risks of Asthma
R827027C002 Growth and Development/Evaluation of Carcinogenic Risks
R827027C003 Research Project on Asthma