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Center for the Study of Environmental Factors in the Etiology of Autism
EPA Grant Number: R829388Center: CECEHDPR - University of California at Davis Center for the Study of Environmental Factors in the Etiology of Autism
Center Director: Pessah, Isaac N.
Title: Center for the Study of Environmental Factors in the Etiology of Autism
Investigators: Pessah, Isaac N.
Institution: University of California - Davis
EPA Project Officer: Saint, Chris
Project Period: November 1, 2001 through October 31, 2006
Project Amount: $7,325,232
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001)
Research Category: Children's Health , Health Effects
Description:
Objective:We intend to establish a Center for the Study of Environmental Factors in the Etiology of Autism at U.C. Davis that will investigate environmental risk factors contributing to the incidence and severity of childhood autism. Autism is a neurodevelopmental disorder defined by deficiencies of social reciprocity and communication, and by repetitive behavior. The majority of cases seem likely to arise from a -multiplicity of yet unidentified genetic and environmental factors. Surveys in California have indicated an apparent 210% increase in the cases of profound autism in children diagnosed over the last 10 years. Recent estimates indicate the frequency of mild to severe autism may be as high as 1:150 (Lord et al 2000). Thus there is growing concern from both parents and health professionals that prenatal and postnatal exposure to xenobiotic (e.g. mercurials, halogenated aromatics, and pesticides) and biotic (e.g. vaccine antigens) factors may act synergistically with unidentified susceptibility-genetic factors to produce autistic spectrum disorders.. To understand how the interaction of susceptibility genes with exposure to "environmental" chemicals may increase the risk and severity of autism and to identify which combination of chemical exposures confer the greatest threat, we propose to establish an interdisciplinary Center that addresses this complex problem at several levels. Project I proposes the first case-controlled epidemiological study of environmental factors in the etiology of autism. Tissue samples and exhaustive information will be collected from geographically distinct areas of California. Project two proposes to identify for the first time how known neurotoxicants of concern to children's health influence the development of social behavior and mediating brain regions such as the amygdala. Project III integrates elements of Projects I and 11 in order to examine molecular mechanisms underlying neurodevelopmental disorders associated with human autism and animal models of autism. The three research project are integrated within a center framework that provides extensive facility core capabilities in xenobiotic/lipid analysis (Core 1), cell activation biomarkers (Core 11), and molecular biomarkers (Core III). Our ultimate goal is to understand common patterns of dysfunction in autism and elucidate mechanisms by which chemicals known to be toxic to the nervous system contribute to abnormal development of social behavior in children so that rational strategies for treatment and prevention can be undertaken.
Journal Articles: 142 Displayed | Download in RIS Format
| Other center views: | All 153 publications | 143 publications in selected types | All 142 journal articles |
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Aleman M, Riehl J, Aldridge BM, Lecouteur RA, Stott JL, Pessah IN. 2004. Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermia. Muscle and Nerve 30(3):356-365. |
R829388 (2006) R829388C006 (2005) |
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Anderson, PJ, Lango J, Carkeet C, Britten A, Krautler B, Hammock BD and JR Roth. One pathway can incorporate either adenine or dimethylbenzimidazole as an alpha-axial ligand of B12 cofactors in Salmonella enterica. Journal of Bacteriology 2008;190:1160-1171. |
R829388 (2006) |
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Aronov PA, Dettmer K, Christiansen JA, Cornel AJ, Hammock BD. Development of a HPLC/tandem-MS method for the analysis of the larvicides methoprene, hydroprene and kinoprene at trace levels using Diels-Alder derivatization. Journal of Agricultural and Food Chemistry 2005;53(9):3306-3312. |
R829388 (2006) R829388C001 (2005) |
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Aronov PA, Hall LM , Dettmer K, Stephensen CB, Hammock BD. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2008;391:1917-1930. |
R829388 (2006) |
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Ashwood P, Van de Water J. Is autism an autoimmune disease? Autoimmune Review 2004;3(7-8):557-562. |
R829388 (2006) R829388C002 (2005) |
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Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water JA (2007). Plasma leptin levels are elevated in autism: Association with early onset phenotype? Journal of Autism and Developmental Disorders 2007 Mar 9 [Epub ahead of print]. |
R829388 (2006) |
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Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water J. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? Journal of Autism and Developmental Disorders 2008;38(1):169-175. |
R829388 (2006) |
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Baron CA, Liu SY, Hicks C, Gregg JP (2006). Utilization of Lymphoblastoid Cell Lines as a System for the Molecular Modeling of Autism. Journal of Autism and Developmental Disorders 2006 Nov;36(8):973-982. |
R829388 (2006) |
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Baron CA, Tepper CG, Liu SY, Davis RR, Wang NJ, Schanen NC, Gregg JP. Genomic and Functional Profiling of Duplicated Chromosome 15 Cell Lines Reveal Regulatory Alteration. Human Molecular Genetics 2006;15:853-69. |
R829388 (2006) |
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Baron CA, Liu SY, Hicks C, Gregg JP. Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism. Journal of Autism and Developmental Disorders 2006;36(8):973-82. |
R829388 (2006) |
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Bauman MD, Lavenex P, Mason WA, Capitanio JP, Amaral DG. The development of social behavior following neonatal amygdala lesions in rhesus monkeys. Journal of Cognitive Neuroscience 2004;16:1388-411. |
R829388 (2006) |
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Berman RF, Pessah IN, Mouton P, Mav D, Harry J. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicology Science 2008;101(2):294-309. |
R829388 (2006) |
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Berman RF, Pessah IN, Mouton PR, Mav D, Harry GJ. Modeling neonatal thimerosal exposure in mice. Toxicology Science 2008;103(2):416. |
R829388 (2006) |
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Braunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, VandeWater JA. Maternally derived antibodies specific for fetal brain proteins. Neurotoxicology 2008;29(2):226-231. |
R829388 (2006) |
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Bu B, Ashwood P, Harvey D, King IB, Water JV, Jin LW. Fatty Acid Compositions of Red Blood Cell Phospholipids in Children With Autism. Prostaglandins, Leukotrienes and Essential Fatty Acids 2006;74:215-21. |
R829388 (2006) |
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Burke K, Cheng Y, Li B, Petrov A, Joshi P, Berman RF, Reuhl KR, DiCicco-Bloom E. Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell regulator, cyclin E. Neurotoxicology 2006;27(6):970-981. Epub 2006 Sep 15. |
R829388 (2006) R829388C005 (2005) R829391 (2006) |
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Cabanlit M, Wills S, Goines P, Ashwood P, VandeWater J. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Annals of the New York Academy of Sciences 2007;1107:92-103. |
R829388 (2006) |
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Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock BD, Roth JR, Anderson PJ. 2006. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled (14)C-cobalamin. Proceedings of the National Academy of Sciences, USA 2006;103(15):5694-5699. |
R829388 (2006) |
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Chang Ahn K, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kültz D, Chang DPY, Gee SJ and Hammock BD. In Vitro Biological Activities of the Antimicrobials Triclocarban, its Analogues, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens. Environmental Health Perspectives 2008;116(9):1203–1210. |
R829388 (2006) |
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Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. 2006. Heat-and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB Journal 20(2):329-30. |
R829388 (2006) |
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Chen L, Estéve E, Sabatier JM, Ronjat M, De Waard M, Allen PD. Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1 (RyR1), revealing a proportional gating mechanism. Journal of Biological Chemistry 2003;278(18):16095-16106. |
R829388 (2006) R829388C006 (2003) R829388C006 (2005) |
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Cherednichenko G, Hurne A, Fessenden JD, Lee EH, Allen PD, Beam KG, and Pessah IN. 2004. Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proceedings of the National Academy of Sciences, USA 101(44): 15793–15798. |
R829388 (2006) R829388C006 (2005) |
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Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN. 2004. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circulation Research 94(4):478-86. |
R829388 (2006) R829388C006 (2005) |
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Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J. Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. Archives of Pediatrics & Adolescent Medicine 2005;159(2):151-157. |
R829388 (2006) R829388C004 (2005) |
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Dai JJ, Lieu L, Rocke D. Dimension Reduction for Classification With Gene Expression Microarray Data. Statistical Applications in Genetics and Molecular Biology 2006;5(6). |
R829388 (2006) |
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Dai JJ, Lieu L, Rocke D. Dimension reduction for classification with gene expression microarray data. Stat Appl Genet Mol Biol 2006;5:Article6. |
R829388 (2006) |
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Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2222-2227. |
R829388 (2006) R829388C001 (2002) R829388C001 (2005) |
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Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. Journal of Pharmacology and Experimental Therapeutics 2006;316:815-21. |
R829388 (2006) |
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Denning L, Anderson JA, Davis R, Gregg JP, Kuzdenyi J, Maselli RA. High throughput genetic analysis of congenital myasthenic syndromes using resequencing microarrays. PLoS ONE 2007;2(9):e918. |
R829388 (2006) |
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Dettmer K, Hanna D, Whetstone P, Hansen R, Hammock BD. Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory. Analytical and Bioanalytical Chemistry 2007;388(8):1643-51. |
R829388 (2006) |
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Dettmer K, Aronov PA, Hammock BD. Mass spectrometry-based metabolomics. Mass Spectrometry Reviews 2007;26(1):51-78. |
R829388 (2006) |
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Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obesity Research 2004;12(8):1278-1289. |
R829388 (2006) R829388C001 (2005) |
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Dietrich KM, Eskenazi B, Shantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in environmental health: from the Centers for Children's Environmental Health and Disease prevention research. Environmental Health Perspectives 2005;113(10):1437-46. |
R829388 (2006) |
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Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. |
R829388 (2006) R829389 (2005) R829390 (2005) R829390C002 (2005) R831710 (2005) R832141 (2006) |
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Dodds ED, German JB, Lebrilla CB. Enabling MALDI-FTICR-MS/MS for High-Performance Proteomics through Combination of Infrared and Collisional Activation. Analytical Chemistry 2007;79:9547-9556. |
R829388 (2006) |
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Du X, Tang Y, Xu H, Lit L, Walker W, Ashwood P, Gregg JP, Sharp FR. 2006. Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Genomics 87(6):693-703. |
R829388 (2006) |
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DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicological Sciences 2004;78:187-95. |
R829388 (2006) |
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Easterling DR. Development of regional climate scenarios using a downscaling approach. Climatic Change 1999;41(3-4):615-634. |
R829388 (2006) R824995 (1999) R824995 (2000) R824995 (Final) |
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Enstrom A, Onore C, Tarver A, Hertz-Picciotto I, Hansen R, Croen L, VandeWater J, Ashwood P. Detection of IL-17 and IL-23 in plasma samples of children with autism. American Journal of Biochemistry and Biotechnology 2007;4:114-120. |
R829388 (2006) |
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Enstrom A, Onore C, Tarver A, Hertz-Picciotto I, Hansen R, Croen L, VandeWater J, Ashwood P. Peripheral blood leukocyte production of BDNF following mitogen stimulation in early onset and regressive autism. American Journal of Biochemistry and Biotechnology 2007;4(2):121-129. |
R829388 (2006) |
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Estýýve E, Smida-Rezgui S, Sarkozi S, Szegedi C, Regaya I, Chen L, Altafaj X, Rochat H, Allen P, Pessah IN, Marty I, Sabatier JM, Jona I, De Waard M, Ronjat M. Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. Journal of Biological Chemistry 2003;278:37822-31. |
R829388 (2006) |
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Fang X, Weintraub NL, Oltman CL, Stoll LL, Kaduce TL, Harmon S, Dellsperger KC, Morisseau C, Hammock BD, Spector AA. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. American Journal of Physiology-Heart and Circulatory Physiology 2002;283(6):H2306-H2314. |
R829388 (2006) R829388C001 (2003) R829388C001 (2005) |
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Fang X, Weintraub NL, McCaw RB, Hu S, Harmon SD, Rice JB, Hammock BD, Spector AA. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. American Journal of Physiology-Heart and Circulatory Physiology 2004;287(6):H2412-H2420. |
R829388 (2006) R829388C001 (2005) |
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Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. Journal of Pharmacology and Experimental Therapeutics 2005;314:260-70. |
R829388 (2006) |
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Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. Journal of Pharmacology and Experimental Therapeutics 2005;314(1):260-70. |
R829388 (2006) |
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Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN. Homer regulates gain of ryanodine receptor type 1 channel complex. Journal of Biological Chemistry 2002;277(47):44722-44730. |
R829388 (2006) R829388C006 (2003) R829388C006 (2005) |
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Fleming EJ, Mack EE, Green PG, Nelson DC. Mercury methylation from unexpected sources: molybdate-inhibited freshwater sediments and an iron-reducing bacterium. Applied and Environmental Microbiology 2006;72(1):457-464. |
R829388C001 (2005) R828676C003 (2004) |
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Folkerts MM, Parks EA, Dedman JR, Kaetzel MA, Lyeth BG, Berman RF. Phosphorylation of calcium calmodulin-dependent protein kinase II following lateral fluid percussion brain injury in rats. Journal of Neurotrauma 2007;24(4):638-50. |
R829388 (2006) |
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Gafni, J., Wong, P. W., and Pessah, I. N. 2004. Noncoplanar 2,2’,3,5’,6-pentachlorobiphenyl (PCB 95) and rapamycin amplify ryanodine receptor signaling and Ca2+ entry mediated by ionotrophic glutamate receptors in cerebellar granule neurons. Toxicological Sciences 77, 72-82. |
R829388 (2006) R829388C006 (2005) |
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Gao J, Voss AA, Pessah IN, Lauer FT, Penning TM and Burchiel SW. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicology Science 87(2):419-426. |
R829388 (2006) R829388C006 (2005) |
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Geller SC, Gregg JP, Hagerman P, Rocke DM. Transformation and normalization of oligonucleotide microarray data. Bioinformatics 2003;19(14):1817-1823. |
R829388 (2006) R829388C003 (2004) |
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German JB, Watkins SM, Fay L-B. Metabolomics in practice: emerging knowledge to guide future dietetic advice toward individualized health. Journal of the American Dietetic Association 2005;105(9):1425-1432. |
R829388 (2006) R829388C001 (2005) |
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German JB, Gillies LA, Smilowitz JT, Zivkovic AM, Watkins SM. Lipidomics and lipid profiling in metabolomics. Current Opinion in Lipidology 2007;18:66-71. |
R829388 (2006) |
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German JB, Hammock BD, Watkins SM. 2005. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 1(1):3-9. |
R829388 (2006) |
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Gibney MJ, Walsh M, Brennan L, Roche HM, German B, van Ommen B. Metabolomics in human nutrition: opportunities and challenges. The American Journal of Clinical Nutrition 2005;82(3):497-503. |
R829388 (2006) R829388C001 (2005) |
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Goines P, Schauer J, Heuer L, Ashwood P, VandeWater J. Beta-2-microglobulin in autism spectrum disorders. American Journal of Biochemistry and Biotechnology 2007;3:91-95. |
R829388 (2006) |
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Goth SR, Chu RA, Pessah IN. 2006. Oxygen tension regulates the maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression. Journal of Immunological Methods 2006;308(1-2):179-191. |
R829388 (2006) R829388C006 (2005) |
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Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN. 2006. Uncoupling of ATP-Mediated Calcium Signaling and Dysregulated Interleukin-6 Secretion in Dendritic Cells by Nanomolar Thimerosal. Environmental Health Perspectives 114(7):1083-91. |
R829388 (2006) |
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Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN. Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal. Environmental Health Perspectives 2006;114(7):1083-91. |
R829388 (2006) |
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Goth SR, Chu R, Gregg JP, Cherednichenko G and Pessah I. Transient nanomolar thimerosal exposure uncouples ATP-mediated calcium signaling and dysregulates IL-6 secretion in dendritic cells. Environmental Health Perspectives |
R829388C006 (2005) |
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Greco CM, Berman RF, Martin RM, Tassone F, Schwartz PH, Chang A, Trapp BD, Iwahashi C, Brunberg J, Grigsby J, Hessl D, Becker EJ, Papazian J, Leehey MA, Hagerman RJ, Hagerman PJ. Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain 2006;129(1):243-255. |
R829388 (2006) R829388C005 (2005) |
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Gregg J, Lit L, Baron C, Hertz-Picciotto I, Walker W, Davis R, Croen LA, Ozonoff S, Hansen R, Pessah I, Sharp FR. Gene expression changes in children with autism. Genomics 2008;91(1):22-9. |
R829388 (2006) |
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Hansen ME, Pessah IN, Matsumura F (2006). Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells. Toxicology 220, 218-231. |
R829388 (2006) R829388C006 (2005) |
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Hansen RL, Ozonoff S, Krakowiak P, Angkustsiri K, Jones C, Deprey LJ, Le D-N, Croen L, Hertz-Picciotto I. Regression in autism: prevalence and associated factors in the CHARGE Study. Ambulatory Pediatrics 2008;8(1):25-31. |
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Hertz-Picciotto I, Charles MJ, James RA, Keller JA, Willman E, Teplin S. In utero polychlorinated biphenyl exposures in relation to fetal and early childhood growth. Epidemiology 2005;16:648-56. |
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Hertz-Picciotto I, Park H-Y, Dostal M, Kocan A, Trnovec T, Sram R. Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development. Basic & Clinical Pharmacology & Toxicology 2005;102(2):146-54. |
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Hertz-Picciotto I, Croen LA, Hansen R, Jones CR, van de Water J, Pessah IN. The CHARGE Study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environmental Health Perspectives 2006;114(7):1119-1125. |
R829388 (2006) R829388C004 (2005) |
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Hertz-Picciotto I, Baker RJ, Yap PS, Dostal M, Joad JP, Lipsett M, Greenfield T, Herr CE, Benes I, Shumway RH, Pinkerton KE, Sram R. Early childhood lower respiratory illness and air pollution. Environmental Health Perspectives 2007;115(10):1510-8. |
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Hertz-Picciotto I, Jusko TA, Willman EJ, Baker RJ, Keller JA, Teplin SW, Charles MJ. A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio. Environmental Health 2008;7(1):37. |
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Hillyard SL, German JB. Non-essential dietary factors: from test tube to lifespan. Journal of the Science of Food and Agriculture 2007;87(10):1802-1805. |
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Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicology and Applied Pharmacology 2003;190:72-86. |
R829388 (2006) R829388C006 (2005) |
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Howard, A. S., Fitzpatrick, R., Pessah, I. N., Kostyniak, P., Lein, P. J. PCBs induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicology and Applied Pharmacology 2003;190(1):72-86. |
R829388 (2006) R829388C006 (2003) |
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Howards PP, Hertz-Picciotto I. Invited commentary: disinfection by-products and pregnancy loss--lessons. American Journal of Epidemiology 2006;164:1052-5. |
R829388 (2006) |
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Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chemical Research in Toxicology 2005;18(3):516-527. |
R829388C001 (2005) |
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Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chemical Research in Toxicology 2005;18(3):516-27. |
R829388 (2006) |
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Huang H, Nishi K, Gee SJ, Hammock BD. Evaluation of chiral alpha-cyanoesters as general fluorescent substrates for screening enantioselective esterases. Journal of Agricultural and Food Chemistry 2006;54:694-699. |
R829388 (2006) |
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Hurne AM, O'Brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG, Pessah IN. Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion. Journal of Biological Chemistry 2005;280(44):36994-37004. |
R829388 (2006) R829388C006 (2005) |
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Inceoglu B, Lango J, Pessah IN, Hammock BD. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity. Toxicon 2005;45(6):727-733. |
R829388 (2006) R829388C001 (2005) |
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Inceoglu B, Lango J, Pessah IN, Hammock BD. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity. Toxicon 2005;45:727-733. |
R829388 (2006) |
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Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins & Other Lipid Mediators 2007;82(1-4):42-9. |
R829388 (2006) |
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Jaubert PJ, Golub MS, Lo YY, Germann SL, Dehoff MH, Worley PF, Kang SH, Schwarz MK, Seeburg PH, Berman RF. Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes, Brain and Behavior 2007;6(2):141-154. |
R829388 (2006) R829388C005 (2005) |
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Jusko TA, Koepsell TD, Baker RJ, Greenfield TA, Willman EJ, Charles MJ, Teplin SW, Checkoway H, Hertz-Picciotto I. Maternal DDT Exposures in Relation To Fetal and 5-Year Growth. Epidemiology 2006;17:692-700. |
R829388 (2006) |
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Kenet T, Froemke RC, Schreiner CE, Pessah IN, Merzenich MM. Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex. Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7646-51. |
R829388 (2006) |
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Kenet T, Froemcke R, Schreiner C, Pessah IN, Merzenich MM. Abnormal auditory cortex development in PCB exposed rats. Proceedings of the National Academy of Sciences of the United States of America. |
R829388 (2006) |
not available |
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Kim HJ, Ahn KC, Ma SJ, Gee SJ, Hammock BD. Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure. Journal of Agricultural and Food Chemistry 2007;55:3750-3757. |
R829388 (2006) |
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Kim I-H, Morisseau C, Watanabe T, Hammock BD. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. Journal of Medicinal Chemistry 2004;47(8):2110-2122. |
R829388 (2006) R829388C001 (2005) |
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Kim I-H, Heirtzler FR, Morisseau C, Nishi K, Tsai H-J, Hammock BD. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. Journal of Medicinal Chemistry 2005;48(10):3621-3629. |
R829388 (2006) R829388C001 (2005) |
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Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN and Schantz SL. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicology Science 2005;88(2):400-411. |
R829388 (2006) R829388C006 (2005) R829390 (2005) |
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Krakowiak P, Goodlin-Jones B, Hertz-Picciotto I, Croen LA, Hansen RL). Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study. Journal of Sleep Research 2008;17(2):197-206. |
R829388 (2006) |
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Lange MC, Lemay DA, German JB. A multi-ontology framework to guide agriculture and food towards diet and health. Journal of the Science of Food and Agriculture 2007;87(8):1427-1434. |
R829388 (2006) |
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Lawler CP, Croen LA, Grether JK, Van de Water J. 2004. Identifying environmental contributions to autism: provocative clues and false leads. Mental Retardation & Developmental Disabilities Research Reviews 2004;10:292-302. |
R829388 (2006) R829388C002 (2005) |
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Lemay DG, Zivkovic AM, German JB. Building the Bridges to Bioinformatics in Nutrition Research. American Journal of Clinical Nutrition 2007;86:1261-1269. |
R829388 (2006) |
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Lemay DG, Neville MC, Rudolph MC, Pollard KS, German JB. Gene regulatory networks in lactation: identification of global principles using bioinformatics. BMC Systems Biology 2007; 1:56. |
R829388 (2006) |
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Li L, Li H. Dimension reduction methods for microarrays with application to censored survival data. Bioinformatics 2004;20(18):3406-3412. |
R829388 (2006) R829388C003 (2005) |
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Li L. Survival prediction of diffuse large-B-cell lymphoma based on both clinical and gene expression information. Bioinformatics 2006;22(4):466-71. |
R829388 (2006) |
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Martin LA, Ashwood P, Braunschweig D, Cabanlit M, VandeWater J, Amaral DG. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behavior and Immunity 2008;22(6):806-816. |
R829388 (2006) |
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Matsuno M, Pessah IN, Olmstead M, Molinski TF. Simplified cyclic analogs of bastadin-5. Structure activity relationships of modulation of the RyR1/FKBP12 Ca2+ channel. Journal of Medicinal Chemistry 2006;49:4497-4511. |
R829388 (2006) |
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Merin N, Young GS, Ozonoff S, Rogers SJ. Visual fixation patterns during reciprocal social interaction distinguish a subgroup of 6-month-old infants at-risk for autism from comparison infants. Journal of Autism and Developmental Disorders 2007;37(1):108-21. |
R829388 (2006) |
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Nadig AS, Ozonoff S, Young GS, Rozga A, Sigman M, Rogers SJ. A prospective study of response to name in infants at risk for autism. Archives of Pediatrics & Adolescent Medicine 2007;161(4):378-83. |
R829388 (2006) |
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Newman JW, Watanabe T, Hammock BD. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. Journal of Lipid Research 2002;43(9):1563-1578. |
R829388 (2006) R829388C001 (2003) R829388C001 (2005) |
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Newman JW, Morisseau C, Harris TR, Hammock BD. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1558-1563. |
R829388 (2006) R829388C001 (2003) R829388C001 (2005) |
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Newman JW, Morisseau C, Hammock BD. Epoxide hydrolases: Their roles and interactions with lipid metabolism. Progress in Lipid Research 2005;44:1-51. |
R829388 (2006) R829388C001 (2005) |
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Nguyen DV, Senturk D. Distortion diagnostics for covariate-adjusted regression: graphical techniques based on local linear modeling. Journal of Data Science 2007;5:471-490. |
R829388 (2006) |
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Nguyen DV, Senturk D. Multicovariate-adjusted regression models. Journal of Statistical Computation and Simulation 2008;78(9):813-827. |
R829388 (2006) |
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Ninonuevo MR, Park Y, Yin H, Zhang J, Ward RE, Clowers BH, German JB, Freeman SL, Killeen K, Grimm R, Lebrilla CB. A Strategy for Annotating the Human Milk Glycome. Journal of Agricultural and Food Chemistry 2006;54:7471-80. |
R829388 (2006) |
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Ninonuevo MR, Ward RE, LoCascio RG, German JB, Freeman SL, Barboza M, Mills DA, Lebrilla CB. Methods for the quantitation of human milk oligosaccharides in bacterial fermentation by mass spectometry. Analytical Biochemistry 2007;361:15-23. |
R829388 (2006) |
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Ninonuevo MR, Perkins PD, Francis J, Lamotte L, LoCascio RG, German JB, Freeman SL, Grimm R, Lebrilla CB. Daily variations in oligosaccharides of human milk determined by microfluidic chips and mass spectrometry. Journal of Agricultural and Food Chemistry 2008;56(2):618–626. |
R829388 (2006) |
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Ostrovskaya O, Goyal R, Osman N, McAllister CE, Pessah IN, Hume JR, Wilson SM. Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 2007;323(1):381-390. |
R829388 (2006) |
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Ozonoff S, Young GS, Goldring S, Greiss-Hess L, Herrera AM, Steele J, Macari S, Hepburn S, Rogers SJ. Gross motor development, movement abnormalities, and early identification of autism. Journal of Autism and Developmental Disorders 2008;38(4):644-56. |
R829388 (2006) |
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Palkovicova L, Ursinyova M, Hladikova V, Yu Z, Hertz-Picciotto I. Maternal amalgam dental fillings as a major source of mercury in the developing fetus and newborn. Journal of Exposure Science and Environmental Epidemiology 2008;18(3):326-31. |
R829388 (2006) |
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Park H-Y, Hertz-Picciotto I, Petrik J, Palkovicova L, Kocan A, Trnovec T. Prenatal PCB exposure and thymus size at birth in neonates in Eastern Slovakia. Environmental Health Perspectives 2008;116(1):104-109. |
R829388 (2006) |
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Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do Z, Kim KH, and Wong PW. 2006. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chemical Research in Toxicology 19(1):92-101. |
R829388 (2006) R829388C006 (2005) |
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Pessah IN, Seegal RF, Lein PJ, Lasalle J, Yee BK, Van de Water J, Berman RF. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 2008;29(3):532-545. |
R829388 (2006) |
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Phimister AJ, Lango J, Lee EH, Ernst-Russell MA, Takeshima H, Ma J, Allen PD, Pessah IN. Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. Journal of Biological Chemistry 2007;282:8667-77. |
R829388 (2006) |
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Ran R, Pan R, Lu A, Xu H, Davis RR, Sharp FR. A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Molecular and Cellular Neuroscience 2007;36(3):392-407. |
R829388 (2006) |
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Riehl J, Pessah IN (2006). 2,2’-Dibromodiphenyl Ether Selectively Enhances the Activity of the Skeletal Isoform of the Ryanodine Receptor (RyR1). |
R829388 (2006) |
not available |
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Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY, Greenough WT, Pessah IN, Schantz SL. Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicology and Teratology 2006;28(1):74-85. |
R829388 (2006) R829388C006 (2005) R829390 (2005) R829390C001 (2005) |
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Sakimura JN, Dang MT, Ballard KB, Hansen RL. Cognitive and temperament profiles in 3 to 5-year-old children with aggressive behavior. Journal of School Health 2008;78(1):38-45. |
R829388 (2006) |
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Schmelzer KR, Kubala L, Newman JW, Kim IH, Eiserich JP, Hammock BD. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proceedings of the National Academy of Sciecnes, USA 2005;102:9772-7. |
R829388 (2006) |
not available |
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Schmelzer KR, Kubala L, Newman JW, Kim IH, Eiserich JP, Hammock BD. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proceedings of the National Academy of Sciences 2005;102(28):9772-9777. |
R829388 (2006) |
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Schmelzer KR, Inceoglu B, Kubala L, Kim IH, Jinks SL, Eiserich JP, Hammock BD. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences 2006;103(37):13646-51. |
R829388 (2006) |
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Schmelzer KR, Wheelock AM, Dettmer K, Morin D, Hammock BD. The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways. Environmental Health Perspectives 2006;114(9):1354-60. |
R829388 (2006) |
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Shearer GC, Newman JW, Hammock BD, Kaysen GA. Graded effects of proteinuria on HDL structure in nephrotic rats. Journal of the American Society of Nephrology 2005;16:1309-19. |
R829388 (2006) |
not available |
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Smilowitz JT, Dillard CJ, German JB. Milk beyond essential nutrients: the metabolic food. Australian Journal of Dairy Technology 2005;60(2):77-83. |
R829388 (2006) |
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Smith KR, Pinkerton KE, Watanabe T, Pedersen TL, Ma SJ, Hammock BD. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2186-2191. |
R829388 (2006) R829388C001 (2005) |
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Sonneborn D, Park HY, Petrik J, Kocan A, Palkovicova L, Trnovec T, Nguyen DV, Hertz-Picciotto I. Prenatal PCB exposures in Eastern Slovakia modify effects of social factors on birthweight. Paediatric and Perinatal Epidemiology 2008;22:202-213. |
R829388 (2006) |
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Ta TA, Feng W, Molinski TF,Pessah IN. Hydroxylated Xestospongins Block Inositol-1,4,5-trisphosphate-Induced Ca2+ Release and Sensitive Ca2+-Induced Ca2+ Release Mediated by Ryanodine Receptors. Molecular Pharmacology 2005;69(2):532-538. |
R829388 (2006) R829388C006 (2005) |
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Ta TA, Pessah IN (2006). Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). Neurotoxicology. |
R829388 (2006) |
not available |
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Viswanathan S, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. Journal of the American College of Nutrition 2003;22(6):502-510. |
R829388 (2006) R829388C001 (2005) |
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Voss AA, Lango J, Ernst-Russell M, Morin D, and Pessah IN. Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. Journal of Biological Chemistry 2004;279:34514-20. |
R829388 (2006) R829388C006 (2005) |
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Ward CW, Feng W, Tu J, Pessah IN, Worley PK, Schneider MF. Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle. Journal of Biological Chemistry, 2004;279(7):5781-5787. |
R829388 (2006) R829388C006 (2005) |
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Ward RE, Niñonuevo M, Mills DA, Lebrilla CB, German JB. In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri. Applied and Environmental Microbiology 2006;72:4497-4499. |
R829388 (2006) |
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Ward RE, Niñonuevo M, Mills DA, Lebrilla CB, German JB. In vitro fermentability of human milk oligosaccharides by several strains of bifidobacteria. Molecular Nutrition & Food Research 2007;51(11):1398-405. |
R829388 (2006) |
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Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, VandeWater J. Autoantibodies in autism spectrum disorders (ASD). Annals of the New York Academy of Sciences 2007;1107:79-91. |
R829388 (2006) |
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Yang T, Riehl J, Esteve E, Matthaei KI, Goth S, Allen PD, Pessah IN, Lopez JR. Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology 2006;105:1164-1175. |
R829388 (2006) |
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Yang T, Allen PD, Pessah IN, Lopez JR. Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RYR1 MH mutations. The Journal of Biological Chemistry 2007;282(52):37471-8. |
R829388 (2006) |
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Yang W, Yaoi T, Huang S, Yang Q, Hatcher S, Seet H, Gregg JP. Detecting the C282Y and H63D mutations of the HFE gene by Holliday Junction-based allele-specific genotyping methods. Clinical Chemistry 2005;51(1):210-213. |
R829388 (2006) |
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Zhao X, Yamamoto T, Newman JW, Kim I-H, Watanabe T, Hammock BD, Stewart J, Pollock JS, Pollock DM, Imig JD. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. Journal of the American Society of Nephrology 2004;15(5):1244-1253. |
R829388 (2006) R829388C001 (2005) |
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Inceoglu B., Lango J., Jing J., Chen L., Doymaz F., Pessah I.N., Hammock B.D. One scorpion, two venoms: Prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proceedings of the National Academy of Sciences, USA 2003;100;922-927. |
R829388 (2006) |
not available |
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Ashwood P and Van de Water J. A review of autism and the immune response. Clinical and Developmental Immunology 11(2):165-174. |
R829388C002 (2005) |
not available |
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Paolini C, Fessenden JD, Pessah IN and Franzini-Armstrong C. Evidence for conformational coupling between two calcium channels. Proceedings of the National Academy of Sciences 101(34):12748-12752. |
R829388C006 (2005) |
not available |
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Ashwood P, Wills S, Van de Water J. The immune response in autism: a new frontier for autism research. Journal of Leukocyte Biology 2006;80(1):1-15. |
R829388 (2006) |
not available |
Toxics, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Susceptibility/Sensitive Population/Genetic Susceptibility, Toxicology, Biology, Risk Assessments, Disease & Cumulative Effects, genetic susceptability, Health Risk Assessment, Physical Processes, Epidemiology, Chemistry, Children's Health, pesticides, biomarkers, exposure assessment, xenobiotics, neurological development, autism, synergistic interactions, mechanisms, mercurials, human health risk, susceptibility, halogenated aromatics, etiology, gene-environment interaction, pesticide exposure, neurotoxic, biological markers, children, neurobehavioral, halogenated aromatic hydrocarbons, chemical exposure, exposure, biomarker, neurobehavioral effects, human exposure, neurodevelopmental, neurotoxicity
Progress and Final Reports:
2006 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829388C001 Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
R829388C002 Environmental Factors in the Etiology of Autism; Cell Activation/Signaling Core
R829388C003 Environmental Factors in the Etiology of Autism; Molecular Biomakers Core
R829388C004 Environmental Factors in the Etiology of Autism; Childhood Autism Risks from Genetics and the Environment (The CHARGE Study)
R829388C005 Environmental Factors in the Etiology of Autism; Animal Models of Autism
R829388C006 Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism