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Center for Childhood Neurotoxicology and Assessment
EPA Grant Number: R829391Center: CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment
Center Director: Lambert, George H.
Title: Center for Childhood Neurotoxicology and Assessment
Investigators: Lambert, George H.
Institution: University of Medicine and Dentistry of New Jersey
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2001 through October 31, 2006
Project Amount: $6,751,466
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001)
Research Category: Health Effects , Children's Health
Description:
Objective:The unifying theme of the Center for Childhood Neurotoxicology and Assessment is to determine and influence of exposure to neurotoxicants on child neurological health and development with autism and related learning disabilities as a focus. The objectives of the Center are to detect, understand and prevent environmental health problems as they relate to children. These objectives are achieved by facilitating interdisciplinary research, enhancing community and advocacy group involvement, and disseminating results to the public through publications, conferences and community outreach. The multidisciplinary research of the Center is based on three main project areas. The Basic Sciences Projects examine facets of brain development, beginning with neurogenesis and proceeding through to behavior in the intact animal. The Clinical Sciences Projects are interactive with community groups representing children with learning disabilities and their families, with particular emphasis on autism. These projects explore the linkage between environmental neurotoxicants, clinical course of autism, regional brain growth and a possible new gene-environment interaction with autism. The Exposure Assessment and Intervention Project (EAIP) will characterize the personal, residential and general community of exposure of children selected by the Clinical Sciences Projects. The EAIP will then determine the need for interventions to reduce neurotoxicant exposure among learning disabled children and assess the impact of such interventions. The Exposure Assessment Facility Core will provide innovative video techniques to assess the relationship between the behavior of the child with autism and his/her potential to contact with neurotoxicants. The overall mission of the Center is to improve environmental and public health of children through research, assessment, treatment and outreach.
Journal Articles: 51 Displayed | Download in RIS Format
| Other center views: | All 101 publications | 52 publications in selected types | All 51 journal articles |
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Akland GG, Pellizzari ED, Hu Y, Roberds M, Rohrer CA, Leckie JO, Berry MR. Factors influencing total dietary exposures of young children. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(Suppl 6):710-722. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2005) |
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Ayotte P, Dewailly E, Lambert GH, Perkins SL, Poon R, Feeley M, Larochelle C, Pereg D. Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines. Environmental Health Perspectives 2005;113(10):1318-1324. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) |
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Benayed R, Gharani N, Rossman I, Mancuso V, Lazar G, Kamdar S, Bruse SE, Tischfield S, Smith BJ, Zimmerman RA, DiCicco-Bloom E, Brzustowicz LM, Millonig JH. Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. American Journal of Human Genetics 2005;77(5):851-868. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C001 (2006) |
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Black K, Shalat SL, Freeman NCG, Jimenez M, Donnelly KC, Calvin JA. Children’s mouthing and food-handling behavior in an agricultural community on the US/Mexico border. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(3):244-251. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2004) R829391C004 (2005) |
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Brenz Verca MS, Bahi A, Boyer F, Wagner GC, Dreyer J-L. Distribution of α- and γ-synucleins in the adult rat brain and their modification by high-dose cocaine treatment. European Journal of Neuroscience 2003;18(7):1923-1938. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C003 (2005) |
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Burke K, Cheng Y, Li B, Petrov A, Joshi P, Berman RF, Reuhl KR, DiCicco-Bloom E. Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell regulator, cyclin E. Neurotoxicology 2006;27(6):970-981. Epub 2006 Sep 15. |
R829391 (2006) R829388 (2006) R829388C005 (2005) |
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Buyske S, Williams TA, Mars AE, Stenroos ES, Ming SX, Wang R, Sreenath M, Factura MF, Reddy C, Lambert GH, Johnson WG 2006. Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autism. BMC Genetics 2006 Feb 10;7(1):8. |
R829391 (2006) |
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Calafat AM, Needham LL, Silva MJ, Lambert G. Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit. Pediatrics 2004;113(5):e429-e434. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) |
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Carlson KM, Wagner GC. Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum. Life Sciences 2005;77(4):372-385. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C003 (2006) |
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Carmody DP, Dunn SM, Boddie-Willis AS, DeMarco JK, Lewis M. A quantitative measure of myelination development in infants, using MR images. Neuroradiology 2004;46(9):781-786. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) |
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Carmody DP, Moreno R, Mars AE, Seshadri K, Lambert GH, Lewis M. Brief report: brain activation to social words in a sedated child with autism. Journal of Autism and Developmental Disorders. 2007 Aug;37(7):1381-5. |
R829391 (2006) |
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Cheh MA, Millonig JH, Roselli LM, Ming X, Jacobsen E, Kamdar S, Wagner GC 2006. En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Brain Research. 2006 Oct 20;1116(1):166-76. |
R829391 (2006) |
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Chen T-F, Zhang Y-L, Xu W-L, Li Z-Q, Hou B, Wang C-L, Fan M, Qian L-J, Zhou R-P, Zhang C-G. Prokaryotic expression, polyclonal antibody preparation, and sub-cellular localization of Na+, K+-ATPase β2 subunit. Protein Expression and Purification 2004;37(1):47-52. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2006) |
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Chen Z-Y, Sun C, Reuhl K, Bergemann A, Henkemeyer M, Zhou R. Abnormal hippocampal axon bundling in EphB receptor mutant mice. Journal of Neuroscience 2004;24(10):2366-2374. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2005) |
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Davidovics Z, DiCicco-Bloom E. Moderate lead exposure elicits neurotrophic effects in cerebral cortical precursor cells in culture. Journal of Neuroscience Research 2005;80(6):817-825. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C001 (2006) |
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Falluel-Morel A, Sokolowski K, Sisti HM, Zhou X, Shors TJ, Dicicco-Bloom E 2007. Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty. Journal of Neurochemistry 2007 Dec;103(5):1968-81. |
R829391 (2006) |
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Fitzgerald EF, Hwang SA, Lambert G, Gomez M, Tarbell A. PCB exposure and in vivo CYP1A2 activity among Native Americans. Environmental Health Perspectives 2005;113(3):272-277. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) |
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Freeman NCG, Sheldon L, Jimenez M, Melnyk L, Pellizzari E, Berry M. Contribution of children’s activities to lead contamination of food. Journal of Exposure Analysis and Environmental Epidemiology 2001;11(5):407-413. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2005) |
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Freeman NCG, Jimenez M, Reed KJ, Gurunathan S, Edwards RD, Roy A, Adgate JL, Pellizzari ED, Quackenboss J, Sexton K, Lioy PJ. Quantitative analysis of children’s microactivity patterns: the Minnesota Children’s Pesticide Exposure Study. Journal of Exposure Analysis and Environmental Epidemiology 2001;11(6):501-509. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2005) |
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Freeman NCG, Shalat SL, Black K, Jimenez M, Donnelly KC, Calvin A, Ramirez J. Seasonal pesticide use in a rural community on the U.S./Mexico border. Journal of Exposure Analysis and Environmental Epidemiology 2004;14(6):473-478. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2004) |
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Georgopoulos PG, Lioy PJ 2006. From a theoretical framework of human exposure and dose assessment to computational system implementation: the Modeling ENvironment for TOtal Risk Studies (MENTOR).Journal of Toxicology and Environmental Health, Part B. 2006 June;9(6):457-83. |
R829391 (2006) |
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Halladay AK, Kusnecov A, Michna L, Kita T, Hara C, Wagner GC. Relationship between methamphetamine-induced dopamine release, hyperthermia, self-injurious behaviour and long term dopamine depletion in BALB/c and C57BL/6 mice. Pharmacology & Toxicology 2003;93(1):33-41. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C003 (2004) |
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Halladay AK, Tessarollo L, Zhou R, Wagner GC. Neurochemical and behavioral deficits consequent to expression of a dominant negative EphA5 receptor. Molecular Brain Research 2004;123(1-2):104-111. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C003 (2005) |
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Halladay AK, Wagner GC, Sekowski A, Rothman RB, Baumann MH, Fisher H. Alterations in alcohol consumption, withdrawal seizures, and monoamine transmission in rats treated with phentermine and 5-hydroxy-L-tryptophan. Synapse 2006;59(5):277-289. |
R829391 (2005) R829391 (2006) R829391C003 (2006) |
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Halladay AK, Wilson DT, Wagner GC, Reuhl KR. Trimethyltin-induced alterations in behavior are linked to changes in PSA-NCAM expression. NeuroToxicology 2006;27(2):137-146. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2005) |
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Hsu PC, Lai TJ, Guo NW, Lambert GH, Leon Guo Y. Serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans. Journal of Toxicology and Environmental Health, Part A. 2005 Sep;68(17-18):1447-56. |
R829391 (2006) |
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Hsu P-C, Huang W, Yao W-J, Wu M-H, Guo YL, Lambert GH. Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans. Journal of the American Medical Association 2003;289(22):2943-2944 (research letter). |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2004) |
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Hu Z, Yue X, Shi G, Yue Y, Crockett DP, Blair-Flynn J, Reuhl K, Tessarollo L, Zhou R. Corpus callosum deficiency in transgenic mice expressing a truncated ephrin-A receptor. Journal of Neuroscience 2003;23(34):10963-10970. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2005) |
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Hu Z, Cooper M, Crockett DP, Zhou R. Differentiation of the midbrain dopaminergic pathways during mouse development. Journal of Comparative Neurology 2004;476(3):301-311. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2006) |
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Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) R826710 (Final) R831709 (2005) R831709C003 (2005) R831709C003 (2006) R831710 (2004) R831710 (2005) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Johnson SK, Carlson KM, Lee J, Burr LE, Wagner GC. Effects of nicotine on target biting and resident-intruder attack. Life Sciences. 2003 Jun 6;73(3):311-7. |
R829391 (2006) |
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Johnson WG, Scholl TO, Spychala JR, Buyske S, Stenroos ES, Chen X. Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm delivery. American Journal of Clinical Nutrition 2005;81(3):664-668. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) |
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Kita T, Wagner GC, Nakashima T. Current research on methamphetamine-induced neurotoxicity: animal models of monoamine disruption. Journal of Pharmacological Sciences 2003;92(3):178-195. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C003 (2005) |
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Lioy PJ, Freeman NC, Millette JR. Dust: a metric for use in residential and building exposure assessment and source characterization. Environmental Health Perspectives. 2002 Oct;110(10):969-83. |
R829391 (2006) |
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Lioy PJ. Employing dynamical and chemical processes for contaminant mixtures outdoors to the indoor environment: the implications for total human exposure analysis and prevention. Journal of Exposure Science & Environmental Epidemiology 2006;16(3):207-224. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2006) |
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Martin JV, Nolan B, Wagner GC, Fisher H 2004. Effects of dietary caffeine and alcohol on liver carbohydrate and fat metabolism in rats. Medical Science Monitor. 2004 Dec;10(12):BR455-61. |
R829391 (2006) |
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Ming X, Stein TP, Brimacombe M, Johnson WG, Lambert GH, Wagner GC. Increased excretion of a lipid peroxidation biomarker in autism. Prostaglandins, Leukotrienes and Essential Fatty Acids 2005;73(5):379-384. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C003 (2006) |
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Prozialeck WC, Grunwald GB, Dey PM, Reuhl KR, Parrish AR. Cadherins and NCAM as potential targets in metal toxicity. Toxicology and Applied Pharmacology 2002;182(3):255-265. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2004) |
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Shalat SL, Donnelly KC, Freeman NCG, Calvin JA, Ramesh S, Jimenez M, Black K, Coutinho C, Needham LL, Barr DB, Ramirez J. Nondietary ingestion of pesticides by children in an agricultural community on the U.S./Mexico border: preliminary results. Journal of Exposure Analysis and Environmental Epidemiology 2003;13(1):42-50. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2004) R829391C004 (2005) |
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Turan VK, Sanchez RI, Li JJ, Li SA, Reuhl KR, Thomas PE, Conney AH, Gallo MA, Kauffman FC, Mesia-Vela S. The effects of steroidal estrogens in ACI rat mammary carcinogenesis: 17beta-estradiol, 2-hydroxyestradiol, 4-hydroxyestradiol, 16alpha-hydroxyestradiol, and 4-hydroxyestrone. Journal of Endocrinology. 2004 Oct;183(1):91-9. |
R829391 (2006) |
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Wagner GC, Avena N, Kita T, Nakashima T, Fisher H, Halladay AK. Risperidone reduction of amphetamine-induced self-injurious behavior in mice. Neuropharmacology 2004;46(5):700-708. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C003 (2004) |
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Wagner GC, Reuhl KR, Cheh M, McRae P, Halladay AK. A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate. Journal of Autism and Developmental Disorders 2006;36(6):779-793. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2006) R829391C003 (2004) |
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Wagner GC, Reuhl KR, Ming X, Halladay AK. Behavioral and neurochemical sensitization to amphetamine following early postnatal administration of methylmercury (MeHg). Neurotoxicology. 2007 Jan;28(1):59-66. |
R829391 (2006) |
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Williams TA, Mars AE, Buyske SG, Stenroos ES, Wang R, Factura-Santiago MF, Lambert GH, Johnson WG. Risk of autistic disorder in affected offspring of mothers with a glutathione S-transferase P1 haplotype. Archives of Pediatric Adolescent Medicine. 2007 Apr;161(4):356-61. |
R829391 (2006) |
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Wilson DT, Polunas MA, Zhou R, Halladay AK, Lowndes HE, Reuhl KR. Methylmercury alters eph and ephrin expression during neuronal differentiation of P19 embryonal carcinoma cells. NeuroToxicology 2005;26(4):661-674. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2005) |
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Yang C-Y, Yu M-L, Guo H-R, Lai T-J, Hsu C-C, Lambert G, Guo YL. The endocrine and reproductive function of the female Yucheng adolescents prenatally exposed to PCBs/PCDFs. Chemosphere 2005;61(3):355-360. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) |
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Ye X, Fitzgerald EF, Gomez MI, Lambert GH, Longnecker MP. The ratio of specific polychlorinated biphenyls as a surrogate biomarker of cytochrome P4501A2 activity: a pharmaco-metabonomic study in humans. Cancer Epidemiology Biomarkers & Prevention. 2008 Apr;17(4):1013-5. |
R829391 (2006) |
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Yu CH, Yiin LM, Lioy PJ 2006. The bioaccessibility of lead (Pb) from vacuumed house dust on carpets in urban residences. Risk Anal. 2006 Feb;26(1):125-34. |
R829391 (2006) |
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Zartarian VG, Ferguson, AC, Leckie JO. Quantified dermal activity data for a four-child pilot field study. Journal of Exposure Analysis and Environmental Epidemiology 1997;7(4):543-552. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2005) |
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Zartarian VG, Ferguson AC, Leckie JO. Quantified mouthing activity data from a four-child pilot field study. Journal of Exposure Analysis and Environmental Epidemiology 1998;8(4):543-553. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C004 (2005) |
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Zhang C, Meng F, Wang C, Guo H, Fan M, Liu S, Zhou R, He F. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. Molecular Brain Research 2004;130(1-2):68-80. |
R829391 (2004) R829391 (2005) R829391 (2006) R829391C002 (2006) |
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Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Toxicology, Biology, Risk Assessments, Disease & Cumulative Effects, genetic susceptability, Health Risk Assessment, Ecological Risk Assessment, Children's Health, Environmental Chemistry, exposure assessment, public health, neurological development, neuropathological damage, autism, developmental disorders, developmental effects, environmental toxicant, assessment of exposure, outreach and education, gene-environment interaction, neurotoxic, children, residential populations, childhood learning, behavioral deficits, assessment technology, behavioral assessment, environmental health hazard, neurodevelopmental
Progress and Final Reports:
2004 Progress Report
2005 Progress Report
2006 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829391C001 Neurotoxicant Effects on Cell Cycle Regulation of Neurogenesis
R829391C002 Adhesion and Repulsion Molecules in Developmental Neurotoxic Injury
R829391C003 Disruption of Ontogenic Development of Cognitive and Sensory Motor Skills
R829391C004 Exposure Assessment and Intervention Project (EAIP)
R829391C005 Clinical Sciences Project