Journal Publications for Center:
University of Iowa Children's Environmental Airway Disease Center
Grant Number R826711
Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. | NATURE GENETICS | Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA | Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genetics 2000;25(2):187-191. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
not available |
Journal Article | Subchronic endotoxin inhalation causes chronic airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA | Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA. Subchronic endotoxin inhalation causes chronic airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(6):L755-L761. |
R826711 (Final) R826711C004 (Final) |
not available |
Journal Article | Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. | JOURNAL OF IMMUNOLOGY | Butler NS, Monick MM, Yarovinsky TO, Powers LS, Hunninghake GW | Butler NS, Monick MM, Yarovinsky TO, Powers LS, Hunninghake GW. Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. Journal of Immunology 2002;169(7):3700-3709. |
R826711 (Final) R826711C003 (Final) |
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Journal Article | Endotoxin augments viral replication and the inflammatory response in respiratory syncytial virus-infected epithelium. | JOURNAL OF IMMUNOLOGY | Carter AB, Donohue MR, Knudtson KL, Gudmundsson G, Monick MM, Hunninghake GW | Carter AB, Donohue MR, Knudtson KL, Gudmundsson G, Monick MM, Hunninghake GW. Endotoxin augments viral replication and the inflammatory response in respiratory syncytial virus-infected epithelium. Journal of Immunology. |
R826711C001 (2000) |
not available |
Journal Article | Asthma prevalence and morbidity among rural Iowa schoolchildren. | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J | Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J. Asthma prevalence and morbidity among rural Iowa schoolchildren. Journal of Allergy and Clinical Immunology 2004;113(1):66-71 and erratum in Journal of Allergy and Clinical Immunology 113(3):391. |
R826711 (Final) R826711C002 (Final) |
not available |
Journal Article | Endotoxin responsiveness and subchronic grain dust-induced airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | George CL, Jin H, Wohlford-Lenane CL, O’Neill ME, Phipps JC, O’Shaughnessy P, Kline JN, Thorne PS, Schwartz DA | George CL, Jin H, Wohlford-Lenane CL, O’Neill ME, Phipps JC, O’Shaughnessy P, Kline JN, Thorne PS, Schwartz DA. Endotoxin responsiveness and subchronic grain dust-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Biology 2001;280(2):L203-L213. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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Journal Article | Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | George CL, White M, O’Neill ME, Thorne PS, Schwartz DA, Snyder JM | George CL, White M, O’Neill ME, Thorne PS, Schwartz DA, Snyder JM. Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(6):L1337-L1344. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | The role of toll-like receptor 4 in environmental airway injury in mice. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Hollingsworth JW, Cook DN, Brass DM, Walker JK, Morgan DL, Foster WM, Schwartz DA | Hollingsworth JW, Cook DN, Brass DM, Walker JK, Morgan DL, Foster WM, Schwartz DA. The role of toll-like receptor 4 in environmental airway injury in mice. American Journal of Respiratory and Critical Care Medicine 2004;170(2):106-107. |
R826711 (Final) R826711C004 (Final) |
not available |
Journal Article | Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. | JOURNAL OF APPLIED PHYSIOLOGY | Kline JN, Jagielo PJ, Watt JL, Schwartz DA | Kline JN, Jagielo PJ, Watt JL, Schwartz DA. Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. Journal of Applied Physiology 2000;89(3):1172-1178. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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Journal Article | Variable airway responsiveness to inhaled lipopolysaccharide. | AMERICAN JOURNAL OF PHYSIOLOGY | Kline JN, Cowden JD, Hunninghake GW, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA | Kline JN, Cowden JD, Hunninghake GW, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA. Variable airway responsiveness to inhaled lipopolysaccharide. American Journal of Respiratory and Critical Care Medicine 1999;160(1):297-303, 1999. |
R826711C001 (2000) R826711C002 (2000) |
not available |
Journal Article | Genes other than TLR4 are involved in the response to inhaled LPS. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA | Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA. Genes other than TLR4 are involved in the response to inhaled LPS. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;281(5):L1106-L1114. |
R826711 (Final) R826711C004 (Final) |
not available |
Journal Article | Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. | JOURNAL OF IMMUNOLOGY | Monick MM, Staber JM, Thomas KW, Hunninghake GW | Monick MM, Staber JM, Thomas KW, Hunninghake GW. Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. Journal of Immunology 2001;166(4):2681-2687. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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Journal Article | Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. | JOURNAL OF BIOLOGICAL CHEMISTRY | Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW | Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. Journal of Biological Chemistry 2003;278(52):53035-53044. |
R826711 (Final) R826711C003 (Final) |
not available |
Journal Article | TNF -alpha and IL-1 beta are not essential to the inflammatory response in LPS -induced airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA | Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA. TNF-α and IL-1β are not essential to the inflammatory response in LPS -induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Biology 2001;280(1):L173-L180. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
not available |
Journal Article | CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA | Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA. CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease. American Journal of Respiratory Cell and Molecular Biology 2002;27(4):474-480. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. | JOURNAL OF IMMUNOLOGY | Moreland JG, Bailey G, Nauseef WM, Weiss JP | Moreland JG, Bailey G, Nauseef WM, Weiss JP. Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. Journal of Immunology 2004;172(1):426-432. |
R826711 (Final) R826711C001 (Final) |
not available |
Journal Article | IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. | JOURNAL OF APPLIED PHYSIOLOGY | Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA | Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA. IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. Journal of Applied Physiology 2000;88(1):173-179. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
not available |
Journal Article | Neutrophils play a critical role in the development of LPS-induced airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Savov JD, Gavett SH, Brass DM, Costa DL, Schwartz DA | Savov JD, Gavett SH, Brass DM, Costa DL, Schwartz DA. Neutrophils play a critical role in the development of LPS-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2002;283(5):L952-L962. |
R826711 (Final) R826711C004 (Final) |
not available |
Journal Article | Fibrinolysis in LPS -induced chronic airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Savov JD, Brass DM, Berman KG, McElvania E, Schwartz DA | Savov JD, Brass DM, Berman KG, McElvania E, Schwartz DA. Fibrinolysis in LPS -induced chronic airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(4):L940-L948. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | Ozone-induced acute pulmonary injury in inbred mouse strains. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Savov JD, Whitehead GS, Wang J, Liao G, Usuka J, Peltz G, Foster WM, Schwartz DA | Savov JD, Whitehead GS, Wang J, Liao G, Usuka J, Peltz G, Foster WM, Schwartz DA. Ozone-induced acute pulmonary injury in inbred mouse strains. American Journal of Respiratory Cell and Molecular Biology 2004;31(1):69-77. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize LPS-induced inflammation in the lower respiratory tract through an IL-12 dependent pathway. | JOURNAL OF IMMUNOLOGY | Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM | Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize LPS-induced inflammation in the lower respiratory tract through an IL-12 dependent pathway. Journal of Immunology 1999;163:224-231. |
R826711C001 (2000) R826711C002 (2000) |
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Journal Article | The etiology and pathogenesis of airway disease in children and adults from rural communities. | ENVIRONMENTAL HEALTH PERSPECTIVES | Schwartz DA | Schwartz DA. Etiology and pathogenesis of airway disease in children and adults from rural communities. Environmental Health Perspectives, 1999; 107 (Suppl 3):393-401. |
R826711C001 (2000) R826711C002 (2000) |
not available |
Journal Article | Does inhalation of endotoxin cause asthma? | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Schwartz DA | Schwartz DA. Does inhalation of endotoxin cause asthma? American Journal of Respiratory and Critical Care Medicine 2001;163(2):305-306. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | Inhibition of LPS -induced airway hyperresponsiveness and airway inflammation by LPS antagonists. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Schwartz DA, Christ WJ, Kleeberger SR, Wohlford-Lenane CL | Schwartz DA, Christ WJ, Kleeberger SR, Wohlford-Lenane CL. Inhibition of LPS -induced airway hyperresponsiveness and airway inflammation by LPS antagonists. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;280(4):L771-L778. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | RSV inhibits apoptosis and induces NF-κB activity through a PI-3K dependent pathway. | JOURNAL OF BIOLOGICAL CHEMISTRY | Thomas KW, Monick MM, Staber JM, Yarovinsky TO, Carter AB, Hunninghake GW | Thomas KW, Monick MM, Staber JM, Yarovinsky TO, Carter AB, Hunninghake GW. RSV inhibits apoptosis and induces NF-κB activity through a PI-3K dependent pathway. Journal of Biological Chemistry 2002;277(1):492-501. |
R826711 (Final) R826711C003 (Final) |
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Journal Article | Beta-arrestin-2 regulates the development of allergic asthma. | THE JOURNAL OF CLINICAL INVESTIGATION | Walker JK , Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ | Walker JK , Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ. Beta-arrestin-2 regulates the development of allergic asthma. The Journal of Clinical Investigation 2003;112(4):566-574. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | Susceptibility to asbestos-induced and transforming growth factor-beta 1-induced fibroproliferative lung disease in two strains of mice. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Warshamana GS, Pociask DA, Sime P, Schwartz DA, Brody AR | Warshamana GS, Pociask DA, Sime P, Schwartz DA, Brody AR. Susceptibility to asbestos-induced and transforming growth factor-beta 1-induced fibroproliferative lung disease in two strains of mice. American Journal of Respiratory Cell and Molecular Biology 2002;27(6):705-713. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | Allergen -induced airway disease is mouse strain dependent. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Whitehead GS, Walker JK , Berman KG, Foster WM, Schwartz DA | Whitehead GS, Walker JK , Berman KG, Foster WM, Schwartz DA. Allergen -induced airway disease is mouse strain dependent. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(1):L32-L42. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | Cytokine gene expression following inhalation of corn dust. | AMERICAN JOURNAL OF PHYSIOLOGY | Wohlford-Lenane CL, Deetz DC, Schwartz DA | Wohlford-Lenane CL, Deetz DC, Schwartz DA. Cytokine gene expression following inhalation of corn dust. American Journal of Physiology: Lung Cell Molecular Biology 1999;276:L736-L743. |
R826711C001 (2000) R826711C002 (2000) |
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Journal Article | Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Zeldin DC, Wohlford-Lenane C, Chulada P, Bradbury JA, Scarborough PE, Roggli V, Langenbach R, Schwartz DA | Zeldin DC, Wohlford-Lenane C, Chulada P, Bradbury JA, Scarborough PE, Roggli V, Langenbach R, Schwartz DA. Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. American Journal of Respiratory Cell and Molecular Biology 2001;25(4):457-465. |
R826711 (Final) R826711C004 (Final) |
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Journal Article | Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8. | EXPERIMENTAL LUNG RESEARCH | Chen W, Monica MM, Carter AB, Hunninghake GW | Chen W, Monica MM, Carter AB, Hunninghake GW. Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8. Experimental Lung Research 2000;6(1):13-26. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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Journal Article | Effects of ragweed and Th-2 cytokines on the secretion of IL-8 in human airway epithelial cells. | EXPERIMENTAL LUNG RESEARCH | Chen W, Hunninghake GW | Chen W, Hunninghake GW. Effects of ragweed and Th-2 cytokines on the secretion of IL-8 in human airway epithelial cells. Experimental Lung Research 2000;26(4):229-239. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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