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2002 Progress Report: CECEHDPR - University of Michigan
EPA Grant Number: R826710Center: Michigan Center for the Environment and Children’s Health
Center Director: Israel, Barbara A.
Title: CECEHDPR - University of Michigan
Investigators: Israel, Barbara A. , Brown, Randall , Keeler, Gerald J. , Lin, Xihong , Parker, Edith , Philbert, Martin , Remick, Daniel , Robins, Thomas
Current Investigators: Israel, Barbara A.
Institution: University of Michigan - Ann Arbor
EPA Project Officer: Fields, Nigel
Project Period: September 1, 1998 through August 31, 2003 (Extended to August 31, 2005)
Project Period Covered by this Report: September 1, 2001 through August 31, 2002
Project Amount: $2,830,746
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects
Description:
Objective:The Center for Children’s Environmental Health and Disease Prevention – University of Michigan consists of three core projects as follows:
Core 1: Community-Based Intervention to Reduce Environmental Triggers for
Asthma Among Children, and
Core 2: Indoor and Outdoor Air Contaminant Exposures
Please note: The Intervention and Exposure Cores of MCECH continue to have the same specific aims as stated in the proposal, but because the two are so integrated and have the same participants and current goals, their research teams and activities have been combined into one "meta"-project called: Community Action Against Asthma, or CAAA.
Specific Aims and Significance: There have been no changes in the specific aims. The asthma intervention core will test the ability of individually tailored interventions to reduce exposure to environmental contaminants and to improve asthma related health status. At the same time, the intervention will provide direct benefit to the children and families enrolled in the study. The central hypothesis being addressed in the asthma exposure core is that exposure to ambient air contaminants will aggravate the health status of asthmatic children largely through the potentiation of the adverse effects of common indoor air contaminants. Proving or refuting this hypothesis will lead to substantial advances in scientific knowledge and have a direct impact on public health recommendations.
Core 3: Chemokines in the Pathogenesis of Asthma
This research project will test the hypothesis that asthma-like pulmonary injury
is mediated by the local production of specific mediators, which are called
chemokines. Chemokines are small molecular weight proteins which induce the
movement and recruitment of inflammatory cells. The chemokines are powerful
mediators with long lasting and potent biological activities. The first specific
aim is to determine the acute and chronic pulmonary inflammation that develops
after direct injection of the chemokines into the lung. The assessment of
the injury will include a microscopic analysis of the lung as well as an
assessment of the nerves within the airways. The second specific aim is to
develop a mouse model of asthma-like pulmonary inflammation in response to
cockroach allergens. For this specific aim, a model in mice which is similar
to humans will be set up to attempt to decipher the specific mediators that
cause the lung injury. This model will be established by locating households
with high levels of cockroach allergens and using this material to immunize
the mice. The mice will be challenged by exposure to aerosols containing
the dust with the cockroach allergens and the pulmonary injury carefully
quantitated including an analysis of innervation of the airways. The third
specific aim is to investigate the signals responsible for inducing the cells
to make the chemokines. This will be done in cells sensitized and then challenged
with cockroach allergens. This will focus on reactive oxygen and reactive
nitrogen intermediates since they have been demonstrated to increase the
synthesis of chemokines. The last specific aim is to rigorously test the
central hypothesis that chemokines are important in causing asthma. This
will be tested by blocking the biological activity of the chemokines with
specific therapies to inhibit the chemokines and then determining if there
is a reduction in the pulmonary inflammation induced by repeated exposures
to the cockroach allergens. Successful completion of this project will both
delineate the underlying mechanisms of disease and identify potential novel
targets for intervention.
See individual Progress Reports for details – (R826710C001 – R826710C003 – 2002 Progress Reports)
Journal Articles: 26 Displayed | Download in RIS Format
| Other center views: | All 46 publications | 26 publications in selected types | All 26 journal articles |
| Type | Citation | ||
|---|---|---|---|
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Clark NM, Brown RW, Parker EA, Robins TG, Remick DG, Philbert MA, et al. Childhood asthma. Environmental Health Perspectives. 1999;107:421-429. |
R826710 (Final) R826710C001 (1999) R826710C002 (1999) R826710C003 (1999) |
not available |
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Dvonch T, Marsik FJ, Keeler GJ, Robins TG, Yip F, Morishita M. Field comparison of PM2.5 TEOM and PM2.5 manual filter-based measurement methods in urban atmospheres. Journal of Aerosol Science. 2000;31:S190-S191 |
R826710 (Final) |
not available |
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Edgren KK, Parker EA, Israel BA, Lewis TC, Salinas M, Robins TG, Hill YR. Conducting a health education intervention and an epidemiological research project involving community members and community partner organizations: The Community Action Against Asthma Project.Health Promotion Practice2005;6(3):263-269. |
R826710 (Final) |
not available |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned from the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R826710 (Final) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R831710 (2004) R831710 (2005) R831861 (2005) R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) R832141 (2006) |
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Farquhar SA, Parker EA, Israel BA. In their words: A qualitative analysis of the effects of the physical environment on Detroit residents.Local Environment2005;10(3): 259-274. |
R826710 (Final) |
not available |
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Farquhar SA, Parker EA, Schulz AJ, Israel BA. In their words: How Detroit residents perceive the effects of their physical environment. Local Environment. 2005;10(3):259-274. |
R826710 (Final) |
not available |
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Farquhar SA, Parker EA, Israel BA, Schulz AS. The effects of the physical environment on health and well-being in residents of eastside and southwest Detroit, Michigan. Journal of Environmental Psychology. |
R826710 (2002) |
not available |
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|
Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R826710 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R827027 (2002) R831845 (2005) R831861 (2004) R831861 (2005) R832141 (2006) |
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Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) R831709 (2005) R831709C003 (2005) R831709C003 (2006) R831710 (2004) R831710 (2005) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Israel BA, Schulz AJ, Parker EA, Becker AB, Allen AJ, Guzman JR. Critical issues in developing and following community-based participatory research principles. In: M Minkler and N Wallerstein, editors. Community-Based Participatory Research for Health. San Francisco, CA: Jossey-Bass; 2003:56-73. |
R826710 (Final) |
not available |
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Keeler GJ, Dvonch JT, Yip F, Parker EA, Israel BA, Marsik FJ, et al. Assessment of personal and community-level exposures to particulate matter among children with asthma in Detroit, Michigan, as part of Community Action Against Asthma (CAAA). Environmental Health Perspectives. 2002;110:173-181. |
R826710 (2002) R826710 (Final) |
not available |
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Kim J, Merry AC, Nemzek JA, Bolgos GL, Siddiqui J, Remick DG. Eotaxin Represents the Principal Eosinophil Chemoattractant in a Novel Murine Asthma Model Induced by House Dust Containing Cockroach Allergens. Journal of Immunology 2001;167:2808-2815. |
R826710 (2002) R826710 (Final) |
not available |
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Kim J, McKinley L, Natarajan S, Bolgos GL, Siddiqui J, Copeland S, Remick DG. Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust.Clinical and Experimental Allergy2006;36(1):122-132. |
R826710 (Final) |
not available |
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Kim J, McKinley L, Siddiqui J, Bolgos G, Remick DG. Prevention and reversal of pulmonary inflammation and airway hyperresponsiveness by dexamethasone treatment in a murine model of asthma induced by house dust. American Journal of Physiology - Lung Cellular & Molecular Physiology. 2004;287(3):L503-L509. |
R826710 (Final) |
not available |
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Lewis TC, Robins TG, Dvonch JT, Keeler GJ, Yip FY, Mentz GB, et al. Air pollution associated changes in lung function among asthmatic children in Detroit. Environmental Health Perspectives2005;113(8):1068-1075. |
R826710 (Final) |
not available |
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Lopéz ED, Parker EA, Edgren KK, Brakefield-Caldwell W. Lessons learned while using a CBPR approach to plan and conduct forums to disseminate research findings back to partnering communities. Metropolitan Universities Journal 2005;16(1):57-76. |
R826710 (Final) |
not available |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. CXC chemokines modulate IgE secretion and pulmonary inflammation in a model of allergic asthma. Cytokine2005;32(3-4):178-85. |
R826710 (Final) |
not available |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG.Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice.Respiratory Research2006;7:129. |
R826710 (Final) |
not available |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. Reproducibility of a novel model of murine asthma-like pulmonary inflammation. Clinical & Experimental Immunology. 2004;136:224-231. |
R826710 (Final) |
not available |
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Parker EA, Israel BA, Robins TG, Mentz G, Lin X, Brakefield-Caldwell W, Ramirez E, Edgren KK, Salinas M, Lewis TC. Evaluation of Community Action Against Asthma: A community health worker intervention to improve children's asthma-related health by reducing household environmental triggers for asthma. Health Education and Behavior2008;35(3):376-395. |
R826710 (Final) |
not available |
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Parker EA, Israel BA, Brakefield-Caldwell W, Keeler GJ, Lewis TC, Ramirez E, et al. Community Action Against Asthma: Examining the partnership process of a community-based participatory research project. Journal of General Internal Medicine. 2003;18(7):558-567. |
R826710 (Final) |
not available |
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Parker EA, Robins TG, Israel BA, Brakefield-Caldwell W, Edgren KK, Wilkins D. Developing and implementing guidelines for dissemination: The experience of the Community Action Against Asthma project. In: BA Israel, E Eng, AJ Schulz and E Parker, editors. Methods in Community-Based Participatory Research for Health. San Francisco, CA: Jossey-Bass; 2005:285-306. |
R826710 (Final) |
not available |
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Parker EA, Baldwin GT, Israel BA. Health promotion models and theories for environmental health. Health Education & Behavior. 2004;31(4):491-509. |
R826710 (Final) |
not available |
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Trout D, Weissman DN, Lewis D, Brundage RA, Franzblau A, Remick D. Evaluation of hypersensitivity pneumonitis among workers exposed to metal removal fluids. Applied Occupational and Environmental Hygiene2003;18: 953-60. |
R826710 (Final) |
not available |
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Yip F, Keeler GJ, Dvonch JT, Robins T, Parker E, Israel BA, et al. Personal exposures to particulate matter among children with asthma in Detroit, Michigan. Atmospheric Environment. 2004;38:5227-5236. |
R826710 (Final) |
not available |
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Lewis TC, Robins TG, Joseph CLM, Parker EA, Israel BA, Rowe Z, et al. Identification of gaps in the diagnosis and treatment of childhood asthma using a community-based participatory research approach. Journal of Urban Health. 2004;81(3):472-488. |
R826710 (Final) |
not available |
Children's Health, asthma, community-based intervention, indoor air quality, human health risk, human exposure, particulate matter, environmental monitoring, Michigan, exposure assessment. , HUMAN HEALTH, Air, Geographic Area, Scientific Discipline, Health, RFA, Molecular Biology/Genetics, Health Effects, Indoor Air Pollution, indoor air, Risk Assessments, Health Risk Assessment, Children's Health, Environmental Chemistry, Allergens/Asthma, State, exposure assessment, asthma indices, airborne urban contaminants, allergen, environmental tobacco smoke, inhalation, respiratory problems, respiratory disease, children's environmental health, asthmatic children, air quality, second hand smoke, cigarette smoke, assessment of exposure, childhood respiratory disease, human health risk, susceptibility, cockroaches, acute lung injury, air pollution, airborne pollutants, airway disease, children, exposure, children's vulnerablity, indoor air chemistry, asthma triggers, allergic response, asthma, human exposure, Human Health Risk Assessment, airway inflammation
Relevant Websites:
"Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation
Among Children (Asthma Exposure)"
http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1069/report/2002
"Chemokines in the Pathogenesis of Asthma (Asthma Chemokines)"
http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1076/report/2002
"A Community-Based Intervention to Reduce Environmental Triggers for
Asthma Among Children (Asthma Intervention)"
http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1077/report/2002
Progress and Final Reports:
2000 Progress Report
Original Abstract
Final Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826710C001 Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure)
R826710C002 Chemokines in the Pathogenesis of Asthma (Asthma Chemokines)
R826710C003 A Community-Based Intervention to Reduce Environmental Triggers for Asthma Among Children (Asthma Intervention)