Award Abstract #0333196
IGERT: Integrative Education and Research on Biointerfacial Engineering

NSF Org:	DGE Division of Graduate Education
Initial Amendment Date:	September 24, 2003
Latest Amendment Date:	July 6, 2007
Award Number:	0333196
Award Instrument:	Continuing grant
Program Manager:	Carol Van Hartesveldt DGE Division of Graduate Education EHR Directorate for Education & Human Resources
Start Date:	October 1, 2003
Expires:	September 30, 2009 (Estimated)
Awarded Amount to Date:	$3746381
Investigator(s):	Prabhas Moghe moghe@rci.rutgers.edu (Principal Investigator) Yves Chabal (Co-Principal Investigator) Martin Yarmush (Co-Principal Investigator) Martin Grumet (Co-Principal Investigator) Kathryn Uhrich (Co-Principal Investigator) Theodore Madey (Former Co-Principal Investigator)
Sponsor:	Rutgers University New Brunswick 3 RUTGERS PLAZA NEW BRUNSWICK, NJ 08901 732/932-0150
NSF Program(s):	EAPSI, HUMAN RESOURCES DEVELOPMENT, IGERT FULL PROPOSALS
Field Application(s):	0000099 Other Applications NEC
Program Reference Code(s):	SMET, 9179, 5980, 5918, 1335
Program Element Code(s):	7316, 1360, 1335

ABSTRACT

This IGERT program at Rutgers University, focused on integratively engineered biointerfaces, will be an intimately collaborative effort of 32 selected faculty from graduate programs in Molecular Biosciences, Physical Sciences (Physics, Chemistry & Chemical Biology), and Engineering (Biomedical Engineering, Ceramics and Materials Engineering, Chemical and Biochemical Engineering, Mechanical and Aerospace Engineering).

Intellectual Merit: The program derives strength from the highly cross-disciplinary nature of over fifteen research project areas identified at the cutting edge of the field of biointerfaces, and programmatic partnerships with five strategic centers of excellence to promote cohesive access for the IGERT community to state-of-the-art research infrastructure. A wide range of thesis project themes is planned for the IGERT trainees, developed around three research and educational thrusts, (1) living cell-based interfaces, (2) microengineered and nanoengineered biointerfaces, (3) biosensing and bioresponsive interfaces. The five major partnering Centers for the IGERT program are: Keck Center for Collaborative Neuroscience, Center for Nanomaterials Research, New Jersey Center for Biomaterials, the Laboratory for Surface Modification, and the Rutgers Center for Computational Design. The educational core of the proposed IGERT program will intimately support the research program, and includes graduate courses in the integrative areas of biointerfacial engineering, as well as course modules on responsible conduct of research, technical communications, entrepreneurship and effective teaching/learning methods.

Broader Impact: The IGERT curriculum is designed to foster a community featuring the next generation of biointerfacial and biomaterials engineers by offering IGERT graduate fellows a range of interactive experiences at multiple levels: multi-disciplinary coursework, lab rotations in two cross-cutting research groups, biannual participation in symposia, and participation in a national/international conference resulting in a white paper. To maximize its impact, the IGERT program will offer varied programmatic pathways to promote diverse modes of professional development of IGERT graduate fellows: (1) Summer research internships at selected international sites for academically inclined students; and (2) Translational research and industrial summer internships for students interested in industrial and entrepreneurial careers. Through a partnership with the Robert Davis Learning Institute of the Rutgers Graduate School of Education Institute, the IGERT program will establish a COLTS (Community of Learners and Thought Shapers) program, inspired by communication-driven cognition models, to encourage IGERT fellows to develop as learners by dynamically communicating their research on integratively engineered biointerfaces.

IGERT is an NSF-wide program intended to meet the challenges of educating U.S. Ph.D. scientists and engineers with the interdisciplinary background, deep knowledge in a chosen discipline, and the technical, professional, and personal skills needed for the career demands of the future. The program is intended to catalyze a cultural change in graduate education by establishing innovative new models for graduate education and training in a fertile environment for collaborative research that transcends traditional disciplinary boundaries. In this sixth year of the program, awards are being made to institutions for programs that collectively span the areas of science and engineering supported by NSF.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Anthony, L.J..  "Rutgers Launches New Cross-Disciplinary Program on Engineered Biointerfaces,"  Biomaterials Forum,  v.Spring,  2004,  p. 14.

Dasgupta, A., Hughey, R., Larue, L., and Moghe, P.V..  "E-cadherin expression synergistically induces hepatospecific phenotype and maturation in murine embryonic stem cells in conjunction with hepatotrophic factors.,"  Biotechnol. Bioeng.,  v.92,  2005,  p. 257.

Knapinska, A., Irizarry-Barreto, P., Androulakis, Y., and Brewer, G..  "Molecular mechanisms regulating mRNA stability: Physiological and Pathological Significance.,"  Current Genomics,  v.6,  2005,  p. 471.

Knapinska, A., Peppelenbosch, M., Milano, F., Ferreira, C., Dikiks, S., and Spek, C..  "RNA-based gene therapy for haemophilia B.,"  Current Genomics,  v.6,  2005,  p. 401.

Knapinska, A., Ranganathan, H., Vaidyanathan, H., and Ramos, J..  "Phosphorylation of PEA-15 Switches: Binding Specificity from ERK MAP kinase to FADD.,"  Biochem. J.,  v.390,  2005,  p. 729.

Lin, D., Langrana, N., Yurke, B..  "Force-displacement relations for spherical inclusions in finite elastic media.,"  J. Appl. Phys.,  v.97,  2005,  p. 042510.

Lin, D., Yurke, B., and Langrana, N..  "Inducing reversible stiffness changes in DNA-crossliked gels.,"  J. Mat. Res.,  v.20,  2005,  p. 1456-64.

Lin, D.C., Yurke, B., and Langrana, N.A..  "Mechanical properties of a reversible, DNA-crosslinked polyacrylamide hydrogel.,"  Journal of Biomechanical Engineering,  v.126,  2004,  p. 104.

Maguire, T., Novik, E., Schloss, R., and Yarmush, M.L..  "Alginate-PLL microencapsulation: Effect on the differentiation of embryonic stem cells into hepatocytes.,"  Biotechnology and Bioengineering,  v.93,  2006,  p. 581.

Sharma, R.I., Kohn, J., and Moghe, P.V..  "Poly(ethylene glycol) enhances cell motility on protein-based poly(ethylene glycol)-polycarbonate substrates: a mechanism for cell-guided ligand remodeling,"  Journal of Biomedical Materials Research,  v.69A,  2004,  p. 114.

Steege, K., Grant, C., DeRitter, M., Fadeeva, T., and Castner, E..  "Fluorescence probing of interior, interfacial, and exterior regions in solution aggregates of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers.,"  Langmuir,  v.21,  2005,  p. 1745.

Steege, K., Grant, C., Derriter, M., Fadeva, T., and Castner, E..  "Microviscosity in multiple regions of complex aqueous solutions of poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide).,"  J. Phys. Chem. B.,  v.109,  2005,  p. 22273.

Stickle, M., Kortan, R., Bao, Z., Katz, H., and Chabal, Y..  "Structural characterization of a functionalized organic semiconductor.,"  Proc. Mater. Res. Soc. Symp.,  v.I3,  2005,  p. 16.

Varughese, P., Li, J., Tao, J., Huang, R-B., Zheng, L-S., Lin, L., and Li, J-T..  "A three-dimensional coordination polymer featuring effective ferromagnetic hydroxide bridged manganese (II) chaims.,"  Inorg. Chem.,  v.44,  2005,  p. 4448.


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