![[logo] US EPA](https://webarchive.library.unt.edu/eot2008/20081110095835im_/http://www.epa.gov/epafiles/images/logo_epaseal.gif){kind=logo}
Study Details
format for print in landscape orientation
Information Source
|
Powers, B.E., et al. 2006. "Auditory Deficits in Rats Exposed to an Environmental PCB Mixture during Development." Toxicological Sciences 89(2):415-522. |
|||||
|---|---|---|---|---|---|---|
| Age when Exposed* age description below |
| |||||
| Age when Assessed* age description below |
|
|||||
| Chemical | Polychlorinated Biphenyls (PCBs) | |||||
| Exposure Source | Experimental | |||||
| Exposure Medium | Breast Milk Blood Experimental |
|||||
| Exposure Route | Placental Transfer Ingestion |
|||||
| Species | Rat | |||||
| Study Description and Health Effects/Endpoints |
This study evaluated possible effects of developmental exposure (during pregnancy and lactation) to polychlorinated biphenyls (PCBs) on auditory (listening) functions in offspring. Offspring showed significant deficits in amplitudes (p=0.001) and frequency (p<0.0001) of distortion product otoacoustic emissions (DPOAEs) as compared to controls. There were also significantly elevated thresholds in auditory brainstem responses (ABRs) of exposed offspring as compared to controls (p<0.001). “This study indicates that developmental exposure to PCBs can result in long-lasting deficits on various measures of auditory function.” A comparison of these results with those of other studies was discussed. |
|||||
| Exposure Information and Comments/Notes |
Adult female rats were exposed to a PCB mixture “formulated to mimic the congener profile that is observed in walleye [fish] taken from the Fox River in northeast Wisconsin” at a daily dose of 1-6 mg/kg body weight. The formulated mixture contained PCB Aroclors 1242, 1248, 1254, and 1260 in differing proportions. Exposure of dams began 28 days prior to mating and continued through postnatal day 21, at which time offspring were evaluated by auditory testing. |
|||||
| Editorial Comments | none |
|
||||||||||||||||||
