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Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality

EPA Grant Number: R827355C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
Investigators: Kaufman, Joel D. , Checkoway, Harvey , Koenig, Jane Q. , Sheppard, Lianne , Siscovick, David
Current Investigators: Kaufman, Joel D. , Ishikawa, Naomi , Karr, Catherine , Miller, Kristine , Schreuder, Astrid , Shepherd, Kristine , Sheppard, Lianne , Siscovick, David , Sullivan, Jeff
Institution: University of Washington
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter

Description:

Objective:

This project consists of two related study designs addressing associations between ambient PM exposure and cardiorespiratory disease risks. The first is a time-series analysis of cause-specific mortality in Seattle that relates daily mortality with changes in PM and co-pollutant levels. Its emphasis is cardiovascular and respiratory disease mortality. In parallel with this analysis, we also are performing similar time-series analyses of mortality in Spokane, Washington, and Anchorage, Alaska. The contrasts of results between Seattle, Spokane, and Anchorage, which have different PM compositions, should add significant new information about the relative contributions of particle count, size, and chemical composition to cardiorespiratory mortality. The second design is a "case-crossover" study of roughly 1,100 out-of-hospital sudden cardiac arrest (SCA) cases in Seattle. This design compares PM levels in the days immediately preceding SCA events with levels at previous reference time points.

Publications and Presentations:

Publications have been submitted on this subproject: View all 20 publications for this subproject | View all 191 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 13 journal articles for this subproject | View all 94 journal articles for this center

Supplemental Keywords:

ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility. , Air, Geographic Area, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Susceptibility/Sensitive Population/Genetic Susceptibility, Toxicology, indoor air, Risk Assessments, genetic susceptability, Northwest, Health Risk Assessment, Physical Processes, Incineration/Combustion, Epidemiology, air toxics, Children's Health, Atmospheric Sciences, Biochemistry, particulate matter, Environmental Chemistry, Allergens/Asthma, State, aerosols, combustion contaminants, exposure assessment, incineration, risk assessment, California (CA), PAHs, exposure and effects, environmental hazard exposures, allergen, ambient air quality, cardiovascular disease, health effects, hydrocarbons, indoor air quality, inhalation, mortality, allergens, epidemelogy, air quality, ambient air, cardiopulmonary response, hazardous air pollutants, indoor environment, atmospheric aerosols, assessment of exposure, cardiopulmonary responses, combustion, harmful environmental agents, human health risk, particle exposure, toxics, epidemeology, mortality studies, acute cardiovascular effects, air pollutants, biostatistics, human health effects, particulates, sensitive populations, biological response, ambient particle health effects, air pollution, airborne pollutants, airway disease, atmospheric chemistry, biological markers, children, exposure, children's vulnerablity, human susceptibility, ambient aerosol, asthma, health risks, human exposure, Human Health Risk Assessment, morbidity, animal model, airway inflammation, particle transport

Progress and Final Reports:
1999 Progress Report
2000 Progress Report
2001 Progress Report
2002 Progress Report
2003 Progress Report
Final Report


Main Center Abstract and Reports:
R827355    Airborne PM - Northwest Research Center for Particulate Air Pollution and Health

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
R827355C002 Health Effects
R827355C003 Personal PM Exposure Assessment
R827355C004 Characterization of Fine Particulate Matter
R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
R827355C006 Toxicology Project -- Controlled Exposure Facility
R827355C007 Health Effects Research Core
R827355C008 Exposure Core
R827355C009 Statistics and Data Core
R827355C010 Biomarker Core
R827355C011 Oxidation Stress Makers

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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