IRIS Toxicological Review of Acrylamide (External Review Draft)
Federal Register Notices
Contact
- Robert Dewoskin
- by phone at: 919-541-1089
- by email at: dewoskin.rob@epa.gov
- by email at: dewoskin.rob@epa.gov
Notice
[2/1/08] SAB announces in a February 1, 2008 Federal Register Notice a public teleconference to be held on Feb 20, 2008 with a face-to-face meeting March 10 -12, 2008.
[12/28/07] EPA announces the release of the draft document, Toxicological Review of Acrylamide (CAS No. 79-06-1) In Support of Summary Information on the Integrated Risk Information System (IRIS), in a December 28, 2007 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within the external review period (next 60 days) will be provided to EPA’s Science Advisory Board (SAB) for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions. The deadline for comments was February 26, 2008.
Background
Acrylamide is a chemical used in the production of polyacrylamide polymers. Polyacrylamides are used as a flocculent in water purification, oil recovery, and soil conditioning and stabilization. Other uses include paper making, adhesion-promotion, dye acceptors, and textile additives. Human exposure to acrylamide had been thought to occur primarily in the workplace from dermal contact and inhalation of dust and vapor, with the general public being potentially exposed to low levels of acrylamide primarily through contaminated drinking water.
In addition, the draft toxicological review notes that cigarette smoke (direct and secondary) is another exposure route. In early 2002, Swedish scientists reported high concentrations of acrylamide in certain fried, baked, and deep-fried foods. Subsequent research demonstrated that acrylamide forms de novo during processing of some foods, especially during high temperature cooking of carbohydrate-rich foods that contain asparagine.
This assessment contains the derivation of a chronic reference dose (RfD) and a chronic reference concentration (RfC) for non-cancer effects, as well as an oral slope factor and an inhalation unit risk for carcinogenic effects.
History/Chronology
Jul 2004 | EPA completes the initial draft document for the Toxicological Review of Acrylamide. |
Nov 2006 | EPA completes Internal Agency Review. |
Nov 2007 | EPA completes Inter-Agency Review. |
Dec 2007 | EPA releases the External Review Draft for public comment and review. |
Feb 2008 | SAB announces in a February 1, 2008 Federal Register Notice a public teleconference to be held on Feb 20, 2008 with a face-to-face meeting March 10 -12, 2008. |
Next Steps
Downloads/Related Links
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Acrylamide (CAS No. 79-06-1) in Support of Summary Information on the Integrated Risk Information System (IRIS) External Review Draft (PDF) (337 pp, 2 MB, about PDF)
Additional Information
Contact Information
For communications and outreachLinda Tuxen
by phone at: 703–347–8609
by e-mail at : tuxen.linda@epa.gov
For technical and scientific questions
Robert Dewoskin
by phone at: 919-541-1089
by email at: dewoskin.rob@epa.gov
Citation