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Characterization of a Mouse Model of Iimmunosuppression Using a Single Does of Methylprednisolone Acetate
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| Abstract: | Immunosuppression is a widely used but rarely defined term. To the transplant specialist it is the state at which the transplanted organ is not rejected. For the HIV patient it is the point when AIDS begins. In research, immunosuppression is achieved through the use of glucocorticoids, usualy for prolong period of time. In this model a single dose of methylprednisolone acetate (Depomedrol) was used to produce immunosuppression. The circulating CD3, CD4 and CD8 lymphocyte levels were analyzed to characterize the immunologic changes induced. A drop of greater than 80% was needed to re-establish a Cryptosporidium muris infection in mice who had fully recovered from an initial infection. When compared, the ID50 for mice who were immunosuppressed was three times higher than the ID50 for normal mice, showing immunosuppressed mice were less susceptible to C. muris invasion. |
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| Citation: | Miller, T. A., and F. W. Schaefer. Characterization of a Mouse Model of Iimmunosuppression Using a Single Does of Methylprednisolone Acetate. Presented at Society of Comparative Endocrinology, Asheville, NC, June 1-4, 2003. |
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| Contact: |
Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
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| Division: |
Microbiological & Chemical Exposure Assessment Division |
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| Branch: |
Biohazard Assessment Research Branch |
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| Product Type: |
Abstrct/Oral |
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| Presented: |
06/01/2003 |
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