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PM Characterization and Exposure Assessment (Project 2)
EPA Grant Number: R832417C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R832417
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Johns Hopkins Particulate Matter Research Center
Center Director: Samet, Jonathan M.
Title: PM Characterization and Exposure Assessment (Project 2)
Investigators: Geyh, Alison , Breysse, Patrick
Institution: Johns Hopkins University
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: October 1, 2005 through September 30, 2010
RFA: Particulate Matter Research Centers (2004)
Research Category: Particulate Matter
Description:
Objective:The focus of Project 2 will be on the measurement of specific chemical components and physical characteristics of PM from different areas of the country, which will be used to identify those characteristics of PM that determine toxicity
Approach:We will collect bulk PM samples for bioassays and bulk and integrated samples for detailed characterization to include mass, inorganic ions, elemental carbon and organic compounds, specifically polycyclic aromatic hydrocarbons , elemental metals and their oxides, and sulfur isotope ratios. We will also evaluate PM characteristics in relation to particle size. We will use this matrix of information to characterize differences in PM composition and biological response by location. The objectives of Project 2 include: 1) developing new methods for collecting bulk PM for use in biological assays; 2) developing a portable system the characterization of chemical and physical properties of ambient PM; 3) identifying specific regional differences in PM characteristics that may contribute to differential biological responses in vitro and in vivo bioassay systems; and 4) assessing a relationship between human exposure to PM2.5 and biological response during a high PM2.5 exposure period and a low PM2.5 exposure periods. By successfully completing this project, we anticpate providing a better understanding of how differences in physiochemical composition impact PM health effects.
Expected Results:We anticipate that the results of this project will inform PM air quality regulations, suggesting new PM exposure metrics that can be used to modify existing air monitoring networks. Project investigators are well qualified to conduct this research and this project leverages support from a wide range of funded projects, including data from existing air quality databases and resources from a previously EPA funded PM Supersite.
Supplemental Keywords: air pollution, PM10, mobile sources,
,
Air, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Risk Assessments, Health Risk Assessment, Physical Processes, Epidemiology, particulate matter, cardiovascular disease, ultrafine particulate matter, particulate matter components, aersol particles, human health risk, acute cardiovascular effects, atmospheric particles, ambient particle health effects, airway disease, atmospheric particulate matter, exposure, long term exposure, atmospheric aerosol particles
Progress and Final Reports:
2006 Progress Report
2007 Progress Report
2008 Progress Report
Main Center Abstract and Reports:
R832417 Johns Hopkins Particulate Matter Research Center
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832417C001 Estimation of the Risks to Human Health of PM and PM Components
R832417C002 PM Characterization and Exposure Assessment (Project 2)
R832417C003 Biological Assessment of the Toxicity of PM and PM Components