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Immunologic Basis of Environmental Lung Disease
EPA Grant Number: R825702Center: Environmental Lung Disease Center (National Jewish Medical and Research Center)
Center Director: Mason, Robert
Title: Immunologic Basis of Environmental Lung Disease
Investigators: Mason, Robert J.
Current Investigators: Mason, Robert J. , Gelfand, Erwin , Rabinovitch, Nathan , White, Carl W.
Institution: National Jewish Medical and Research Center
EPA Project Officer: Glenn, Barbara
Project Period: February 16, 1998 through February 28, 2003 (Extended to February 28, 2004)
Project Amount: $7,269,177
RFA: Environmental Lung Disease Center (National Jewish Medical and Research Center) (1998)
Research Category: Targeted Research
Description:
Objective:The objectives of the Environmental Lung Disease Center are to improve the understanding of lung disease, and develop innovative early disease detection, prevention and treatment approaches. The center's research involves: 1) determining the molecular mechanisms of environmental and occupational lung disease, 2) identifying the genetic and molecular basis for individual susceptibility, and 3) identifying the risk and effects of air pollution on human population with preexisting pulmonary diseases, and the exposure/host response relationship that leads to disease. Besides immunologic diseases, the project will focus on respiratory, allergic, and infectious diseases, through an integrated program of basic and clinical research.
Journal Articles: 39 Displayed | Download in RIS Format
| Other center views: | All 69 publications | 39 publications in selected types | All 39 journal articles |
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Ahmad S, Ahmad A, McConville G, Schneider BK, Allen CB, Manzer R, Mason RJ, White CW. Lung epithelial cells release ATP during ozone exposure: signaling for cell survival. Free Radical Biology and Medicine 2005;39(2):213-226. |
R825702C014 (Final) |
not available |
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Ahmad S, Ahmad A, McConville G, Schneider BK, Allen CB, Manzer R, Mason RJ, White CW. Lung epithelial cells release ATP during ozone exposure: signaling for cell survival. Free Radical Biology and Medicine 2005;39(2):213-226. |
R825702 (Final) |
not available |
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Allen MJ, Harbeck R, Smith B, Voelker DR, Mason RJ. Binding of rat and human surfactant proteins A and D to Aspergillus fumigatus conidia. Infection and Immunity 1999;67(9):4563-4569. |
R825702 (Final) R825702C001 (Final) |
not available |
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Allen MJ, Voelker DR, Mason RJ. Interactions of surfactant proteins A and D with Saccharomyces cerevisiae and Aspergillus fumigatus. Infection and Immunity 2001;69(4):2037-2044. |
R825702 (Final) R825702C001 (Final) |
not available |
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Allen MJ, Laederach A, Reilly PJ, Mason RJ. Polysaccharide recognition by surfactant protein D: novel interactions of a C-type lectin with nonterminal glucosyl residues. Biochemistry 2001;40(26):7789-7798. |
R825702 (Final) R825702C001 (Final) |
not available |
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Allen MJ, Laederach A, Reilly PJ, Mason RJ, Voelker DR. Arg343 in human surfactant protein D governs discrimination between glucose and N-acetylglucosamine ligands. Glycobiology 2004;14(8):693-700. |
R825702 (Final) R825702C001 (Final) |
not available |
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Cui Z-H, Joetham A, Aydintug MK, Hahn YS, Born WK, Gelfand EW. Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on gammadelta T cells. American Journal of Respiratory and Critical Care Medicine 2003;168(11):1324-1332. |
R825702 (Final) R825702C012 (Final) |
not available |
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Dakhama A, Kraft M, Martin RJ, Gelfand EW. Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-beta 1 in airway epithelial cells by Mycoplasma pneumoniae. American Journal of Respiratory Cell and Molecular Biology 2003;29(3 Pt 1):344-351. |
R825702 (Final) R825702C012 (Final) |
not available |
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Gelfand EW, Joetham A, Cui Z-H, Balhorn A, Takeda K, Taube C, Dakhama A. Induction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitization. Journal of Immunology 2004;173(2):1298-1306. |
R825702 (Final) R825702C012 (Final) |
not available |
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Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I, Irvin CG, Lee JJ, Kikutani H, Conrad D, Gelfand EW. CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2000;161(3 Pt 1):952-960. |
R825702 (Final) R825702C012 (Final) |
not available |
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Kanehiro A, Takeda K, Joetham A, Tomkinson A, Ikemura T, Irvin CG, Gelfand EW. Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice. American Journal of Respiratory and Critical Care Medicine 2000;162(3 Pt 1):1132-1139. |
R825702 (Final) R825702C012 (Final) |
not available |
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Kanehiro A, Ikemura T, Makela MJ, Lahn M, Joetham A, Dakhama A, Gelfand EW. Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. American Journal of Respiratory and Critical Care Medicine 2001;163(1):173-184. |
R825702 (Final) R825702C012 (Final) |
not available |
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Kanehiro A, Lahn M, Makela MJ, Dakhama A, Fujita M, Joetham A, Mason RJ, Born W, Gelfand EW. Tumor necrosis factor-alpha negatively regulates airway hyperresponsiveness through gamma-delta T cells. American Journal of Respiratory and Critical Care Medicine 2001;164(12):2229-2238. |
R825702 (Final) R825702C001 (Final) |
not available |
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Kanehiro A, Lahn M, Makela MJ, Dakhama A, Joetham A, Rha YH, Born W, Gelfand EW. Requirement for the p75 TNF-alpha receptor 2 in the regulation of airway hyperresponsiveness by gamma delta T cells. Journal of Immunology 2003;169(8):4190-4197. |
R825702 (Final) R825702C012 (Final) |
not available |
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Kumarathasan P, Blais E, Goegan P, Yagminas A, Guenette J, Adamson IY, Crapo JD, Mason RJ, Vincent R. 90-day repeated inhalation exposure of surfactant protein-C/tumor necrosis factor-alpha, (SP-C/TNF-alpha) transgenic mice to air pollutants. International Journal of Toxicology 2005;24(1):59-67. |
R825702 (Final) R825702C001 (Final) |
not available |
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Makela MJ, Kanehiro A, Dakhama A, Borish L, Joetham A, Tripp R, Anderson L, Gelfand EW. The failure of interleukin-10-deficient mice to develop airway hyperresponsiveness is overcome by respiratory syncytial virus infection in allergen-sensitized/challenged mice. American Journal of Respiratory and Critical Care Medicine 2002;165(6):824-831. |
R825702 (Final) R825702C012 (Final) |
not available |
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Manzer R, Wang J, Nishina K, McConville G, Mason RJ. Alveolar epithelial cells secrete chemokines in response to IL-1beta and lipopolysaccharide but not to ozone. American Journal of Respiratory Cell and Molecular Biology 2006;34(2):158-166. |
R825702 (Final) R825702C001 (Final) |
not available |
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Pan T, Nielsen LD, Allen MJ, Shannon KM, Shannon JM, Selman M, Mason RJ. Serum SP-D is a marker of lung injury in rats. American Journal of Physiology-Lung Cellular and Molecular Physiology 2002;282(4):L824-L832. |
R825702 (Final) R825702C001 (Final) |
not available |
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Park JW, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Donaldson DD, Gelfand EW. Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen. Journal of Allergy and Clinical Immunology 2003;112(6):1078-1087. |
R825702 (Final) R825702C012 (Final) |
not available |
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Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyoera G, Schultz LD, Lambris JD, Giclas P, Holers VM, Gelfand EW. Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. American Journal of Respiratory and Critical Care Medicine 2004;169(6):726-732. |
R825702 (Final) R825702C012 (Final) |
not available |
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Park JW, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim SH, Dinarello CA, Gelfand EW. Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. American Journal of Respiratory Cell and Molecular Biology 2004;30(6):830-836. |
R825702 (Final) R825702C012 (Final) |
not available |
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Pulfer MK, Taube C, Gelfand E, Murphy RC. Ozone exposure in vivo and formation of biologically active oxysterols in the lung. Journal of Pharmacology and Experimental Therapeutics 2005;312(1):256-264. |
R825702 (Final) R825702C014 (Final) |
not available |
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Rabinovitch N, Zhang L, Murphy JR, Vedal S, Dutton SJ, Gelfand EW. Effects of wintertime ambient air pollutants on asthma exacerbations in urban minority children with moderate to severe disease. Journal of Allergy and Clinical Immunology 2004;114(5):1131-1137. |
R825702 (Final) R825702C013 (Final) |
not available |
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Rabinovitch N, Liu AH, Zhang L, Rodes CE, Foarde K, Dutton SJ, Murphy JR, Gelfand EW. Importance of the personal endotoxin cloud in school-age children with asthma. Journal of Allergy and Clinical Immunology 2005;116(5):1053-1057. |
R825702 (Final) R825702C013 (Final) |
not available |
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Rabinovitch N, Liu AH, Zhang L, Foarde K, Rodes CE, Gelfand EW. Increased respirable endotoxin exposure with furry pets. Allergy 2006;61(5):650-651. |
R825702 (Final) R825702C013 (Final) |
not available |
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Rabinovitch N, Strand M, Gelfand EW. Particulate levels are associated with early asthma worsening in children with persistent disease. American Journal of Respiratory and Critical Care Medicine 2006;173(10):1098-1105. |
R825702 (Final) R825702C013 (Final) |
not available |
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Rha Y-H, Taube C, Haczku A, Joetham A, Takeda K, Duez C, Siegel M, Aydintug MK, Born W, Dakhama A, Gelfand EW. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. Journal of Immunology 2002;169(9):5300-5307. |
R825702 (Final) R825702C012 (Final) |
not available |
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Strand M, Vedal S, Rodes C, Dutton SJ, Gelfand EW, Rabinovitch N. Estimating effects of ambient PM2.5 exposure on health using PM2.5 component measurements and regression calibration. Journal of Exposure Science & Environmental Epidemiology 2006;16(5):471. |
R825702 (Final) R825702C013 (Final) |
not available |
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Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL. MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. Journal of Biological Chemistry 2001;276(7):5093-5100. |
R825702 (Final) R825702C012 (Final) |
not available |
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Taylor MD, Van Dyke K, Bowman LL, Miles PR, Hubbs AF, Mason RJ, Shannon K, Reasor MJ. A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity. Toxicology and Applied Pharmacology 2000;167(3):182-190. |
R825702 (Final) R825702C001 (Final) |
not available |
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Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt M-C, Gundel R, Gelfand EW. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. Journal of Immunology 2001;166(9):5792-5800. |
R825702 (Final) R825702C012 (Final) |
not available |
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Zhang F, Pao W, Umphress SM, Jakowlew SB, Meyer AM, Dwyer-Nield LD, Nielsen LD, Takeda K, Gelfand EW, Fisher JH, Zhang L, Malkinson AM, Mason RJ. Serum levels of surfactant protein D are increased in mice with lung tumors. Cancer Research 2003;63(18):5889-5894. |
R825702 (Final) R825702C001 (Final) |
not available |
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Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, Xing Z, Gauldie J, Gelfand EW. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. American Journal of Respiratory Cell and Molecular Biology 2000;23(3):327-334. |
R825702 (Final) R825702C012 (Final) |
not available |
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Larsen GL, White CW, Takeda K, Loader JE, Nguyen DD, Joetham A, Groner Y, Gelfand EW. Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway control. American Journal of Physiology-Lung Cellular and Molecular Physiology 2000;279(2):L350-L359. |
R825702 (Final) R825702C012 (Final) |
not available |
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Uhlson C, Harrison K, Allen CB, Ahmad S, White CW, Murphy RC. Oxidized phospholipids derived from ozone-treated lung surfactant extract reduce macrophage and epithelial cell viability. Chemical Research in Toxicology 2002;15(7):896-906. |
R825702 (Final) R825702C014 (Final) |
not available |
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Makela MJ, Tripp R, Dakhama A, Park JW, Ikemura T, Joetham A, Waris M, Anderson LJ, Gelfand EW. Prior airway exposure to allergen enhances virus-induced airway hyperresponsiveness. Journal of Allergy and Clinical Immunology 2003;112(5):861-869. |
R825702 (Final) R825702C012 (Final) |
not available |
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Kodama T, Kuribayashi K, Nakamura H, Fujita M, Fujita T, Takeda K, Dakhama A, Gelfand EW, Matsuyama T, Kitada O. Role of interleukin-12 in the regulation of CD4+ T cell apoptosis in a mouse model of asthma. Clinical and Experimental Immunology 2003;131(2):199-205. |
R825702 (Final) R825702C012 (Final) |
not available |
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Dakhama A, Larsen GL, Gelfand EW. Calcitonin gene-related peptide: role in airway homeostasis. Current Opinion in Pharmacology 2004;4(3):215-220. |
R825702 (Final) R825702C012 (Final) |
not available |
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Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha Y-H, Park JW, Joetham A, Poch K, Dakhama A, Dinarello CA, Gelfand EW. Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. American Journal of Respiratory Cell Molecular Biology 2004;30(6):837-843. |
R825702 (Final) R825702C012 (Final) |
not available |
Air, Scientific Discipline, Health, Biology, Risk Assessments, Disease & Cumulative Effects, Health Risk Assessment, Epidemiology, air toxics, Atmospheric Sciences, Biochemistry, health effects, environmental toxicant, human health risk, susceptibility, genetic susceptibility, air pollutants, occupational exposure, acute lung injury, airway disease, lung disease, lung epithelial cells, human exposure, animal studies
Progress and Final Reports:
Final Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R825702C001 SP-A and SP-D in Environmental Lung Disease
R825702C003 Adaptation to Nitrogen Dioxide: Role of Altered Glycolytic Pathway Enzyme Expression and NF-κB-Dependent Cellular Defenses Against Apoptosis
R825702C005 Inhalation of Particulate Matter Alters the Allergic Airway Response to Inhaled Allergen
R825702C006 Particle-Induced Lung Inflammation and Extracellular EC-SOD
R825702C007 Indoor-Outdoor Relationships of Airborne Particle Count and Endotoxin Concentrations
R825702C008 The Role of Mitochondrial DNA Mutations in Oxidant-Mediated Lung Injury
R825702C009 Immunopathogenesis of Hypersensitivity Pneumonitis in the Mouse
R825702C010 Activation of Natural T Lymphocytes by Diesel Exhaust Particulates Leads to Their Production of Interleukin-4 and TH2 Lymphocyte Differentiation to Allergen
R825702C011 Latex Antigen Levels During Powdered and Powderless Glove Use
R825702C012 Adjuvant Effects of Ozone in a Model of Allergen-Induced Airway Inflammation and Hyperresponsiveness
R825702C013 Acute Exposure to Particulate Air Pollution in Childhood Asthma
R825702C014 Mechanisms of Ozone Toxicity to the Lung