Science Policy Issues & Guidance Documents

EPA worked with the Tolerance Reassessment Advisory Committee (TRAC) to identify science policy issues that are key to the implementation of the Food Quality Protection Act (FQPA) and tolerance reassessment. Although EPA has sought independent review and public participation on a wide variety of issues, the Agency agreed that the implementation process would benefit from a more thorough process of public notice and comment. In an October 29, 1998 Federal Register Notice, EPA published a framework to describe these issues. The papers associated with each issue are listed below. Planned papers are shown in gray.

There are no open comment periods at this time.

1. FQPA 10-Fold Safety Factor
2. Dietary Exposure and Risk Assessment
3. Threshold of Regulation
4. Drinking Water Exposure
5. Residential Exposure
6. Aggregrate Exposure and Risk Assessment
7. Cumulative Risk Assessment for Pesticides with a Common Mechanism of Toxicity
8. Chollinesterase Inhibition End Point
9. Use and Usage Information

Note: Some of these documents are in PDF format and require the Acrobat Reader.

Dietary Exposure and Risk Assessment

Title	Federal Register Notice of Availability
Guidance for the Submission of Probabilistic Human Health Exposure Assessments to the Office of Pesticide Programs	November 5, 1998 Docket Number: OPP-00559
Choosing a Percentile of Acute Dietary Exposure as a Threshold of Regulatory Concern (PDF) > Responses to Public Comments	March 22, 2000 Docket Number: OPP-00593A
Use of the Pesticide Data Program (PDP) in Acute Dietary Assessment	May 26, 1999 Docket Number: OPP-00600
Available EPA Information on Assessing Exposure to Pesticides in Food--A User's Guide (Revised) (PDF)	July 12, 2000 Docket Number: OPP-00576A
Data for Refining Anticipated Residue Estimates Used in Acute Dietary Probabilistic Risk Assessments (Revised) (PDF)	June 23, 2000 Docket Number: OPP-00591A
Guidelines for the Conduct of Bridging Studies for Use in Probabilistic Risk Assessment (merged with "Data for Refining Anticipated Residue Estimates...")	June 23, 2000 Docket Number: OPP-00591A
Guidelines for the Conduct of Residue Decline Studies for Use in Probabilistic Risk Assessment (merged with "Data for Refining Anticipated Residue Estimates...")	June 23, 2000 Docket Number: OPP-00591A

Threshold of Regulation

Title	Federal Register Notice of Availability
A Statistical Method for Incorporating Nondetected Pesticide Residues into Human Health Dietary Exposure Assessments (161 KB, PDF) Assigning Values to Nondetected / Nonquantified Pesticide Residues in Human Health Dietary Exposure Assessments (161 KB, PDF) > Response to Public Comments (98 KB, PDF)	March 31, 2000 Docket Number: OPP-00571 Docket Number: OPP-00570A
Threshold of Regulation Policy--Deciding Whether a Pesticide With a Food Use Pattern Needs a Tolerance   (Revised)	October 27, 1999 Docket Number: OPP-00569B

Drinking Water Exposure

Title	Federal Register Notice of Availability
Estimating the Drinking Water Component of a Dietary Exposure Assessment  (Revised) (148 KB, PDF)	November 10, 1999 Docket Number: OPP-00577A
Drinking Water Screening Level Assessment (110 KB, PDF) Standard Operating Procedure for Incorporating Screening-Level Estimates of Drinking Water Exposure in Aggregate Risk Assessments (132 KB, PDF)	October 11, 2000 Docket Number: OPP-00679
Quantitative Assessment of Uses of Concern for Drinking Water	To be determined
Water Treatment Effects on Pesticide Removal and Transformation (269 KB, PDF)	November 21, 2001 Docket Number: OPP-00731

Residential Exposure

Title	Federal Register Notice of Availability
Standard Operating Procedures (SOPs) for Residential Exposure Assessment (368 KB, PDF) Framework for Assessing Non-occupational / Non-dietary (Residential) Exposure to Pesticides	January 4, 1999 Docket Number: OPP-00578 Docket Number: OPP-00579

Aggregating Exposure and Risk Assessment

Title	Federal Register Notice of Availability
General Principles for Performing Aggregate Exposure and Risk Assessments (Revised) (427 KB PDF) > Response to Public Comments (418 KB, PDF)	November 28, 2001 Docket Number: OPP-00732

Cumulative Risk Assessment for Pesticides with a Common Mechanism of Toxicity

Title	Federal Register Notice of Availability
Guidance for Identifying  Pesticide Chemicals and Other Substances That Have a Common Mechanism of Toxicity  (Revised) (76 KB, PDF)	February 5, 1999 Docket Number: OPP-00542
Guidance on Cumulative Risk Assessment of Pesticide Chemicals That Have a Common Mechanism of Toxicity (491 KB, PDF) > Response to Public Comments (581 KB, PDF)	January 16, 2002 Docket Number: OPP-00658B
Application of the 10X Safety Factor in Cumulative Risk Assessment (120 KB, PDF)	February 28, 2002 Docket Number: OPP-00759

Cholinesterase Inhibition End Point

Title	Federal Register Notice of Availability
The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides (128 KB, PDF) > Response to Public Comments (123 KB, PDF) > Docket Index (Lists documents available in the OPP Public Regulatory Docket; some documents are available on the Web)	September 8, 2000 Docket Number: OPP-00560A

Use and Usage Information

Title	Federal Register Notice of Availability
The Role of Use-Related Information in Pesticide Risk Assessment and Risk Management (Revised) (204 KB, PDF)	October 11, 2000 Docket Number: OPP-00609A

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