Acetone Quickview (CASRN 67-64-1)

Status of Data for Acetone

File First On-Line: 03/31/1987; Last Significant Revision: 07/31/2003

Category (section)	Status	Last Revised
Oral RfD Assessment	On-line	07/31/2003
Inhalation RfC Assessment	Discussion	07/31/2003
Carcinogenicity Assessment	On-line	07/31/2003

Synonyms

67-64-1 Dimethylformaldehyde Dimethyl ketone Ketone, dimethyl beta-Ketopropane

Methyl ketone Propanone Pyroacetic acid Pyroacetic ether more...

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect	Point of Departure*	UF	MF	RfD
Nephropathy	NOAEL : 900 mg/kg-day	1000	1	0.9 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

• Principal and Supporting Studies (Oral RfD)
  • Subchronic drinking water study in rats, Dietz, et., al, 1991; NTP, 1991
• Confidence in the Oral RfD
  • Study -- Medium
  • Database -- Medium
  • RfD -- Medium

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • Data are inadequate for an assessment of human carcinogenic potential
• Weight-of-Evidence Narrative:
  • In accordance with the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999) data are inadequate for an assessment of the human carcinogenic potential of acetone.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

• Not Assessed under the IRIS Program.

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

• Not Assessed under the IRIS Program.