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Our database is focused on immunologically-related genes classified under the following categories:

• Apoptosis
• CD markers
• Chemokines
• Chemokine receptors
• Cytokines
• Cytokine receptors
• Dendritic cell associated genes
• Type 1 IFN induced proteins
• Inflammation
• NFKB signaling pathway
• Toll receptor signaling pathway
• T cell activation
• TH1 cell development
• TH2 cell development

Immunologically-related genes associated with the susceptibility to or pathology of the following diseases are emphasized:

• Allergy
• Asthma
• Atherosclerosis

The database is focused on genes involved in the transport or metabolism of:

• Iron
• Selenium
• Vitamin D
• Vitamin A

Nutritionally-related genes associated with the susceptibility to or pathology of the following diseases are emphasized:

• Atherosclerosis
• Diabetes
• Obesity

This process identified 3,100 candidate genes.

We identified porcine homologues to human genes of interest by searching online sources of porcine gene information.  

Genbank (NR, EST, GSS, HTGS and Trace Archive databases) was searched by discontiguous Megablast using human Reference Sequence Accession numbers.

A similar search was conducted in the following databases using the human reference sequence, human Unigene number and/or HUGO gene symbols;

The DFCI (formerly TIGR) Gene Index

http://compbio.dfci.harvard.edu/tgi/tgipage.html

NIH Intramural Sequencing Center (NISC)

http://www.nisc.nih.gov/projects/zooseq/comp_seq_org_targets.cgi?org=pig

Swine UniGene

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=unigene

Pig EST Data Explorer

HomoloGene

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=homologene

The database contains 1,410 real-time PCR assays (including 237 human cross reactive probes).  Our database also contains comprehensive information regarding antibody availability.  If you use a real-time PCR assay from this database, please cite our web address: http://199.133.11.115/fmi/iwp/cgi?-db=PINdb&-loadframes.

Click HERE to enter into the PIN database