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2004 Progress Report: Inner City Toxicants and Neurodevelopment in Urban Children
EPA Grant Number: R831711Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research.
Center Director: Wolff, Mary S.
Title: Inner City Toxicants and Neurodevelopment in Urban Children
Investigators: Wolff, Mary S. , Barr, Dana , Claudio, Luz , Deych, Elena , Godbold, James , Lapinski, Robert , Moshier, Erin , Teitelbaum, Susan
Current Investigators: Wolff, Mary S. , Claudio, Luz , Galvez, Maria , Godbold, James , Teitelbaum, Susan
Institution: Mount Sinai School of Medicine , Centers for Disease Control and Prevention
Current Institution: Mount Sinai School of Medicine
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2003 through October 31, 2008
Project Period Covered by this Report: May 7, 2004 through October 31,2004
Project Amount: $3,948,091
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Children's Health , Health Effects
Description:
Objective:Children in America’s cities are at risk of exposure to multiple known and potential developmental toxicants, and particular concern has been raised about newly identified, widely prevalent chemicals—the so-called endocrine disruptors (EDs), which include phthalates and alkyl phenols. They have become widely dispersed in the urban built-environment, and significant levels of phthalates are now nearly ubiquitous in the bodies of Americans. Highest exposures occur in children and in minorities. Yet little is known, either of children’s pathways of exposure to EDs or their presence and their levels in children, or of the human developmental toxicity of EDs. To address these gaps, the Mount Sinai Center is undertaking research to: (1) characterize the levels and sources of children’s exposures to contemporary-use EDs in the urban built environment; (2) study relationships between EDs and neurobehavioral development; (3) study relationships among ED exposures, diet, physical activity, and somatic growth; and (4) characterize enzymatic polymorphisms that may modulate individual susceptibility to EDs. This research is underway, and preliminary findings indicate broad, variable exposures and disparate built-environment characteristics in our neighborhood.
Community Outreach and Translation Core
The goals of the Community Outreach and Translation Core (COTC) are to provide educational activities to study participants in the epidemiological project in order for the community to receive direct benefits from the study. The educational activities that will be offered will include hands-on workshops for study participants and their mothers that will help them understand the scientific process in which they will take part. These educational activities will be reinforced by providing related materials such as books, games, and exercise equipment that the participants will take home and will serve also as incentives for participation in the study. The educational activities will be culturally appropriate to the community of East Harlem, which is the partner community in this study.
Administration Core
No changes have been made in the Specific Aims.
The Core provides overall direction to the Mount Sinai Center for Children’s Environment Health and Disease Prevention Research by: (1) coordinating and integrating the academic research projects, The Community-Based Prevention Research (CBPR) Project (R831711C001), the COTC , and the Facilities Cores; (2) overseeing the Center’s Advisory Boards; and (3) providing fiscal management. The Administration Core links the Center to the Mount Sinai Pediatric Environmental Health Specialty Unit (PEHSU) and to the Pediatric Environmental Health Fellowship Program, supported by the Ambulatory Pediatric Association. The Administration Core coordinates the Center’s interactions with other Children’s Environmental Health Centers across the United States, the National Institute of Environmental Health Sciences (NIEHS), U.S. Environmental Protection Agency (EPA), and the Centers for Disease Control and Prevention (CDC), as well as with individuals and organizations interested in pediatric environmental health research and disease prevention. The Administration Core is responsible for linking the Center to the larger research effort in pediatric environmental health and developmental biology, recently established at the Mount Sinai School of Medicine and supported by core funding from the Office of the Dean.
Biostatistics and Data Management Core
No changes have been made in the Specific Aims.
The primary, service-oriented goal of the Biostatistics and Data Management Core is to provide a resource for data management and biostatistical analysis to investigators in the Center. The specific aims of the core are to: (1) provide a shared resource in biostatistical services, including consultation in study design, statistical analysis, and interpretation of results; (2) provide opportunities for education in biostatistical methods that int egrate diverse domains of environmental health research; and (3) provide a resource for the establishment of databases and for monitoring the quality of the databases.
Exposure Assessment Core
No changes have been made in the Specific Aims.
The primary, service-oriented goal of the Exposure Assessment Core is to provide a high-quality, comprehensive, and cost-effective resource in exposure assessment for all of the research projects within the Center. The secondary, research-oriented goal is to evaluate new approaches to the assessment and quantification of children’s exposures to developmental toxicants in the urban environment.
Objectives of the Core, which remain unchanged since the previous application, are to: (1) develop markers of exposure that will permit precise individual assessment of exposures in infants and children (w e have extended this goal in this proposal to identify markers from other laboratories, i.e., CDC, which may be more specific and/or cost effective ); (2) quantify children’s exposures to known environmental toxicants, using analyses of environmental as well as of biological samples; (3) evaluate and quantify exposure pathways; (4) identify new developmental toxicants in the urban environment; (5) access and store environmental and biological samples; and (5) provide quality assurance/quality control (QA/QC) for all analyses conducted in Center projects.
Inner City Toxicants, Child Growth and Development
No changes have been made in the Goals or Specific Aims. Dr. Teitelbaum has identified the combined effect of multiple exposures on human health as a particular interest. Her goal is to apply advanced statistical techniques not yet commonly used by epidemiologists, such as factor analysis and hierarchical regression modeling, to advance the understanding of environmentally related disease.
Specific aims, which remain unchanged since the previous application, are: (1) identify the appropriate statistical modeling techniques for investigating multiple and multilevel exposures in environmental epidemiology analyses; (2) apply the identified statistical techniques to improve the questionnaire assessment of ED exposure (to be used in Projects 1 and 2 [R831711C001 and R831711C002, respectively]) to examine the relation between reported product use and household survey with urinary biomarker levels of ED exposure ascertained in the CBPR pilot study; (3) apply the identified statistical techniques to examine the multilevel and combined multiple exposures of the urban built environment and their relationship with obesity among the children of East Harlem, New York (CBPR – Project 1, R831711C001); and (4) apply the identified statistical techniques to examine the combined effect of multiple exposures on growth and development among the children in Project 2 (R831711C002).
Approach:During years 1-5 of the Center, we studied effects of exposure to environmental chemicals on children’s growth and neurobehavioral development. We characterized children’s exposures to pesticides, polychlorinated biphenyls (PCBs), DDT, chlordane and lead in three birth cohorts from East and Northern Harlem, New York City. We also evaluated susceptibility factors related to certain exposures. With the East Harlem community, we developed, deployed and field-tested integrated pest management methods to reduce children’ exposures to neurotoxic pesticides. In a population of African-American men whose mothers had participated in the Collaborative Perinatal Project during the 1960s, we measured in utero exposure to PCBs and found associated decrements in intelligence that were still evident at age 17 years. We are now studying timing of pubertal development. PCBs, but not DDE, were strongly associated with income, a socioeconomic status indicator, in this cohort. In two recently established (1998-2001) East Harlem birth cohorts, we found evidence for common (but not universal) exposure to organophosphate and pyrethroid pesticides. Exposures to PCBs and related chlorinated hydrocarbons were quite low, but PCB levels were still associated with fish intake. In utero exposure to organophosphates was associated with decreased head circumference of infants at birth, but only in mothers with low PON1 activity. In years 6-10, we continue to follow the birth cohorts established in the first grant cycle, to evaluate effects on later childhood development of these prenatal exposures as well as the prevalent ED exposures.
Progress Summary:During years 1-5 of the Center (under Science To Achieve Results grant R827039), we studied effects of exposure to environmental chemicals on children’s growth and neurobehavioral development. We characterized children’s exposures to pesticides, polychlorinated biphenyls (PCBs), dichloro-diphenyl-trichloroethane (DDT), chlordane, and lead in three birth cohorts from East and Northern Harlem, New York City. We also evaluated susceptibility factors related to certain exposures. With the East Harlem community, we developed, deployed, and field-tested integrated pest management methods to reduce children’s exposures to neurotoxic pesticides. In a population of African-American men whose mothers had participated in the Collaborative Perinatal Project during the 1960s, we measured in utero exposure to PCBs and found associated decrements in intelligence that were still evident at age 17 years. Timing of pubertal development is now being studied. PCBs, but not 1,1-dichloro-2,2-bis(p-dichlorodiphenyl)ethylene (DDE), were strongly associated with income, a socioeconomic status indicator, in this cohort. In two recently established (1998-2001) East Harlem birth cohorts, we found evidence for common (but not universal) exposure to organophosphate and pyrethroid pesticides. Exposures to PCBs and related chlorinated hydrocarbons were quite low, but PCB levels were still associated with fish intake. In utero exposure to organophosphates was associated with decreased head circumference of infants at birth but only in mothers with low paraoxonase (PON1) activity. In years 6-10 of the Center, we continue to follow the birth cohorts established in the first grant cycle (R827039), to evaluate effects on later childhood development of these prenatal exposures as well as the prevalent ED exposures.
Project 1 (R831711C001) is a CBPR project that is studying childhood obesity in relation to structural features and ED exposures in of the urban built environment of East Harlem. We are assessing accessibility to physical activity resources and to healthy foods. We have begun a pilot study to assess biomarkers in 6- to 8- year-old children of phthalates, phenols, and phytoestrogens and the sources of those chemicals. A 3-year longitudinal study will be done to evaluate risk for obesity in relation to built- environment factors and ED exposures.
Project 2 (R831711C002) is a continuing prospective epidemiologic study of an ethnically diverse birth cohort of infants born at Mount Sinai. Over 470 mothers were recruited, with 432 births, yielding 317 newborn, 213 1-year, and 305 2-year assessments. The aim is to assess whether in utero and/or childhood exposure to pesticides and endocrine disruptors, specifically organophosphates, pyrethroids, PCBs, phthalates, and bisphenol A, are associated with childhood growth and neurodevelopment in children in New York City. The possible modulating influences of polymorphisms and enzymatic activity involving paraoxonases, lipases, and glucuronidases will also be evaluated, in collaboration with Project 3.
Project 3 (R831711C003) has been studying seven genetic polymorphisms in the enzymes that activate and detoxify organophosphates and other pesticides in the population of mothers and infants enrolled in Project 2 (R831711C002). Genotypes and phenotypes have been assessed in 656 samples, including maternal and cord bloods. Genotype-phenotype associations of PON1 vary by allele, are independent of race/ethnicity, and are stronger for infants than mothers. Results suggest that infants may be more susceptible to toxic effects of PON1 substrates. High throughput technology has been developed and used in this project. High throughput assays for UGT2B7 and lingual lipase are under development to address our aims to investigate these new ED-related susceptibility factors during the next 4 years.
Two new investigators have joined the Center. Susan Teitelbaum, Ph.D., has been trained in both epidemiology and biostatistics, with experience in environmental cancer epidemiology. She has now joined our Children’s Center to collaborate on applying advanced statistical methodology to the analysis of children’s health risks associated with the combined effect of multiple exposures. Maida Galvez, M.D., was one of first Fellows in Environmental Pediatrics to be trained here at Mount Sinai. Through the Inner City Toxicants, Child Growth and Development project, she is developing her research interests in risk factors in inner-city structural environment that may be associated with obesity and adverse child development.
The Center contains Facilities Cores in Exposure Assessment and Biostatistics/Data Management as well as an Administration Core.
Community Outreach and Translation Core
The COTC has partnered with community-based organizations that have expertise in providing quality supplemental education for minority children and their families. These community-based organizations are:
- Girls, Inc.—expertise in issues related to puberty in girls, including growth, maturation, pregnancy avoidance, and child-parent relationships.
- Community Science Specialists—develops hand-on workshops that help students experience science beyond textbooks.
- Harlem Children’s Zone—offers children communication outlets such as a youth newspaper and video spots that can help children express their views on issues affecting their own communities.
- New York City Parks Foundation—expertise in using the urban outdoor environment as a site for incorporating exercise into daily life.
The organizations listed above have established strong links of collaboration with the COTC to adapt existing educational materials to the needs of the epidemiology study participants. Specifically, the partner community-based organizations are working with Dr. Claudio to modify workshops that have already been developed to the children participating in the Center studies. Collaboration with the community-based organizations listed above also involves the review of existing educational materials that can be used as incentives to be provided in the study. Relevant children’s materials from the National Institutes of Health (NIH) and Scholastic have been reviewed for their appropriateness in this context.
The COTC has held the following workshops for participants in the study:
|
Event Title |
Community Partner |
Participants Attended |
Family Guests |
Total |
|
A Day in the Park |
City Parks Foundation |
15 |
17 |
32 |
|
Cells R Us |
Mount Sinai Laboratory |
02 |
04 |
06 |
|
Ice Skating |
City Parks Foundation |
07 |
11 |
18 |
|
The Foods We Eat |
Little Sisters |
09 |
14 |
23 |
|
Making the video |
Harlem Children’s Zone |
04 |
07 |
11 |
|
Making Hand Lotion |
Mount Sinai Laboratory |
05 |
11 |
16 |
|
Mini-golf |
Randall Island Sport Fdn. |
03 |
11 |
14 |
Significance. The COTC of the Children’s Center has been successful in providing educational opportunities to study participants and their families. It will continue to provide this service to the study. In addition, the COTC has generated a number of fact sheets, newsletters, and other printed material that serve to inform the community about the study. Finally, partnership with the above community organizations has provided support for the study, particularly in the area of recruitment and retention of participants in the study. For example, the Little Sisters of the Assumption expressly stated that they were motivated to participate in the recruitment effort because of the educational opportunities that would be provided to the families they serve.
Administration Core
During the sixth year of the Children’s Center, the Administration Core has worked closely with all Research Projects to publish previous findings and to make the transition to the new grant period. The Core worked closely with the two n ew i nvestigators to begin their research. We participated in the Community Advisory Board meetings convened by Project 1 (R831711C001). We held an External Scientific Advisory Board (ESAB) meeting in March 2003, prior to submission of the competing renewal, and we shall hold another meeting with the new ESAB within the next few months. The Center Director and the co-Principal Investigators (PIs) have represented the Center at national and international meetings during the past year, including special sessions on the Children’s Centers at the Neurotoxicology Annual Meeting in Hawaii (February 2004) and the International Society of Environmental Epidemiology (August 2004), when we also hosted an informal meeting of the Children’s Center Directors. The Core convenes monthly Center meetings to monitor progress and to fine-tune ongoing research.
Significance. The Center is progressing well, in completing studies from the past 5 years and moving forward to the new generation of research on endocrine disruptors, the built-environment, and child growth and development, as planned for the coming cycle.
Biostatistics and Data Management Core
During the sixth year of the Children’s Center, the Core worked closely with the investigators who are following the birth cohort to study the effects of pesticides on neuro development. Dr. Teitelbaum worked with data provided from the Exposure Assessment Core to construct new variables for measures of exposure to pesticides. Some of these variables reflected external exposure, derived from dust and air samples, while other variables reflected internal exposure, derived from blood and/or urine.
A tracking database was established for use in the study of childhood obesity in East Harlem. Also, a database was established for the data collected in the pilot study to assess the inter- and intra-individual variability of urinary biomarkers. Dr. Teitelbaum established this database for the pilot study and has developed plans to analyze the data collected in the pilot study.
The Biostatistics Core sponsors a monthly journal club where methodological papers are presented. This journal club is attended not only by members of this core but also by investigators in other projects in the Center. Methodological issues relating to projects in the Center are addressed in papers chosen for presentation.
Significance. The tracking database that has been set up is essential for the successful implementation of the follow-up study of children in East Harlem. The programming to construct derived variables from data obtained from the Exposure Assessment Core was essential to have meaningful measures of exposure, both external and internal, to relate to health outcomes in the birth cohort.
Exposure Assessment Core
During the sixth year of the Children’s Center, the Exposure Assessment Core has worked closely with all r esearch p rojects to develop and implement methods of environmental sampling and analysis. During the past year, the Exposure Assessment Core has provided logistic support for sample analyses and field survey methods in research Projects 1, 2, and 3 (R831711C001, R831711C002, and R831711C003, respectively). The Core worked with Project 1 (R831711C001) and Drs. Britton and Teitelbaum to start the urinary biomarker pilot project for Project 1 (R831711C001) and to develop biospecimen protocols and the environmental questionnaires to be used in Projects 1 and 2 (R831711C001 and R831711C002, respectively). Samples collected by Project 2 (R831711C002) will be used by Project 3 (R831711C003). The first round of samples will be sent to CDC for analysis before the end of this fiscal year.
Although they are not formally part of the Exposure Assessment Core, both Drs. Susan Teitelbaum and Julie Britton have contributed significantly to various aspects of the Core and will continue to work closely to integrate all aspects of the biomarker and interview measurements into the three Research Projects.
Significance. The pilot study is underway and will provide important information on intrapersonal variation and environmental sources of the endocrine disruptors we plan to measure as biomarkers. No results are yet available.
Inner City Toxicants, Child Growth and Development
During the past year, Dr. Teitelbaum has been one of the principal contributors in the development of study protocols for Project 1 (R831711C001) and several of the protocols being implemented in Project 2 (R831711C002). Additionally, Dr. Teitelbaum has worked closely with Dr. Britton, Project 1 (R831711C001), and the Exposure Assessment Core to start the pilot project for Project 1 (R831711C001) and to develop biospecimen protocols and the environmental questionnaires to be used in Projects 1 and 2 (R831711C001 and R831711C002, respectively). The first round of samples will be sent to CDC for analysis before the end of this fiscal year.
Significance. The pilot study is underway and will provide important information on intrapersonal variation and environmental sources of the endocrine disruptors we plan to measure as biomarkers. No results are yet available.
Expected Results:Project 1 is a Community-Based Participatory Research (CBPR) project that is studying childhood obesity in relation to structural features and endocrine disruptor (ED) exposures in the urban built environment of East Harlem. We are assessing accessibility to physical activity resources and to healthy foods. Quantitative physical activity is being assessed using a newly developed protocol that records daily pedometer readings and activity diaries. Children’s usage patterns of EDs are being determined through a “product-use” questionnaire (developed in our CBPR). We have completed a 6-month study to evaluate biomarker protocols in 34 6-8 year-old children of phthalates, phenols, and phytoestrogens and the sources of those chemicals, with data analysis underway. Reported product usage is being compared with children’s body burdens of new-age EDs as determined in urine. Findings will guide sample collection and analysis for both Projects 1 and 2, as well as lead to an improved product-use questionnaire. A 3-year longitudinal study has begun in 150 6-8 yr-old children to evaluate risk for obesity in relation to built environment factors and ED exposures.
We will continue to examine temporal variability and reliability of the EDs in order to determine optimal urine sampling strategies, to examine ED exposure levels and their relationship to diet, physical activity level and weight, and to compare availability, proximity and density of resources (GIS data) with individual level factors (Neighborhood questionnaire) such as access, knowledge, utilization, dietary quality and physical activity level.
Project 2 is a continuing prospective epidemiologic study of an ethnically diverse birth cohort of infants born at Mount Sinai. We are now conducting neurobehavioral and anthropometric assessments, including %-body fat, at the child’s 4th, 6th, and 7th year. The aim is to assess whether in utero and/or childhood exposure to pesticides and endocrine disruptors, specifically organophosphates, pyrethroids, PCBs, phthalates, and bisphenol A, are associated with childhood growth and neurodevelopment in children in New York City. The possible modulating influences of polymorphisms and enzymatic activity involving paraoxonases, lipases, and glucuronidases will also be evaluated, in collaboration with Project 3.
We are finalizing the statistical analyses of birth outcomes in relationship with maternal prenatal exposure to alkylphosphate pesticide metabolites, PCBs and DDT, lead, and paraoxonase activity as well as genotypes. We have started our analysis of prenatal exposure to pesticide metabolites, PCBs and DDT, lead, and PON expression and the Brazelton Neonatal Behavioral Assessment, which was given within 48 hours of delivery, and the Bayley Scales of Infant Development which were given at years 1 and 2.
Project 3 has been studying seven genetic polymorphisms in the enzymes that activate and detoxify organophosphates and other pesticides in the population of mothers and infants enrolled in Project 2. Genotype-phenotype associations of PON1 vary by allele, are independent of race/ethnicity, and are stronger for infants than mothers. Results suggest that infants may be more susceptible to toxic effects of PON1 substrates. We have developed a new robust single molecule-based haplotyping technology that was verified by showing haplotype-based variation in PON1 activity in mothers heterozygous at two loci, a result that could not have been determined by genotyping or by haplotype inference. High throughput assays for UGT2B7 and lingual lipase are under development, to address our aims to investigate these new ED-related susceptibility factors.
We will complete the examination inferred versus molecular paraoxonase-1 haplotypes in our population. We have found that twenty of the 137 individuals showed different molecular haplotypes than the inferred haplotypes, a 15% disconcordancy, suggesting caution in the use of statistical inference for haplotypes. When the most probable predicted diplotype had a probability of 50-65%, 14 of 31 were discordant (45%). The UGT2B7 promoters of our African-American population will be resequenced. The UGT2B7 results will be compared to exposure measurements and with outcome measurements from Project 2.
In addition, the lipase/amylase data will be used to select individuals with varying lipase/amylase ratios for analysis of phthalate metabolism in collaboration with Dr. Dana Barr at the CDC by HPLC-MS. Goals include establishing an inexpensive biomarker assay to permit large population studies of human variation in phthalate metabolism, and to compare these biomarker results with exposure measurements and outcome measurements from Project 2.
Future Activities:Community Outreach and Translation Core
The COTC has developed tracking database queries in order to evaluate the effects of the outreach activities . We shall monitor progress closely to optimize our outreach effectiveness.
Administration Core
We shall continue to lead the research efforts in the Center and to coordinate cross-Center research; national conference calls have been planned by NIEHS to facilitate this effort. A National Center Director’s retreat is planned for December 2004 in North Carolina. We continue to work on the national level with NIEHS and EPA to disseminate relevant research findings to the national arena and to appropriate policy initiatives.
Biostatistics and Data Management Core
The data from the pilot study will become available for analysis in Year 2. A database will be established to collect scientific data from the Growing Up Healthy in East Harlem study (R831711C001). Monitoring the quality of data in the databases is an ongoing task.
Exposure Assessment Core
The second round of analyses will be done in year 2, and data from the pilot study should be available.
Inner City Toxicants, Child Growth and Development
As soon as the biomarker data from the pilot study are obtained from the CDC, Dr. Teitelbaum will begin statistical analyses that will address Objective 2.
Journal Articles: 142 Displayed | Download in RIS Format
| Other center views: | All 306 publications | 174 publications in selected types | All 141 journal articles |
| Type | Citation | ||
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Anderson HA, Wolff MS. Environmental contaminants in human milk. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(Suppl 6):755-760. |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Anderson HA, Wolff MS. Importance of environmental contaminants in human milk. Journal of Exposure Analysis and Environmental Epidemiology 2000;10:1-6. |
R831711 (2007) |
not available |
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Anderson HA, Wolff MS. Introductory commentary: special fish contaminants issue. Environmental Research 2005;97(2):125-126. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Anderson HA, Wolff MS. Special fish contaminants issue. Environmental Research 2005;97(2):125-126 [introductory commentary]. |
R831711 (2004) |
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Belogolovkin V, Engel SM, Ferrara L, Eddleman KA, Stone JL. Does placental location predict fetal birth-weight in diamniotic twins? Journal of Ultrasound in Medicine 2007;26:187-191. |
R831711 (2007) |
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Berkowitz GS, Wolff MS, Matte T, Susser E, Landrigan PJ. The rationale for a national prospective cohort study of environmental exposure and childhood development. Environmental Research 2001;85(2):59-68. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R827039 (2002) R827039C004 (2002) |
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Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, Landrigan PJ, Wolff MS. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environmental Health Perspectives 2003;111(1):79-84. |
R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R827039 (2002) R827039C004 (2002) |
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Berkowitz GS, Wetmur JG, Birman-Deych E, Obel J, Lapinski RH, Godbold JH, Holzman IR, Wolff MS. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environmental Health Perspectives 2004;112(3):388-391. |
R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2004) R831711C003 (2006) |
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Bienenfeld LA, Golden AL, Garland EJ. Consumption of fish from polluted waters by WIC participants in east Harlem. Journal of Urban Health 2003;80:349-58. |
R831711 (2005) |
not available |
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Borrell LN, Factor-Litvak P, Wolff MS, Susser E, Matte TD. Effect of socioeconomic status on exposures to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) among pregnant African-American women. Archives of Environmental Health 2004;59(5):250-255. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Borrell LN, Factor-Litvak P, Wolff M, Susser E, et al. The effect of socioeconomic indicators on polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) exposure in pregnant women. Archives of Environmental Health 2004;59(5):250-255. |
R831711 (2005) |
not available |
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Braganza SF, Galvez MP, Mencin AA, Ozuah PO. Weighing the appropriate uses of supplemental zinc. Contemporary Pediatrics 2006:23(7):66-74. |
R831711 (2005) R831711 (2007) |
not available |
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Braganza SF, Galvez MP, Mencin AA, Ozuah PO. Weighting the appropriate uses of supplemental zinc. Contemporary Pediatrics 2006;23(7):66-74. |
R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Braganza SF, Galvez MP, Ozuah PO. When parents ask about diet therapy for ADHD. Contemporary Pediatrics 2006;23(5):47-49. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Brand SR, Engel SM, Canfield RL, Yehuda R. The effect of maternal ptsd following in utero trauma exposure on behavior and temperament in the 9-month old infant. Annals of the New York Academy of Sciences 2006;1071:454-454. |
R831711 (2007) |
not available |
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Brenner BL, Markowitz S, Rivera M, Romero H, Weeks M, Sanchez E, Deych E, Garg A, Godbold J, Wolff MS, Landrigan PJ, Berkowitz G. Integrated pest management in an urban community: a successful partnership for prevention. Environmental Health Perspectives 2003;111(13):1649-1653. |
R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2004) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Brenner B. Implementing a community intervention program for health promotion. Social Work in Health Care 2002;35(1-2):359-379. |
R831711 (2005) R831711 (2007) R831711C001 (2006) R831711C003 (2006) |
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Britton JA, Teitelbaum SL, Wolff MS. Correspondence re: Schoen et al., Lack of association between adipose tissue distribution, and insulin-like growth factor-I and insulin-like growth factor binding protein-3 in men and women. Cancer Epidemiology Biomarkers & Prevention 2002;11:581-586 (letter to the editor). |
R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Britton JA, Teitelbaum SL, Wolff MS. Letter to the Editor. Cancer Epidemiology Biomarkers & Prevention 2002;11:581-586. |
R831711 (2005) |
not available |
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Britton JA, Wolff MS, Lapinski R, Forman J, Hochman S, Kabat GC, Godbold J, Larson S, Berkowitz GS. Characteristics of pubertal development in a multi-ethnic population of nine-year-old girls. Annals of Epidemiology 2004;14(3):179-187. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Carpenter DO, Chew FT, Damstra T, Lam LH, Landrigan PJ, Makalinao I, Peralta GL, Suk WA. Environmental threats to the health of children: the Asian perspective. Environmental Health Perspectives 2000;108(10):989-992. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Chemtob CM, Conroy DL, Hochauser CJ, Laraque D, Banks J, Schmeidler J, Dela Cruz M, Nelsen WC, Landrigan PJ. Children who lost a parent as a result of the terrorist attacks of September 11, 2001: registry construction and population description. Death Studies 2007;31(1):87-100. |
R831711 (2007) |
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Chen A, Zhang J, Zhou L, Gao E, et al. DDT serum concentration and menstruation among young Chinese women. Environmental Research 2005;99(3):397-402 |
R831711 (2005) |
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Chen J, Germer S, Higuchi R, Berkowitz G, Godbold J, Wetmur JG. Kinetic polymerase chain reaction on pooled DNA: a high-throughput, high-efficiency alternative in genetic epidemiological studies. Cancer Epidemiology, Biomarkers & Prevention 2002;11(1):131-136. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R827039 (2002) R827039C001 (2002) |
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Chen J, Kumar M, Chan W, Berkowitz G, Wetmur JG. Increased influence of genetic variation on PON1 activity in neonates. Environmental Health Perspectives 2003;111(11):1403-1409. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2004) R831711C003 (2006) |
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Chen J, Chan W, Wallenstein S, Berkowitz G, Wetmur JG. Haplotype-phenotype relationships of paraoxonase-1. Cancer Epidemiology Biomarkers & Prevention 2005;14(3):731-734. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Claudio L, Torres T, Sanjurjo E, Sherman LR, Landrigan PJ. Environmental health sciences education—a tool for achieving environmental equity and protecting children. Environmental Health Perspectives 1998;106(Suppl 3):849-855. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Claudio L, Tulton L, Doucette J, Landrigan PJ. Socioeconomic factors and asthma hospitalization rates in New York City. Journal of Asthma 1999;36(4):343-350. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Claudio L, Stingone J. Disparities in use of urgent health care services among asthmatic children. Annals of Allergy Asthma Immunology 2006;97:244-250. |
R831711 (2007) |
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Claudio L, Stingone JA, Godbold J. Prevalence of childhood asthma in urban communities: the impact of ethnicity and income. Annals of Epidemiology 2006;16(5):332-340. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Claudio L, Stingone J. Improving sampling and response rates in school-based research through participatory methods. Journal of School Health 2008;78:445-451. |
R831711 (2007) |
not available |
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Cohn BC, Cirillo PM, Wolff MS, Schwingl PJ, et al. In utero DDT and DDE exposure may alter time to pregnancy in daughters 30 years later. Lancet 2003;361(9376):2205-2006. |
R831711 (2005) |
not available |
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Dunson DB, Herring AH, Engel SM. Bayesian selection and clustering of polymorphisms in functionally-related genes. Journal of the American Statistical Association 2007;103(482):534-546. |
R831711 (2007) |
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Edwards ES, Green N, Henry CJ, Landrigan PJ, Swartz D. Tracking children’s health to age 21. Science 2003;302(5646):781 (letter). |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Engel SM, Olshan AF, Siega-Riz AM, Savitz DA, Chanock SJ. Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth. American Journal of Obstetrics and Gynecology 2006;195(5):1231.e1-1231.e11. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Engel SM, Hertz-Picciotto I, Schramm M, Watt-Morse M. Recreational Physical Activity Practices Before and During Pregnancy. Obstetrics and Gynecology 2006. |
R831711 (2005) |
not available |
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Engel SM, Levy B, Liu Z, Kaplan D, Wolff MS. Xenobiotic phenols in early pregnancy amniotic fluid. Reproductive Toxicology 2006;21(1):110-112. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C002 (2007) R831711C003 (2006) |
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Engel S, Berkowitz G, Barr DB, Teitelbaum SL, Siskind J, Meisel SJ, Wetmur JG, Wolff MS. Prenatal exposure to organophosphates and organochlorines and performance on the Brazelton neonatal behavioral assessment scale in a multiethnic pregnancy cohort. American Journal of Epidemiology 2007;165:1397-1404. |
R831711 (2007) |
not available |
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Eskenazi B, Landrigan PJ. Environmental Health Perspectives and children’s environmental health. Environmental Health Perspectives 2002;110(10):A559-A560 (editorial). |
R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Eskenazi B, Landrigan PJ. Environmental Health Perspects and children’s environmental health. Environmental Health Perspectives 2002;110:721-728. |
R831711 (2005) R831711 (2007) |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829390 (2005) R831709 (2005) R831709C001 (2004) R831710 (2005) R832141 (2005) |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodological issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R831711 (2007) R829390 (2005) R829390C002 (2005) |
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Etzel RA, Balk SJ, Reigart JR, Landrigan PJ. Environmental health for practicing pediatricians. Indian Pediatrics 2003;40(9):853-860. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Etzel RA, Crain EF, Gitterman BA, Oberg C, Scheidt P, Landrigan PJ. Pediatric environmental health competencies for specialists. Ambulatory Pediatrics 2003;3(1):60-63. |
R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children’s pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. |
R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R827027 (2002) R828609 (Final) R831709 (2005) R831710 (2004) R831710 (2005) R832141 (2006) |
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Fewtrell LJ, Pruss-Ustun A, Landrigan P, Ayuso-Mateos JL. Estimating the global burden of disease of mild mental retardation and cardiovascular diseases from environmental lead exposure. Environmental Research 2004;94(2):120-133. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Flores G, Fuentes-Afflick E, Barbot O, Carter-Pokras O, Claudio L, Lara M, McLaurin JA, Pachter L, Ramos-Gomez FJ, Mendoza F, Valdez RB, Villarruel AM, Zambrana RE, Greenberg R, Weitzman M. The health of Latino children:urgent priorities, unanswered questions, and a research agenda. JAMA 2002;288(1):82-90. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Forman J, Moline J, Cernichiari E, Sayegh S, Torres JC, Landrigan MM, Hudson J, Adel HN, Landrigan PJ. A cluster of pediatric metallic mercury exposure cases treated with meso-2,3-dimercaptosuccinic acid (DMSA). Environmental Health Perspectives 2000;108(6):575-577. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Galvez MP, Frieden TR, Landrigan PJ. Obesity in the 21st century. Environmental Health Perspectives 2003;111(13):A684-A685 (editorial). |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Galvez MP, Peters R, Graber N, Forman J. Effective risk communication in children’s environmental health: lessons learned from 9/11. Pediatric Clinics of North America 2007;54(1):33-46. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Galvez MP, Morland K, Raines C, Kobil J, Siskind J, Godbold J, Brenner B, Godbold J. Race and food store availability in an inner city neighborhood. Public Health Nutrition 2008;11(6):624-631. |
R831711 (2005) R831711 (2007) R831711C001 (2007) |
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Galvez M, Vanable L, Forman JA, Landrigan PJ, Akeredolu E, Leighton J, Nagin D. Childhood lead poisoning from commercially manufactured French ceramic dinnerware-New York City, 2003. Morbidity and Mortality Weekly Reports 2004;53(26):584-586. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Garg A, Landrigan PJ. Children’s environmental health: new gains in science and policy. The Annals of the American Academy of Political and Social Science 2002;584(1):135-144. |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Garg A, Landrigan PJ. Children’s environmental health: new gains in science and policy. Annals of the American Academy of Political and Social Science 2002;584:135-144. |
R831711 (2007) |
not available |
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Goldman L, Falk H, Landrigan PJ, Balk SJ, Reigart JR, Etzel RA. Environmental pediatrics and its impact on government health policy. Pediatrics 2004;113(Suppl 4):1146-1157. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Gore AC. Environmental toxicant effects on neuroendocrine function. Endocrine 2001;14(2):235-246. |
R831711 (2005) R831711 (2007) R831711C001 (2006) R831711C003 (2006) R827039 (2002) R827039C002 (2002) |
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Gore AC, Wu TJ, Oung T, Lee JB, Woller MJ. A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone (GnRH) neurones. Journal of Neuroendocrinology 2002;14(10):814-823. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R827039 (2002) R827039C002 (2002) |
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Gore AC. Organochlorine pesticides directly regulate gonadotropin-releasing hormone (GnRH) gene expression and biosynthesis in the GT1-7 hypothalamic cell line. Molecular and Cellular Endocrinology 2002;192(1-2):157-170. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R827039 (2002) R827039C002 (2002) |
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Grandjean P, Landrigan PJ. Developmental neurotoxicity of industrial chemicals. Lancet 2006;368:2167-78. |
R831711 (2007) |
not available |
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Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) R831709 (2005) R831709C003 (2005) R831709C003 (2006) R831710 (2004) R831710 (2005) |
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Kadlubar FF, Berkowitz GS, Delongchamp RR, Wang C, Green BL, Tang G, Lamba J, Schuetz E, Wolff MS. The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. Cancer Epidemiology Biomarkers and Prevention 2003;12(4):327-331. |
R831711 (2005) |
not available |
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Kriegsfeld LJ, Silver R, Gore AC, Crews D. Vasoactive intestinal polypeptide contacts on gonadotropin-releasing hormone neurones increase following puberty in female rats. Journal of Neuroendocrinology 2002;14(9):685-690. |
R831711 (2005) |
not available |
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Lamb MR, Taylor S, Liu X, Wolff MS, Borrell L, Matte TD, Susser ES, Factor-Litvak P. Prenatal exposure to polychlorinated biphenyls (PCBs) and postnatal growth: a structural analysis. Environmental Health Perspectives 2006;114(5):779-785. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Lambertini L, Diplas AI, Lee MJ, Sperling R, Chen J, Wetmur J. A sensitive functional assay reveals frequent loss of genomic imprinting in human placenta. Epigenetics 2008;3(5). |
R831711 (2007) |
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Landrigan PJ, Suk WA, Amler RW. Chemical wastes, children's health, and the Superfund Basic Research Program. Environmental Health Perspectives 1999;107(6):423-427. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Claudio L, Markowitz SB, Berkowitz GS, Brenner BL, Romero H, Wetmur JG, Matte TD, Gore AC, Godbold JH, Wolff MS. Pesticides and inner-city children: exposures, risks, and prevention. Environmental Health Perspectives 1999;107(Suppl 3):431-437. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2004) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R827039 (2002) R827039C002 (2002) R827039C003 (2000) |
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Landrigan PJ. Risk assessment for children and other sensitive populations. In: Uncertainty in the Risk Assessment of Environmental and Occupational Hazards: An International Workshop. Annals of the New York Academy of Sciences 1999;895(1):1-9. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ. Pediatric lead poisoning: is there a threshold? Public Health Reports 2000;115(6):530-531. |
R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ. Children’s environmental health: lessons from the past and prospects for the future. Pediatric Clinics of North America 2001;48(5):1319-1330. |
R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ. Children's environmental health. Lessons from the past and prospects for the future. Pediatric Clinics of North America 2001;48(5):1319-1330. |
R831711 (2005) |
not available |
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Landrigan PJ. Children’s environmental health: lessons from the past and prospects for the future. Pediatrics Clinics of North America 2001;48:1319-1330. |
R831711 (2007) |
not available |
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Landrigan PJ. Pesticides and polychlorinated biphenyls (PCBs): an analysis of the evidence that they impair children’s neurobehavioral development. Molecular Genetics and Metabolism 2001;73(1):11-17. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ. Pesticides, PCBs, and the Risk to Children. Contemporary Pediatrics 2001;18(2):110-126. |
R831711 (2005) R831711 (2007) |
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Landrigan PJ, Sonawane B, Mattison D, McCally M, Garg A. Chemical contaminants in breast milk and their impacts on children’s health: an overview. Environmental Health Perspectives 2002;110(6):A313-A315. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Clinical Toxicology 2002;40(4):449-456. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Schechter CB, Lipton JM, Fahs MC, Schwartz J. Environmental pollutants and disease in American children: estimates of morbidity, mortality, and costs for lead poisoning, asthma, cancer, and developmental disabilities. Environmental Health Perspectives 2002;110(7):721-728. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ. The worldwide problem of lead in petrol. Bulletin of the World Health Organization 2002;80(10):768 (editorial). |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Kimmel CA, Correa A, Eskenazi B. Children’s health and the environment: public health issues and challenges for risk assessment. Environmental Health Perspectives 2003;112:257-265. |
R831711 (2007) |
not available |
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Landrigan PJ, Slutsky J. Are Learning Disabilities Linked to Environmental Toxins? Journal of Learning Disabilities 2004;15:7-12. |
R831711 (2005) R831711 (2007) |
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Landrigan PJ. Children as a vulnerable population. International Journal of Occupational Medicine and Environmental Health 2004;17(1):175-177. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Kimmel CA, Correa A, Eskenazi B. Children’s health and the environment: public health issues and challenges for risk assessment. Environmental Health Perspectives 2004;112(2):257-265. |
R831711 (2005) R831711C001 (2006) R831711C003 (2006) R831710 (2004) R831710 (2005) R831710C001 (2004) |
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Landrigan PJ, Kimmel CA, Correa A, Eskenazi B. Children's health and the environment: public health issues and challenges for risk assessment. Environmental Health Perspectives 2004;112(2):257-265. |
R831711 (2005) |
not available |
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Landrigan PJ. Environmental factors and pediatric disease: new developments in research and education. Journal of San Francisco Medical Society 2004;77(4):18-19, 26. |
R831711 (2005) R831711 (2007) |
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Landrigan PJ, Newman B. Children and other high-risk workers as a special challenge to occupational health services. Scandinavian Journal of Work, Environment & Health 2005;(1):43-45. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Tamburlini G. Children’s health and the environment: a transatlantic dialogue. Environmental Health Perspectives 2005;113(10):A646-A647 (editorial). |
R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Tamburlini G. Children's health and the environment: a transatlantic dialogue. Environmental Health Perspectives 2005;113(10):A646-A647. |
R831711 (2005) |
not available |
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Landrigan PJ, Tamburlini G. Children’s health and the environment: a transatlantic dialogue. Environmental Health Perspectives 2005;113:A646-A647. |
R831711 (2007) |
not available |
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Landrigan PJ, Sonawane B, Butler RN, Trasande L, Callan R, Droller D. Early environmental origins of neurodegenerative disease in later life. Environmental Health Perspectives 2005;113(9):1230-1233. |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Sonawane B, Butler RN, Trasande L, Callan R, Droller D. Early environmental origins of neurodegenerative disease in later life. Environmental Health Perspectives 2005;113:1230-1233. |
R831711 (2007) |
not available |
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Landrigan PJ, Sonawane B, Butler RN, Trasande L, Callan R, Droller D. Early environmental origins of neurodegenerative disease in later life. Environmental Health Perspectives 2005;113(9):1230-1233. |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ. Environmental exposures and children’s health challenges. Zero to Three 2005;26:8-10. |
R831711 (2005) R831711 (2007) |
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Landrigan PJ.Environmental threats to children’s health – the promise of the National Children’s Study. New England College of Occupational and Environmental Medicine (NECOEM Reporter) 2005;2:1-2. |
R831711 (2005) R831711 (2007) |
not available |
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Landrigan PJ, Trasande L. More kids chronically ill. Poughkeepsie Journal 2005. |
R831711 (2005) R831711 (2007) |
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Landrigan PJ. Environmental pediatrics and the ecological imperative. EcoHealth 2006;3(2):75-76. |
R831711 (2005) R831711 (2007) R831711C001 (2006) R831711C003 (2006) |
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Landrigan PJ, Trasande L, Thorpe LE, Gwynn C, Lioy PJ, D’Alton ME, Lipkind HS, Swanson J, Wadhwa PD, Clark EB, Rauh VA, Perera FP, Susser E. The National Children’s Study: a 21-year prospective study of 100,000 American children. Pediatrics 2006;118(5):2173-2186. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Woolf AD, Gitterman B, Lanphear B, Forman J, Karr C, Moshier EL, Godbold J, Crain E. The Ambulatory Pediatric Association Fellowship in Pediatric Environmental Health: a five-year assessment. Environmental Health Perspectives 2007;115(110):1383-1387. |
R831711 (2007) |
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Landrigan PJ, Trasande L, Swanson JM. Genetics, altruism and the National Children’s Study. American Journal of Medical Genetics Part A 2008;146A:294-296. |
R831711 (2007) |
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Landrigan PJ, Forman J, Galvez M, Newman B, Engel SM, Chemtob C. Impact of September 11 World Trade Center disaster on children and pregnant women. Mount Sinai Journal of Medicine 2008;75:129-134. |
R831711 (2007) |
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Landrigan PJ, Trasande L: More kids chronically ill. Poughkeepsie Journal, January 2, 2005. |
R831711 (2007) |
not available |
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Landrigan P, Garg A, Droller DBJ. Assessing the effects of endocrine disruptors in the National Children’s Study. Environmental Health Perspectives 2003;111(13):1678-1682. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan, PJ. Children’s health and the environment. European Journal of Oncology 1999;4:661-664. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C002 (2006) |
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Liu Z, Wolff MS, Moline J. Analysis of environmental biomarkers in urine using an electrochemical detector. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2005;819:155-159. |
R831711 (2005) R831711 (2007) |
not available |
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Longnecker MP, Wolff MS, Gladen BC, Brock JW, Granjean P, Jacobson JL, Korrick SA, Rogan WJ, Weisglas-Kuperus N, Herz-Picciotto I, Ayotte P, Stewart P, Winneke G, Charles MJ, Jacobson SW, Dewailly E, Boersma ER, Altshul LM, Heinzow B, Pagano JJ, Jensen AA. Comparison of polychlorinated biphenyls (PCBs) levels across studies of human neurodevelopment. Environmental Health Perspectives 2003;111(1):65-70. |
R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Magdo HS, Forman J, Graber N, Newman B, Klein K, Satlin L, Amler RW, Winston JA, Landrigan PJ. Grand rounds: nephrotoxicity in a young child exposed to uranium from contaminated well water. Environmental Health Perspectives 2007;115(8):1237-1241. |
R831711 (2007) |
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Needleman HL, Landrigan PJ. What level of lead in blood is toxic for a child? American Journal of Public Health 2004;94(1):8 (letter). |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Pirisi A. Profile: Philip Landrigan: Children’s Health Crusader. Lancet 2005;365:1281-1360. |
R831711 (2007) |
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Salama J, Chakraborty TR, Ng L, Gore AC. Effects of polychlorinated biphenyls (PCBs) on estrogen receptor-β expression in the anteroventral periventricular nucleus. Environmental Health Perspectives 2003;110(10):1278-1282. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Sarcinelli PN, Pereira AC, Mesquita SA, Oliveira-Silva JJ, et al. Dietary and reproductive determinants of plasma organochlorine levels in pregnant women in Rio de Janeiro. Environmental Research 2003;91(3):143-150. |
R831711 (2005) |
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Savitz DA, Ananth CV, Berkowitz GS, Lapinski R. Concordance among measures of pregnancy outcome based on fetal size and duration of gestation. American Journal of Epidemiology 2000;151(6):627-633. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Stingone JA, Claudio L. Asthma and enrollment in special education among urban schoolchildren. American Journal of Public Health 2006;96(9):1593-1598. (Awarded Best Paper at American Public Health Association Conference, Philadelphia, PA, December 10-14, 2005.) |
R831711 (2007) |
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Stingone JA, Claudio L. Disparities in the use of urgent health care services among asthmatic children. Annals of Allergy Asthma & Immunology 2006;97(2):244-250. |
R831711 (2005) R831711 (2007) |
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Stingone J. Association between asthma and Special Education in a Large, Urban School System. American Journal of Public Health 2006;96:1593-1598. |
R831711 (2007) |
not available |
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Stingone J, Claudio L. Disparities in allergy testing and health outcomes among urban children with asthma. Journal of Allergy and Clinical Immunology 2008;122(4):748-753. |
R831711 (2007) |
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Suk WA, Ruchirawat KM, Balakrishnan K, Berger M, Carpenter D, Damstra T, deGarbino JP, Koh D, Landrigan PJ, Makalinao I, Sly PD, Xu Y, Zheng BS. Environmental threats to children’s health in Southeast Asia and the western Pacific. Environmental Health Perspectives 2003;111(10):1340-1347. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Susser EB, Brown A, Matte TD. Prenatal factors and adult mental and physical health. Canadian Journal of Psychiatry 1999;44(4):326-334. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Susser E, Matte TD. Early antecedents of adult health. Journal of Urban Health 1998;75(2):236-241. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Susser E, Terry MB, Matte T. The birth cohorts grow up: new opportunities for epidemiology. Paediatric and Perinatal Epidemiology 2000;14(2):98-100. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Teitelbaum SL, Britton JA, Calafat AM, Ye X, Silva MJ, Reidy JA, Galvez MP, Brenner BL, Wolff MS. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environmental Research 2008;106(2):257-269. |
R831711 (2007) R831711C001 (2007) |
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Torres-Arreola L, Berkowitz G, Torres-Sánchez L, López-Cervantes M, Cebrian ME, Uribe M, López-Carrillo L. Preterm birth in relation to maternal organochlorine serum levels. Annals of Epidemiology 2003;13(3):158-162. |
R831711 (2005) |
not available |
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Trasande L, Landrigan PJ. The National Children’s Study: a critical national investment. Environmental Health Perspectives 2004;112(14):A789-A790 (editorial). |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Trasande L, Schechter C, Landrigan PJ. Public health and economic consequences of environmental methylmercury toxicity to the developing brain. Environmental Health Perspectives 2005;113(5):590-596. |
R831711 (2005) R831711 (2007) |
not available |
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Trasande L, Schechter CB, Haynes KA, Landrigan PJ. Mental retardation and prenatal methylmercury toxicity. American Journal of Industrial Medicine 2006;49:153-158. |
R831711 (2005) R831711 (2007) |
not available |
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Trasande L, Schapiro ML, Falk R, Haynes KA, Behrmann A, Vohmann M, Stremski ES, Eisenberg C, Evenstad C, Anderson HA, Landrigan PJ. Pediatrician attitudes, clinical activities, and knowledge of environmental health in Wisconsin. Wisconsin Medical Journal 2006;105(2):45-49. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Trasande L, Cronk CE, Leuthner SR, Hewitt JB, Durkin MS, McElroy JA, Anderson HA, Landrigan PJ. The National Children’s Study and the children of Wisconsin. Wisconsin Medical Journal 2006;105(2):50-54. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Trasande L, Boscarino J, Graber N, Falk R, Schechter C, Galvez M, Dunkel G, Geslani J, Moline J, Kaplan-Liss E, Miller RK, Korfmacher K, Carpenter D, Forman J, Balk SJ, Laraque D, Frumkin H, Landrigan P. The environment in pediatric practice: a study of New York pediatricians' attitudes, beliefs, and practices towards children's environmental health. Journal of Urban Health 2006;83(4):760-772. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Trasande L, Landrigan PJ, Schechter CB, Bopp RF. Methylmercury and the developing brain. Environmental Health Perspectives 2007;115(8):A396-A397. |
R831711 (2007) |
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Wallenstein S, Chen J, Wetmur JG. Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype data. Molecular Genetics and Metabolism 2006;89(3):270-273. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Weiss B, Landrigan PJ. The developing brain and the environment: an introduction. Environmental Health Perspectives 2000;108(Suppl 3):373-374. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Wetmur JG, Kumar M, Zhang L, Palomeque C, Wallenstein S, Chen J. Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes. Nucleic Acids Research 2005;33(8):2615-2619. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Wolff MS, Anderson HA. Body mass and serum levels of organochlorines. Cancer Epidemiology Biomarkers & Prevention 1999;8:951-952. |
R831711 (2005) |
not available |
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Wolff MS, Anderson HA. Correspondence re: J.M. Schildkraut et al., Environmental contaminants and body fat distribution. Cancer Epidemiol. Biomark. Prev. 8: 179-183, 1999. Cancer Epidemiology Biomarkers & Prevention 1999;8(10):951-952 (letter). |
R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Wolff MS. Half-life of organochlorines (OCs) in humans. Archives of Environmental Contamination and Toxicology 1999;36:504 (letter). |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Wolff MS, Landrigan PJ. Organochlorine chemicals and children’s health. The Journal of Pediatrics 2002;140(1):10-13. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Wolff MS, Britton JA, Wilson VP. Environmental risk factors for breast cancer among African-American women. Cancer 2003;97(1 Suppl):289-310. |
R831711 (2005) |
not available |
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Wolff MS, Teitelbaum SL, Lioy PJ, Santella RM, Wang RY, Jones RL, Caldwell KL, Sjodin A, Turner WE, Li W, Georgopoulos P, Berkowitz GS. Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environmental Health Perspectives 2005;113(6):739-748. |
R831711 (2005) R830827 (2004) R830827 (Final) |
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Wolff MS, Deych E, Ojo F, Berkowitz GS. Predictors of organochlorines in New York City pregnant women, 1998-2001. Environmental Research 2005;97(2):170-177. |
R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) |
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Wolff MS, Britton JA, Russo J. TCDD and puberty in girls. Environmental Health Perspectives 2005;113(1):A17;author reply A18. |
R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Wolff MS. Endocrine disruptors: challenges for environmental research in the 21st century. Annals of the New York Academy of Sciences 2006;1076:228-238. |
R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Wolff MS, Teitelbaum SL, Windham G, Pinney SM, Britton JA, Chelimo C, Godbold J, Biro F, Kushi LH, Pfeiffer CM, Calafat AM. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environmental Health Perspectives 2007;115(1):116-121. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Wolff MS, Engel S, Berkowitz G, Teitelbaum S, Siskind J, Barr DB, Wetmur J. Prenatal pesticide and PCB exposures and birth outcomes. Pediatric Research 2007;61(2):243-250. |
R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C002 (2007) R831711C003 (2006) R831711C003 (2007) |
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Wolff MS, Britton JA, Boguski L, Hochman S, Maloney N, Serra N, Liu Z, Berkowitz G, Larson S, Forman J. Environmental exposures and puberty in inner-city girls. Environmental Research 2008;107:393-400. |
R831711 (2007) |
not available |
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Wolff MS, Engel SM, Berkowitz G, Zhu C, Wetmur J, Calafat AI. Prenatal phenol and phthalate exposures and birth outcomes. Environmental Health Perspectives 2008;116:1092–1097. |
R831711 (2007) |
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lipase, paraoxonase, fast food, obesity, endocrine disruptors, neurodevelopment,
, POLLUTANTS/TOXICS, ENVIRONMENTAL MANAGEMENT, Scientific Discipline, Health, RFA, Endocrine Disruptors - Environmental Exposure & Risk, Risk Assessment, Health Risk Assessment, endocrine disruptors, Chemicals, Children's Health, Biochemistry, Environmental Chemistry, Endocrine Disruptors - Human Health, neurodevelopmental toxicity, endocrine disrupting chemicals, children's environmental health, childhood development, exposure pathways, pesticide exposure, environmental health, phthalates, phtalates, pesticides, children's vulnerablity, exposure studiesRelevant Websites:
http://www.childenvironment.org/
Progress and Final Reports:
Original Abstract
2005 Progress Report
2006 Progress Report
2007 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831711C001 Growing Up Healthy in East Harlem (Community-Based Participatory Research)
R831711C002 Pesticides, Endocrine Disruptors, Childhood Growth and Development (Birth Cohort)
R831711C003 Genetics of Phthalate and Bisphenol A Risk in Minority Populations (Individual Susceptibility)