CECEHDPR - University of Southern California
EPA Grant Number: R826708Center: CECEHDPR - University of Southern California
Center Director: Gong, Henry
Title: CECEHDPR - University of Southern California
Investigators: Gong, Henry
Current Investigators: Gong, Henry , Avol, Edward L. , Diaz-Sanchez, David , Gauderman, William , Gilliland, Frank , Hinds, William C. , Jones, Craig , McConnell, Rob , Peters, John M.
Institution: University of California - Los Angeles
EPA Project Officer: Fields, Nigel
Project Period: August 1, 1998 through July 31, 2003
Project Amount: $2,895,926
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Health Effects , Children's Health
Description:
Objective:The focus of the University of Southern California (USC) Children's Environmental Health Center is to develop a better understanding of how host susceptibility and environmental exposures contribute to children's respiratory disease. This research will provide health and environmental officials with a variety of useful intervention tools. USC intends to investigate the relationship between environmental tobacco smoke (ETS) and asthma in children. This center will determine the biological mechanisms by which ETS alters normal allergic responses in children.
Journal Articles: 50 Displayed | Download in RIS Format
Other center views: | All 80 publications | 52 publications in selected types | All 50 journal articles |
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Berhane K, McConnell R, Gilliland F, Islam T, Gauderman WJ, Avol E, London SJ, Rappaport E, Margolis HG, Peters JM. Sex specific effects of asthma on pulmonary function in children. American Journal of Respiratory and Critical Care Medicine 2000;162(5):1723-1730. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2001) R826708C003 (2001) R831861 (2004) R831861 (2005) |
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Chang MC, Sioutas C, Kim S, Gong Jr H, Linn WS. Reduction of nitrate losses from filter and impactor samplers by means of concentration enrichment. Atmospheric Environment 2000;34(1):85-98. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Corren J, Diaz-Sanchez D, Saxon A, Deniz Y, Reimann J, Sinclair D, Davancaze T, Adelman D. Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis. Annals of Allergy, Asthma and Immunology 2004;93(3):243-248. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Diaz-Sanchez D, Proietti L, Polosa R. Diesel fumes and the rising prevalence of atopy: an urban legend? Current Allergy and Asthma Reports 2003;3(2):146-152. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Diaz-Sanchez D, Riedl M. Diesel effects on human health: a question of stress? American Journal of Physiology—Lung Cellular and Molecular Physiology 2005;289(5):L722-L723. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Enright PL, Linn WS, Avol EL, Margolis HG, Gong H Jr, Peters JM. Quality of spirometry test performance in children and adolescents: experience in a large field study. Chest 2000;118(3):665-671. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2005) |
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Finkelman FD, Yang M, Orekhova T, Clyne E, Bernstein J, Whitekus M, Diaz-Sanchez D, Morris SC. Diesel exhaust particles suppress in vivo IFN-γ production by inhibiting cytokine effects on NK and NKT cells. Journal of Immunology 2004;172(6):3808-3813. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters J. Association between air pollution and lung function growth in southern California children. American Journal of Respiratory and Critical Care Medicine 2000;162(4 Pt 1):1383-1390. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C001 (2001) R826708C003 (2001) R831861 (2004) R831861 (2005) |
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Gilliland FD, McConnell R, Peters J, Gong H Jr. A theoretical basis for investigating ambient air pollution and children’s respiratory health. Environmental Health Perspectives 1999;107(Suppl 3):403-407. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C003 (2000) R831861 (2004) R831861 (2005) |
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Gilliland FD, Linn W, Rappaport E, Avol E, Gong H, Peters J. Effect of spirometer temperature on FEV1 in a longitudinal epidemiological study. Occupational and Environmental Medicine 1999;56(10):718-720. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2005) |
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Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Vora H, Rappaport EB, Avol E, Peters JM. Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax 2000;55(4):271-276. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C003 (2000) R831861 (2004) R831861 (2005) |
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Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine 2001;163(2):429-436. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2001) R831861 (2005) |
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Gilliland FD, Berhane K, Rappaport EB, Thomas DC, Avol E, Gauderman WJ, London SJ, Margolis HG, McConnell R, Islam KT, Peters JM. The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology 2001;12(1):43-54. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2001) R831861 (2004) R831861 (2005) |
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Gilliland FD, Berhane KT, Li YF, Kim DH, Margolis HG. Dietary magnesium, potassium, sodium, and children’s lung function. American Journal of Epidemiology 2002;155(2):125-131. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2000) R831861 (2005) |
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Gilliland FD, Berhane KT, Li Y-F, Gauderman WJ, McConnell R, Peters J. Children’s lung function and antioxidant vitamin, fruit, juice, and vegetable intake. American Journal of Epidemiology 2003;158(6):576-584. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, Gilliland SS, Avol E, Peters JM. Obesity and the risk of newly diagnosed asthma in school-age children. American Journal of Epidemiology 2003;158(5):406-415. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Glutathione-S-Transferase M1 and P1 genotypes protect against xenobiotic enhancement of allergic responses. Lancet 2004;363:119-125. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C002 (Final) R831861 (2004) R831861 (2005) |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826710 (Final) R827027 (2002) R831845 (2005) R831861 (2004) R831861 (2005) R832141 (2006) |
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Gong H, Sioutas C, Linn WS, Clark KW, Terrell SL, Terrell LL, Anderson KR, Kim S, Chang M-C. Controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles: methodology and preliminary health-effect findings. Inhalation Toxicology 2000;12(1):107-119. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) |
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Gong H. Urban air pollution and health inequities: a workshop report. Environmental Health Perspectives 2001;109(Suppl 3):357-374. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2005) |
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Gong Jr H, Linn WS, Terrell SL, Anderson KR, Clark KW. Anti-inflammatory and lung function effects of montelukast in asthmatic volunteers exposed to sulfur dioxide. Chest 2001;119:402-408. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2005) |
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Harrington-Brock K, Cabrera M, Collard DD, Doerr CL, McConnell R, Moore MM, Sandoval H, Fuscoe JC. Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile: a pilot study. Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis 1999;431(2):247-257. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) |
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Kim S, Sioutas C, Chang M-C, Gong Jr H. Factors affecting the stability of the performance of ambient fine-particle concentrators. Inhalation Toxicology 2000;12(11, Suppl 4):281-298. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R825513C024 (Final) R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R828598C700 (Final) R829095C004 (2005) |
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Kunzli N, McConnell R, Bates D, Bastain TM, Hricko A, Lurmann F, Avol E, Gilliland FD, Peters JM. Breathless in Los Angeles: The exhausting search for clean air. American Journal of Public Health 2003;93(9):1494-1499. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Li YF, Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Rappaport EB, Peters JM. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. American Journal of Respiratory and Critical Care Medicine 2000;162(6):2097-2104. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2001) R826708C003 (2001) R831861 (2005) |
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Li YF, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. Intercellular adhesion molecule-1 and childhood asthma. Human Genetics 2005;117(5):476-484. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Li Y-F, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 2005;127:1232-1241. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Li Y-F, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. American Journal of Respiratory and Critical Care Medicine 2006;173(9):970-976. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Linn WS, Gong Jr H, Clark KW, Anderson KR. Day-to-day particulate exposures and health changes in Los Angeles area residents with severe lung disease. Journal of the Air & Waste Management Association 1999;49(9 PM):108-115. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Linn WS, Szlachcic Y, Gong Jr H, Kinney PL, Berhane KT. Air pollution and daily hospital admissions in metropolitan Los Angeles. Environmental Health Perspectives 2000;108(5):427-434. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R827352 (2004) R827352 (Final) R827352C012 (Final) |
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Linn WS, Adkins RH, Gong Jr H, Waters RL. Pulmonary function in chronic spinal cord injury: a cross-sectional survey of 222 Southern California adult outpatients. Archives of Physical Medicine and Rehabilitation 2000;81(6):757-763. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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McConnell R, Berhane K, Gilliland F, London SJ, Vora H, Avol E, Gauderman WJ, Margolis HG, Lurmann F, Thomas DC, Peters JM. Air pollution and bronchitic symptoms in Southern California children with asthma. Environmental Health Perspectives 1999;107(9):757-760. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R831861 (2004) R831861 (2005) |
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McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM. Asthma in exercising children exposed to ozone: A cohort study. Lancet 2002;359(9304):386-391. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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McConnell R, Berhane K, Gilliland FD, Molitor J, Thomas D, Lurmann F, Avol E, Gauderman WJ, Peters JM. Prospective study of air pollution and bronchitic symptoms in children with asthma. American Journal of Respiratory and Critical Care Medicine 2003;168(7):790-797. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (Final) R827352 (2004) R827352 (Final) R827352C007 (Final) R827352C009 (Final) R831861 (2004) R831861 (2005) |
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McConnell R, Milam J, Richardson J, Galvan J, Jones C, Thorne PS, Berhane K. Educational intervention to control cockroach allergen exposure in the homes of hispanic children in Los Angeles: results of the La Casa study. Clinical & Experimental Allergy 2005;35(4):426-433. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (Final) R831861 (2004) R831861 (2005) R831861C001 (2005) |
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Peters JM, Avol E, Navidi W, London SJ, Gauderman WJ, Lurmann F, Linn WS, Margolis H, Rappaport E, Gong H, Thomas DC. A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. American Journal of Respiratory and Critical Care Medicine 1999;159(3):760-767. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Peters JM, Avol E, Gauderman WJ, Linn WS, Navidi W, London SJ, Margolis H, Rappaport E, Vora H, Gong H Jr, Thomas DC. A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. American Journal of Respiratory and Critical Care Medicine 1999;159(3):768-775. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Richardson JL, Milam JE, Galvan J, Jones C, McConnell R. Knowledge of skin test results among parents of asthmatic children. Journal of Asthma 2005;41(2):199-204. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Riedl MA, Landaw EM, Saxon A, Diaz-Sanchez D. Initial high-dose nasal allergen exposure prevents allergic sensitization to a neoantigen. Journal of Immunology 2005;174(11):7440-7445. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Riedl M, Diaz-Sanchez D. Biology of diesel exhaust effects on respiratory function. Journal of Allergy and Clinical Immunology 2005;115(2):221-228. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Rumold R, Jyrala M, Diaz-Sanchez D. Secondhand smoke induces allergic sensitization in mice. The Journal of Immunology 2001;167(8):4765-4770. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C002 (2001) R831861 (2005) |
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Salam MT, Gilliland F, Li Y-F, Langholz B. Early life environmental risk factors for asthma: Findings from the Children’s Health Study. Environmental Health Perspectives 2004;112(6):760-765. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861C001 (2005) |
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Salam MT, Langholz B, Li Y-F, Gilliland FD. Maternal fish consumption during pregnancy and risk of childhood asthma. Journal of Asthma 2005;42(6):513-518. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Saxon A, Diaz-Sanchez D. Air pollution and allergy: you are what you breathe. Nature Immunology 2005;6(3):223-226. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Sioutas C, Kim S, Chang M, Terrell LL, Gong Jr H. Field evaluation of a modified DataRAM MIE scattering monitor for real-time PM2.5 mass concentration measurements. Atmospheric Environment 2000;34(28):4829-4838. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R827352 (Final) R827352C012 (Final) R827352C014 (Final) |
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Thorne PS, Metwali N, Avol E, McConnell RS. Surface sampling for endotoxin assessment using electrostatic wiping cloths. Annals of Occupational Hygiene 2005;49(5):401-406. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Wan J, Diaz-Sanchez D. Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles. Journal of Immunology 2006;177(5):3477-3483. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2005) |
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Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. American Journal of Respiratory and Critical Care Medicine 2005;172:1563-1568. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. The Journal of Immunology 2002;168(5):2560-2567. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (Final) R826708C002 (Final) R827352 (Final) R827352C002 (Final) R831861 (2004) R831861 (2005) |
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Xie B, Gilliland FD, Li YF, Rockett HR. Effects of ethnicity, family income, and education on dietary intake among adolescents. Preventive Medicine 2003;36(1):30-40. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Geographic Area, Scientific Discipline, Health, RFA, Risk Assessments, Health Risk Assessment, Epidemiology, Children's Health, Allergens/Asthma, State, California (CA), asthma indices, allergen, respiratory problems, respiratory disease, children's environmental health, asthmatic children, second hand smoke, cigarette smoke, childhood respiratory disease, human health risk, susceptibility, acute lung injury, air pollution, airborne pollutants, airway disease, children, tobacco smoke, exposure, children's vulnerablity, asthma triggers, allergic response, asthma, human exposure
Progress and Final Reports:
2000 Progress Report
2001 Progress Report
2002 Progress Report
Final Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826708C001 Asthma in Children: A Community-based Intervention Project
R826708C002 Children's Exposure to Environmental Tobacco Smoke: Changes in Allergic Response
R826708C003 Respiratory Disease and Prevention Center