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2004 Progress Report: Johns Hopkins Center for Childhood Asthma in the Urban Environment
EPA Grant Number: R832139Center: Johns Hopkins Center for Childhood Asthma in the Urban Environment
Center Director: Breysse, Patrick
Title: Johns Hopkins Center for Childhood Asthma in the Urban Environment
Investigators: Breysse, Patrick , Kanchanaraksa, Sukon
Current Investigators: Breysse, Patrick , Matsui, Elizabet
Institution: Johns Hopkins University
EPA Project Officer: Fields, Nigel
Project Period: August 1, 2003 through July 31, 2008
Project Period Covered by this Report: August 1, 2003 through July 31, 2004
Project Amount: $4,046,103
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Children's Health , Health Effects
Description:
Objective:The objectives of the Center are to: (1) understand how exposures to environmental pollutants and allergens may relate to airway inflammation and respiratory morbidity in children with asthma in the inner city of Baltimore; and (2) develop effective strategies to reduce morbidity by changing these exposures. We propose to address these goals with four projects:
- “Epidemiology of Susceptibly to Particulates and Allergens in Asthma in African Americans” (R832139C001; Greg Diette, M.D., M.S.)—This project will examine the relationship of the effect of polymorphisms in genes encoding IL13, TLR4, and BADr to susceptibility to home pollutant and allergen exposure in asthmatic and control children;
- “A Randomized Controlled Trial of Behavioral Changes in Home Exposure Control” (R832139C002; Peyton Eggleston, M.D.)—This project will conduct a randomized controlled clinical trial of methods to increase the effectiveness of current intervention methods to reduce hazardous exposures and their adverse health effects;
- “Mechanisms of Particulate-Induced Allergic Asthma” (R832139C003; Marsha Wills-Karp, Ph.D.)—This project will examine the mechanisms by which particulate matter may exacerbate an allergen-driven inflammatory response in the airways; and
- “Dendritic Cell Activation by Particulate Matter and Allergen” (R832139C004; Steven Georas, M.D.)—This project will examine the effect of Baltimore ambient particulates on maturation of peripheral blood monocytes to dendritic cells.
The objectives of the Data Management Core are to provide research planning, data management, and data analysis support for the Intervention and Epidemiology projects.
The overall goal of the Exposure Assessment (EA) Core is to provide a centralized resource for the conduct of exposure assessment activities related to children’s asthma research. The objectives were to provide input into research design, field sampling equipment, and support and analytical services. The specific objectives of the Core are to: (1) collaborate in the development and conduct of epidemiologic, intervention, and exposure assessment studies; (2) facilitate the development of exposure assessment protocols; (3) provide the infrastructure necessary for conducting detailed exposure assessments; (4) assist in the design of data collection systems and the maintenance of exposure assessment databases; and (5) participate in the preparation of scientific reports and manuscripts.
Progress Summary:Difficulties and Remedial Action
The primary difficulties in Year 1 were caused by a delay in funding from the sponsor. Funds that were planned for November 2003 to continue personnel and to continue the Center’s activities were delayed. These difficulties were resolved in June 2004 and the Center received authorization to fund activities beginning in November 2003. During the previous 8 months before the Center received funding, the Administrative Core ensured that ongoing projects funded under the previous grant (EPA Agreement No. R826764) such as the epidemiologic project were completed, Center personnel who were considered nonessential were reassigned to other projects, and those considered essential such as the Data Management and EA Cores were supported while the Center’s projects were completed and publications created. Communication with the External Advisory and the Community Advisory Committees was maintained with periodic meetings or written communication so that they were apprised of the Center’s activities and the status of funding. Finally, the Research Conferences were continued because the costs were minimal, and they contributed to the morale of the Center personnel.
Results to Date
The Administrative Core is responsible for fiscal and administrative policy and reports, for calling meetings, maintaining records of all Center meetings, arranging meetings, and creating progress reports. This office arranges the biweekly research conferences, as well as meetings of the Outside Advisory Committee, the Internal Advisory Committee, and the Community Advisory Committee. The unit also arranges for Center personnel to attend annual program meetings. The creation of any public communications originates from this office. The newly recruited faculty program is administered through this Core, although the selection of the scientist is conducted by a committee that has no conflict of interest.
The EA Core assisted all projects requesting funding as a part of this application as well as the initial new investigator exposure assessment project. In support of these projects, a total of 670 home assessments were conducted. During peak periods of productivity, home assessments were being conducted at a rate of 10 per week. Because each home assessment covers a 3-day period this represents 5.5 years (2,010 days) of environmental monitoring. Four thousand four hundred fifty-three air samples of all types were collected and 14,070 individual allergen assays were conducted (seven allergens per sample) during this period.
In addition to the environmental assessment activity, Table 1 lists some additional activities of the EA Core. When considered as a whole, the activities summarized in Table 1 present an impressive output. This exceptional output demonstrates the value of the EA core to the Center investigators and is indicative of the overall high level of productivity within the Center investigations.
Table 1. Other Activities Conducted by the EA Core
| Conducted ambient monitoring (more than 4 years of PM10, PM2.5, and MIE PM data) |
Implosion exposure study |
Pilot study of personal monitoring on small children |
Developed O3 analytical capability inhouse |
Developed nicotine analytical capability inhouse |
Developing nicotine assay for settled dust |
Evaluating gas chromatography/mass spectrometry methods for nicotine analysis |
Conducted > 20 hrs of training for field assessors |
Maintained balance room for sensitive filter weighing |
Collected bulk PM for biologic studies |
The Data Management Core has been productive in the past year. Most of the work was focused on cleaning the data and generating preliminary results. Some of the results already have been published and additional publications are in progress.
Research Conferences
The Center’s research conferences have been presented throughout the year. In addition to several speakers from the university and from Center staff, we have invited speakers from other centers and projects to discuss work related to the Center’s goals.
Future Activities:The Administrative Core will continue to be responsible for fiscal and administrative policy and reports, scheduling meetings, maintaining records of all Center meetings, arranging meetings, and creating progress reports. This office arranges the biweekly research conferences, as well as meetings of the Outside Advisory Committee, the Internal Advisory Committee, and the Community Advisory Committee. The unit also arranges for Center personnel to attend annual program meetings. The creation of any public communications originates for this office. The newly recruited faculty program is administered through this core, although the selection of the scientist is conducted by a committee with no conflict of interest.
The Data Management Core will continue its present activities with emphasis on data set preparation and data analysis. Preliminary and final data analysis will be performed during this year for both the Intervention and the Cohort study components.
The EA Core will continue its present activities. As the Intervention and Cohort studies progress to completion, we anticipate that the environmental measurement load will decrease and data analysis activities will increase. In addition, we will be assisting in preparing publications of study findings.
Journal Articles: 38 Displayed | Download in RIS Format
| Other center views: | All 39 publications | 39 publications in selected types | All 38 journal articles |
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Alberg AJ, Diette GB, Ford JG. Invited commentary: Attendance and absence as markers of health status—the example of active and passive cigarette smoking. American Journal of Epidemiology 2003;157(10):870-873. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Barnes KC, Caraballo L, Munoz M, Zambelli-Weiner A, Ehrlich E, Burki M, Jimenez S, Mathias RA, Stockton ML, Deindl P, Mendoza L, Hershey GK, Nickel R, Wills-Karp M. A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations. Clinical and Experimental Allergy 2004;34(5):736-744. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Bartlett SJ, Krishnan JA, Riekert KA, Butz AM, Malveaux FJ, Rand CS. Maternal depressive symptoms and adherence to therapy in inner-city children with asthma. Pediatrics 2004;113(2):229-237. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Breysse PN, Buckley TJ, Williams D, Beck CM, Jo SJ, Merriman B, Kanchanaraksa S, Swartz LJ, Callahan KA, Butz AM, Rand CS, Diette GB, Krishnan JA, Moseley AM, Curtin-Brosnan J, Durkin NB, Eggleston PA. Indoor exposures to air pollutants and allergens in the homes of asthmatic children in inner-city Baltimore. Environmental Research 2005;98(2):167-176. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Butz AM, Riekert KA, Eggleston P, Winkelstein M, Thompson RE, Rand C. Factors associated with preventive asthma care in inner-city children. Clinical Pediatrics 2004;43(8):709-719. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Callahan KA, Eggleston PA, Rand CS, Kanchanaraksa S, Swartz LJ, Wood RA. Knowledge and practice of dust mite control by specialty care. Annals of Allergy, Asthma & Immunology 2003;90(3):302-307. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Diette GB, Krishnan JA, Wolfenden LL, Skinner EA, Steinwachs DM, Wu AW. Relationship of physician estimate of underlying asthma severity to asthma outcomes. Annals of Allergy, Asthma & Immunology 2004;93(6):546-552. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Eggleston PA. Cockroach allergen abatement in inner-city homes. Annals of Allergy, Asthma & Immunology 2003;91(6):512-514. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Eggleston PA. Environmental control for fungal allergen exposure. Current Allergy and Asthma Reports 2003;3(5):424-429. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Eggleston PA, Butz A, Rand C, Curtin-Brosnan J, Kanchanaraksa S, Swartz L, Breysse P, Buckley T, Diette G, Merriman B, Krishnan JA. Home environmental intervention in inner-city asthma: a randomized controlled clinical trial. Annals of Allergy Asthma & Immunology 2005;95(6):518-524. |
R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) |
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Eggleston PA. Improving indoor environments: reducing allergen exposures. Journal of Allergy and Clinical Immunology 2005;116(1):122-126. |
R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned from the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) R826710 (Final) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R831710 (2004) R831710 (2005) R831861 (2005) R832141 (2006) |
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Ferrari E, Tsay A, Eggleston PA, Spisni A, Chapman MD. Environmental detection of mouse allergen by means of immunoassay for recombinant Mus m 1. Journal of Allergy and Clinical Immunology 2004;114(2):341-346. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Hansel NN, Hilmer SC, Georas SN, Cope LM, Guo J, Irizarry RA, Diette GB. Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma. The Journal of Laboratory and Clinical Medicine 2005;145(5):263-274. |
R832139 (2004) R832139 (2005) R832139C001 (2005) |
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Hawlisch H, Wills-Karp M, Karp CL, Kohl J. The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma. Molecular Immunology 2004;41(2-3):123-131. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Huang I-C, Frangakis C, Dominici F, Diette GB, Wu AW. Application of a propensity score approach for risk adjustment in profiling multiple physician groups on asthma care. Health Services Research 2005;40(1):253-278. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Huang I-C, Dominici F, Frangakis C, Diette GB, Damberg CL, Wu AW. Is risk-adjustor selection more important than statistical approach for provider profiling? Asthma as an example. Medical Decision Making 2005;25(1):20-34. |
R832139 (2004) R832139 (2005) R832139C001 (2005) |
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Huang I-C, Diette GB, Dominici F, Frangakis C, Wu AW. Variations of physician group profiling indicators for asthma care. The American Journal of Managed Care 2005;11(1):38-44. |
R832139 (2004) R832139 (2005) R832139C001 (2005) |
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Limb SL, Brown KC, Wood RA, Wise RA, Eggleston PA, Tonascia J, Hamilton RG, Adkinson Jr NF. Adult asthma severity in individuals with a history of childhood asthma. Journal of Allergy and Clinical Immunology 2005;115(1):61-66. |
R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) |
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Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Curtin-Brosnan J, Eggleston PA. Cockroach allergen exposure and sensitization in suburban middle-class children with asthma. Journal of Allergy and Clinical Immunology 2003;112(1):87-92. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Matsui EC, Krop EJM, Diette GB, Aalberse RC, Smith AL, Eggleston PA. Mouse allergen exposure and immunologic responses: IgE-mediated mouse sensitization and mouse-specific IgG and IgG4 levels. Annals of Allergy, Asthma & Immunology 2004;93(2):171-178. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Eggleston PA. Mouse allergen exposure and mouse skin test sensitivity in suburban, middle-class children with asthma. Journal of Allergy and Clinical Immunology 2004;113(5):910-915. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Matsui EC, Simons E, Rand C, Butz A, Buckley TJ, Breysse P, Eggleston PA. Airborne mouse allergen in the homes of inner-city children with asthma. Journal of Allergy and Clinical Immunology 2005;115(2):358-363. |
R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) |
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Okelo SO, Wu AW, Krishnan JA, Rand CS, Skinner EA, Diette GB. Emotional quality-of-life and outcomes in adolescents with asthma. Journal of Pediatrics 2004;145(4):523-529. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Perry T, Matsui E, Merriman B, Duong T, Eggleston P. The prevalence of rat allergen in inner-city homes and its relationship to sensitization and asthma morbidity. Journal of Allergy and Clinical Immunology 2003;112(2):346-352. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Phipatanakul W, Cronin B, Wood RA, Eggleston PA, Shih M-C, Song L, Tachdjian R, Oettgen HC. Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma. Annals of Allergy, Asthma & Immunology 2004:92(4):420-425. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Polack FP, Teng MN, Collins PL, Prince GA, Exner M, Regele H, Lirman DD, Rabold R, Hoffman SJ, Karp CL, Kleeberger SR, Wills-Karp M, Karron RA. A role for immune complexes in enhanced respiratory syncytial virus disease. Journal of Experimental Medicine 2002;196(6):859-865. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Riekert KA, Butz AM, Eggleston PA, Huss K, Winkelstein M, Rand CS. Caregiver-physician medication concordance and undertreatment of asthma among inner-city children. Pediatrics 2003;111(3):e214-e220. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Rubinson L, Wu AW, Haponik EF, Diette GB. Why is it that internists do not follow guidelines for preventing intravascular catheter infections? Infection Control and Hospital Epidemiology 2005;26(6):525-533. |
R832139 (2004) R832139 (2005) R832139C001 (2005) |
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Sapkota A, Symons JM, Kleissl J, Wang L, Parlange MB, Ondov J, Breysse PN, Diette GB, Eggleston PA, Buckley TJ. Impact of the 2002 Canadian forest fires on particulate matter air quality in Baltimore city. Environmental Science & Technology 2005;39(1):24-32. |
R832139 (2004) R832139 (2005) R832139C001 (2005) |
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Schweitzer IB, Smith E, Harrison DJ, Myers DD, Eggleston PA, Stockwell JD, Paigen B, Smith AL. Reducing exposure to laboratory animal allergens. Comparative Medicine 2003;53(5):487-492. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Skinner EA, Diette GB, Algatt-Bergstrom PJ, Nguyen TT, Clark RD, Markson LE, Wu AW. The Asthma Therapy Assessment Questionnaire (ATAQ) for children and adolescents. Disease Management 2004;7(4):305-313. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Swartz LJ, Callahan KA, Butz AM, Rand CS, Kanchanaraksa S, Diette GB, Krishnan JA, Breysse PN, Buckley TJ, Mosley AM, Eggleston PA. Methods and issues in conducting a community-based environmental randomized trial. Environmental Research 2004;95(2):156-165. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Walters DM, Breysse PN, Schofield B, Wills-Karp M. Complement factor 3 mediates particulate matter–induced airway hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology 2002;27(4):413-418. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nature Reviews Genetics 2004;5(5):376-387. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Wolfenden LL, Diette GB, Krishnan JA, Skinner EA, Steinwachs DM, Wu AW. Lower physician estimate of underlying asthma severity leads to undertreatment. Archives of Internal Medicine 2003;163(2):231-236. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Yurk RA, Diette GB, Skinner EA, Dominici F, Clark RD, Steinwachs DM, Wu AW. Predicting patient-reported asthma outcomes for adults in managed care. The American Journal of Managed Care 2004;10(5):321-328. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Zeldin DC, Eggleston P, Chapman M, Piedimonte G, Renz H, Peden D. How exposures to biologics influence the induction and incidence of asthma. Environmental Health Perspectives 2006;114(4):620-626. |
R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) |
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childhood asthma, airway inflammation, respiratory morbidity, allergens, particulates, dendritic cells, settled dust allergen, children’s health,
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HUMAN HEALTH, Geographic Area, Scientific Discipline, Health, Health Effects, Risk Assessments, Health Risk Assessment, Epidemiology, Biochemistry, Genetics, State, adolescents, Maryland (MD), urban environment, airborne urban contaminants, environmental tobacco smoke, respiratory disease, asthmatic children, ozone, cigarette smoke, children's health, human health risk, air pollution, airway disease, particulate matter, allergic airway disease, asthma, human exposure
Progress and Final Reports:
Original Abstract
2005 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832139C001 The Epidemiology of Susceptibility to Airborne Particulates and Allergens to Asthma in African Americans
R832139C002 A Randomized Controlled Trial of Behavior Changes in Home Exposure Control
R832139C003 Mechanisms of Particulate-Induced Allergic Asthma
R832139C004 Dendritic Cell Activation by Particulate Matter and Allergen