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1999 Progress Report: A National Research Center on Statistics and the Environment

EPA Grant Number: R825173
Title: A National Research Center on Statistics and the Environment
Investigators: Gutorp, Peter
Institution: University of Washington - Seattle
EPA Project Officer: Saint, Chris
Project Period: October 1, 1996 through September 30, 2001
Project Period Covered by this Report: October 1, 1998 through September 30, 1999
Project Amount: $4,997,429
RFA: Environmental Statistics (1996)
Research Category: Environmental Statistics

Description:

Objective:

The National Center for Environmental Statistics is a research organization, dealing with problems of statistical methodology for environmental applications. The Center has a core group of faculty at the University of Washington, and anticipates a large number of visitors from other institutions. In addition, collaborative research technologies will be employed to enable long distance collaborative work. While many projects will originate in particular EPA problems, the Center work will focus in five areas: environmental sampling, space-time modeling, model assessment, ecological assessment, and risk assessment.

The work at the Center will enable environmental scientists and EPA personnel to use the most modern statistical methodology in complex situations. It also will spearhead the development of environmental statistics as a mature subarea of statistics.

Progress Summary:

The third year of operation of NRCSE (October 1, 1998?September 30, 1999) has been very productive. Two major workshops, on particulate matter air pollution, and on quality assurance of environmental models have been held, with large attendance from a broad range of academic, private, and government scientists. The Center has had a rich visitors program, and a substantial number of papers, research reports, and presentations in a large variety of areas have been produced. A program of outreach to EPA laboratories has been initiated. Several Center members have received national professional recognition. The Center has moved to a new location adjacent to the statistics department. Outreach activities include seminars, middle school curriculum development, and of course the Center Web site (http://www.nrcse.washington.edu ). In order to broaden the base of the Center research, a number of subcontracts and joint projects have been initiated with different environmental statistics research groups in the United States, Canada, and Europe.

The seminar series during the academic year 1998-1999 had a quarterly theme. In fall 1998, the theme was particulate matter air pollution, while in winter the theme was assessment of environmental and ecological models. The spring quarter seminar series focused on student and post-doctoral researchers presenting their current work, and was carried out jointly with the graduate program on Quantitative Ecology and Resource Management. During fall and winter, all seminars were videotaped and made available on the World Wide Web at URL http://www.nrcse.washington.edu/ .

The Center Web pages, located at http://www.nrcse.washington.edu , are the main source of information about the Center. During the time period of this report, there were 145,905 successful requests for pages from over 12,000 different hosts. On average, about 10 Mb of data were transferred per day. About 20 percent of the visitors came from .edu domains, 18 percent from .com, and 10 percent from each of .net and .gov/.us domains. Germany, France and Canada were the leading non-U.S. domains. About 20 percent of the hosts could not be identified. The most visited directory was the research directory, where project descriptions and research reports are stored.

The Center has initiated a series of workshops at various EPA locations intended to give EPA researchers a feel for the kind of research being conducted and to initiate new research contacts. The first of these workshops took place at the EPA laboratory in Corvallis, Oregon, on April 13, 1999. Ten Center members and graduate students participated in the workshop, giving seven talks to a fairly large audience (at most presentations 20-30 EPA and OSU researchers were present).

The U.S. Environmental Protection Agency (EPA) promulgated revised air quality standards for particulate matter on July 18, 1997. At that time, President Clinton committed EPA to complete the next Particulate Matter National Ambient Air Quality Standards (NAAQS) review within the 5-year statutory period required by the Clean Air Act. Due to the time required to establish PM2.5 monitoring networks, determine whether or not a location is in or out of compliance with the standard(s), and, if out, to develop a State Implementation Plan (SIP) to achieve compliance, implementation of the revised regulations for particulate matter would not begin for approximately ten years, well after the next NAAQS review. Also in this time frame, Congress directed EPA to arrange to have the National Research Council (NRC) to conduct a study to identify research priorities relevant to setting regulatory standards for ambient particulate matter. NRC responded by forming the Committee on Research Priorities for Airborne Particulate Matter, which quickly produced its first of four planned reports, Research Priorities for Airborne Particulate Matter: I. Immediate Priorities and a Long-Range Research Portfolio, referred to here as the NRC Report. Research Topic 10 of this report, Analysis and Measurement, deals almost exclusively with statistical issues.

Soon after the release of the NRC Report, NRCSE and the EPA Office of Research and Development decided to organize a workshop focused on Topic 10. With co-sponsorship from the National Institute of Statistical Sciences and the Health Effects Institute, the NRCSE/EPA Particulate Methodology Workshop was held October 19-22, 1998, at the University of Washington in Seattle. The objective of the workshop was to bring together an interdisciplinary group of statistical and other scientists to illuminate statistical issues articulated in or raised by Topic 10, to identify priority statistical research bearing upon these issues, and to organize interdisciplinary research projects on these topics, targeted for completion prior to the end of the second Particulate Matter NAAQS review. Twenty-five invited speakers, discussants, and session chairs participated together with 36 other attendees.

The workshop was organized around formal presentations and discussion covering measurement, atmospheric transport, and modeling of particulate matter; understanding and developing models of particulate matter exposure and health effects; particle transformation; source apportionment; regulatory issues; and new or enhanced statistical research questions and findings stemming from particulate matter studies. All presentations were videotaped and are available at the Web (http://www.nrcse.washington.edu/) . The core of the Workshop was the deliberations of seven working groups meeting each afternoon. The 19 research questions raised under Topic 10 of the NRC Report were grouped under six headings for discussion: time series analysis; assessment of current epidemiological studies; exposure-response models; study design towards estimation of long and short term effects of exposure; study design and the effects of measurement error in health effects modeling; and space-time modeling and estimation methods for more accurate estimates of individual exposures to particulate air pollution. A seventh group addressed Case-Crossover Studies. Summary reports of the working group discussions are posted on the NRCSE discussion board at http://www.nrcse.washington.edu/ .

The NRCSE/EPA Workshop on Particulate Methodology raised meaningful issues regarding the role of statistical science in the study of particulate matter air pollution. Leaders from statistical and environmental science shared their expertise and concerns and appeared to benefit from the interaction.

Over the past decade, the number of models constructed by EPA scientists has increased remarkably. Many models are used in policy development and environmental regulation. Increasingly models are constructed that simulate ecological and environmental processes. The complex structure of these models, and in some cases the limited data associated with them, has led to concerns about model assessment.

EPA responded to this concern by establishing a committee to produce a white paper for the Science Policy Council "Nature and Scope of Issues on Adoption of Model Use Acceptability Guidance." NRCSE was involved in writing this paper and, as an outcome of its discussions and deliberations, a joint EPA/NRCSE workshop on Quality Assurance of Environmental Models was organized at the University of Washington September 7?10, 1999. Some 60 participants from universities, regulatory agencies and consulting firms listened to 17 presented papers and contributed to discussions in four different areas: Life cycles of models; Peer review of modes; Very High Order Models; and Tool Chest for Model Assessment.

The papers read ranged through a wide spectrum of aspects of model assessment. Among the presenters the first day with theme "Defining the problems of Model Assessment and Quality Assurance" were Naomi Oreskes, UC San Diego; David Ford, University of Washington; Jan Rotmans, ICIS, Maastricht, The Netherlands; and Robin Dennis, EPA. The second day, on "Development of Methodological and Quantitative Techniques," featured Andrea Saltelli, EC Joint Research Centre, Italy; Adrian Raftery, University of Washington; Tony O'Hagan, University of Sheffield, U.K.; Joel Reynolds, Alaska Department of Game and Fish; and Wendy Meiring, UC Santa Barbara. Among the third day speakers, on "Assurance of Models Used in Environmental Regulation," were David Stanners, European Environment Agency; Tom Barnwell, EPA; Linda Kirkland, EPA; and Helen Dawson, EPA. All presentations were videotaped, and will be available on the NRCSE Web page at:

http://www.nrcse.washington.edu/

In addition, summaries of the discussion groups are available at:

http://www.nrcse.washington.edu/

A number of Center members and graduate students have given presentations and organized sessions at national and international meetings of various scientific organizations. These include the Society for Risk Analysis annual meeting, EPA Conference on Environmental Statistics and Information, the Joint Statistical Meetings, and Environmetrics.

During the 1998-1999 academic year, NRCSE supported the development of "The TRUTH about Science." This is a 5th-8th grade scientific research curriculum that guides students through the process of conducting scientific research: asking a testable research question, designing and conducting an independent field project, organizing and analyzing data, and presenting results as both poster and oral presentations. The curriculum is composed of 40 individual lessons, which are available at the NRCSE Web site:

http://www.nrcse.washington.edu/

About half of the lessons are stand-alone lessons to teach basic research skills such as developing hypotheses, setting up controls, random selection of observations, calculating an average and a t-statistic, and graphing data. The other half of the lessons apply the concepts to the Long-Term Research Project (LTRP). Students work in groups to design and carry out their own LTRP. For example, students investigated whether mushrooms in the shade were healthier than mushroom in the sun or whether there were more aphids on red maple versus red alder trees. The curriculum culminates in a celebration night at which students display posters of their research and give 5-minute presentations to their parents and classmates.

Paul D. Sampson was awarded the Distinguished Achievement Medal of the American Statistical Association Section on Statistics and the Environment.

Loveday Conquest, Peter Guttorp, and Jim Karr were among the recipients of twentieth century distinguished service awards at the Ninth Lukacs Conference in Bowling Green, OH, for contributions to the synergistic development and direction of statistics, ecology, environment, and society.

June Morita received the University of Washington Distinguished Teaching Award. She is the fourth Center member to receive this honor. Previous NRCSE recipients are Loveday Conquest, Gerald Van Belle, and David Madigan.

David Ford participated in the EPA Science Policy Council Model Acceptance Criteria and Peer Review White Paper Working Group which produced the document "White Paper on the Nature and Scope of Issues on Adoption of Model Use Acceptability Guidance." Paul Sampson and Alison Cullen participated in peer reviews for the U.S. EPA, Health Canada and Environment Canada.

Alison Cullen has been commissioned by the Society for Risk Analysis to write a white paper entitled "Risk and Uncertainty: Quantitative and Precautionary Approaches" for their Year 2000 Symposium on Risk Analysis. The Symposium will be held in June 2000 and will focus on the discussion of 10 white papers on all aspects of risk analysis, risk management and decision making.

Peter Guttorp is a member of the Scientific Advisory Board of the recently awarded EPA Northwest Particulate Matter Center at the University of Washington, and also is a Senior Statistical Adviser for the PM Center. In addition, he is a member of the Science Advisory Council for the Geophysical Statistics Project at the National Center for Atmospheric Research in Boulder, Colorado.

Loveday Conquest is the current Chair of the American Statistical Association Section on Statistics and the Environment. June Morita is Chair-elect of the American Statistical Association Council of Chapters. Adrian Raftery continues as Applications Editor of the Journal of the American Statistical Association. Alison Cullen is a Council member of the Society for Risk Analysis.

The internal NRCSE research funds are allocated annually by the Executive Committee after a competitive application process. Criteria for awards include: (1) scientific merit, (2) relevance to the Center's agenda, (3) evidence of involvement by EPA scientists, (4) feasibility of project and likelihood of substantial products, and (5) results and EPA contacts of previous NRCSE support.

Detailed descriptions of the projects listed below can be found on the NRCSE Web site: http://www.nrcse.washington.edu/ , and progress descriptions can be found in the full annual report at: http://www.nrcse.washington.edu/.

Ranked Set Sampling: Costs and Application
Center member: Loveday L. Conquest
EPA collaborator: Barry Nussbaum
WESTAT collaborator: David Marker

Assessment of Deterministic Models
Center members: David Ford and Joel Reynolds
Statistical modeling of censored data
Center member: Mary Lou Thompson

Statistical Adjustment of Ozone for Meteorological Variables
Center members: Mary Lou Thompson, Joel Reynolds, Peter Guttorp, and Paul Sampson
EPA collaborator: Larry Cox

Evaluation and Development of a Stochastic Precipitation Model
Center members: Jim Hughes, Peter Guttorp

Statistical Aspects of Setting and Implementing Environmental Standards
Center members: Peter Guttorp, Paul Sampson, and Mary Lou Thompson
EPA collaborator: Larry Cox

Graphical Modeling of Factors Influencing Benthic Populations in Streams
Center members: Thomas Richardson, Peter Guttorp

Nonhomogeneous Global Covariance Estimation
Center members: Peter Guttorp, Paul Sampson, and Tillman Gneiting
NCAR collaborator: Doug Nychka

Trend Estimation Using Wavelets
Center members: Don Percival, Peter Guttorp

Global Warming and Pacific Northwest Snowpack
Center member: Chris Bretherton
UW collaborators: Nate Mantua, Phil Mote

A Comparison of SVD and CCA Analyses in Climate Prediction
Center member: J.M. Wallace
Bayesian methods for assessment of environmental fate and transport models
Center members: Alison C. Cullen, Adrian Raftery

ORCA: A Visualization Toolkit for High-Dimensional Data
Center member: Thomas Lumley
Other investigators: Dianne Cook (Iowa State), Peter Sutherland, and Tony Rossini

Bayesian Estimation of Nonstationary Spatial Covariance Structure
Center members: Paul D. Sampson, Peter Guttorp

Agricultural Modeling for Watershed Management
Center member: Alison Cullen
EPA Region X collaborators: Chris Feise and Karl Arne

Particulate Matter Field Study in Slovakia
Center member: Alison Cullen
EPA collaborator: John Vandenberg
Other collaborators: Michael Brauer, UBC, Canada; Eleanora Fabianova, Eva Mikhalikova, Peter Miskovic, Frantiska Hruba, SUHE, Slovakia.

Composite Sampling
Center member: Gerald van Belle
WESTAT collaborator: David Marker

Toxicodynamic Models for Model Toxicant-Induced Developmental Toxicity in Rodents
Center members: Rafael Ponce and Elaine Faustman
EPA collaborators: Woody Setzer, Chris Lau
UW Collaborator: W.C. Griffith

Integrated Exposure and Uptake Biokinetic Lead Model (IEUBK)
Center member: Elaine Faustman
UW collaborators: JH Shirai, AC Pierce, and JC Kissel

A Linked Toxicokinetic-Toxicodynamic Model of Methylmercury-Induced Developmental Neurotoxicity in the Fetal Rat
Center researchers: Rafael Ponce and Elaine Faustman
UW collaborator: W.C. Griffith

Temporal Fallacies in Biomarker Based Exposure Inference
Center researchers: Rafael Ponce and Elaine Faustman
EPA collaborator: Anne Jarabek
UW collaborator: W.C. Griffith

NRCSE has considerable funds available for researchers at other institutions. These are used in two different categories: funds for visiting researchers, who spend substantial time at the Center, and funds for subcontracts, where the bulk of the work is done at the researcher's home institution.

Under separate EPA funding, a project on particulate matter air pollution was initiated in 1998. Participants include researchers from Iowa State, Ohio State, NISS, University of British Columbia, Duke, Chapman University and NRCSE. Subcontracts are in place with NISS and UBC.

The project has three components: a research arm aiming at producing a special issue of Environmetrics during spring of 2000, in time for the scientific assessment of PM air pollution for the revision of the NAAQS; a workshop on particulate matter air pollution; and a series of presentations at scientific meetings.

The Center aims at building a national and international network of environmental statistical research. To that effect, we cooperate with a variety of other research groups.

National Center for Atmospheric Research. An NRCSE research assistant, Barnali Das, is spending Autumn quarter 1999 at the Geophysical Statistics Project at NCAR working on the development of statistical methods for data collected on a globe. This visit is jointly funded by NRCSE and NCAR/GSP. In addition, plans for joint funding of postdoctoral researchers are under discussion, and the two groups are planning a joint workshop on large data sets for the summer of 2000. The organizing committee for this workshop consists of Dianne Cook, Iowa State; David Madigan, AT&T; Chris Wikle, U. Missouri; Doug Nychka, NCAR; and Peter Guttorp, NRCSE.

National Institute for Statistical Sciences. A subcontract with NISS on particulate matter work funded a research assistant to Richard Smith during the summer of 1999.

Other Research Groups. The Center has a subcontract with Penn State to work on the followup from the 1997 workshop on combining data from multiple sources. The investigator is Mark Handcock, and the subcontract covers a research assistant.

A subcontract with the University of British Columbia covers particulate matter work under the leadership of Jim Zidek and John Petkau. Other collaborators in this context include Mark Kaiser at Iowa State, Noel Cressie at Ohio State, Merlise Clyde at Duke, and the NISS group mentioned previously.

During Guttorp's visit to Europe in Autumn 1998, a collaboration with European Union scientists was initiated. This resulted in a joint proposal "Estimation of human impact in the presence of natural fluctuations" to the European Commission from researchers at University of Linkoping (Sweden), Lancaster University (UK), the Finnish Meteorological Institute, The European Commission Joint Research Center (Italy), GKSS (Germany), and ARMINES (France). The proposal was funded at the level of 900,000 euro, and is aimed at creating tools for times series decomposition into meteorologically induced fluctuations and estimates of human impact; significance tests permitting retrospective impact assessment; and model reduction procedures that facilitate merging of statistical and mechanistic approaches.

Future Activities:

On January 20, 2000, the Center is holding an internal workshop. This has a dual purpose: (1) to give Center members, students, and postdocs a better understanding of the research being done at NRCSE, and (2) to think about future research projects and, more generally, the future direction of the Center.

Center members will continue to present their work to EPA laboratories. A workshop is scheduled in Las Vegas for December 14-15. We are tentatively discussing a workshop at Research Triangle Park in March. We are hoping that these workshops will help develop stronger ties with individual EPA researchers who are interested in the type of work we are doing, and develop new links and research directions for Center members.

An international workshop on Exposure Assessment in Environmental and Occupational Health will take place October 25-26, 1999, in Donovaly, Slovakia. This workshop is co-sponsored by the Slovakia State Health Institute, the U.S. EPA, University of British Columbia, and NRCSE. Alison Cullen, NRCSE, John Vandenberg, EPA; and Michael Brauer, UBC are North American members of the planning committee. Currently, three other research workshops are in the planning stage. Jointly, with NCAR/GSP, we are planning a workshop on large data sets in Boulder in July 2000. Jay Ver Hoef, University of Alaska at Fairbanks, and David Higdon, Duke, are planning a workshop at NRCSE in Seattle on spatial moving average models, tentatively scheduled for October 2000. Paul Sampson, NRCSE, is planning a small workshop on monitoring network design. No date has yet been set for this workshop. A teaching workshop, entitled Statistical Basis of Human Health Assessment, and aimed at employees of EPA Region X and other agencies. The purpose of the workshop, which is organized by Center members Rafael Ponce and Elaine Faustman together with EPA's Patricia Cirone is to ensure some understanding of the statistical issues underlying risk analysis problems occurring at the EPA.

The NRCSE are sponsoring two invited sessions at the Joint Statistical Meetings in Indianapolis, August 2000. Both are co-sponsored by the ASA Section on Statistics and the Environment. One session is entitled Modeling Heterogeneous Spatial Covariance, and has David Higdon, Duke, Olivier Perrin, U. Toulouse-I, and Alexandra Schmidt, U. of Sheffield as speakers with Paul Sampson, NRCSE as discussant. The second is entitled Statistical Approaches to the Assessment of Environmental Models, with speakers Samantha Bates, Peter Guttorp, and David Ford, all from NRCSE.

Two Center members, Lumley and Sheppard, form the statistical core of the recently formed EPA Northwest PM Center. We expect to assist the PM Center with methodological developments appropriate to their research projects, and expect to be able to use data collected by them in our research. The two Centers plan to collaborate closely.

We intend to make several pieces of software publicly available during 1999-2000. This includes POMAC 1.0, an S-Plus 4.0 port of Doug Nychka's FUNFIT programs, and software for estimating nonstationary spatial covariance structures.

The Center currently has no full year visitors planned for the academic year 1999-2000, but expect at least one full year visitor for 2000-2001. A number of short-term visitors are coming. The executive committee will consider a variety of approaches to strengthen the visitors program. In addition, we hope to continue broadening the base of research collaboration through subcontracts and separate grants and contracts.


Journal Articles on this Report: 61 Displayed | Download in RIS Format

Other project views: All 165 publications 103 publications in selected types All 64 journal articles

Type Citation Project Document Sources
Journal Article Aylin P, Maheswaran R, Wakefield J, Cockings S, Jarup L, Arnold R, Wheeler G, Elliott P. A national facility for small area disease mapping and rapid initial assessment of apparent disease clusters around a point source: the UK Small Area Health Statistics Unit. Journal of Public Health Medicine 1999;21(3):289-298. R825173 (1999)
R825173 (2000)
not available
Journal Article Bartell SM, Faustman EM. Comments on "An approach for modeling noncancer dose responses with an emphasis on uncertainty" and "A probabilistic framework for the reference dose (probabilistic R&D)." Risk Analysis 1998;18(6):663-664. R825173 (1999)
not available
Journal Article Bartell SM, Ponce RA, Takaro TK, Hill JP, Omenn GS, Faustman EM. Risk assessment and screening strategies for beryllium exposure. Technology 2000;7:241-250. R825173 (1999)
not available
Journal Article Bartell SM, Ponce RA, Takaro TK, Zerbe RO, Omenn GS, Faustman EM. Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention. Risk Analysis 2000;20(1):87-99. R825173 (1999)
R831709 (2005)
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Journal Article Bellone E, Hughes JP, Guttorp P. A hidden Markov model for downscaling synoptic atmospheric patterns to precipitation amounts. Climate Research 2000;15(1):1-12. R825173 (1999)
not available
Journal Article Best N, Wakefield J. Accounting for inaccuracies in population counts and case registration in cancer mapping studies. Journal of the Royal Statistical Society, Series A-Statistics in Society 1999;162(Part 3):363-382. R825173 (1999)
R825173 (2000)
not available
Journal Article Billheimer D. Compositional receptor modeling. Environmetrics 2001;12(5):451-467. R825173 (1999)
R825173 (2000)
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Journal Article Bowling LC, Storck P, Lettenmaier DP. Hydrologic effects of logging in western Washington, United States. Water Resources Research 2000, Volume: 36 , Number: 11 (NOV) , Page: 3223-3240. R825173 (1999)
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Journal Article Brauer M, Hruba F, Mihalikova E, Fabianova E, Miskovic P, Plzikova A, Lendacka M, Vandenberg J, Cullen A. Personal exposure to particles in Banska Bystrica, Slovakia. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(5):478-487. R825173 (1999)
R825173 (2000)
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Journal Article Charles SP, Bates BC, Hughes JP. A spatiotemporal model for downscaling precipitation occurrence and amounts. Journal of Geophysical Research-Atmospheres 1999;104(D24):31657-31669. R825173 (1999)
not available
Journal Article Charles SP, Bates BC, Whetton PH, Hughes JP. Validation of downscaling models for changed climate conditions: A case study in southwestern Australia. Climate Research 1999;12(1):1-14. R825173 (1999)
not available
Journal Article Clyde M, Guttorp P, Sullivan E. Effects of ambient fine and coarse particles on mortality in Phoenix, Arizona. Journal of Exposure Analysis and Environmental Epidemiology 2000. R825173 (1999)
R825173 (2000)
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Journal Article Craigmile PF, Guttorp P, Percival DB. Wavelet-based parameter estimation for polynomial contaminated fractionally differenced processes. IEEE Transactions on Signal Processing 2005;53(8):3151-3161 Part 2. R825173 (1999)
R825173 (2000)
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Journal Article Cullen A. Addressing uncertainty - Lessons from probabilistic exposure analysis. Inhalation Toxicology 1999;11(6-7):603-610. R825173 (1999)
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Journal Article Damian D, Sampson PD, Guttorp P. Bayesian estimation of semi-parametric non-stationary spatial covariance structures. Environmetrics 2001;12(2):161-178. R825173 (1999)
R825173 (2000)
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Journal Article Diggle PJ, Morris SE, Wakefield JC. The analysis of matched case-control studies in spatial epidemiology. Biostatistics 2000;1:89-105. R825173 (1999)
R825173 (2000)
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Journal Article Doberstein CP, Karr JR, Conquest LL. The effect of fixed-count subsampling on macroinvertebrate biomonitoring in small streams. Freshwater Biology 2000;44(2):355-371. R825173 (1999)
R825173 (2000)
R825284 (Final)
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Journal Article Elliott P, Arnold R, Cockings S, Eaton N, Jarup L, Jones J, Quinn M, Rosato M, Thornton I, Toledano M, Tristan E, Wakefield J. Risk of mortality, cancer incidence, and stroke in a population potentially exposed to cadmium. Occupational and Environmental Medicine 2000;57(2):94-97. R825173 (1999)
R825173 (2000)
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Journal Article Faustman EM, Bartell SM. Review of noncancer risk assessment: Applications of benchmark dose methods. Human and Ecological Risk Assessment 1997;3(5):893-920. R825173 (1999)
not available
Journal Article Faustman EM, Lewandowski TA, Ponce RA, Bartell SM. Biologically based dose-response models for developmental toxicants: lessons from methylmercury. Inhalation Toxicology 1999;11(6-7):559-572. R825173 (1999)
R825358 (Final)
R831709 (2005)
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Journal Article Faustman EM. Implications of research for remediation technology design. Risk Excellence Notes 1999;1(9):9. R825173 (1999)
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Journal Article Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA. Mechanisms underlying children’s susceptibility to environmental toxicants. Environmental Health Perspectives 2000;108(Suppl 1):13-21. R825173 (1999)
R825173 (2000)
R826886 (2000)
R831709 (2005)
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  • Journal Article Freeman EA, Ford ED. Effects of data quality on analysis of ecological pattern using the K(d) over-cap(d) statistical function. Ecology 2002;83(1):35-46. R825173 (1999)
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    Journal Article Gertler N, Cullen A. Effects of a transient cancer scare on property values: Implications for risk valuation and the value of life. Human and Ecological Risk Assessment Volume 6, Issue 5, 2000, Pages 731-745. R825173 (1999)
    R825173 (2000)
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    Journal Article Gneiting T. Correlation functions for atmospheric data analysis. Quarterly Journal of the Royal Meteorological Society, 1999 , Volume: 125 , Number: 559,A (OCT) , Page: 2449-2464. R825173 (1999)
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    Journal Article Gneiting T. Isotropic correlation functions on d-dimensional balls. Advances in Applied Probability 1999;31(3):625-631. R825173 (1999)
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    Journal Article Gneiting T, Sasvari Z. The characterization problem for isotropic covariance functions. Mathematical Geology 1999;31(1):105-111. R825173 (1999)
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    Journal Article Gneiting T. The correlation bias for two-dimensional simulations by turning bands. Mathematical Geology 1999;31(2):95-211. R825173 (1999)
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    Journal Article Gneiting T. Addendum to 'isotropic correlation functions on d-dimensional balls'. Advances in Applied Probability 2000;32(4):960-961 R825173 (1999)
    R825173 (2000)
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    Journal Article Gneiting T. Power-law correlations, related models for long-range dependence, and their simulation. Journal of Applied Probability 2000;37(4):1104-1109. R825173 (1999)
    R825173 (2000)
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    Journal Article Gneiting T. Compactly supported correlation functions. Journal of Multivariate Analysis 2002;83(2):493-508. R825173 (1999)
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    Journal Article Gneiting T. Nonseparable, stationary covariance functions for space-time data. Journal of the American Statistical Association 2002;97(458):590-600. R825173 (1999)
    R825173 (2000)
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    Journal Article Guttorp P. Environmental statistics. Journal of the American Statistical Association 2000;95(449):289-292 R825173 (1999)
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    Journal Article Heagerty PJ, Lumley T. Window subsampling of estimating functions with application to regression models. Journal of the American Statistical Association 2000;95(449):197-211. R825173 (1999)
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    Journal Article Hedley NR, Lee A, Drew CH, Arfin EA. Hagerstrand revisited: interactive space-time visualizations of complex spatial data. Informatica 1999;23(2):197-211 R825173 (1999)
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    Journal Article Hedley NR. Uncertainty in environmental research: beyond conceptual difficulties and synthetic frameworks. Journal of Risk and Uncertainty 1999. R825173 (1999)
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    Journal Article Henry RC, Park ES, Spiegelman CH. Comparing a new algorithm with the classic methods for estimating the number of factors. Chemometrics and Intelligent Laboratory Systems 1999;48(1):91-97. R825173 (1999)
    R826238 (2001)
    R826238 (Final)
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  • Journal Article Kang SH, Park ES. The actual size of the chi-squared and the likelihood ratio test of independence in a contingency table. Journal of Statistical Computation and Simulation 2000. R825173 (1999)
    R825173 (2000)
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    Journal Article Levy D, Lumley T, Sheppard L, Kaufman J, Checkoway H. Referent selection in case-crossover analyses of acute health effects of air pollution. Epidemiology 2001;12(2):186-192. R825173 (1999)
    R825173 (2000)
    R827355 (2004)
    R827355 (Final)
    R827355C001 (2000)
    R827355C001 (2001)
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  • Full-text: Wolters Kluwer Full Text
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  • Journal Article Lumley T, Sheppard L. Assessing seasonal confounding and model selection bias in air pollution epidemiology using positive and negative control analyses. Environmetrics 2000;11(6):705-717. R825173 (1999)
    R827355 (2001)
    R827355 (Final)
    R827355C001 (2000)
    R827355C001 (2001)
    R827355C009 (Final)
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  • Journal Article Lumley T, Levy D. Bias in the case-crossover design: implications for studies of air pollution. Environmetrics 2000;11(6):689-704. R825173 (1999)
    R827355 (2001)
    R827355 (Final)
    R827355C009 (Final)
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  • Journal Article Maheswaran R, Morris S, Falconer S, Grossinho A, Perry I, Wakefield J, Elliott P. Magnesium in drinking water supplies and mortality from acute myocardial infarction in north west England. Heart 1999;82:455-460. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Mode NA, Conquest LL, Marker DA. Ranked set sampling for ecological research: Accounting for the total costs of sampling. Environmetrics 1999;10(2):179-194. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Mode NA, Conquest LL, Marker DA. Incorporating prior knowledge in environmental sampling: ranked set sampling and other double sampling procedures. Environmetrics 2002;13(5-6):513-521 R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Morris SE, Sale RC, Wakefield JC, Falconer S, Elliott P, Boucher BJ. Hospital admissions for asthma and chronic obstructive airways disease in east London hospitals and proximity to main roads. Journal of Epidemiology and Community Health 2000;54(1):75-76. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Park ES, Spiegelman CH, Henry RC. Bilinear estimation of pollution source profiles and amounts by using multivariate receptor models. Environmetrics 2002;13(7):775-798. R825173 (1999)
    R825173 (2000)
    R826238 (Final)
  • Abstract: InterScience Abstract
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  • Journal Article Park ES, Henry RC, Spiegelman CH. Estimating the number of factors to include in a high-dimensional multivariate bilinear model. Communications in Statistics – Simulation and Computation 2000;29(3):723-746. R825173 (1999)
    R825173 (2000)
    R826238 (Final)
  • Abstract: InformaWorld Abstract
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  • Journal Article Park ES, Guttorp P, Henry RC. Multivariate receptor modeling for temporally correlated data by using MCMC. Journal of the American Statistical Association 2001;96(456):1171-1183. R825173 (1999)
    R825173 (2000)
    R826238 (2001)
    R826238 (Final)
  • Abstract: American Statistical Association Abstract
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  • Journal Article Park ES, Oh MS, Guttorp P. Multivariate receptor models and model uncertainty. Chemometrics and Intelligent Laboratory Systems, Volume 60, Issues 1-2, 28 January 2002, Pages 49-67. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Pascutto C, Wakefield JC, Best NG, Richardson S, Bernardinelli L, Staines A, Elliott P. Statistical issues in the analysis of disease mapping data. Statistics in Medicine 2000;19(17-18):2493-2519. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Ponce RA, Bartell SM, Kavanagh TJ, Woods JS, Griffith WC, Lee RC, Takaro TK, Faustman EM. Uncertainty analysis methods for comparing predictive models and biomarkers: A case study of dietary methyl mercury exposure. Journal of Regulatory Toxicology and Pharmacology 1998;28(2):96-105. R825173 (1999)
    not available
    Journal Article Poole D, Raftery AE. Inference for deterministic simulation models: The Bayesian melding approach. Journal of the American Statistical Association 2000;95(452):1244-1255. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Sheppard L, Levy D, Checkoway H. Correcting for the effects of location and atmospheric conditions on air pollution exposures in a case-crossover study. Journal of Exposure Science and Environmental Epidemiology 2001;11(2):86-96. R825173 (1999)
    R825173 (2000)
    R827355 (2004)
    R827355 (Final)
    R827355C001 (2001)
    R827355C009 (Final)
  • Abstract from PubMed
  • Full-text: Nature Publishing Group Full Text
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  • Other: Nature Publishing Group PDF
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  • Journal Article Steel EA, Guttorp P, Anderson JJ, Caccia DC. Modeling juvenile salmon migration using a simple Markov chain. Journal of Agricultural, Biological, and Environmental Statistics 2001;6(1):80-88 R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Steel EA, Neuhausser S. Comparison of methods for measuring visual water clarity. Journal of the North American Benthological Society 2002;21(2):326-335. R825173 (1999)
    not available
    Journal Article Thompson M.L., Reynolds J., Cox L.H., Guttorp P. and Sampson P.D. A review of statistical methods for the meteorological adjustment of tropospheric ozone. Atmospheric Environment, Volume 35, Issue 3, 2001, Pages 617-630. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Vorhees DJ, Cullen AC, Altshul LM. Polychlorinated biphenyls in house dust and yard soil near a Superfund site. Environmental Science & Technology 1999;33(13):2151-2156. R825173 (1999)
    not available
    Journal Article Wakefield J, Elliott P. Issues in the statistical analysis of small area health data. Statistics in Medicine 1999;18(17-18):2377-2399. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Whitcher B, Guttorp P, Percival DB. Multiscale detection and location of multiple variance changes in the presence of long memory. Journal of Statistical Computation and Simulation 2000;68(1):65-87. R825173 (1999)
    R825173 (2000)
    not available
    Journal Article Whitcher B, Guttorp P, Percival DB. Wavelet analysis of covariance with application to atmospheric time series. Journal of Geophysical Research Atmospheres 2000;105(D11):14941-14962. R825173 (1999)
    not available
    Journal Article Van Belle G, Griffith WC, Edland SD. Compositions to composite sampling. Environmental and Ecological Statistics 2001;8(2):171-180 R825173 (1999)
    R825173 (2000)
    not available
    Supplemental Keywords:

    particulate matter, PM, air pollution, modeling, NAAQS. , Economic, Social, & Behavioral Science Research Program, Scientific Discipline, RFA, Social Science, Environmental Statistics, Environmental Monitoring, risk assessment, University of Washington, statistical models, model assessment, statistical methods, ecosystem assessment, environmental risks, National Research Center on Statistics & the Environment, environmental sampling
    Relevant Websites:

    http://www.nrcse.washington.edu exit EPA

    Progress and Final Reports:
    Original Abstract
    2000 Progress Report

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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.


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