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2003 Progress Report: Investigating Chronic Effects of Exposure to Particulate Matter
EPA Grant Number: R827353C006Subproject: this is subproject number 006 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Investigating Chronic Effects of Exposure to Particulate Matter
Investigators: Dockery, Douglas W.
Current Investigators: Dockery, Douglas W. , Laden, Francine , Schwartz, Joel
Institution: Harvard University
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2002 through May 31, 2003
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter
Description:
Objective:The objective of this research project is to assess the cumulative effect of long-term exposures to particulate matter (PM).
This is one of 10 projects funded by the Center. The progress for the other nine projects is reported separately (see reports for R827353C001 through R827353C005, and R827353C007 through R827353C011).
Progress Summary:We have followed up the Harvard Six Cities Study cohort in an effort to assess the cumulative effect of long-term exposures to PM on the incidence of lung cancer, nonmalignant respiratory disease, cardiovascular disease, and cause-specific mortality. More specifically, vital status was determined for the 8,111 participants in the Harvard Six Cities adult cohort for an additional 9 years of followup (1990-1998). We identified 1,430 additional deaths, bringing the total to 2,737 deaths.
Survival analyses of all-cause mortality shows that life expectancy continues to be reduced in the more polluted cities, with the survival relative ranking being the same as that observed in the original study. Monitoring of PM2.5 and PM10 was included as part of the original study, but it was not continued in the more recent period of followup. Therefore, we have been modeling PM2.5 for this time period using data from nearby monitors in the U.S. Environmental Protection Agency Air Quality System monitoring network. A paper showing a decrease in the relative risk from mortality consistent with decreased air pollution levels in specific cities is in preparation by Laden, et al. . This paper, as well as one in preparation by Schwartz, et al. (2004), also focuses on the effect of yearly changes in PM2.5.
Future Activities:We will continue to assess the cumulative effect of long-term exposures to PM and submit papers for publication that focus on the decrease in the relative risk from mortality consistent with decreased air pollution levels in specific cities and the effect of yearly changes in PM2.5.
Journal Articles on this Report: 1 Displayed | Download in RIS Format
| Other subproject views: | All 4 publications | 4 publications in selected types | All 4 journal articles |
| Other center views: | All 149 publications | 149 publications in selected types | All 148 journal articles |
| Type | Citation | ||
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Clancy L, Goodman P, Sinclair H, Dockery DW. Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study. Lancet 2002;360(9341):1210-1214. |
R827353 (Final) R827353C006 (2001) R827353C006 (2002) R827353C006 (2003) R827353C006 (Final) |
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exposure, health effects, biology, epidemiology, toxicology, environmental chemistry, monitoring, air pollutants, air pollution, air quality, ambient air, ambient air monitoring, ambient air quality, ambient measurement methods, ambient monitoring, ambient particle health effects, ambient particles, exposure assessment, biological mechanism, biological response, cardiopulmonary, cardiopulmonary response, cardiovascular disease, chemical exposure, environmental health hazard, exposure and effects, health risks, human exposure, human health, human health effects, human health risk, indoor air quality, indoor exposure, inhalation, inhalation toxicology, inhaled particles, particle exposure, particulate exposure, particulates, pulmonary, pulmonary disease, respiratory, respiratory disease, risk assessment. , ENVIRONMENTAL MANAGEMENT, Air, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Susceptibility/Sensitive Population/Genetic Susceptibility, Molecular Biology/Genetics, Toxicology, Risk Assessment, Biology, Risk Assessments, genetic susceptability, Microbiology, Physical Processes, Epidemiology, air toxics, Children's Health, Atmospheric Sciences, Environmental Engineering, Environmental Microbiology, particulate matter, Environmental Chemistry, Environmental Monitoring, tropospheric ozone, ambient measurement methods, cardiopulmonary, exposure assessment, exposure and effects, ambient air quality, cardiovascular disease, chronic effects, elderly, health effects, indoor air, indoor air quality, inhalation, developmental effects, epidemelogy, lung cancer, respiratory disease, inhalation toxicology, air quality, ambient air, cardiopulmonary response, indoor exposure, molecular epidemiology, measurement methods, assessment of exposure, cardiopulmonary responses, human health risk, interindividual variability, monitoring, susceptibility, genetic susceptibility, particle exposure, toxics, epidemeology, air pollutants, human health effects, particulates, respiratory, sensitive populations, measurement methods , biological response, ambient particle health effects, air pollution, ambient monitoring, children, inhaled, lung, stratospheric ozone, ambient air monitoring, chemical exposure, dosimetry, exposure, inhaled particles, pulmonary, human health, atmospheric monitoring, human susceptibility, environmental health hazard, biological mechanism , health risks, human exposure, Human Health Risk Assessment, particle size, pulmonary disease
Relevant Websites:
https://cfserver.hsph.harvard.edu/cfdocs/eer/epa/
Progress and Final Reports:
2000 Progress Report
2001 Progress Report
2002 Progress Report
Original Abstract
2004 Progress Report
Final Report
Main Center Abstract and Reports:
R827353 EPA Harvard Center for Ambient Particle Health Effects
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological
Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards
Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to
Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate
Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition,
and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters,
Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core