Chesapeake Bay Program - this site provides information about the restoration of the Chesapeake Bay as well as data and information about this unique ecosystem.

Columbia River Basin: Designated as a critical ecosystem in EPA's strategic plan, this 260,000 square mile watershed is targeted for wetland restoration, contaminated sediment cleanup and an overall reduction in contaminant concentrations in water and fish tissue.

Great Lakes National Program Office - the site is dedicated to communicating information about the Great Lakes ecosystem and the human health, monitoring, and sediment issues present there.

Great Lakes Information Network - this site is a partnership that provides one place online for people to find information relating to the binational Great Lakes region of North America.  

Gulf of Mexico Program - this site is a developmental effort designed to make Gulf of Mexico ecosystem data and information readily available and to facilitate communications between parties involved in Gulf of Mexico projects and programs.

Lake Champlain Basin Program - A federal, state and local initiative to restore and protect Lake Champlain (Vermont and New York) and its surrounding watershed for future generations.  

Long Island Sound Program - this site offers access to information about the Long Island Sound and this program to research and monitor conditions in the Sound, identify priority problems, and develop strategies to address those problems.

Mid-Atlantic Integrated Assessment (MAIA) - a research, monitoring, and assessment initiative to develop high-quality scientific information on the condition of the natural resources of the Mid-Atlantic region of the eastern United States, including the watersheds of the Delaware and Chesapeake Bays, Albemarle-Pamlico Sound, and the Delmarva Coastal Bays.

National Estuary Program - a program to protect and restore the health of estuaries while supporting economic and recreational activities. To date, 28 local NEPs are demonstrating practical and innovative ways to revitalize and protect their estuaries.

Puget Sound Georgia Basin: A critical marine ecosystem situated in the United States and Canada, the Puget Sound portion has been designated as a critical ecosystem in EPA's strategic plan. A comprehensive environmental indicators report is one of the tools used to assess our progress toward improving water quality and shellfish harvesting, remediating contaminated sediments, wetland restoration and diesel emission reductions.

Puget Sound Initiatives - this site provides information about an effort by state and provincial governments to address, plan for and resolve the environmental problems associated with population growth in Puget Sound and the Georgia Basin.

Regional Geographic Initiative - this program provides grants for projects that are identified as high priority by an EPA Region, state or locality, that pose a high human health or ecosystem risk, and have significant potential for risk reduction.

U.S. - Mexico Border 2012 - is a binational, interagency program aimed at protecting and improving the environment and environmental health while fostering sustainable development in the U.S./Mexico border area.

U.S. - Mexico Border Environmental Health Program - this site offers information about this interagency committe including the program strategy and information about on-going and planned projects.