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2003 Progress Report: Assessing Life-Shortening Associated with Exposure to Particulate Matter
EPA Grant Number: R827353C005Subproject: this is subproject number 005 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Assessing Life-Shortening Associated with Exposure to Particulate Matter
Investigators: Schwartz, Joel
Current Investigators: Schwartz, Joel , Bateson, T. , Coull, Brent , O’Neill, M. , Zanobetti, Antonella
Institution: Harvard University
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2003 through May 31, 2004
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter
Description:
Objective:During the first 2 years of this project, the research dealt with issues related to harvesting. The objective for the next year is to develop statistical methods for investigating confounding, dose-response relationships, and other particle health effects issues.
This is one of 10 projects funded by the Center. The progress for the other nine projects is reported separately (see reports for R827353C001 through R827353C004, and R827353C006 through R827353C011).
Progress Summary:We continued analyses investigating harvesting in 10 European cities by examining all cause, respiratory, and cardiovascular deaths for all ages and stratifying by age groups. Our research project confirms that most of the effect of air pollution is not simply advanced by a few weeks and that effects persist for more than 1 month after exposure. We found that the effect size estimate for PM10 doubles when longer term effects for all mortality and cardiovascular mortality were considered and becomes five times higher for respiratory mortality. We found similar effects when stratifying by age groups (Zanobetti, et al., 2003).
A great deal of work was focused on the reanalysis of all of the previous studies that used generalized additive models to assess particulate matter (PM) health outcomes. In particular, recent work has shown that current approaches misestimate the standard errors of parametric terms when controlling for smooth functions, and this has raised questions about the entire approach. In addition to reanalyzing these data using different convergence criteria and natural splines, we have developed alternative approaches, including the penalized spline method (Zanobetti and Schwartz, 2003c). The results of the reanalysis did not change substantially from previously reported results (Schwartz, et al., 2003; Zanobetti and Schwartz, 2003b; Zanobetti and Schwartz, 2003c).
Future Activities:We will continue to develop statistical methods for investigating confounding, dose-response relationships, and other particle health effects issues.
Journal Articles on this Report: 9 Displayed | Download in RIS Format
| Other subproject views: | All 22 publications | 22 publications in selected types | All 22 journal articles |
| Other center views: | All 149 publications | 149 publications in selected types | All 148 journal articles |
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Bateson TF, Schwartz J. Selection bias and confounding in case-crossover analyses of environmental time-series data. Epidemiology 2001;12(6):654-661. |
R827353 (Final) R827353C004 (2002) R827353C004 (2003) R827353C004 (2004) R827353C004 (Final) R827353C005 (2001) R827353C005 (2002) R827353C005 (2003) R827353C005 (Final) |
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Braga ALF, Zanobetti A, Schwartz J. Do respiratory epidemics confound the association between air pollution and daily deaths? European Respiratory Journal 2000;16(4):723-728. |
R827353 (Final) R827353C005 (2000) R827353C005 (2002) R827353C005 (2003) R827353C005 (Final) |
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Braga ALF, Zanobetti A, Schwartz J. The lag structure between particulate air pollution and respiratory and cardiovascular deaths in 10 US cities. Journal of Occupational and Environmental Medicine 2001;43(11):927-933. |
R827353 (Final) R827353C005 (2001) R827353C005 (2002) R827353C005 (2003) R827353C005 (Final) |
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Dockery DW. Epidemiologic evidence of cardiovascular effects of particulate air pollution. Environmental Health Perspectives 2001;109(Suppl. 4):483-486. |
R827353 (Final) R827353C005 (2002) R827353C005 (2003) R827353C005 (Final) |
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Goodman PG, Dockery DW, Clancy L. Cause-specific mortality and the extended effects of particulate pollution and temperature exposure. Environmental Health Perspectives 2004;112(2):179-185. |
R827353 (Final) R827353C005 (2003) R827353C005 (Final) R827353C006 (Final) |
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O’Neill MS, Loomis D, Borja Aburto VH, Gold D, Hertz-Picciotto I, Castillejos M. Do associations between airborne particles and daily mortality in Mexico City differ by measurement method, region, or modeling strategy? Journal of Exposure Analysis and Environmental Epidemiology 2004;14(6):429-439. |
R827353 (Final) R827353C005 (2003) R827353C005 (Final) |
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Schwartz J, Zanobetti A. Using meta-smoothing to estimate dose-response trends across multiple studies, with application to air pollution and daily death. Epidemiology 2000;11(6):666-672. |
R827353 (Final) R827353C005 (2000) R827353C005 (2002) R827353C005 (2003) R827353C005 (Final) |
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Schwartz J, Ballester F, Saez M, Perez-Hoyos S, Bellido J, Cambra K, Arribas F, Canada A, Perez-Boillos MJ, Sunyer J. The concentration-response relation between air pollution and daily deaths. Environmental Health Perspectives 2001;109(10):1001-1006. |
R827353 (Final) R827353C005 (2000) R827353C005 (2002) R827353C005 (2003) R827353C005 (Final) |
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Zanobetti A, Schwartz J. Cardiovascular damage by airborne particles: Are diabetics more susceptible? Epidemiology 2002;13(5):588-592. |
R827353 (Final) R827353C004 (2001) R827353C004 (2002) R827353C004 (2003) R827353C004 (Final) R827353C005 (2003) R827353C005 (Final) |
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exposure, health effects, susceptibility, mortality, cardiovascular mortality, biology, epidemiology, toxicology, air pollutants, air pollution, air quality, ambient air, ambient air monitoring, ambient air quality, ambient monitoring, ambient particle health effects, ambient particles, exposure assessment, biological mechanism, biological response, cardiopulmonary, cardiopulmonary response, cardiovascular disease, chemical exposure, environmental health hazard, exposure and effects, health risks, human exposure, human health, human health effects, human health risk, human susceptibility, indoor air quality, indoor exposure, outdoor exposure, inhalation, inhalation toxicology, inhaled particles, particle exposure, particulate exposure, particulates, pulmonary, pulmonary disease, respiratory, respiratory disease, risk assessment, sensitive populations. , Air, Geographic Area, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Molecular Biology/Genetics, Toxicology, Biology, Risk Assessments, genetic susceptability, Microbiology, Epidemiology, Atmospheric Sciences, Environmental Engineering, Environmental Microbiology, particulate matter, Environmental Chemistry, Environmental Monitoring, State, ambient measurement methods, risk assessment, ambient air quality, cardiovascular disease, elderly, indoor air quality, inhalation, developmental effects, epidemelogy, lung cancer, respiratory disease, inhalation toxicology, pre-existing conditions, air quality, cardiopulmonary response, indoor exposure, molecular epidemiology, cardiopulmonary responses, human health risk, interindividual variability, genetic susceptibility, particle exposure, toxics, mortality studies, human health effects, particulates, respiratory, sensitive populations, ambient particle health effects, air pollution, children, Utah (UT), Connecticut (CT), ambient air monitoring, chemical exposure, dosimetry, exposure, inhaled particles, pulmonary, Illinois (IL), human susceptibility, biological mechanism , health risks, human exposure, Human Health Risk Assessment, pulmonary disease, Massachusetts (MA)
Relevant Websites:
https://cfserver.hsph.harvard.edu/cfdocs/eer/epa/
Progress and Final Reports:
1999 Progress Report
2000 Progress Report
2001 Progress Report
2002 Progress Report
Original Abstract
Final Report
Main Center Abstract and Reports:
R827353 EPA Harvard Center for Ambient Particle Health Effects
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological
Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards
Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to
Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate
Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition,
and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters,
Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core