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2000 Progress Report: Inner City Toxicants and Neurodevelopmental Impairment
EPA Grant Number: R827039Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Center Director: Wolff, Mary S.
Title: Inner City Toxicants and Neurodevelopmental Impairment
Investigators: Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Fields, Nigel
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Period Covered by this Report: August 1, 1999 through July 31, 2000
Project Amount: $3,136,392
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects
Description:
Objective:Children in America’s cities are at risk of exposure to multiple known and potential developmental toxicants—pesticides, polychlorinated biphenyls (PCBs), and lead. The goal of the Mount Sinai Center for Children’s Environmental Health and Disease Prevention Research is to identify, elucidate, and prevent developmental deficits that result from exposures to environmental toxicants in the inner city.
Progress Summary:Children in America's cities are at risk of exposure to multiple known and potential developmental toxicants--pesticides, polychlorinated biphenyls (PCBs), and lead. The goal of the Mount Sinai Center for Children's Environmental Health and Disease Prevention is to identify, elucidate and prevent developmental deficits that result from exposures to environmental toxicants in the inner city.
Project 1 is a community-based prevention program that is being undertaken in East Harlem, New York City, in partnership with Boriken Health Center. In years 1 and 2, we are enrolling 120-150 mothers. The goal is to reduce exposures to pesticides and other developmental toxicants among expectant mothers. A non-intervention comparison group will consist of expectant mothers in similar housing enrolled in Project 2. Dust pesticide levels and roach infestation levels are assessed serially in both groups. In years 3 and 4, Integrated Pest Management (IMP) will be generalized to housing and schools throughout East Harlem using community intervention strategies.
Project 2 is a prospective epidemiologic study of an ethnically diverse birth cohort of infants born at Mount Sinai including 150 volunteers from Project 1. We have enrolled 216 mothers and our first “birthday” was celebrated in May 1999. To date, blood lead has been measured. Initial neurologic assessments have been made. Other measures (PCBs, pesticides) will be made on donated blood and urine. We will assess whether in utero exposures to pesticides and other toxicants are associated with developmental delays.
Project 3 is studying polymorphisms in the enzymes that activate and detoxify organophosphates and other pesticides in the population of mothers and infants enrolled in Project 2. To date, over 300 genetic polymorphisms have been determined by PCR and 115 phenotypes assessed.
Project 4, a retrospective study of African-American men enrolled in the Collaborative Perinatal Project, will assess whether in utero exposures to PCBs are associated with disordered neuropsychological function in adolescent or adult life. Specimens have been assembled and will be analyzed shortly.
Project 5 will examine the mechanisms by which environmental toxicants affect neuroendocrine development. Experiments in neuron cells and a female rat model have been initiated in order to characterize interactions between toxicants and hypothalamic gonadotropin releasing hormone (GnRH) neurosecretory neurons, key regulators of reproductive development. Early results are promising for this new model of environmental reproductive toxicants.
The Center relies upon Facilities Cores in Exposure Assessment and Biostatistics/Data Management as well as an Administration Core.
Journal Articles: 7 Displayed | Download in RIS Format
| Other center views: | All 13 publications | 8 publications in selected types | All 7 journal articles |
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Berkowitz GS, Wolff MS, Matte T, Susser E, Landrigan PJ. The rationale for a national prospective cohort study of environmental exposure and childhood development. Environmental Research 2001;85(2):59-68. |
R827039 (2002) R827039C004 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, Landrigan PJ, Wolff MS. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environmental Health Perspectives 2003;111(1):79-84. |
R827039 (2002) R827039C004 (2002) R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Chen J, Germer S, Higuchi R, Berkowitz G, Godbold J, Wetmur JG. Kinetic polymerase chain reaction on pooled DNA: a high-throughput, high-efficiency alternative in genetic epidemiological studies. Cancer Epidemiology, Biomarkers & Prevention 2002;11(1):131-136. |
R827039 (2002) R827039C001 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Gore AC. Environmental toxicant effects on neuroendocrine function. Endocrine 2001;14(2):235-246. |
R827039 (2002) R827039C002 (2002) R831711 (2005) R831711 (2007) R831711C001 (2006) R831711C003 (2006) |
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Gore AC, Wu TJ, Oung T, Lee JB, Woller MJ. A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone (GnRH) neurones. Journal of Neuroendocrinology 2002;14(10):814-823. |
R827039 (2002) R827039C002 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Gore AC. Organochlorine pesticides directly regulate gonadotropin-releasing hormone (GnRH) gene expression and biosynthesis in the GT1-7 hypothalamic cell line. Molecular and Cellular Endocrinology 2002;192(1-2):157-170. |
R827039 (2002) R827039C002 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Landrigan PJ, Claudio L, Markowitz SB, Berkowitz GS, Brenner BL, Romero H, Wetmur JG, Matte TD, Gore AC, Godbold JH, Wolff MS. Pesticides and inner-city children: exposures, risks, and prevention. Environmental Health Perspectives 1999;107(Suppl 3):431-437. |
R827039 (2002) R827039C002 (2002) R827039C003 (2000) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2004) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Toxics, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, genetic susceptability, Epidemiology, Children's Health, pesticides, environmentally caused disease, environmental hazard exposures, neurodevelopmental toxicity, respiratory problems, urban air, children's environmental health, lead, assessment of exposure, childhood respiratory disease, human health risk, PCBs, susceptibility, developmental neurotoxicity, childhood lead exposure, pesticide exposure, environmental health, lead exposure, developmental lead exposure, airway disease, children, environmental risks, age dependent response, growth & development, children's vulnerablity, health risks, human exposure, Human Health Risk Assessment
Relevant Websites:
http://www.childenvironment.org/
Progress and Final Reports:
Original Abstract
2002 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides