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Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
EPA Grant Number: R827039C004Subproject: this is subproject number 004 , established and managed by the Center Director under grant R827039
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Center Director: Wolff, Mary S.
Title: Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
Investigators: Susser, Ezra , Matte, Thomas , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Fields, Nigel
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Health Effects , Children's Health
Description:
Objective:The original two specific aims of this project have not changed and correspond to the two phases of the project. Briefly restated, the aim of the phase 1 project (planned for years 1 and 2), is to evaluate the relation of prenatal polychlorinated biphenyl (PCB) exposure, to be measured in stored maternal sera, to neurodevelopmental outcomes in adolescence based on neuropsychologic, neurologic, behavioral, and psychiatric assessments performed during a previous study. Subjects are a sub-cohort 162 African-Americans from the Collaborative Perinatal Project (CPP) cohort enrolled at Columbia-Presbyterian Medical Center (CPMC). The aim of the phase 2 project is to evaluate the relation of prenatal PCB exposure to neurodevelopmental outcomes at age 39 and over the life course through that age in the same sub-cohort studied in phase 1. Outcomes will be measured by tracing and recruiting subjects to undergo an examination battery designed based on findings from the phase 1 study.
Publications and Presentations:Publications have been submitted on this subproject: View all 3 publications for this subproject | View all 13 publications for this center
Journal Articles:Journal Articles have been submitted on this subproject: View all 2 journal articles for this subproject | View all 7 journal articles for this center
Supplemental Keywords:Toxics, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, genetic susceptability, Health Risk Assessment, Epidemiology, Children's Health, Biochemistry, pesticides, Environmental Chemistry, exposure assessment, neurological development, environmental hazard exposures, neurodevelopmental toxicity, developmental disorders, health effects, assessment of exposure, growth and development, harmful environmental agents, PCBs, pesticide residues, dietary exposure, exposure pathways, pesticide exposure, sensitive populations, biological response, children, exposure, growth & development, environmental health hazard, health risks, human exposure, Human Health Risk Assessment, neurotoxicity
Progress and Final Reports:
2000 Progress Report
2002 Progress Report
Main Center Abstract and Reports:
R827039 Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides