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University of Washington

Grant Number R826886


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  • Abstract (13)
  • Article/Press Release (4)
  • Book Chapter (4)
  • Dissertation/Thesis (3)
  • Journal Article (47)
  • NCER STAR Report (1)
  • Presentation (11)
  • Reference Type Citation Progress Report Year Document Sources
    Abstract Faustman EM, Yu X, Sidhu J, Robinson J. Toxicant affects on ubiquitin-proteosome systems: lessons from cross-compound and cross-system assessments. The Toxicologist 2005;84(S1):1655. R831709C001 (2005)
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    Abstract Faustman EM, Griffith WC, Vigoren E. Lessons learned from longitudinal studies to identify high exposure groups using OP pesticide urinary biomarkers. Toxicology Letters 2006;164(Supplement 1):S161. R831709 (2005)
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    Abstract Fenske R, Kissel J, Lu C, Simcox NJ, Knutson D, Koch D. Biologically based analysis of organophosphorus pesticide exposures in children in agricultural communities. Epidemiology 1999;10(4 Suppl). R826886C004 (2001)
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    Abstract Giordano G, Afsharinejad Z, Kavanagh T, Costa L. Reactive oxygen species mediate the neurotoxicity induced by organophosphorus insecticides in mouse cerebellar granule cells. The Toxicologist 2006;90:301. R831709 (2005)
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    Abstract Gohlke JM, Griffith WC, Faustman EM. Computational models for the acquisition of neocortical neurons in the developing humans, monkey, and mouse: cross species comparison of toxicodynamics. The Toxicologist 2005;84(S1):69. R831709C001 (2005)
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    Abstract Gribble EJ, Yu X, Hong S, Faustman EM. A role for p53 in mouse midbrain neural precursor cell (NPC) cell cycle arrest and premature neuronal differentiation following methylmercury exposure. The Toxicologist 2006;90:366. R831709 (2005)
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    Abstract Kissel J, Kedan G, Wawrukiewicz A, Fenske R. Attempted reconciliation of predicted children’s exposures to organophosphate pesticides with measured metabolite levels in urine. Epidemiology 1999;10(4 Suppl):S110. R826886C004 (2001)
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    Abstract Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman EM. Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts. The Toxicologist 2005;84(S1):2257. R831709C001 (2005)
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    Abstract Robinson J, Yu X, Hong S, Kim E, Sullivan R, Griffith W, Faustman E. Differential impact of cadmium on gene expression during neuralation in the C57BL/6 and SWV. Birth Defects Research Part A 2006;76(5):392. R831709 (2005)
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    Abstract Robinson JF, Yu X, Gribble EJ, Hong S, Kim E, Sidhu JS, Faustman EM. Examination of arsenic-induced alterations in cell cycle progression and global gene expression in p53 transgenic mouse embryonic fibroblasts. The Toxicologist 2006;90:91-92. R831709 (2005)
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    Abstract Yu X, Sidhu J, Robinson J, Hong S, Faustman EM. Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic, and methylmercury: induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation. The Toxicologist 2005;84(S1):1155. R831709C001 (2005)
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    Abstract Yu X, Griffith WC, Hanspers K, Ong H, Faustman EM. A system based approach to identify potential signalling pathways during gonad development from microarray data. Birth Defects Research Part A 2006;76(5):339. R831709 (2005)
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    Abstract Yu X, Griffith WC, Hanspers K, Robinson J, Faustman EM. Functional interpretation of dose- and time-dependent microarray data: quantitative integration of GO ontology analysis for toxicology and risk assessment. The Toxicologist 2006;90:182-183. R831709 (2005)
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    Article/Press Release Fenske R. Pesticide exposure and children. Part 3: Estimating doses for children. Agrichemical and Environmental News, June 2000, Issue 170, pp. 1-3. R826886C004 (2001)
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    Article/Press Release Fenske R. Organophosphates and the risk cup. Agrichemical and Environmental News, November 1999, Issue 163, pp. 6-8. R826886C004 (2001)
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    Article/Press Release Fenske R. Pesticide exposure and children. Part 1: Why focus on kids? Agrichemical and Environmental News, February 2000, Issue 166, pp. 7-8. R826886C004 (2001)
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    Article/Press Release Fenske R. Pesticide exposure and children. Part 2: Children in agricultural communities. Agrichemical and Environmental News, March 2000, Issue 167, pp. 16-18. R826886C004 (2001)
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    Book Chapter Brophy VH, Jarvik GP, Furlong CE. PON1 polymorphisms. Chapter 3. In: Costa LG, Furlong CE, eds. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Kluwer Academic Publishers, 2002. R826886C002 (2001)
    R826886C002 (2002)
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  • Book Chapter Costa LG, Li W-F, Richter RJ, Shih DM, Lusis AJ, Furlong CE. PON1 and organophosphate toxicity. Chapter 8. In: Costa LG, Furlong CE, eds. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Kluwer Academic Publishers, 2002. R826886C002 (2001)
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  • Book Chapter Costa LG, Furlong CE. Perspectives in PON1 research. Chapter 10. In: Costa LG, Furlong CE, eds. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Kluwer Academic Publishers, 2002. R826886C002 (2002)
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  • Book Chapter Faustman EM, Ponce RA, Seeley MR, Whittaker SG. Experimental approaches to evaluate mechanisms of developmental toxicity. In: Hood RD, ed. Developmental and Reproductive Toxicology: A Practical Approach. Boca Raton, FL: CRC Press, Inc., 2004. R831709 (2005)
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    Dissertation/Thesis Adams JC. A physiologically-based toxicokinetic model of xylene inhalation exposure in Caucasian men and a correlation study of individual kinetic and anthropometric parameters determined from physiologic modeling of controlled xylene exposure. M.S. Thesis. Department of Environmental Health, University of Washington, Seattle, WA, 2000. R826886 (2000)
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    Dissertation/Thesis Curl C. Evaluation of organophosphorus pesticide exposure in children of agricultural families in the Lower Yakima Valley. M.S. Thesis. Department of Environmental Health, University of Washington, Seattle, WA, August 2000. R826886 (2000)
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    Dissertation/Thesis Palcisko G. Children’s exposure to lead and arsenic in orchard soils. M.S. Thesis. Department of Environmental Health, University of Washington, Seattle, WA, August 2000. R826886 (2000)
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    Journal Article Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE. Effects of 5’ regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. American Journal of Human Genetics 2001;68(6):1428-1436. R826886C002 (2001)
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  • Journal Article Brophy V H, Hastings MD, Clendenning JB, Richter RJ, Jarvik GP, Furlong CE. Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics 2001;11(1):77-84. R826886C002 (2001)
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  • Journal Article Caughlan A, Newhouse K, Namgung U, Xia Z. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicological Sciences 2004;78(1):125-134. R831709C001 (2004)
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    Journal Article Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chemico-Biological Interactions 1999;119-120:429-438. R826886C002 (2000)
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  • Journal Article Costa LG. The emerging field of ecogenetics. NeuroToxicology 2000;21(1-2):85-89. R826886C002 (2000)
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  • Journal Article Costa LG, Cole TB, Jarvik GP, Furlong CE. Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annual Review of Medicine 2003;54:371-392. R826886C002 (2002)
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  • Journal Article Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003;8(1):1-12. R826886C002 (2002)
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  • Journal Article Costa LG. Current issues in organophosphate toxicology. Clinica Chimica Acta 2006;366(1-2):1-13. R831709 (2005)
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  • Journal Article Costa LG, Cole TB, Furlong CE. Gene-environment interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity. Lab Medicine 2006;37(2):109-113. R831709 (2005)
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    Journal Article Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Frontiers in Bioscience 2008;13(4):1240-1249. R831709 (2005)
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  • Journal Article Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TW, Griffith W, Coronado G, Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environmental Health Perspectives 2002;110(12):A787-A792. R826886C003 (2001)
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  • Journal Article Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, Sonawane B, Bruckner J, Breslin W. A framework for assessing risks to children from exposure to environmental agents. Environmental Health Perspectives 2004;112(2):238-256. R831709C001 (2004)
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    Journal Article Elgethun K, Fenske RA, Yost MG, Palcisko GJ. Time-location analysis for exposure assessment studies of children using a novel global positioning system instrument. Environmental Health Perspectives 2003;111(1):115-122. R826886C004 (2002)
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  • Journal Article Elgethun K, Yost MG, Fitzpatrick CTE, NyergesTL, Fenske RA. Comparison of global positioning system (GPS) tracking and parent-report diaries to characterize children's time–location patterns. Journal of Exposure Science and Environmental Epidemiology 2007;17(2):196-206. R831709 (2005)
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  • Abstract: Nature
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  • Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. R827027 (2002)
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  • Journal Article Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA. Mechanisms underlying children’s susceptibility to environmental toxicants. Environmental Health Perspectives 2000;108(Suppl 1):13-21. R825173 (1999)
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  • Journal Article Faustman EM, Gohlke, JM, Judd NL, Lewandowski TA, Bartell SA, Griffith WC. Modeling developmental processes in animals: Applications in neurodevelopmental toxicology. Environmental Toxicology and Pharmacology 2005;19(3):615-624. R831709 (2005)
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  • Journal Article Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH, Keifer MC. Biologically based pesticide dose estimates for children in an agricultural community. Environmental Health Perspectives 2000;108(6):515-520. R826886C004 (2001)
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  • Journal Article Fenske RA, Lu C, Simcox NJ, Loewenherz C, Touchstone J, Moate TF, Allen EH, Kissel JC. Strategies for assessing children’s organophosphorus pesticide exposures in agricultural communities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Suppl 2):662-671. R825171 (2000)
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  • Journal Article Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). NeuroToxicology 2000;21(1-2):91-100. R826886C002 (2000)
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  • Journal Article Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG. The PON1 gene and detoxication. NeuroToxicology 2000;21(4):581-587. R826886C002 (2001)
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  • Journal Article Furlong CE, Li W-F, Shih DM, Lusis AJ, Richter RJ, Costa LG. Genetic factors in susceptibility:serum PON1 variation between individuals and species. Human and Ecological Risk Assessment 2002;8(1):31-43. R826886C002 (2002)
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  • Journal Article Furlong CE, Cole TB, Jarvik GP, Costa LG. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenomics 2002;3(3):341-348. R826886C002 (2002)
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  • Journal Article Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology 2007;219(2-3):181-189. R831709 (2005)
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  • Journal Article Gohlke JM, Griffith WC, Faustman EM. The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse. Developmental Brain Research 2004;151(1-2):43-54. R831709 (2005)
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    Journal Article Gohlke JM, Griffith WC, Faustman EM. A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. Toxicology Science 2005;86:470-84. R831709 (2004)
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    Journal Article Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 2005;215(3):182-190. R831709 (2005)
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  • Journal Article Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis. Developmental Brain Research 2003;141(1-2):117-128. R831709 (2005)
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    Journal Article Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis: potential cross-species differences and implications for risk assessment. Toxicological Sciences 2003;75(1):124-133. R831709 (2005)
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    Journal Article Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. Catalytic efficiency determines the in- vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics 2000;10(9):767-779. R826886C002 (2000)
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  • Journal Article Lu C, Fenske RA. Dermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications. Environmental Health Perspectives 1999;107(6):463-467. R826886C004 (2001)
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  • Journal Article Lu C, Fenske RA, Simcox NJ, Kalman D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environmental Research 2000;84(3):290-302. R826886C004 (2001)
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  • Journal Article Mirkes PE, Little SA. Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicology and Applied Pharmacology 2000;162(3):197-206. R826886C001 (2001)
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  • Journal Article Mirkes PE, Wilson KL, Cornel LM. Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos. Teratology 2000;62(1):14-25. R826886C001 (2001)
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  • Journal Article Moate TF, Lu C, Fenske RA, Hahne RMA, Kalman DA. Improved cleanup and determination of dialkyl phosphates in the urine of children exposed to organophosphorus insecticides. Journal of Analytical Toxicology 1999;23(4):230-236. R825171 (1999)
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  • Journal Article Moate TF, Furia M, Curl C, Muniz JF, Yu J, Fenske RA. Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust. Journal of AOAC International 2002;85(1):36-43. R826886C004 (2001)
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  • Journal Article Namgung U, Xia Z. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicology and Applied Pharmacology 2001;174(2):130-138. R826886C001 (2002)
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  • Journal Article Ramaprasad J, Tsai M-Y, Elgethun K, Hebert VR, Felsot A, Yost MG, Fenske RA. The Washington aerial spray drift study: assessment of off-target organophosphorus insecticide atmospheric movement by plant surface volatilization. Atmospheric Environment 2004;38(33):5703-5713. R831709 (2005)
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    Journal Article Sidhu JS, Ponce RA, Vredevoogd MA, Yu X, Gribble E, Hong S-W, Schneider E, Faustman EM. Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Toxicological Sciences 2006;89(2):475-484. R831709 (2005)
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  • Journal Article Thompson B, Coronado G, Puschel K, Allen E. Identifying constituents to participate in a project to control pesticide exposure in children of farmworkers. Environmental Health Perspectives 2001;109(Suppl 3):443-448. R826886C003 (2001)
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  • Journal Article Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, Curl CL, Shirai JH, Kissel JC, Fenske RA. Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. Journal of Occupational and Environmental Medicine 2003;45(1):42-53. R826886C003 (2002)
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  • Journal Article Tsai M-Y, Elgethun K, Ramaprasad J, Yost MG, Felsot AS, Hebert VR, Fenske RA. The Washington aerial spray drift study:modeling pesticide spray drift deposition from an aerial application. Atmospheric Environment 2005;39(33):6194-6203. R831709 (2005)
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  • Journal Article Umpierre CC, Little SA, Mirkes PE. Co-localization of active caspase-3 and DNA fragmentation (TUNEL) in normal and hyperthermia-induced abnormal mouse development. Teratology 2001;63(3):134-143. R826886C001 (2001)
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  • Journal Article Vicini P, Pierce CH, Dills RL, Morgan MS, Kalman DA. Individual prior information in a physiological model of 2H8-toluene kinetics: an empirical Bayes estimation strategy. Risk Analysis 1999;19(6):1127-1134. R826886 (2000)
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  • Journal Article Weppner S, Elgethun K, Lu C, Herbert V, Yost MG, Fenske RA. The Washington aerial spray drift study: children's exposure to methamidophos in an agricultural community following fixed-wing aircraft applications. Journal of Exposure Science and Environmental Epidemiology 2006;16(5):387-396. R831709 (2005)
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  • Abstract: Nature
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  • Journal Article Yu X, Griffith WC, Hanspers K, Dillman III JF, Ong H, Vredevoogd MA, Faustman EM. A system-based approach to interpret dose-and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences 2006;92(2):560-577. R831709 (2005)
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  • Journal Article Gribble EJ, Hong S-W, Faustman EM. The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53 dependent. Birth Defects Research Part A: Clinical and Molecular Teratology 2005;73(1):29-38. R831709 (2005)
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    NCER STAR Report Faustman EM, Gohlke, JM, Judd NL, Lewandowski TA, et al. Modeling developmental processes in animals: applications in neurodevelopmental toxicology. Washington, DC: National Center for Environmental Assessment, 2004, EPA/600/P-04/110A. R831709C001 (2005)
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    Presentation Curl C, Kissel J, Fenske R, Shirai J, et al. Baseline data from an EPA/NIEHS Children’s Environmental Health Center Community Intervention Project in Washington State. Presented at the Annual Meeting of the ISEA, Monterey, CA. R826886 (2000)
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    Presentation Faustman EM. Post-application methamidophos residues on indoor and outdoor surfaces and children’s hands. Presented at the Fifth International Symposium—The Future of Rural Peoples: Rural Economy, Healthy People, Environment, Rural Communities, Saskatoon, Saskatchewan, Canada, October 19-23, 2003 (abstract #307). R831709C004 (2004)
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    Presentation Faustman EM, Yu X, Sidhu JS, Hong S, et al. Integration of toxicogenomic and knowledge-based pathway mapping for elucidating shared molecular mechanisms of metal toxicity. Poster presented at the 10th International Congress of Toxicology, Tampere, Finland, July 11-15, 2004. R831709C001 (2005)
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    Presentation Faustman EM, Yu X, Sidhu J, Robinson J. Toxicant affects on ubiquitin-proteosome systems: lessons from cross-compound and cross-system assessments. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005. R831709C001 (2005)
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    Presentation Gohlke JM, Griffith WC, Faustman EM. Computational model for dose-response comparisons of two mechanistic hypotheses for ethanol-induced neurodevelopmental toxicity. Presented at the Society for Risk Analysis 2004 Annual Meeting, Palm Springs, CA, December 5-8, 2004. R831709C001 (2005)
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    Presentation Gohlke JM, Griffith WC, Faustman EM. Computational models for the acquisition of neocortical neurons in the developing humans, monkey, and mouse: cross species comparison of toxicodynamics. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005. R831709C001 (2005)
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    Presentation Ramaprasad J, Tsai T, Elgethun K, Herbert V, et al. Increased pesticide exposure among agricultural communities in Washington caused by volatilization from sprayed fields. Presented at the Society for Risk Analysis 2004 Annual Meeting, Palm Springs, CA, December 5-8, 2004. R831709C004 (2005)
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    Presentation Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman EM. Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005. R831709C001 (2005)
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    Presentation Tsai M, Yost MG, Felsot AS, Galvin K, Fenske RA, Larson TV. Pesticide spray drift monitoring of orchard airblast application: New approaches. Presented at the Joint ISEE/ISEA Conference on Environmental Epidemiology and Exposure (18th ISEE Conference and 16th ISEA Conference), Paris, France, September 2-6, 2006. R831709C004 (2007)
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    Presentation Yost M, Tsai MY, Fenske R. Air Blast Applications: Pesticide drift deposition modeling. Presented at at the Health & Safety in Western Agriculture Conference: Research to Practice. Agrochemical/Respiratory Protection Session-R2P, Pacific Grove, CA, September 20-22, 2006. R831709C004 (2007)
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    Presentation Yu X, Sidhu J, Robinson J, Hong S, Faustman EM. Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic, and methylmercury: induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005. R831709C001 (2005)
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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.


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