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Acetaldehyde Quickview (CASRN 75-07-0)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Acetaldehyde

File First On-Line: 06/30/1988; Last Significant Revision: 10/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment On-line 10/01/1991
Carcinogenicity Assessment On-line 01/01/1991
Under Re-Assessment
Synonyms
  • Acetaldehyd
  • Acetaldehyde
  • Acetylaldehyde
  • Aldehyde acetique
  • Ethanal
  • Ethyl aldehyde
  • NCI-C56326
  • RCRA Waste Number u001
  • UN 1089
  • more...
Acetaldehyde Source Documents
Revision History
Date Section Description
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
 UF MF RfC
Degeneration of olfactory epithelium NOAEL (HEC): 8.7 mg/m3 1000 1 9x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Based on increased incidence of nasal tumors in male and female rats and laryngeal tumors in male and female hamsters after inhalation exposure.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
2.2 x10-6 per ug/m3 Linearized multistage-variable exposure input form (extra risk)

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 5x101 ug/m3
E-5 (1 in 100,000) 5 ug/m3
E-6 (1 in 1,000,000) 5x10-1 ug/m3

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