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Acenaphthylene (CASRN 208-96-8)
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0443
Acenaphthylene; CASRN 208-96-8
Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of chronic toxicity data by U.S. EPA health scientists from several Program Offices and the Office of Research and Development. The summaries presented in Sections I and II represent a consensus reached in the review process. Background information and explanations of the methods used to derive the values given in IRIS are provided in the Background Documents.
STATUS OF DATA FOR Acenaphthylene
File First On-Line 01/01/1991
Category (section) |
Status |
Last Revised |
|---|---|---|
| Oral RfD Assessment (I.A.) | no data | |
| Inhalation RfC Assessment (I.B.) | no data | |
| Carcinogenicity Assessment (II.) | on-line | 01/01/1991 |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Acenaphthylene
CASRN — 208-96-8
Not available at this time.
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Acenaphthylene
CASRN — 208-96-8
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Acenaphthylene
CASRN — 208-96-8
Last Revised — 01/01/1991
Section II provides information on three aspects of the carcinogenic assessment for the substance in question; the weight-of-evidence judgment of the likelihood that the substance is a human carcinogen, and quantitative estimates of risk from oral exposure and from inhalation exposure. The quantitative risk estimates are presented in three ways. The slope factor is the result of application of a low-dose extrapolation procedure and is presented as the risk per (mg/kg)/day. The unit risk is the quantitative estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m air breathed. The third form in which risk is presented is a drinking water or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1 in 1,000,000. The rationale and methods used to develop the carcinogenicity information in IRIS are described in The Risk Assessment Guidelines of 1986 (EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries developed since the publication of EPA's more recent Proposed Guidelines for Carcinogen Risk Assessment also utilize those Guidelines where indicated (Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to Section I of this IRIS file for information on long-term toxic effects other than carcinogenicity.
_II.A. Evidence for Human Carcinogenicity
__II.A.1. Weight-of-Evidence Characterization
Classification — D; not classifiable as to human carcinogenicity
Basis — Based on no human data and inadequate data from animal bioassays.
__II.A.2. Human Carcinogenicity Data
None.
__II.A.3. Animal Carcinogenicity Data
Inadequate. No tumors were observed in a lifetime study, when 0.25% acenaphthylene (purity not specified) was applied to the skin (dose, frequency and duration not stated) of mice (sex and strain not specified) (Cook, 1932). Survival was 65% at 6 months, and 35% at 1 year. It is not stated whether a control group was used. In the series of experiments, however, the dermal application of other polycyclic aromatic hydrocarbons did result in the formation of mouse skin tumors.
__II.A.4. Supporting Data for Carcinogenicity
Acenaphthylene (1 mM) yielded positive results in a Salmonella typhimurium forward mutation assay (Kaden et al., 1979) and was not positive in a Salmonella typhimurium TA98 and TA100 in the presence of hepatic homogenates (Bos et al., 1988).
_II.B. Quantitative Estimate of Carcinogenic Risk from Oral Exposure
None.
_II.C. Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure
None.
_II.D. EPA Documentation, Review, and Contacts (Carcinogenicity Assessment)
__II.D.1. EPA Documentation
Source Document — U.S. EPA, 1990
The 1990 Drinking Water Criteria Document for Polycyclic Aromatic Hydrocarbons has received Agency and external review.
__II.D.2. EPA Review (Carcinogenicity Assessment)
Agency Work Group Review — 02/07/1990
Verification Date — 02/07/1990
__II.D.3. EPA Contacts (Carcinogenicity Assessment)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Acenaphthylene
CASRN — 208-96-8
Last Revised — 01/01/1991
_VI.A. Oral RfD References
None
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
Bos, R.P., J.L.G. Theuws, F.J. Jongeneelen and P.Th. Henderson. 1988. Mutagenicity of bi-, tri-, and tetra-cyclic aromatic hydrocarbons in the "taped-plate assay" and in the conventional Salmonella mutagenicity assay. Mutat. Res. 204: 203-206.
Cook, J.W. 1932. The production of cancer by pure hydrocarbons -- Part II. Proc. Royal Soc. London S.B. 11: 485-496.
Kaden, D.A., R.A. Hites and W.G. Thilly. 1979. Mutagenicity of soot and associated polycyclic aromatic hydrocarbons to Salmonella typhimurium. Cancer Res. 39: 4152-4159.
U.S. EPA. 1990. Drinking Water Criteria Document for Polycyclic Aromatic Hydrocarbons (PAHs). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC. (Final Draft)
_VII. Revision History
Substance Name — Acenaphthylene
CASRN — 208-96-8
|
Date |
Section |
Description |
|---|---|---|
| 01/01/1991 | II. | Carcinogen assessment on-line |
| 01/01/1991 | VI. | Bibliography on-line |
| 01/01/1992 | IV. | Regulatory Action section on-line |
| 04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
_VIII. Synonyms
Substance Name — Acenaphthylene
CASRN — 208-96-8
Last Revised — 01/01/1991
- 208-96-8
- Acenaphthylene
- Cyclopenta(de)naphthalene
- HSDB 2661
- NSC 59821