Allyl alcohol (CASRN 107-18-6)
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0004
Allyl alcohol;
CASRN 107-18-6
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Allyl alcohol
File First On-Line 01/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 08/01/1989 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Allyl alcohol
CASRN — 107-18-6
Last Revised — 08/01/1989
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF
|
MF
|
RfD
|
---|---|---|---|---|
Impaired renal function Subchronic Oral Rat Carpanini et al., 1978 |
NOEL: 50 ppm drinking LOAEL: 100 ppm drinking |
1000
|
1
|
5E-3
mg/kg/day |
*Conversion Factors: based on reported drinking water consumption
__I.A.2. Principal and Supporting Studies (Oral RfD)
Carpanini, F.M.B., I.F. Gaunt, J. Hardy, S.D. Gangalli, K.R. Butterworth and H.G. Lloyd. 1978. Short-term toxicity of allyl alcohol in rats. Toxicology. 9: 29-45.
Carpanini et al. (1978) exposed groups of Wistar rats (15/sex/dose) to drinking water containing 0, 50, 100, 200, or 800 ppm (mg/L) allyl alcohol for 15 weeks. Based on water consumption data, these concentration were equivalent to dosages of 0, 4.8, 8.3, 14.0, and 48.2 mg/kg/day for males and 0, 6.2, 6.9, 17.1, and 58.4 for females, respectively. Food intake and growth were depressed at the 100, 200, and 800 ppm dose levels. Results of hematologic and clinical chemistry tests were unremarkable. There were no histopathologic lesions attributable to treatment in any of the organs examined; however, the relative organ weights of the liver, kidney, and spleen were significantly increased in a dose-related fashion at all except the 50 ppm level. Several tests of renal function were performed, indicating impaired renal function in males at greater than or equal to 100 ppm (8.3 mg/kg/day) and in females at greater than or equal to 200 ppm (17.1 mg/kg/day).
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 1000 was used; 10 for interspecies extrapolation, 10 to approximate chronic exposure, and 10 for intraspecies variability in the human population.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
The results of the Carpanini et al. (1978) study are similar to those found by Dunlap et al. (1958) in which rats treated with allyl alcohol in drinking water for 90 days had significantly increased liver and kidney weights at greater than or equal to 250 ppm. Two subchronic inhalation studies were also available in different species (Dunlap et al., 1958; Torkelson et al., 1959) in which dose-related increased liver and kidney damage was observed, but the magnitude of these effects are not necessarily comparable to the oral route.
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Low
RfD — Low
The study defined a clear NOEL and LOAEL, using a moderate number of animals of both sexes and several dose levels. However, only one species of animal was tested for a subchronic period (15 weeks). The database contains several subchronic oral and inhalation studies which only qualitatively support the findings of the principal study and one supporting subchronic oral study in the same species; however, no chronic or pertinent reproductive data are available. Nor were pertinent epidemiologic studies located. Therefore, a low confidence in the database is recommended. Low confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — U.S. EPA, 1985
Other EPA Documentation — None
Agency Work Group Review — 02/26/1986
Verification Date — 02/26/1986
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Allyl alcohol conducted in September 2002 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Allyl alcohol
CASRN — 107-18-6
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Allyl alcohol
CASRN — 107-18-6
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Allyl alcohol
CASRN — 107-18-6
Last Revised — 08/01/1989
_VI.A. Oral RfD References
Carpanini, F.M.B., I.F. Gaunt, J. Hardy, S.D. Gangalli, K.R. Butterworth and H.G. Lloyd. 1978. Short-term toxicity of allyl alcohol in rats. Toxicology. 9: 29-45
Dunlap, M.K., J.K. Kodama, J.S. Wellington, H.H. Anderson and C.H. Hine. 1958. The toxicity of allyl alcohol. I. Acute and chronic toxicity. AMA Arch. Ind. Health. 18: 303-311.
Torkelson, T.R., M.A. Wolf, R. Oyen and V.K. Rowe. 1959. Vapor toxicity of allyl alcohol as determined on laboratory animals. Am. Ind. Hyg. Assoc. J. 20: 224-229.
U.S. EPA. 1985. Health and Environmental Effects Profile for Allyl Alcohol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Allyl alcohol
CASRN — 107-18-6
Date |
Section |
Description |
---|---|---|
09/30/1987 | V. | Supplementary Data section added |
03/01/1988 | I.A.1. | Dose conversion clarified |
03/01/1988 | I.A.2. | Text deleted |
03/01/1988 | I.A.4. | Text clarified |
03/01/1988 | I.A.5. | Confidence levels revised |
08/01/1989 | I.A.4. | Citations clarified |
08/01/1989 | VI. | Bibliography on-line |
01/01/1992 | I.A.7. | Primary contact changed |
01/01/1992 | IV. | Regulatory action updated |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Allyl alcohol
CASRN — 107-18-6
Last Revised — 01/31/1987
- 107-18-6
- AA
- Allyl Al
- Allyl Alcohol
- Allylic Alcohol
- 3-Hydroxypropene
- Orvinylcarbinol
- 1-Propene-3-ol
- Propenol
- 2-Propen-1-ol
- Propenyl Alcohol
- 2-Propenyl Alcohol
- Shell Unkrautted A
- Vinylcarbinol
- 2-Vinylcarbinol
- Weed Drench