Project Number: 5450-51530-009-07
Project Type: Nonfunded Cooperative Agreement

Start Date: Feb 01, 2007
End Date: Apr 02, 2009

Objective:
To identify micro-nutrient responsive proteins in muscle and other tissues obtained from rodent models.

Approach:
Laboratory rodents of varying ages and, in some cases varying genotypes and phenotypes, will be fed diets containing micronutrients in marginally-deficient and adequate amounts and either exposed to physical training or untrained. Comparisons will be made among established biochemical and physical markers of nutritional status and expression of proteins in selected tissues to determine impacts of sub-clinical micronutrient deficiencies. Emphasis will be muscle mitochondrial complexes and signal transduction in mitogenesis and angiogenesis.