Projects

VITAMIN A VALUE OF GOLDEN RICE IN A U.S. POPULATION Grant (G)   Accession Number: 411314

Publications

Increased apoptosis in high-fat diet induced nonalcoholic steatohepatitis is associated with JNK activation and imbalance of pro- and anti-apoptotic proteins in Bcl-2 family in rats - (Peer Reviewed Journal)

Wang, Y., Ausman, L.M., Russell, R., Greenberg, A.S., Wang, X. 2008. Increased apoptosis in high-fat diet induced nonalcoholic steatohepatitis is associated with JNK activation and imbalance of pro- and anti-apoptotic proteins in Bcl-2 family in rats. Journal of Nutrition. 138(10):1866-1871.

High Dose Lycopene Supplementation Increases Hepatic CYP2E1 Protein and Inflammation in Alcohol-Fed Rats - (Peer Reviewed Journal)

Veeramachaneni, S., Ausman, L.M., Choi, S., Russell, R., Wang, X. 2008. High Dose Lycopene Supplementation Increases Hepatic CYP2E1 Protein and Inflammation in Alcohol-Fed Rats. Journal of Nutrition. 138(7):1329-1335.

Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores - (Peer Reviewed Journal)

Cifelli, C.J., Green, J.B., Wang, Z., Yin, S., Russell, R., Tang, G., Green, M.H. 2008. Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores. Journal of Nutrition. 138:971-977.

A Fluorometric Assay to Determine Antioxidant Activity of Both Hydrophilic and Lipophilic Components in Plant Foods - (Peer Reviewed Journal)

Li, L., Chen, C., Chun, H., Cho, S., Park, K., Lee-Kim, Y., Blumberg, J., Russell, R., Yeum, K. 2008. A fluorometric assay to determine antioxidant activity of both hydrophilic and lipophilic components in plant foods. Journal of Nutritional Biochemistry. doi:10.1016/j.jnutbio.2008.02.006.

Vitamin A equivalence of spirulina beta-carotene in Chinese adults assessed by stable isotope dilution and reference techniques - (Peer Reviewed Journal)

Wang, J., Wang, Y., Wang, Z., Li, L., Qin, J., Lai, W., Fu, Y., Suter, P., Russell, R., Grusak, M.A., Tang, G., Yin, S. 2008. Vitamin A equivalence of spirulina beta-carotene in Chinese adults assessed by stable isotope dilution and reference techniques. American Journal of Clinical Nutrition. 87:1730-1737.

Golden Rice Can Provide Vitamin A Effectively as Assessed Using Isotope Reference Method - (Abstract)

Tang, G., Qin, J., Dolnikowski, G., Russell, R., Grusak, M.A. 2008. Golden Rice Can Provide Vitamin A Effectively as Assessed Using Isotope Reference Method. Experimental Biology. 451.3.

Development of a compartmental model describing the conversion of beta-carotene to vitamin A in US and Chinese adults - (Abstract)

Cifelli, C.J., Wang, Z., Yin, S., Tang, G., Russell, R., Green, M.H. 2008. Development of a compartmental model describing the conversion of beta-carotene to vitamin A in US and Chinese adults. Experimental Biology. 865.2.

Determination of carotenoids in yellow maize, the effects of saponification, and food preparations - (Abstract)

Muzhingi, T., Tang, G., Johnson, E., Yeum, K., Qin, J., Russell, R. 2008. Determination of carotenoids in yellow maize, the effects of saponification, and food preparations. Experimental Biology. 451.2.

Nutrition and Gastric Cancer Risk: An Update - (Review Article)

Liu, C., Russell, R. 2008. Nutrition and Gastric Cancer Risk: An Update. Nutrition Reviews. 66(5)237-49.

Nonalcoholic steatohepatitis is associated with increased hepatocyte apoptosis, JNK activation and Bax protein - (Abstract)

Wang, Y., Ausman, L., Russell, R., Greenberg, A.S., Wang, X. 2008. Nonalcoholic steatohepatitis is associated with increased hepatocyte apoptosis, JNK activation and Bax protein. FASEB Journal. 22:297.6.

Modified MyPyramid for Older Adults - (Peer Reviewed Journal)

Lichtenstein, A.H., Russell, R., Rasmussen, H., Yu, W., Epstein, S. 2008. Modified MyPyramid for Older Adults. Journal of Nutrition. 138(1):5-11.

Determination of 9-cis beta-Carotene and zeta-Carotene in Biological Samples - (Peer Reviewed Journal) - (14-Aug-07)

Doxorubicin as an Antioxidant: Maintenance of Myocardial Levels of Lycopene under Doxorubicin Treatment - (Peer Reviewed Journal)

Ferreira, A.L., Yeum, K., Matsubara, L.S., Matsubara, B.B., Correa, C.R., Pereira, E.J., Russell, R., Krinsky, N.I., Tang, G. 2007. Doxorubicin as an Antioxidant: Maintenance of Myocardial Levels of Lycopene under Doxorubicin Treatment. Free Radicals in Biology and Medicine. 43:740-751.

Doxorubicin as an Antioxidant: Maintenance of Myocardial Levels of Lycopene under Doxorubicin Treatment - (Peer Reviewed Journal) - (02-May-07)

Apo-10'-lycopenoic acid suppresses lung cancer cell growth by activating retinoic acid receptor Beta in vitro, and inhibits lung tumorigenesis in vivo in the A/J mouse model - (Peer Reviewed Journal)

Lian, F., Smith, D., Ernst, H., Russell, R., Wang, X. 2007. Apo-10'-lycopenoic acid suppresses lung cancer cell growth by activating retinoic acid receptor Beta in vitro, and inhibits lung tumorigenesis in vivo in the A/J mouse model. Carcinogenesis. 28:1567-1574.

Vitamin A kinetics and utilization in US vs Chinese adults - (Abstract)

Cifelli, C.J., Wang, Z., Yin, S., Russell, R., Tang, G., Green, M.H. 2007. Vitamin A kinetics and utilization in US vs Chinese adults. Experimental Biology. 865.2.

The correlation between intakes of vitamin A and total-body vitamin A stores assessed by the labeled-retinol-dilution method in American adults - (Abstract)

Lei, L., Rasmussen, H., Jian, Q., Shian, Y., Tang, G., Russell, R. 2007. The correlation between intakes of vitamin A and total-body vitamin A stores assessed by the labeled-retinol dilution method in American adults. Experimental Biology. 865.2.

Vitamin A Value of Spirulina B-carotene in Chinese Adults Assessed by Stable Isotope Dilution Technique - (Abstract)

Wang, J., Wang, Z., Lei, L., Qin, J., Shian, Y., Russell, R., Grusak, M.A., Tang, G. 2007. Vitamin A Value of Spirulina B-carotene in Chinese Adults Assessed by Stable Isotope Dilution Technique. Federation of American Societies for Experimental Biology Conference. 21:546.13.

Phytonutrients Affecting Hydrophilic & Lipophilic Antioxidant Activities in Fruits, Vegetables and Legumes - (Peer Reviewed Journal)

Cho, Y., Yeum, K., Chen, C., Beretta, G., Tang, G., Krinsky, N.I., Yoon, S., Lee-Kim, Y.C., Blumberg, J., Russell, R. 2007. Phytonutrients Affecting Hydrophilic & Lipophilic Antioxidant Activities in Fruits, Vegetables and Legumes. Journal of the Science of Food and Agriculture. 87(6):1096-1107.

Effect of Lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological, and morphometrical assessment - (Peer Reviewed Journal)

Ferreira, A., Russell, R., Rocha, N., Ladeira, M.S., Salvadori, D.M., Nascimiento, M.C., Matsui, M., Carvalho, F., Tang, G., Matsubara, L.S., Matsubara, B. 2007. Effect of Lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological, and morphometrical assessment. Pharmacology and Toxicology. 101:16-24.

The Effects of Combined Antioxidant Supplementation on Antioxidant Capacity, DNA Single-Strand Breaks and Regulation of Insulin Growth Factor-1/IGF-Binding Protein 3 in the Ferret Model of Lung Cancer - (Peer Reviewed Journal)

Kim, Y., Lian, F., Yeum, K., Chongviriyaphan, N., Choi, S., Russell, R., Wang, X. 2007. The Effects of Combined Antioxidant Supplementation on Antioxidant Capacity, DNA Single-Strand Breaks and Regulation of Insulin Growth Factor-1/IGF-Binding Protein 3 in the Ferret Model of Lung Cancer. International Journal of Cancer. 120(9):1847-1854.

Quantitative Determinations of Vitamin A Value of Golden Rice Given as Single or Multiple Meals - (Abstract)

Tang, G., Qin, J., Grusak, M.A., Russell, R. 2007. Quantitative Determinations of Vitamin A Value of Golden Rice Given as Single or Multiple Meals. Micronutrient Forum. W29.

Inhibition of Lung Carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis Retinoic Acid in the A/J Mouse Model: Evidence of Retinoid Mitigation of Vitamin D Toxicity - (Peer Reviewed Journal)

Mernitz, H., Smith, D., Wood, R., Russell, R., Wang, X. 2007. Inhibition of Lung Carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis Retinoic Acid in the A/J Mouse Model: Evidence of Retinoid Mitigation of Vitamin D Toxicity. International Journal of Cancer. 120: 1402-1407.

Apo-10'-lycopenoic acid suppresses lung cancer cell growth by activating retinoic acid receptor Beta in vitro, and inhibits lung tumorigenesis in vivo in the A/J mouse model - (Abstract)

Lian, F., Russell, R., Smith, D., Wang, X. Apo-10¿-lycopenoic acid suppresses lung cancer cell growth by activating retinoic acid receptor Beta in vitro, and inhibits lung tumorigenesis in vivo in the A/J mouse model. 5th Annual American Association for Cancer Research International Conference: Frontiers in Cancer Prevention Research. Nov. 12-15, 2006, Boston, MA. Abstract No. A76.

THE MULTIFUNCTIONAL CAROTENOIDS: INSIGHTS INTO THEIR BEHAVIOR - (Proceedings/Symposium)

Russell, R. 2006. The multifunctional carotenoids: insights into their behavior. Journal of Nutrition. 136(10):2690S-2S

CAROTENOIDS: FUNCTIONAL BIOAVAILABILITY AND EFFECTS ON GENOMIC STABILITY - (Abstract)

Yeum, K., Zhao, X., Aldini, G., Johnson, E., Obermueller-Jevic, U., Krinsky, N.I., Russell, R. 2006. Carotenoids: functional bioavailability and effects on genomic stability. International Conference of the Society for Free Radical Research/6th COSTAM International Meeting. Kuching, Sarawak, Malaysia, June 29- July 2, 2006.

Beta-Cryptoxanthin Suppresses the Growth of Immortalized Human Bronchial Epithelial Cells - (Peer Reviewed Journal)

Lian, F., Hu, K., Russell, R., Wang, X. 2006. Beta-Cryptoxanthin Suppresses the Growth of Immortalized Human Bronchial Epithelial Cells. International Journal of Cancer. 119(3): 2084-2089.

TOTAL ANTIOXIDANT PERFORMANCE (TAP): A VALIDATED FLUORESCENCE ASSAY FOR THE MEASUREMENT OF PLASMA OXIDIZABILITY - (Peer Reviewed Journal)

Beretta, G., Aldini, G., Facino, R.M., Russell, R., Krinsky, N.I., Yeum, K. 2006. Total antioxidant performance (tap): a validated fluorescence assay for the measurement of plasma oxidizability. Analytical Chemistry. 354(2):290-8.

THE BIOCHEMICAL CHARACTERIZATION OF FERRET CAROTENE-9', 10'-MONOOXYGENASE CATALYZING CLEAVAGE OF CAROTENOIDS IN VITRO AND IN VIVO - (Peer Reviewed Journal)

Hu, K., Liu, C., Ernst, H., Krinsky, N.I., Russell, R.M., Wang, X. 2006. The biochemical characterization of ferret carotene-9', 10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. Journal of Biological Chemistry. 281:19327-19338.

Bioconversion of spinach beta-carotene to vitamin A in Chinese children with normal or marginal vitamin A status - (Abstract)

Li, L., Wang, Y., Yin, S., Grusak, M.A., Russell, R.M., Tang, G. 2006. Bioconversion of spinach beta-carotene to vitamin A in Chinese children with normal or marginal vitamin A status. Federation of American Societies for Experimental Biology Conference. April 1, 2006: San Francisco, CA. Abstract no. 824.6.

EFFECT OF 2 WEEKS OF LOW FRUIT AND VEGETABLE DIETS ON PLASMA ANTIOXIDANT NUTRIENTS & ANTIOXIDANT CAPACITY IN POSTMENOPAUSAL WOMEN - (Abstract)

Yeum, K., Johnson, E.J., Aldini, G., Beretta, G., Krinsky, N.I., Russell, R.M. 2006. Effect of 2 weeks of low fruit and vegetable diets on plasma antioxidant nutrients & antioxidant capacity in postmenopausal women. Federation of American Societies for Experimental Biology Conference, April 1-5, 2006, San Francisco, CA. Abstract No. 824.4.

FAT-SOLUBLE ANTIOXIDANT CONCENTRATIONS AND LIPOPHILIC ANTIOXIDANT ACTIVITIES IN FRUITS, VEGETABLES AND LEGUMES HARVESTED IN KOREA - (Abstract)

Cho, Y., Yeum, K., Beretta, G., Tang, G., Yoon, S., Blumberg, J., Russell, R., Lee-Kim, Y.C. 2006. Fat-soluble antioxidant concentrations and lipophilic antioxidant activities in fruits, vegetables and legumes harvested in korea. Federation of American Societies for Experimental Biology Conference. San Francisco, CA. April 1-5, 2006. Abstract no. 123.15.

INHIBITION OF LUNG CARCINOGENESIS BY 9-CIS RETINOIC ACID AND 1 ALPHA, 25-DIHYDROXYVITAMIN D3 IN THE A/J MOUSE MODEL: EVIDENCE OF RETINOID ANTAGONISM OF VITAMIN D - (Abstract)

Mernitz, H., Smith, D.E., Wood, R., Russell, R., Wang, X. 2006. Inhibition of lung carcinogenesis by 9-cis retinoic acid and 1 alpha, 25-dihydroxyvitamin D3 in the A/J mouse model: evidence of retinoid antagonism of vitamin d. Federation of American Societies for Experimental Biology Conference. San Francisco, CA: April 1-5, 2006. Abstact no. 122.1.

MODIFICATION OF LYMPHOCYTE DNA DAMAGE BY CAROTENOID SUPPLEMENTATION IN POSTMENOPAUSAL WOMEN - (Peer Reviewed Journal)

Zhao, X., Aldini, G., Johnson, E.J., Rasmussen, H., Kraemer, K., Woolf, H., Musaeus, N., Krinsky, N.I., Russell, R.M., Yeum, K. 2006. Modification of lymphocyte dna damage by carotenoid supplementation in postmenopausal women. American Journal of Clinical Nutrition. 83(1):163-169.

APO-10'-LYCOPENOIC ACID, A METABOLITE OF LYCOPENE, INHIBITS THE PROLIFERATION OF NON-SMALL CELL LUNG CANCER CELLS - (Abstract)

Lian, F., Russell, R., Wang, X. 2005. Apo-10'-lycopenoic acid, a metabolite of lycopene, inhibits the proliferation of non-small cell lung cancer cells [abstract]. Journal of Federation of American Societies for Experimental Biology. 19:A1458.

COMBINED ANTIOXIDANT (BETA-CAROTENE, ALPHA-TOCOPHEROL AND ASCORBIC ACID) SUPPLEMENTATION PROTECTS AGAINST OXIDATIVE DNA DAMAGE AND CHEMICAL CARCINOGEN (NNK) INDUCED LUNG CARCINOGENESIS IN SMOKE EXPOSED FERRETS - (Abstract)

Kim, Y., Russell, R., Wang, X. 2005. Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation protects against oxidative DNA damage and chemical carcinogen (NNK) induced lung carcinogenesis in smoke exposed ferrets [abstract]. Journal of Federation of American Societies for Experimental Biology. 19:A474.

EFFECTS OF CHRONIC ETHANOL FEEDING ON HEPATIC CELL PROLIFERATION, ERK ACTIVATION AND ALTERED HEPATIC FOCI FORMATION IN DIETHYLNITROSAMINE-INITIATED RATS - (Abstract)

Chavez, P.R., Russell, R., Mason, J.B., Ordovas, J.M., Wang, X. 2005. Effects of chronic ethanol feeding on hepatic cell proliferation, ERK activation and altered hepatic foci formation in diethylnitrosamine-initiated rats [abstract]. Journal of Federation of American Societies for Experimental Biology. 19:A78.