Projects

NUTRITION, AGING AND VISUAL FUNCTION Appropriated (D)   Accession Number: 408273

NUTRITION, AGING, AND VISUAL FUNCTION Specific Cooperative Agreement (S)   Accession Number: 411654

Publications

OXIDATIVE INACTIVATION OF THE PROTEASOME IN RPE: A POTENTIAL LINK BETWEEN OXIDATIVE STRESS AND UPREGULATION OF IL-8 - (Peer Reviewed Journal)

Fernandes, A.F., Zhou, J., Zhang, X., Sparrow, J., Taylor, A., Pereira, P., Shang, F. 2008. Oxidative inactivation of the proteasome in rpe: a potential link between oxidative stress and upregulation of il-8. Journal of Biological Chemistry. DOI: 10.1074/jbc.M800268200.

THE PROTEASOME IS A TARGET OF OXIDATIVE DAMAGE IN HUMAN RETINA PIGMENT EPITHELIAL CELLS - (Peer Reviewed Journal)

Zhang, X., Zhou, J., Fernandes, A.F., Sparrow, J., Pereira, P., Taylor, A., Shang, F. 2008. The proteasome is a target of oxidative damage in human retina pigment epithelial cells. Investigative Ophthalmology and Visual Science. DOI: 10.1167/iovs.07-1559.

EXPRESSION OF K6W-UBIQUITIN IN LENS EPITHELIAL CELLS LEADS TO UP-REGULATION OF A BROAD SPECTRUM OF MOLECULAR CHAPERONES - (Peer Reviewed Journal)

Bian, Q., Fernandes, A.F., Taylor, A., Wu, M., Pereira, P., Shang, F. 2008. Expression of k6w-ubiquitin in lens epithelial cells leads to up-regulation of a broad spectrum of molecular chaperones. Molecular Vision. 14:403-412.

DIETARY CARBOHYDRATE AND PROGRESSION OF AGE-RELATED MACULAR DEGENERATION, A PROSPECTIVE STUDY FROM THE AGE-RELATED EYE DISEASE STUDY - (Peer Reviewed Journal)

Chiu, C., Milton, R.C., Klein, R., Gensler, G., Taylor, A. 2007. Dietary carbohydrate and progression of age-related macular degeneration, a prospective study from the age-related eye disease study. American Journal of Clinical Nutrition. 86(4):1210-8.

DIETARY LINOLENIC ACID INTAKE IS POSITIVELY ASSOCIATED WITH FIVE-YEAR CHANGE IN EYE LENS NUCLEAR DENSITY - (Peer Reviewed Journal)

Lu, M., Taylor, A., Chylack, L.T., Rogers, G., Hankinson, S., Willett, W., Jacques, P. 2007. Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density. Journal of Nutrition. 26(2):133-140.

Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesions - (Peer Reviewed Journal)

Morris, M., Jacques, P., Chylack, L.T., Hankinson, S.E., Willett, W.C., Taylor, A. 2007. Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesions. Ophthalmic Epidemiology. 14:288-298.

Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells - (Peer Reviewed Journal)

Liu, Q., Shang, F., Zhang, X., Li, W., Taylor, A. 2006. Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells. Review Article. 12:931-6.

Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells - (Peer Reviewed Journal)

Liu, Q., Shang, F., Zhang, X., Li, W., Taylor, A. 2006. Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells. Molecular Vision. 12:931-6.

Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells - (Peer Reviewed Journal)

Fernandes, A.F., Guo, W., Zhang, X., Gallagher, M., Mircea, I., Taylor, A., Pereira, P., Shang, F. 2006. Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells. Experimental Eye Research. 83(6):1472-81.

Nutritional antioxidants and age-related cataract and maculopathy - (Review Article)

Chiu, C., Taylor, A. 2007. Nutritional antioxidants and age-related cataract and maculopathy. Experimental Eye Research. 84(2):229-45.

Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation - (Peer Reviewed Journal)

Guo, W., Shang, F., Liu, Q., Urim, L., Zhang, M., Taylor, A. 2006. Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation. Investigative Ophthalmology and Visual Science. 47(6):2569-75.

DIETARY CARBOHYDRATE INTAKE AND GLYCEMIC INDEX IN RELATION TO CORTICAL AND NUCLEAR LENS OPACITIES IN THE AGE-RELATED EYE DISEASE STUDY 1-4 - (Peer Reviewed Journal)

Chiu, C., Milton, R.C., Gensler, G., Taylor, A. 2006. Dietary carbohydrate intake and glycemic index in relation to cortical and nuclear lens opacities in the age-related eye disease study 1-4.. American Journal of Clinical Nutrition. 83(5):1177-84.

UBIQUITIN-CONJUGATING ENZYME 3 DELAYS HUMAN LENS EPITHELIAL CELLS IN METAPHASE - (Peer Reviewed Journal)

Liu, Q., Shang, F., Whitcomb, E., Guo, W., Li, W., Taylor, A. 2006. Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase. Investigative Ophthalmology and Visual Science. 47(4):1302-9.

PROTEIN QUALITY CONTROL BY THE UBIQUITIN PROTEOLYTIC PATHWAY: ROLES IN RESISTANCE TO OXIDATIVE STRESS AND DISEASE - (Peer Reviewed Journal)

Shang, F., Dudek, E., Liu, Q., Boulton, M.E., Taylor, A. 2006. Protein quality control by the ubiquitin proteolytic pathway: roles in resistance to oxidative stress and disease. Israel Journal of Chemistry. 46(2): 145-158.

THE TRIAGE OF DAMAGED PROTEINS: DEGRADATION BY THE UBIQUITIN-PROTEASOME PATHWAY OR REPAIR BY MOLECULAR CHAPERONES - (Peer Reviewed Journal)

Marcques, C., Guo, W., Pereira, P., Taylor, A., Patterson, C., Evans, P.C., Shang, F. 2006. The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. Federation of American Societies for Experimental Biology Conference. 20(6):741-3.

Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration - (Peer Reviewed Journal)

Chiu, C., Hubbard, L.D., Armstrong, J., Rogers, G., Jacques, P.F., Chylack, L.T., Hankinson, S.E., Willett, W.C., Taylor, A. 2006. Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration. American Journal of Clinical Nutrition. 83(4):880-6.