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Safety and Health Topics: |
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| Aniline |
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General Description
Synonyms: Aminobenzene; Phenylamine; Aniline oil
OSHA IMIS Code Number: 0220
Chemical Abstracts Service (CAS) Registry Number: 62-53-3
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: BW6650000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1547 153
NIOSH Pocket Guide to Chemical Hazards, Aniline: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 ppm, 19 mg/m3 TWA; Skin
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 5 ppm, 19 mg/m3 TWA; Skin
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 ppm, 19 mg/m3 TWA; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 2 ppm, 7.6 mg/m3 TWA; Skin; Appendix A3, Confirmed Animal Carcinogen with Unknown Relevance to Humans; BEI
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix A - NIOSH Potential Occupational Carcinogens
Health Factors
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 3, not classifiable as to its carcinogenicity to humans
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 100 ppm
Potential symptoms: Headache; weakness; lethargy; dizziness; drowsiness; confusion, disorientation; unconsciousness; ataxia; eye irritation; respiratory irritation (dryness of throat, coughing, wheezing); dyspnea on effort; tachycardia; cyanosis, jaundice; nausea; sometimes vomiting, ringing in the ears; anorexia, weight loss, anemia; skin lesions; symptoms of bladder cancer (painful urination, blood in the urine, lumps in groin or lower abdomen, pain in lower abdomen or back).
Health Effects: Hematologic (Blood) Disturbances---Methmoglobinemia (HE13) Acute Toxicity--- short-term high hazard effects (HE4); Suspect carcinogen (bladder cancer) (HE2); LD50 (oral, rat) 440 mg/kg.
Affected organs: Blood, cardiovascular system, liver, kidneys, eyes, respiratory system, skin.
Note: Interacts with cytochrome P450 2E1 (both as substrate and inhibitor of other substrates), so there is a potential for interaction with ethanol and acetaminophen.
Date Last Revised: 12/15/2003
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Aniline.
- International Chemical Safety Cards (WHO/IPCS/ILO): Aniline.
- Klotz, U. and Ammon, E.: Clinical and toxicological consequences of the inductive potential of ethanol. Eur. J. Clin. Pharmacol. 54(1): 7-12, 1998.
- Pohanish, R.P. (editor): Aniline. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 207-210.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Coated XAD-7 Tube (80/40 mg sections) Coating is 10% Phosphoric Acid.
analytical solvent: 0.2 N NH4OH in Methanol
maximum volume: 30 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Manual of Analytical Methods (OSHA PV2079)
method classification: Partially Validated
On-Site Sampling Techniques/Methods:
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device: Detector Tube
manufacturer: Dräger
model/type: Aniline 0.5/a, order no. 81 01711
sampling information: 20 strokes
upper measurement limit: 10 ppm
detection limit: approximately 0.2 ppm
overall uncertainty: approximately 25%
method reference: on-site air secondary (manufacturer)
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device: Detector Tube
manufacturer: Gastec
model/type:181
sampling information: 2 to 5 strokes
upper measurement limit: 60 ppm
detection limit: 0.25 ppm
overall uncertainty: 16% for 2.5 to 10 ppm, 8% for 10 to 30 ppm
method reference: on-site air secondary (manufacturer)
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device: Detector Tube
manufacturer: Matheson-Kitagawa
model/type: 8014-181S
sampling information: 1 or 2 strokes
upper measurement limit: 30 ppm
detection limit: approximately 0.5 ppm
overall uncertainty: unknown
method reference: on-site air secondary (manufacturer)
Wipe sampling: Yes, with Glass Fiber Filter.
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