[Federal Register: March 2, 2004 (Volume 69, Number 41)]
[Notices]
[Page 9831]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr02mr04-56]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, DHHS.
ACTION: Notice.
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SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: (301) 496-7057; fax: (301) 402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
Methods for Imaging the Lymphatic System Using Dendrimer-Based Contrast
Agents
Martin W. Brechbiel (NCI); U.S. Patent Application No. 10/756,948
filed 13 Jan 2004 (DHHS Reference No. E-338-2003/0-US-01); Licensing
Contact: Michael Shmilovich; 301/435-5019; shmilovm@mail.nih.gov.
Available for licensing are methods for lymphatic system imaging
using 4D Magnetic Resonance lymphography and a 240kD contract agent
based on generation-6 polyamidoamine dendrimer (G6). The disclosed
methods are applicable to the imaging of all lymphatic structures, but
in particular embodiments are particularly suited for imaging specific
parts of the lymphatic system such as lymph nodes or lymphatic vessels.
The methods permit the assessment of abnormal conditions within the
lymphatic system, such as lymphoma/lymphoproliferative disease,
inflammation, and cancer metastasis. The dendrimer also may be used to
identify and locate sentinel lymph nodes into which lymph fluid flows
from a tumor. The conventional clinically approved MRI contract agent,
Gd-[DTPA]-dimeglumine (<1kD) was unable (in murine models) to depict
lymphatics when used in conjunction with the same imaging system. Thus,
the present dendrimer provides a novel method to visualize lymphatic
drainage that has not been previously reported.
Apparatus and Method for High Speed Countercurrent Chromatography of
Peptides and Proteins
Yoichiro Ito (NHLBI); PCT Application No. PCT/US03/09189 filed 25
Mar 2003, which published as WO 03/087807 on 23 Oct 2003 (DHHS
Reference No. E-148-2001/0-PCT-02); U.S. Provisional Application No.
60/457,058 filed 21 Mar 2003 (DHHS Reference No. E-014-2003/0-US-01);
U.S. Provisional Application No. 60/464,665 filed 24 Apr 2003 (DHHS
Reference No. E-046-2003/0-US-01); Licensing Contact: Michael
Shmilovich; 301/435-5019; shmilovm@mail.nih.gov.
This invention is an improved column design for High Speed Counter
Current Chromatography (HSCCC) that increases partition efficiency by
using novel column geometries. A standard HSCCC centrifuge uses a
multilayer coil as a separation column to produce a high efficiency
separation with good retention of the stationary phase in many solvent
systems. However, the standard HSCCC, when used for highly viscous, low
interfacial tension solvent systems, is unsuccessful at retaining a
suitable amount of the stationary phase. This invention greatly
improves efficiency by modifying the column from a coil to spiral
geometry. Therefore, this invention creates a centrifugal force
gradient, which allows for distribution of the heavier phase in the
peripheral and the lighter phase in the proximal parts of the column.
The effect of the gradient becomes more pronounced as the pitch of the
spiral is increased.
The apparatus can be stacked on a support (E-014-2003) that
provides additive net spiral flow geometry. When mounted, it will
produce efficient separation of proteins and peptides. Also, efficient
stationary phase retention can be achieved through the use of a plate
apparatus (E-046-2003) that comprises a disk shaped column support
having a spiral groove formed on its surface. At least one layer of
fluid flow tubing is positioned substantially within the spiral groove.
The countercurrent chromatography effect is produced by rotating the
disk shaped column on a planar motion device.
Dated: February 24, 2004.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. 04-4529 Filed 3-1-04; 8:45 am]
BILLING CODE 4140-01-P