[Federal Register: February 13, 2004 (Volume 69, Number 30)]
[Notices]
[Page 7237-7238]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr13fe04-90]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, DHHS.
ACTION: Notice.
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SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
[[Page 7238]]
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
UltraRad--A Method and Probe To Enhance Radiation Delivery
C. Norman Coleman (NCI), Robert Miller (NCI), Brian Justus (NRL), and
Alan Huston (NRL)
U.S. Provisional Application No. 60/453,934 filed 11 Mar 2003 (DHHS
Reference No. E-049-2003/0-US-01)
Licensing Contact: Michael Shmilovich; 301/435-5019;
shmilovm@mail.nih.gov.
Available for licensing and commercialization in a novel technique
of locating a tumor in 3-dimensional space to provide a precisely
targeted external radiation beam directed to the tumor. A catheter like
probe equipped with an ultrasound transducer for precise local imaging
of the tumor, and proprietary radiation dosimeters for measuring the
amount of radiation delivered by the external beam. The probe would
also be equipped with a flow-through drug delivery system that could
provide radiation opaque material to protect the area surrounding the
tumor from radiation damage. It is envisioned that controlling the
external radiation beam will be in response to radiation detected by
the probe. Of interest is the utility of the probe in phantom models
and prostate cancer. The method and apparatus utilizes a radiation-
detecting array of radiation sensitive dosimeters for the real-time
remote measurement of radiotherapy at the radiation-detecting array.
The radiation-detecting array is positioned within the patient's body
along the treatment path before or after the identified radiotherapy
target or the device may be positioned beyond the patient to measure
transit dose. A radiation source for emitting radiation for
radiotherapy along a treatment path through the patient to the
identified radiotherapy target is utilized. The method includes
generating a predicted dose pattern of radiation at the placed
radiation-detecting array. The predicted dose pattern assumes an on-
target radiation source emitting the radiotherapy beam along the
treatment path through the patient to the identified radiotherapy
target. Gating of the radiation source can occur responsive to the
comparing of the predicted dose pattern of radiation to the real-time
dose pattern at the radiation-detecting array. Radiation intensity can
vary between low levels to a treatment level responsive to coincidence
of the predicted dose pattern of radiation to the real-time dose
pattern at the radiation-detecting array.
Computer-Aided Classification of Anomalies in Anatomical Structures
Ronald Summers, Marek Franaszek, Gheorge Iordanescu (CC)
U.S. Patent Application No. 10/671,749 filed 26 Sep 2003 (DHHS
Reference No. E-077-2002/0-US-03)
Licensing Contact: Michael Shmilovich; 301/435-5019;
shmilovm@mail.nih.gov.
Available for licensing is a software enabled method for improving
the sensitivity and specificity of computer aided detection (CAD) for
computed tomography (CT) or magnetic resonance imaging (MRI)
colonography. Colonography is an imaging test that identifies polyps
and cancers of the colon and may be useful for reducing the incidence,
morbidity and mortality of colon cancer in human beings. The invention
comprises three main areas of characterization used to substantially
reduce the number of CAD false positives: (1) analysis of the neck of a
colon polyp can help distinguish true positive from false positive
tumor detections (2) characterization of the colon wall thickness in
the proximity of the polyp has been found to be determinative in
distinguishing polyps, and (3) templates that mimic the shape of
different types of polyps (for example, those on folds, sessile polyps,
pedunculated polyps etc.) can improve sensitivity and increase
specificity.
Dated: February 5, 2004.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. 04-3165 Filed 2-12-04; 8:45 am]
BILLING CODE 4140-01-P