Patent Number: 7078384
Docket Number: 6203
Serial Number: 10385317
Date Patented: 07/18/2006

Technology Description:   The invention relates to novel pseudopeptide analogs from the insect allatostatin neuropeptide family, which possess biological activity that mimic naturally occurring neuropeptides.  By adding a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity.  By substituting sterically hindered amino acids or aromatic acids for any or all of the second, third, or fifth amino acid residues of the allatostatic C-terminal pentapeptide, analogs have been produced which are resistant to degradation by insect peptidases while still retaining biological activity.   The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.   Reference:   Please refer to USPN 7,078,384 (Docket #0062.03). AMimetic Insect Allatostatin Analogs for Insect Control,@ which issued on July 18, 2006, and is a divisional of USPN 6,664,371 (Docket #0239.00), which issued on December 16, 2003, and is a divisional of USPN 6,207,643 (Docket #0047.99), which issued on March 27, 2001. Foreign rights are not available.   Inventors:   Ronald J. Nachman Areawide Pest Management Research 2771 F&B Road College Station, TX  77845 Phone: (979)260-9315     Fax: (979)260-9386 nachman@tamu.edu Christopher S. Garside University of Toronto Toronto, Ontario, Canada Phone: (416)978-3517     Fax: (416)978-3522 Peter E. A. Teal Chemistry Research 1600-1700 S.W. 23rd Drive Gainesville, FL  32608 Phone: (352)374-5730     Fax: (352)374-5707 pteal@gainesville.usda.ufl.edu Stephen S. Tobe University of Toronto Toronto, Ontario, Canada Phone: (416)978-3517    Fax: (416)978-3522