Tetrachloroethylene Quickview (CASRN 127-18-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Tetrachloroethylene

File First On-Line: 01/31/1987; Last Significant Revision: 03/01/1988

Category (section)	Status	Last Revised
Oral RfD Assessment	On-line	03/01/1988
Inhalation RfC Assessment	No data
Carcinogenicity Assessment	No data
Under Re-Assessment

Synonyms

127-18-4
Ankilostin
Antisol 1
Carbon bichloride
Czterochloroetylen

Didakene
Dowclene ec
ENT 1,860
Ethylene, tetrachloro-
more...

Critical Effect	Point of Departure*	UF	MF	RfD
Hepatotoxicity in mice, weight gain in rats	NOAEL : 14 mg/kg-day	1000	1	1 x10^-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

Principal and Supporting Studies (Oral RfD)
- 6-week mouse gavage study, Buben and O'Flaherty, 1985
Confidence in the Oral RfD
- Study -- Low
- Database -- Medium
- RfD -- Medium

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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