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FRIENDS Analytical Toxicology Core Facility
EPA Grant Number: R829390C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R829390
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: CECEHDPR - University of Illinois FRIENDS Children’s Environmental Health Center
Center Director: Schantz, Susan L.
Title: FRIENDS Analytical Toxicology Core Facility
Investigators: Kostyniak, Paul J. , Fitzpatrick, Richard , Olson, James
Current Investigators: Kostyniak, Paul J.
Institution: SUNY at Buffalo
EPA Project Officer: Saint, Chris
Project Period: October 17, 2001 through October 16, 2002
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001)
Research Category: Children's Health , Health Effects
Description:
Objective:The objective of the Analytical Toxicology Core Facility (ATCF) is to provide analytical support to both the epidemiological and animal research projects of the FRIENDS Children's Environmental Health Center. The ATCF support involves the development of new analytical techniques, analyses of samples and analyses of data. All procedures are controlled by a strict QC/QA program. The techniques available Include GC with EC, FID, PID and Hall detection, HPLC with diode array, fluorescence and electrochemical detection, GC-MS, AAS, mercury determinations, high temperatures GPC for absolute molecular weight and molecular weight distribution determinations. This laboratory has extensive experience determining specific congeners of PCBs and pesticides and heavy metals at ppb levels in biological samples, and has participated in nationwide proficiency programs for PCBs, pesticides and mercury. The ATCF also performs a reporter gene bioassay for the quantification of total dioxin (TCDD) toxic equivalents (TEQs) in Hepa 1c1c7, mouse hepatoma cells, which are stably transfected with the reporter plasmid p2Dluc containing 2 copies of the DRED consensus sequence.
Supplemental Keywords:PCBs, Methymercury, dioxin-like, TEQ, PBDE. , POLLUTANTS/TOXICS, ENVIRONMENTAL MANAGEMENT, Geographic Area, Scientific Discipline, Health, RFA, Midwest, Susceptibility/Sensitive Population/Genetic Susceptibility, Molecular Biology/Genetics, Toxicology, Risk Assessment, Biology, Risk Assessments, Disease & Cumulative Effects, genetic susceptability, Health Risk Assessment, Epidemiology, Ecological Risk Assessment, Chemicals, Chemistry, Children's Health, exposure assessment, heavy metals, methylmercury, cognitive development, human health risk, PCBs, motor development, electrochemical detection, neurotoxic, children, pesticides, reproductive health, biomedical research, PCB, behavioral deficits, behavioral assessment, human exposure, neurotoxicity, animal model, Wisconsin (WI), human data
Progress and Final Reports:
2002 Progress Report
2003 Progress Report
2004 Progress Report
2005 Progress Report
Main Center Abstract and Reports:
R829390 CECEHDPR - University of Illinois FRIENDS Children’s Environmental Health Center
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829390C001 Neurobehavioral Effects of PCBs and Methylmercury in Rats
R829390C002 Perinatal PCB Exposure and Neuropsychological/Auditory Function
R829390C003 FRIENDS Analytical Toxicology Core Facility
R829390C004 Developmental Effects of PCBs and Methylmercury