Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children| Research Project Database | NCER | ORD

Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children

EPA Grant Number: R827039C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827039
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Center Director: Wolff, Mary S.
Title: Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
Investigators: Berkowitz, Gertrud S. , Matte, Thomas , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Fields, Nigel
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects

Description:

Objective:

Two epidemiologic research projects seek to determine whether pesticides and PCBs have adverse effects on the neurological development of children in the inner city and whether these effects are still evident in adult life. The first of two epidemiologic investigations, closely linked to the Prevention Research Project, is a prospective study of neurodevelopment and health outcomes in relation to antenatal exposures to PCB, chlorpyrifos and other environmental toxicants as well as diet in an ethnically diverse birth cohort of New York City infants delivered at Mount Sinai Hospital. The second epidemiologic investigation is a retrospective cohort study of the relationship between prenatal exposure to polychlorinated biphenyl (PCBs) and neurodevelopmental outcomes in adolescence and adulthood. It will be undertaken in 162 young African American men, now in their 20's and 30's, who have been followed through childhood and adolescence. Their cognitive ability and other domains of neuropsychological status will be re-evaluated in this project. Pre-natal maternal serum samples have been safely stored and will be used to assess pre-natal PCB exposure.

Publications and Presentations:

Publications have been submitted on this subproject: View all 7 publications for this subproject | View all 13 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 4 journal articles for this subproject | View all 7 journal articles for this center

Supplemental Keywords:

children, exposure, pesticides, PCBs, neurological, , Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Endocrine Disruptors - Environmental Exposure & Risk, Risk Assessments, genetic susceptability, Health Risk Assessment, endocrine disruptors, Children's Health, Biochemistry, Environmental Microbiology, Environmental Chemistry, Endocrine Disruptors - Human Health, environmentally caused disease, environmental hazard exposures, neurodevelopmental toxicity, developmental disorders, endocrine disrupting chemicals, health effects, assessment of exposure, harmful environmental agents, PCBs, toxics, sensitive populations, biological response, children, reproductive development, growth & development, human susceptibility, environmental health hazard, human exposure, Human Health Risk Assessment, neurodevelopmental, neurotoxicity

Progress and Final Reports:
2000 Progress Report
2002 Progress Report

Main Center Abstract and Reports:
R827039 Mount Sinai Center for Children's Environmental Health and Disease Prevention Research

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children

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