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Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)

EPA Grant Number: R826886C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R826886
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: University of Washington
Center Director: Faustman, Elaine
Title: Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
Investigators: Faustman, Elaine , Thompson, Beti
Current Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Fields, Nigel
Project Period: August 1, 1998 through December 31, 2003
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Health Effects , Children's Health

Description:

Objective:

This is a the Community Intervention Study that will utilize the results of the Pesticide Exposure Study and will evaluate the impact of modifying the occupational take-home exposure pathway on children's exposure to pesticides. These two studies together will evaluate pesticide exposures in children of farmworkers with the overall aim to reduce pesticide exposures in children. Given the complexity of children's exposure to pesticides, the Pesticide Exposure Pathways Study will estimate the relative' contribution of major pesticide exposure pathways for children of farmworkers. As a long-term objective, they will prioritize efforts to prevent childhood pesticide associated illness. The Exposure Assessment Facility Core will be critical to this project as they will develop source attribution models for the major exposure pathways.

In previous studies by our researchers the worker take-home exposure pathway has been identified as an important pesticide exposure pathway for children; the Community Intervention Study will evaluate the effect of breaking this pathway. Information on what intervention strategies work in agricultural communities to reduce children's exposure to pesticides is critical for our national child health promotion goals. The UW CHC is poised to apply its extensive experience in basic and field based research, and its vast experience working with the public on public health issues, to meet the challenge of improving children's health.

Publications and Presentations:

Publications have been submitted on this subproject: View all 14 publications for this subproject | View all 83 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 11 journal articles for this subproject | View all 47 journal articles for this center

Supplemental Keywords:

children, health, pesticide, exposure. , Toxics, Geographic Area, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, genetic susceptability, Health Risk Assessment, Children's Health, Biochemistry, pesticides, Environmental Chemistry, State, exposure assessment, insecticides, public health, environmental hazard exposures, health effects, Washington (WA), intervention, environmental toxicant, assessment of exposure, farmworkers, exposure prone behavior, harmful environmental agents, pesticide residues, agricultural community, community-based intervention, exposure pathways, pesticide exposure, sensitive populations, biological response, children, environmental risks, exposure, children's vulnerablity, environmental health hazard, dermal exposure, human exposure, Human Health Risk Assessment

Progress and Final Reports:
2000 Progress Report
2001 Progress Report
2002 Progress Report


Main Center Abstract and Reports:
R826886    University of Washington

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826886C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
R826886C002 Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
R826886C003 Community-Based Participatory Research Project
R826886C004 Pesticide Exposure Pathways Research Project

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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