Propionaldehyde Quickview (CASRN 123-38-6)

Status of Data for Propionaldehyde

File First On-Line: 09/30/2008; Last Significant Revision: 09/30/2008

Category (section)	Status	Last Revised
Oral RfD Assessment	Discussion	09/30/2008
Inhalation RfC Assessment	On-line	09/30/2008
Carcinogenicity Assessment	Discussion	09/30/2008

Synonyms

Propanal Propionic Aldehyde Methylacetaldehyde Propyl Aldehyde

Propaldehyde Propylic Aldehyde Propionaldehyde 123-38-6

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect	Point of Departure*	UF	MF	RfC
Atrophy of olfactory epithelium	BMCL10 (HEC): 8 mg/m3	1000	1	8x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

• Principal and Supporting Studies (Inhalation RfC)
  • Subchronic inhalation study in rats, Union Carbide, 1993
• Confidence in the Inhalation RfC
  • Study -- Low/Medium
  • Database -- Low
  • RfC -- Low/Medium

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • Inadequate information to assess carcinogenic potential
• Weight-of-Evidence Narrative:
  • In accordance with the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), there is "inadequate information to assess the carcinogenic potential" for propionaldehyde.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

• Not Assessed under the IRIS Program.

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

• Not Assessed under the IRIS Program.