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Carbon-Carbon Bond Formations in Water and Other Alternative Media

EPA Grant Number: R831813
Title: Carbon-Carbon Bond Formations in Water and Other Alternative Media
Investigators: Li, Chao-Jun
Institution: Tulane University of Louisiana
EPA Project Officer: Nolt-Helms, Cynthia
Project Period: June 1, 2004 through May 31, 2007
Project Amount: $350,000
RFA: Technology for a Sustainable Environment (2003)
Research Category: Pollution Prevention/Sustainable Development

Description:

Objective:

The long-term objective of the proposed research is to develop unconventional, catalytic, highly atom-economical, environmentally-preferable, carbon-carbon bond formation reactions for chemical syntheses that will have a fundamental environmental benefit by using water, liquid carbon dioxide (CO2), and ionic liquid as non-polluting solvents or without any solvents.

Approach:

The intellectual merits of the proposed research are the following: 1) It is a fundamental challenge to develop metal-mediated and catalyzed C-C bond formations in water (and other clean media) since the sensitivity of organometallic reagents towards water is well known and established; 2) asymmetric C-C bond formations will be an event more intellectually challenging undertaking; 3) the scientific merit of developing C-H activation-based C-C bond formation (asymmetric and in water) will not only be valuable for synthesis, but also useful in developing technologies of activating alkanes for energy and material applications.

Expected Results:

The broader impact of the proposed research goes beyond scientific curiosity. First, chemical technologies developed herein will significantly enhance the efficiency of chemical synthesis and reduce the amount of organic waste in reactions and product isolations by saving synthetic steps due to the elimination of unnecessary functional group protection/deprotection steps. Second, recycling of alternative solvents for further reactions has been designed and will further prevent the discharge of chemical wastes. Third, knowledge of C-H activations is important for energy and material applications. Fourth, education for graduate students, undergraduate students and postdoctoral researchers involved in the research will equip a new generation of synthetic chemists with both strong synthetic background and green chemistry knowledge. Finally, the ultimate goal of developing clean technologies for today will impact many future generations.

Supplemental Keywords:

media, air, ambient air, water pollution prevention, green chemistry, alternatives, sustainable development, clean technologies, innovative technology, renewable, waste reduction, waste minimization environmental chemistry, organic chemistry industry- petroleum, chemical, pharmaceutical. , Sustainable Industry/Business, Scientific Discipline, RFA, Technology for Sustainable Environment, Sustainable Environment, Environmental Chemistry

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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