Hazard Characterizations

Introduction
How Hazard Characterizations are Prepared
Contents of Hazard Characterizations
PDFs of Hazard Characterizations

Introduction

This Web page describes EPA's characterization of screening-level hazard (toxicity) data submitted to or otherwise available to the Agency on High Production Volume (HPV) chemicals and Moderate Production Volume (MPV) chemicals. Development of these hazard characterizations is EPA's initial step to use data collected as part of the HPV Challenge Program in the Agency's efforts to protect human health and the environment from potential harm posed by HPV and MPV chemicals.

This Web page contains a list of PDFs of hazard characterizations. These documents will be moved from this page to the ChAMP web page as EPA combines the hazard characterizations with exposure and risk characterizations to develop risk-base prioritization documents.

How the Hazard Characterizations Are Prepared

To create hazard characterization documents, EPA conducted evaluations of hazard (toxicity) data submitted through the High Production Volume Challenge and other methods. Hazard characterizations are prepared from EPA's scientific review of the screening-level hazard data set contained within each HPV Challenge Program submission and/or data identified from a targeted search of publicly available sources of information specifically relevant to characterizing hazards. Hazard characterizations are based on available data for a specific set of "SIDS" (Screening Information Data Set) endpoints that provide basic information on the physical/chemical properties, environmental fate characteristics, and health and environmental effects of chemicals. When identified in the HPV Challenge Program submission or from searching publicly available sources, data for additional non-SIDS endpoints (e.g. irritation, sensitization, cancer, neutotoxicity and immunotoxicity) are also included in the hazard characterization. Agency reviews are performed according to established HPV Challenge Program guidelines and EPA risk assessment guidance.

Contents of Hazard Characterizations

Hazard characterizations for individual chemicals and chemical categories include:

Summary of submitted data
EPA's evaluation of the quality and completeness of the data
EPA's determination of the potential hazards (toxicity) that an individual chemical or chemical category may pose to human health or the environment

EPA hazard characterizations also identify if there are any data gaps for chemicals, which will serve as the basis for a subsequent data-needs assessment where deemed necessary.

PDFs of Hazard Characterizations

To search for hazard characterizations by CAS Number, use the search box on the HPVIS home page. See chemicals with hazard characterizations by CAS Numbers.

*Sort columns by clicking on the arrows beneath the column title

You will need Adobe Acrobat Reader to view some of the files on this page. See EPA's page to learn more about PDF, and for the link to the free Acrobat Reader.

Submission Name

Posted Date

View HPVIS Data

1,1'-(1,2-Ethanediylbis(oxy))bis(2,4,6-tribromobenzene (PDF) (10 pp, 198 KB)

JUNE 2008

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Hazard Characterizations

Introduction

How the Hazard Characterizations Are Prepared

Contents of Hazard Characterizations

PDFs of Hazard Characterizations