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Environmental Particulate Matter (PM2.5) and Risk of Asthmatic Events in Children
EPA Grant Number: U915173Title: Environmental Particulate Matter (PM2.5) and Risk of Asthmatic Events in Children
Investigators: Barber, Kimberly R.
Institution: Michigan State University
EPA Project Officer: Thompson, Delores
Project Period: January 1, 1997 through January 1, 2000
Project Amount: $68,000
RFA: STAR Graduate Fellowships (1997)
Research Category: Fellowship - Epidemiology , Health Effects , Academic Fellowships
Description:
Objective:The objectives of this research project are
to: (1) examine the association between particulate matter (PM) with an aerodiameter
of 
2.5
µm (PM2.5) and the incidence of asthmatic events in children; and (2) explore
dose-response relationships between ambient air quality levels in a Midwestern
community and severity of asthma symptoms.
A multicenter prevalence study is proposed in three to five major metropolitan locations of the tricounty Michigan area (Genesee, Wayne, and Saginaw). Air pollution data will be extracted from the U.S. Environmental Protection Agency's (EPA) air monitoring stations in or near these areas. The PM2.5 level will be collected and averaged over 24-hour periods. Ozone, SO2, and CO are among the pollutant data to be extracted. Daily counts of admission to a hospital for asthma-related illness will be determined over the same 1-year period. Discharge diagnosis for ICD-9th revision code of 943.90 and 943.91 will be used. The plan of analysis will be modeled on a multivariate regression estimating the relative risk of an asthmatic admission for individuals on days with higher pollution levels compared with days of lower pollution levels.
Supplemental Keywords:fellowship, particulate matter, PM, PM2.5, asthmatic events, asthma, air, ambient air, air quality, Midwest, ozone, sulfur dioxide, SO2, carbon monoxide, CO, air pollution, epidemiology, children, Michigan, MI. , HUMAN HEALTH, ENVIRONMENTAL MANAGEMENT, Air, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Susceptibility/Sensitive Population/Genetic Susceptibility, Engineering, Chemistry, & Physics, Molecular Biology/Genetics, Health Effects, Risk Assessment, Biology, Risk Assessments, Disease & Cumulative Effects, genetic susceptability, Microbiology, Physical Processes, Air Pollution Effects, air toxics, Chemistry, Children's Health, particulate matter, Air Pollution, Allergens/Asthma, epidemiology, exposure assessment, ultrafine particles, environmentally caused disease, exposure and effects, environmental hazard exposures, allergen, inhalation, particles, urban air, particle pollutants, air quality, fine particles, cytokines, particulate emissions, human airway epithelial calls, human health risk, urban air , toxics, air pollutants, human health effects, particulates, respiratory, sensitive populations, airborne pollutants, airway disease, children, environmental effects, immunology, stratospheric ozone, disease, exposure, urban air pollution, minority population, airway epithelial cells, asthma, human exposure, particle size