ARS | Publication request: WHEY PROTEIN SUPPRESSES PLASMA GHRELIN CONCENTRATIONS IN OVERWEIGHT AND OBESE MEN AND WOMEN.

Submitted to: Meeting Abstract
Publication Type: Abstract
Publication Acceptance Date: June 1, 2006
Publication Date: September 1, 2006
Citation: Stote, K.S., Rumpler, W.V., Clevidence, B.A., Paul, D., Harris, G.K., Baer, D.J. 2006. Whey protein suppresses plasma ghrelin concentrations in overweight and obese men and women [abstract]. The Obesity Society Annual Meeting, October 20-24, 2006, Boston, MA. p. A543-p.

Technical Abstract: The most satiating macronutrient appears to be dietary protein; however, it is unclear if different dietary protein sources have differing effects on satiety. Few studies that have investigated the effects of whey protein on satiety hormones, such as plasma ghrelin, in overweight and obese men and women. The objective of this study was to determine the effects of consumption of supplemental whey protein, soy protein or an isocaloric amount of carbohydrate on satiety hormones in free-living, overweight and obese, men and women. Ninety subjects were studied in a double-blinded parallel design. Subjects were randomized for 6 months to one of three treatment groups: 1) 60 g/d of whey protein, 2) 60 g/d of soy protein, or 3) a control group receiving 60 g/d of carbohydrate along with their free-living diet. Variables measured at baseline and at the end of the study included ghrelin, peptide YY, leptin and adiponectin. Subjective satiety was assessed daily, prior to consumption of the evening meal, by visual analog scales (VAS). To determine diet intake, 24 hour diet recalls were collected approximately every ten days utilizing the U.S. Department of Agriculture¿s automated multiple pass method. After 6 months, subjects consuming supplemental whey protein had decreased ghrelin concentrations when compared with subjects consuming soy protein or an isocaloric carbohydrate treatment (P<0.05). No significant treatment effects were observed with peptide YY, leptin, adiponectin, VAS, or diet intake. Whey protein suppresses ghrelin concentrations when compared to soy protein and an isocaloric carbohydrate treatment. Whey protein supplementation may be more satiating than soy protein or carbohydrate in free-living, overweight and obese, men and women.