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2000 Progress Report: Health Effects of HAPs Among Inner Urban School Children
EPA Grant Number: R826789Title: Health Effects of HAPs Among Inner Urban School Children
Investigators: Greaves, Ian , Adgate, John L. , Church, Timothy , Ramachandran, Gurumurthy , Sexton, Ken
Institution: University of Minnesota - Twin Cities
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: October 1, 1998 through September 30, 2001 (Extended to September 30, 2003)
Project Period Covered by this Report: October 1, 1999 through September 30, 2000
Project Amount: $633,044
RFA: Urban Air Toxics (1998)
Research Category: Air Quality and Air Toxics
Description:
Objective:This study will: (1) determine whether inner urban, poor, minority children attending grades 2-5 in a new "environmentally safe" school have lower rates of respiratory illnesses and better learning outcomes than similar children attending a nearby older school; (2) determine whether biomarkers of exposure and health effects differ among children in the two schools; (3) model the relationships between biomarkers and health outcomes; (4) collect and analyze data on covariates and confounders; and (5) provide baseline data for a cohort who can be followed to see if childhood environmental exposures are associated with health problems in later life. Two null hypotheses will be tested: (1) the new school has no effect on health or learning outcomes among its students; and (2) biomarkers of exposure are unrelated to health or learning outcomes.
Progress Summary:Students in grades 2-5 and their families from two public schools in south Minneapolis were approached to participate in the study. One school was selected for its recent construction and attention to preventing environmental health problems (Whittier) and the other was a nearby school that had been built in the 1970s (Lyndale). The recruitment strategies and methods used to investigate exposures to hazardous air pollutants (HAPs) of these children have been published (see Publications/Presentations). A pilot study was performed from January to June, 1999 during which recruitment strategies were refined and baseline questionnaires were developed and administered. Students from Lyndale and students from Whittier were interviewed, provided blood and urine samples, and underwent lung spirometry testing. Methods for environmental air sampling also were developed and refined during this period.
More detailed studies of 71 children (plus 30 siblings) at Lyndale and 82 children (plus 21 siblings) at Whittier were performed in Fall/Winter 1999, and repeated in Spring, 2000. Recruitment of the larger student numbers occurred in October 1999-January 2000 during which time baseline questionnaires and home visits to assess indoor air quality were also performed. Initial blood and urine samples from these groups were collected in January-February 2000, and spirometry was performed in February-May 2000.
| Lyndale | Whittier | Total | |||||
| Language category | Ethnicity | No. | Percent | No. | Percent | No. | Percent |
| Non-English | Somali | 19 | 26.8% | 21 | 25.6% | 40 | 26.1% |
| Spanish | 6 | 8.5% | 40 | 48.8% | 46 | 30.1% | |
| Cambodian | 8 | 11.3% | 0 | 0.0% | 8 | 5.2% | |
| Laotian | 4 | 5.6% | 0 | 0.0% | 4 | 2.6% | |
| English | American Indian | 2 | 2.8% | 1 | 1.2% | 3 | 2.0% |
| Black | 22 | 31.0% | 17 | 20.7% | 39 | 25.5% | |
| Hispanic | 2 | 2.8% | 0 | 0.0% | 2 | 1.3% | |
| White | 8 | 11.3% | 3 | 3.7% | 11 | 7.2% | |
| Total | 71 | 46.4% | 82 | 53.6% | 153 | ||
Urine and blood samples were obtained in January-February 2000, and again in
April-May 2000. At least one blood test was obtained from 59 students at Lyndale
and 70 at Whittier; both urine and blood samples were provided by 58 students
at Lyndale and 57 at Whittier. The corresponding rates for at least 1 urine
sample was obtained from 66 students at Lyndale and 72 at Whittier; both samples
coming from 66 students at Lyndale and 65 at Whittier. Participation rates for
blood testing were consistently in the 70-85 percent range, and 80-95 percent
range for urine testing. Spirometry tests were performed successfully by more
than 85 percent of students recruited at both schools. A followup questionnaire
was completed in June-July 2000, by 90 percent of students at Lyndale and 80
percent at Whittier.
Between November 1999 and January 2000, peak flow measurements of lung function were offered on a voluntary basis to children in grades 4 and 5: each student performed several tests three times per day on the Monday, Wednesday, and Friday of a single week. Participation involved 100 volunteers who were in grades 4 and 5 at Lyndale and 100 similar students at Whittier. These tests were repeated in May-June, 2000.
Based on the amount of planning that went into the execution of this study, and special issues encountered with the Institutional Review Boards (IRB) and the institutions of our collaborating colleagues, we have published a description of the study population, the research methods, and the IRB and other administrative matters that relate to using school children for health research.
In addition, urine analysis for nicotine metabolites have been examined for the level of association between cotinine (a nicotine metabolite which reflects recent exposure to tobacco smoke) and NNK (a carcinogen in tobacco that is excreted in the urine and reflects more chronic exposures). These analyses are ongoing.
Urine and blood samples have yet to be analyzed for metals, volatile organic compounds (VOCs), chlorinated hydrocarbons, or pesticides.
Future Activities:October 2000 through July 2001 will constitute a second year of testing. Questionnaires will be administered in Fall/Winter 2000 and again in Summer 2001. Two sets of blood and urine specimens will be obtained, with timing similar to Year 1. Lung spirometry will be repeated in Spring 2001.
Journal Articles on this Report: 2 Displayed | Download in RIS Format
| Other project views: | All 10 publications | 10 publications in selected types | All 10 journal articles |
| Type | Citation | ||
|---|---|---|---|
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Hecht SS, Ye M, Carmella SG, Fredrickson A, Adgate JL, Greaves IA, Church TR, Ryan AD, Mongin SJ, Sexton K. Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children. Cancer Epidemiology, Biomarkers & Prevention 2001;10(11):1109-1116. |
R826789 (2000) R826789 (2001) R826789 (2002) R826789 (Final) R825813 (2001) |
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Sexton K, Greaves IA, Church TR, Adgate JL, Ramachandran G, Tweedie RL, Fredrickson A, Geisser M, Sikorski M, Fischer G, Jones D, Ellringer P. A school-based strategy to assess children’s environmental exposures and related health effects in economically disadvantaged urban neighborhoods. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6):682-694. |
R826789 (2000) R826789 (2001) R826789 (2002) R826789 (Final) R825813 (2000) R825813 (2001) |
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school children, inner urban, low-income, indoor air pollution, heavy metals, hazardous air pollutants, HAPs, volatile organic compounds, VOCs, tobacco smoke, allergies, questionnaires, blood tests, urine tests, lung function, spirometry, asthma, learning, minority groups, African-American, Hispanic, Asian, Cambodian, Somali. , Toxics, Air, Geographic Area, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, indoor air, Risk Assessments, genetic susceptability, Health Risk Assessment, Epidemiology, air toxics, Children's Health, Biochemistry, Environmental Chemistry, VOCs, State, buildings, Minneapolis-St.Paul Metropolitan area, risk assessment, susceptible populations, urban air pollutants, allergen, allergies, ambient air quality, building related illness, indoor air quality, inhalation, respiratory problems, toxicity, ethnic groups, urban air, air quality, ambient air, environmental toxicant, HAPS, hazardous air pollutants, MN, assessment of exposure, childhood respiratory disease, biological sensitivities, emissions, harmful environmental agents, monitoring, pulmonary toxicity, sensitive population, air pollutants, infants, inner urban school children, pesticide exposure, respiratory, sensitive populations, VOC sensitivity, emission inventory, measuring childhood exposure, air pollution, airway disease, autoimmunity, biological markers, children, inhaled, lung, pesticides, schools, urine and blood samples, urban monitoring sites, allergic, atmospheric, disease, exposure, pulmonary, school-based study, sick building syndrome, urban air pollution, human health, children's vulnerablity, urban school children, asthma, health risks, human exposure, Human Health Risk Assessment, urban air toxics
Progress and Final Reports:
Original Abstract
2001 Progress Report
2002 Progress Report
Final Report