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A CONCISE REVIEW OF THE TOXICITY AND CARCINOGENICITY OF DIMETHYLARSINIC ACID |
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Dimethylarsinic acid (DMA) has been used as an herbicide (cacodylic acid) and is the major metabolite formed after exposure to tri- (arsenite) or pentavalent (arsenate) inorganic a...
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A SENSITIVE IMMUNOFLUORESCENCE ASSAY FOR DETECTION OF P53 PROTEIN ACCUMULATION IN SPUTUM |
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p53 mutations are common genetic alterations in lung cancers and usually result in p53 protein accumulation in tumor cells. Sputum is noninvasive to collect and ideal for screening...
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AIRBORNE ASBESTOS HEALTH ASSESSMENT UPDATE |
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Recent data from population studies strengthened the association of asbestos with disease. Lung cancer and mesothelioma are the most important asbestos-related causes of death. The...
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AN UPDATE ON SOME ARSENIC PROJECTS AT THE UNITED STATES ENVIRONMENTAL PROTECTION AGENCY |
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ABSTRACT Exposure to arsenic (As) has been reported to cause many adverse health effects in humans, including internal and skin cancers, vascular, neurological and dermal manifest...
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APPLICATION OF CDNA MICROARRAY TO THE STUDY OF ARSENIC TOXICOLOGY AND CARCINOGENESIS |
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Arsenic (As) is a common environmental toxicant and known human carcinogen. Epidemiological studies link As exposure to various disorders and cancers. However, the molecular mech...
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APPLICATION OF PROTEOMIC METHODS TO ARSENIC EXPOSURE RESEARCH |
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Arsenic, an environmental contaminant, is introduced to drinking water through the leaching of soil and the result of anthropogenic sources such as industrial effluents and combust...
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APPROACHING THE TOXICITY OF DISINFECTION BY-PRODUCTS IN DRINKING WATER AS A MIXTURE PROBLEM |
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Abstract Assessment of human health risk from exposure to disinfection by-products (DBPs) in drinking water is of concern because of the wide spread exposure of persons who u...
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ASBESTOS IN DRINKING WATER AND CANCER IN THE SAN FRANCISCO BAY AREA: 1969-1974 INCIDENCE |
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The relationship between ingested asbestos (through drinking water) and cancer of various body sites was examined. This study was a follow-up to another article that investigated t...
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ASBESTOS IN DRINKING WATER AND CANCER INCIDENCE IN THE SAN FRANCISCO BAY AREA |
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Age-adjusted, sex- and race-specific 1969-1971 cancer incidence ratios for the 722 census tracts of the San Francisco-Oakland Standard Metropolitan Statistical Area were compared w...
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ASSIGNED SHARES IN COMPENSATION FOR RADIATION-RELATED CANCERS |
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The preparation of radioepidemiologic tables requires extensive mathematical modeling because matters such as sex, size of dose, age at exposure, type of cancer, and age at diagnos...
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ASSOCIATION BETWEEN CANCER MORTALITY AND WHEAT ACREAGE AS A SURROGATE FOR CHLOROPHENOXY HERBICIDES IN COUNTIES OF OUR NORTHERN STATES |
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Chlorophenoxy herbicides which have endocrine disrupting properties, are used widely both in cereal grain agriculture and in non-agricultural settings, such as right-of-ways, lawns...
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BROMODICHLOROMETHANE TOXICOKINETICS: LINKING METABOLISM TO EFFECT |
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Bromodichloromethane (BDCM), a trihalomethane (THM), is among the most prevalent disinfection byproducts found in chlorinated drinking water. Weak associations between THM expo...
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CANCER AND DEVELOPMENTAL EXPOSURE TO ENDOCRINE DISRUPTORS |
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ABSTRACT Developing organisms have been shown to have increased susceptibility to cancer if exposed to environmental toxicants during rapid growth and differentiation. Human ...
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CANCER INCIDENCE IN THE AGRICULTURAL HEALTH STUDY |
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The Agricultural Health Study (AHS) was undertaken to ascertain the etiology of cancers observed to be elevated in agricultural populations. Methods: The AHS is a large prospectiv...
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CANCER INCIDENCE IN THE AGRICULTURAL HEALTH STUDY |
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Despite low mortality and cancer incidence rates overall, farmers may experience excess risk of several cancers. These excesses have been observed in some, but not all, retrospe...
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CANCER MORBIDITY INVESTIGATIONS: LESSONS FROM THE DULUTH STUDY OF POSSIBLE EFFECTS OF ASBESTOS IN DRINKING WATER |
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In 1973, 1 to 30 million asbestos-like fibers per liter of tap water were discovered in Duluth drinking water. Previous studies had linked mesothelioma, lung, and gastrointestinal ...
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CANCER MORTALITY AMONG UNITED STATES COUNTIES WITH HAZARDOUS WASTE SITES AND SOLE SOURCE DRINKING WATER CONTAMINATION |
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Since the late 1950's more than 750 million tons of toxic wastes have been discarded in an estimated 30,000 to 50,000 hazardous waste sies (HWS). he uncontrolled discarding of chem...
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CANCER MORTALITY IN FOUR NORTHERN WHEAT PRODUCING STATES |
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Chlorophenoxy herbicides are used both in cereal grain agriculture and in nonagricultural settings such as right-of-ways, lawns, and parks. Minnesota, North Dakota, South Dakota, a...
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CANCER RISK ASSESSMENT AND PREVENTION: WHERE DO WE STAND? |
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This paper reviews selected aspects of progress and setbacks in cancer risk assessment and prevention during the four decades since the founding in 1947 of the Institute of Environ...
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CARCINOGENIC EFFECTS OF LOW DOSES OF IONIZING RADIATION |
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Carcinogenic Effects of Low Doses of Ionizing Radiation
R Julian Preston, Environmental Carcinogenesis Division, NHEERL, U.S. Environmental Protection Agency, Research Trian...
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CASE-CONTROL CANCER MORTALITY STUDY AND CHLORINATION OF DRINKING WATER IN LOUISIANA |
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Several Louisiana parished (counties) using the Mississippi River for their source of public drinking water have the highest mortality rates (1950-69) in the United States for seve...
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CAUSES OF MORTALITY IN AN ARSENIC-AFFECTED AREAS OF INNER MONGOLIA, CHINA |
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Introduction
Shahai is a village in Inner Mongolia, China. In the early 1980s, the primary source of drinking water shifted away from large shallow wells to deeper artesian ...
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CHAPEL HILL BISPHENOL A EXPERT PANEL CONSENSUS STATEMENT:INTEGRATION OF MECHANISMS, EFFECTS IN ANIMALS AND POTENTIAL TO IMPACT HUMAN HEALTH AT CURRENT LEVELS OF EXPOSURE |
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This document is a summary statement of the outcome from the meeting: “Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assess...
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CHEMICAL AND RADIATION LEUKEMOGENESIS IN HUMANS AND RODENTS AND THE VALUE OF RODENT MODELS FOR ASSESSING RISKS OF LYMPHOHEMATOPOIETIC CANCERS |
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This report is intended to provide an up-to-date overview of the lymphoid and hematopoietic diseases induced in humans and rodents following exposure to chemical agents. It include...
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CHEMICAL ENHANCEMENT OF VIRAL TRANSFORMATION IN SYRIAN HAMSTER EMBRYO CELLS BY GASEOUS AND VOLATILE CHLORINATED METHANES AND ETHANES |
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Methods were developed for exposing cells in vitro to gases or vapors of volatilized organic liquids. Compounds were selected for their industrial importance, environmental impact,...
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CHILDREN AS A SENSITIVE SUBPOPULATION FOR THE RISK ASSESSMENT PROCESS |
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Children as a sensitive subpopulation for the risk assessment process Abstract For cancer risk assessment purposes, it is necessary to consider how to incorporate sensitive s...
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CIGARETTE SMOKE AND LUNG CANCER |
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Cigarette smoke has been implicated in a causal relationship with carcinoma of the lung. An intriguing feature of the disease is the site-selectivity with which bronchogenic cancer...
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CONCEPT OF ACTIVITY PROFILES OF ANTIMUTAGENS |
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Experimental evidence suggests that chemical mutagenesis and carcinogenesis are related phenomena such that identification of causative agents and protection from exposure might pr...
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CONSEQUENCES OF ACUTE AND CHRONIC EXPOSURE TO ARSENIC |
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Arsenic is a toxic chemical and may cause adverse health effects in children and adults. It is known to affect the nervous, gastrointestinal, and hematological systems and cause sk...
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CONSISTENT ONCOGENE METHYLATION CHANGES IN EPITHELIAL CELLS CHEMICALLY TRANSFORMED IN VITRO |
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Many cancers occurring in humans and In animals are accompanied by alterations in oncogene DNA secluences, amplification, or changes in expression (1,2). In some cases the changes ...
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CONTROL OF ALKALINE PHOSPHATASE ACTIVITY IN C3H10T1/2 CELLS: ROLE OF RETINOIC ACID AND CELL DENSITY |
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The enzyme alkaline phosphatase (AP) has been shown to be lost or inappropriately expressed during carcinogenesis in some tissues. ecause retinoic acid (RA) appears to play a role ...
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DELETION MUTATIONS IN THE HPRT GENE OF T-LYMPHOCYTES AS A BIOMARKER FOR GENOMIC REARRANGEMENTS IMPORTANT IN HUMAN CANCERS |
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The DNA sequence of 11 in vivo-arising intragenic deletion breaksite junctions occurring in the hypoxanthine guanine phosphoribosyltransferase gene of human T-lymphocytes was deter...
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DEVELOPMENT OF ULTRATRACE LASER SPECTROMETRY TECHNIQUES FOR MEASUREMENTS OF ARSENIC |
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Development of Arsenic Speciation Techniques Based on High Performance Liquid Chromatography and Atomic Fluorescence Spectrometry
J.B. Simeonsson, H.D. Beach and D.J. Th...
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DIFFERENTIAL ACTIVATION OF AP-1 IN HUMAN BLADDER EPITHELIAL CELLS BY INORGANIC AND METHYLATED ARSENICALS |
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Differential Activation of AP-1 in Human Bladder Epithelial Cells by Inorganic and Methylated Arsenicals
Zuzana Drobna, Ilona Jaspers, David J. Thomas, and Miroslav Styblo |
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DISINFECTION BY-PRODUCTS AND OTHER EMERGING CONTAMINANTS IN DRINKING WATER |
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Although drinking water disinfection by-products (DBPs) have been studied for the last 30 years, significant, new concerns have arisen. These concerns include adverse reproductive...
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DOES RESPONSE EVALUATION OF GENE EXPRESSION PROFILES IN THE SKIN OF K6/ODC MICE EXPOSED TO SODIUM ARSENITE |
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Abstract - Chronic drinking water exposure to inorganic arsenic and its metabolites increases tumor frequency in the skin of K6/ODC transgenic mice. To identify potential biomarke...
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DRINKING WATER AND CANCER INCIDENCE IN IOWA. 1. TRENDS AND INCIDENCE BY SOURCE OF DRINKING WATER AND SIZE OF MUNICIPALITY |
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The available data resources in the State of Iowa were used to investigate the relationships of drinking water contaminants and cancer incidence rates for communities. Age-adjusted...
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DRINKING WATER AND CANCER INCIDENCE IN IOWA. 2. RADIOACTIVITY IN DRINKING WATER |
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This paper presents a logical epidemiologic exploration into possible associations between exposures to radium-226 in drinking water and incidence rates for cancers of the bladder,...
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DRINKING WATER AND CANCER INCIDENCE IN IOWA. 3. ASSOCIATION OF CANCER WITH INDICES OF CONTAMINATION |
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With data from the Iowa Cancer Registry, age-adjusted sex-specific cancer incidence rates for the years 1969-1981 were determined for towns with a population of 1,000-10,000 and a ...
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DRINKING WATER AND CANCER MORTALITY |
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The problem of understanding the possible adverse health effects of organic chemical contaminants in drinking water is not new, but national concern has intensified in recent years...
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DRINKING WATER ISSUES |
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According to recent reports by the California Department of Health Services, the State of Maine, and the United State Geological Survey (USGS); the fuel oxygenate methyl teri-butyl...
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EFFECT OF ARSENICALS ON CELL CYCLE DISTRIBUTION AND EXPRESSION OF CELL CYCLE PROTEINS IN HUMAN PRIMARY KERATINOCYTES |
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Environmental exposure to arsenic is a major public health concern. Epidemiological studies have demonstrated a strong correlation between levels of arsenic in drinking water and i...
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EFFECT OF ARSENICALS ON THE EXPRESSION OF CELL CYCLE PROTEINS AND EARLY SIGNALING EVENTS IN PRIMARY HUMAN KERATINOCYTES. |
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Effect of Arsenicals on the Expression of Cell Cycle Proteins and Early Signaling Events in Primary Human Keratinocytes.
Mudipalli, A, Owen R. D. and R. J. Preston, Environm...
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EIGHTH ASPEN CANCER CONFERENCE: MOLECULAR MECHANISMS OF TOXICITY IN RELATION TO THE GENETICS OF ANIMAL AND HUMAN NEOPLASIA |
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Cancers arise as a consequence of the interactions between environmental factors and specific genes. he environmental factors range from the ubiquitous, such as sunlight, to the hi...
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EPIDEMIOLOGY STUDY OF THE USE OF ASBESTOS-CEMENT PIPE FOR THE DISTRIBUTION OF DRINKING WATER IN ESCAMBIA COUNTY, FLORIDA |
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Cancer mortality for the population census tracts of Escambia County, Florida, using asbestos-cement (A/C) pipe for public potable water distribution was compared with cancer morta...
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EVALUATION OF THE CARCINOGENICITY OF UNLEADED GASOLINE |
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In the document the likelihood that unleaded gasoline vapors are carcinogenic to humans is evaluated. From carcinogenicity data in animals, an estimate is made of the magnitude of ...
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EVALUATION OF THE METHODS USED TO DETERMINE POTENTIAL HEALTH RISKS ASSOCIATED WITH ORGANIC CONTAMINANTS IN THE GREAT LAKES BASIN |
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These results suggest that 'lake-bordering' populations (i.e., white populations) experience higher rates of mortality due to stomach and esophageal cancers as compared to 'non-lak...
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EVIDENCE FOR BROMODICHLOROMETHANE METABOLISM BY CYTOCHROME P-450 1A2 |
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EVIDENCE FOR BROMODICHLOROMETHANE METABOLISM BY CYTOCHROME P-450 1A2. T M Ross1, B P Anderson1, G Zhao2, R A Pegram1 and J W Allis1. 1U.S. EPA, ORD, NHEERL, Research Triangle Par...
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EXCESS CANCER MORTALITY IN AGRICULTURAL REGIONS OF MINNESOTA |
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Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); ...
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EXPRESSION OF INDUCIBLE HSP70 ENHANCES THE PROLIFERATION OF MCF-7 BREAST CANCER CELLS AND PROTECTS AGAINST THE CYTOTOXIC EFFECTS OF HYPERTHERMIA |
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Heat shock proteins (HSPs) are ubiquitous proteins that are induced following exposure to sub-lethal heat shock, are highly conserved during evolution and protect cells from damage...
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FEDERAL REGULATIONS RELEVANT TO ASBESTOS POLLUTION CONTROL |
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Health effects and epidemiological studies have established that breathing asbestos fibers can cause asbestosis, lung and other organ cancers, and mesothelioma. This has led to pub...
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FOLATE DEFICIENCY ENHANCES ARSENIC EFFECTS ON EXPRESSION OF GENES INVOLVED IN EPIDERMAL DIFFERENTIATION |
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Chronic arsenic exposure in humans is associated with cancers of the skin, lung, and bladder. There is evidence that folate deficiency may increase susceptibility to arsenic¿s effe...
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HEALTH ASSESSMENT DOCUMENT FOR PHOSGENE. EXTERNAL REVIEW DRAFT |
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Phosgene is primarily manufactured for the synthesis of isocyanate-based polymers, carbonic acid esters, and acid chlorides. Ambient and indoor air concentrations of phosgene are p...
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IDENTIFICATION OF DRINKING WATER CONTAMINANTS IN THE COURSE OF A CHILDHOOD CANCER INVESTIGATION IN TOMS RIVER, NEW JERSEY |
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Using a combination of gas chromatography/mass spectrometry (GC/MS) and gas chromatography/infrared spectroscopy (GC/IR) spectroscopic techniques, chemical contaminants and their h...
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IDENTIFICATION OF THE ROLE OF APOPTOSIS PATHWAYS POTENTIALLY INVOLVED IN FORMALDEHYDE-INDUCED CARCINOGENESIS USING CDNA ARRAYS |
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Identification of the Role of Apoptosis Pathways Potentially Involved in Formaldehyde- Induced Carcinogenesis Using cDNA Arrays.
Formaldehyde (FA) is a genotoxic chemical fo...
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INDUCED AND SPONTANEOUS NEOPLASIA IN ZEBRAFISH. |
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To address the potential of zebrafish as a cancer model, it is important to determine the susceptibility of zebrafish to tumors, and to compare zebrafish tumors with human tumors. ...
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INDUCTION OF CELL PROLIFERATION AND APOPTOSIS IN HL60 AND HACAT CELLS BY ARSENIC, ARSENATE, AND ARSENIC-CONTAMINATED DRINKING WATER |
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Induction of cell proliferation and apoptosis in HL-60 and HaCaT cells by arsenite, arsenate and arsenic-contaminated drinking water. T-C. Zhang, M. Schmitt, J. L. Mumford National...
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INDUCTION OF TRANSTITIONAL CELL HYPERPLASIA IN THE URINARY BLADDER AND ABERRANT CRYPT FOCI IN THE COLON OF RATS TREATED WITH INDIVIDUAL AND A MIXTURE OF DRINKING WATER DISINFECTION BY-PRODUCTS |
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ABSTRACT Cancer of the urinary bladder and colon are significant human health concerns. Epidemiological studies have suggested a correlation between these cancers and the...
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INFLUENCE OF SODIUM ARSENITE ON GAP JUNCTION COMMUNICATION IN RAT LIVER EPITHELIAL CELLS |
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Influence of sodium arsenite on gap junction communication in rat-Iiver epitheiial cells. Arsenic is known to cause certain types of cancers, hepatitis, cirrhosis and neuro...
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INTERSPECIES SENSITIVITY TO CHEMICAL CARCINOGENS: RELATIONSHIPS BETWEEN MOUSE SKIN TUMORS AND HUMAN LUNG CANCER |
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This review focuses on the relationships between mouse skin tumors and human lung cancer and discusses these relationships from several perspectives. hese perspectives include: mou...
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INVESTIGATIONS INTO AGE-RELATED SUSCEPTIBILITY TO ARSENIC CARCONOGENICITY |
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Environmental Issue. Arsenic compounds are ubiquitous throughout the environment and are a major health problem in many parts of the world. Human exposure to arsenic has been ident...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR CHLOROETHANE (EXTERNAL REVIEW DRAFT) |
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Chloroethane (CE) is a gaseous halohydrocarbon under ambient conditions. Its uses include: a topical analgesic, an anesthetic when mixed with nitrous dioxide or trichloroethane, a ...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR FORMALDEHYDE |
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Formaldehyde (HCHO) is a pungent and irritating gas with extensive uses in industrial processes and manufacturing of consumer products. Both natural and anthropogenic mechanisms r...
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LNT IS THE BEST WE CAN DO - TO-DAY |
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Abstract
The form of the dose-response curve for radiation-induced cancers, particularly at low doses, is the subject of an ongoing and spirited debate. The present review d...
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MATHEMATICAL MODEL OF STEROIDOGENESIS: MOLECULAR RESPONSE TO ENDOCRINE DISRUPTOR EXPOSURES. |
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Scientists have identified alterations in the concentration dynamics of specific hormones at risk factors for common cancers such as breast cancer, endometrial cancer, and prostate...
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MEETING AT CAMBRIDGE, MA: GENE EXPRESSION IN NORMAL HUMAN KERATINOCYTES MODULATED BY TRIVALENT ARSENICALS |
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Arsenic exposure has been correlated with the development of several human cancers including those found in the skin, lung, liver, kidney and urinary bladder. Humans are
generally...
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MEETING AT SAN DIEGO, CA: GENE EXPRESSION IN NORMAL HUMAN KERATINOCYTES MODULATED BY TRIVALENT ARSENICALS |
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Arsenic exposure has been correlated with the development of several human cancers including those found in the skin, lung, liver, kidney and urinary bladder. Humans are generally ...
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METHYLATION OF ARSENITE BY SOME MAMMALIAN CELL LINES |
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THIS ABSTRACT WAS SUBMITTED ELECTRONICALLY;. SPACE CONSTRAINTS WERE SEVERE)
Methylation of Arsenite by Some Mammalian Cell Lines.
Methylation of arsenite is thought...
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MODELING ACUTE EXPOSURE TO SOLAR RADIATION |
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One of the major technical challenges in calculating solar flux on the human form has been the complexity of the surface geometry (i.e., the surface normal vis a vis the incident...
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MODELING THE ANATOMICAL DISTRIBUTION OF SUNLIGHT |
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One of the major technical challenges in calculating solar irradiance on the human form has been the complexity of the surface geometry (i.e. the surface normal vis a vis the incid...
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MORTALITY AMONG FARMERS AND SPOUSES IN THE AGRICULTURAL HEALTH STUDY |
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In the Agricultural Health Study we evaluated the mortality experience of 52,395 farmers and 32,347 of their spouses in Iowa and North Carolina obtain information on cancer and o...
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MORTALITY AMONG PARTICIPANTS IN THE AGRICULTURAL HEALTH STUDY |
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Purpose: This analysis of the Agricultural Health Study cohort assesses the mortality experience of licensed pesticide applicators and their spouses.
Methods: This report i...
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Monitoring of Microbes in Drinking Water |
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Internationally there is a move towards managing the provision of safe drinking water by direct assessment of the performance of key pathogen barriers (critical control points), ra...
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NITROBENZENE CARCINOGENICITY |
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Nitrobenzene (NB, CAS No. 98-95-3) oxidizes to p-aminophenol and p-nitrophenol in animals and humans, while being reduced also to nitrosobenzene, phenylhydroxylamine, and aniline. ...
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OBSERVATIONS OF CANCER INCIDENCE SURVEILLANCE IN DULUTH, MINNESOTA |
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In 1973, amphibole asbestos fibers were discovered in the municipal water supply of Duluth, Minnesota. The entire city population of approximately 100,000 was exposed during the la...
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P450 AND METABOLISM IN TOXICOLOGY |
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The cytochromes P450 catalyze the initial phase of detoxification of many environmental chemicals, xenobiotic, drugs and the secondary metabolic product of plants. Plant secondary ...
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P450 GENETIC VARIATION: IMPLICATIONS FOR ENVIRONMENTAL AND WORKPLACE EXPOSURE |
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The Cytochrome P450 array detoxifies many chemicals by catalyzing the conversion of mostly hydrophobic chemicals into more hydrophilic forms that can subsequently be excreted by th...
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POTENTIAL ALTERATIONS IN GENE EXPRESSION ASSOCIATED WITH CARCINOGEN EXPOSURE IN MYA ARENARIA |
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Gonadal cancers in soft-shell clams (Mya arenaria) have been found at high prevalences (20-40%) in populations in eastern Maine. The aetiology of these tumours is unknown. We hypot...
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PRACTICAL CONSIDERATIONS FOR APPROXIMATING RELATIVE RISK BY THE STANDARDIZED MORTALITY RATIO |
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The standardized mortality ratio is a widely used and often criticized summary statistic for studies of occupational mortality. In the paper the authors discuss practical condition...
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PROFILES OF GENE EXPRESSION ASSOCIATED WITH TETRACYCLINE OVER EXPRESSION OF HSP70 IN MCF-7 BREAST CANCER CELLS |
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Profiles of gene expression associated with tetracycline over expression of HSP70 in MCF-7 breast cancer cells. Heat shock proteins (HSPs) protect cells from damage through...
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PROTEOMIC PROFILING OF CULTURED HUMAN BLADDER CELLS AFTER TRIVALENT ARSENICAL EXPOSURES |
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Chronic exposure to arsenic has been associated with human cancers of the bladder, kidney, lung, liver, and skin. Inorganic arsenic is biotransformed in a stepwise manner via both ...
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PROTEOMIC PROFILING OF CULTURED HUMAN BLADDER CELLS AFTER TRIVALENT ARSENICAL EXPOSURES (SOT 2008) |
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Chronic exposure to arsenic has been associated with human cancers of the bladder, kidney, lung, liver, and skin. Inorganic arsenic is biotransformed in a stepwise manner via both ...
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Proteomic Analysis of Arsenic-Induced Oxidative Stress in Human Epidermal Keratinocytes |
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Chronic exposure to inorganic arsenic (IAs) has been associated with the development of several human cancers, including those found in the skin, lung, urinary bladder, liver, pros...
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QUANTITATIVE EVALUATION OF BROMODICHLOROMETHANE METABOLISM BY RECOMBINANT RAT AND HUMAN CYTOCHROME P450S |
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ABSTRACT We report quantitative estimates of the parameters for metabolism of bromodichloromethane (BDCM) by recombinant preparations of hepatic cytochrome P450s (CYPs) from rat...
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RECOMBINANT RAT CYT19, AN ARSENIC METHYLTRANSFERASE, EFFICIENTLY GENERATES TRIMETHYLARSINE OXIDE IN THE ABSENCE OF GLUTATHIONE |
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Chronic exposure to inorganic arsenic (iAs), a toxic metalloid sometimes present in drinking water, is associated with increased prevalences of various cancers and other disorders....
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RESEARCH INVESTIGATIONS ON THE PROTEOME: 1. MECHANISMS OF REGULATING PROTEIN SYNTHESIS, AND 2. GLOBAL CHARACTERIZATION OF PROTEOMIC RESPONSES TO ARSENIC EXPOSURES |
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Eukaryotic Elongation Factor 2 (eEF2) mediates translocation in protein synthesis. eEF2 is modified by two post-translational modifications: the phosphorylation of Thr57 in the G d...
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SPECIAL REPORT ON INGESTED INORGANIC ARSENIC: SKIN CANCER; NUTRITIONAL ESSENTIALITY |
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A Technical Panel of the U.S. Environmental Protection Agency's Risk Assessment Forum has studied three special issues regarding certain health effects, particularly skin cancer, a...
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SPECIAL REPORT ON INGESTED INORGANIC ARSENIC: SKIN CANCER; NUTRITIONAL ESSENTIALITY (SAB REVIEW DRAFT) |
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A technical panel of EPA's Risk Assessment Forum has studied three special issues regarding certain health effects, particularly skin cancer, associated with arsenic ingestion: (1)...
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STABLE VARIANTS OF SPERM ANEUPLOIDY AMONG HEALTHY MEN SHOW ASSOCIATIONS BETWEEN GERMINAL AND SOMATIC ANEUPLOIDY |
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Abstract.
Our objective was to identify men who consistently produced high frequencies of sperm with numerical chromosomal abnormalities (stable variants) and to determine w...
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STRATOSPHERIC OZONE DEPLETION: A FOCUS ON EPA'S RESEARCH (EPA/640/K-95/004) |
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This brochure describes the mechanisms of and problems associated with stratospheric ozone depletion as well as some of the Office of
Research and Development's (ORD) associated re...
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THE EPIDEMIOLOGY OF CHEMICAL CONTAMINANTS OF DRINKING WATER |
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A number of chemical contaminants have been identified in drinking water. These contaminants reach drinking water supplies from various sources, including municipal and i...
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THE USE OF STEM CELLS FOR TOXICOLOGY STUDIES AND RISK ASSESSMENTS |
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In general terms, toxicology studies are used in support of risk assessments of adverse health outcomes as a result of exposures to chemical and physical agents. In particular, tox...
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TRACKING DOWN REPRODUCTIVE HEALTH RISKS FOR HUMANS EXPOSED TO ENVIRONMENTAL CONTAMINANTS |
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Government agencies charged with protecting public health are concerned about the same things you are: being able to conceive and deliver healthy babies, and watching them grow up ...
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TRIBROMOMETHANE EXPOSURE AND DIETARY FOLATE DEFICIENCY IN THE FORMATION OF ABERRANT CRYPT FOCI IN THE COLONS OF F344/N RATS |
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TRIBROMOMETHANE EXPOSURE AND DIETARY FOLATE DEFICIENCY IN THE FORMATION OF ABERRANT CRYPT FOCI IN THE COLONS OF F344/N RATS
David R. Geter', Tanya M. Moore', Michael H. Geor...
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U.S. CANCER DEATH COUNTS 1950-1979 |
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The tape contains death counts by five year age groups ending with age 85 and older by county, state and the U.S., by race-sex (white/non-white for male, female) for 35 groupings o...
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U.S. CANCER MORTALITY RATES AND TRENDS 1950-1979 |
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The report contains cancer mortality rates and changes in rates for counties of the United States for 1950-1959, 1960-1969, and 1970-1979. This report includes the number of deaths...
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UNRECOGNIZED OR POTENTIAL RISK FACTORS FOR CHILDHOOD CANCER |
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Traditional epidemiological studies suggest that the contribution of environmental agents to childhood cancer may be minor. However, epidemiological methods can only seldom identif...
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USE OF THE SPONTANEOUS TSC2 KNOCKOUT (EKER) RAT MODEL OF HEREDITARY RENAL CELL CARCINOMA FOR THE STUDY OF RENAL CARCINOGENS |
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The kidney is a frequent site for chemically induced cancers in rodents and among the ten most frequent sites for cancer in human patients. Renal cell carcinoma (RCC) is the most ...
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USING PROTEOMICS TO MONITOR PROTEIN EXPRESSION IN HUMAN CELLS EXPOSED TO CARCINOGENS |
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People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic properties in experimental systems. It has been estimated that...
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WASTE CRANKCASE OIL HEATER STUDY: PHASE 2. ORGANIC AND INORGANIC SPECIATION ANALYSES |
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The report gives results of measurements of specific chemical species in emissions from two waste-oil-fired commercial heaters. The species were identified earlier in a Level 1 ana...
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