![[logo] US EPA](https://webarchive.library.unt.edu/eot2008/20081105081839im_/http://www.epa.gov/epafiles/images/logo_epaseal.gif){kind=logo}
Abstract: Prospective study of air pollution and bronchitic symptoms in children with asthma.
Site Navigation
 |
Research Project Search
Citation: McConnell R, Berhane K, Gilliland F, Molitor J, Thomas D, Lurmann F, Avol E, Gauderman WJ, Peters JM. Prospective study of air pollution and bronchitic symptoms in children with asthma. American Journal of Respiratory and Critical Care Medicine 2003;168(7):790-797.
Abstract:
The relationship of bronchitic symptoms to ambient particulate matter and
to particulate elemental and organic carbon (OC), nitrogen dioxide (NO2),
and other gaseous pollutants was examined in a cohort of children with asthma
in 12 Southern California communities. Symptoms, assessed yearly by questionnaire
from 1996 to 1999, were associated with the yearly variability of particulate
matter with aerodynamic diameter less than 2.5 mum (odds ratio [OR] 1.09/mug/m3;
95% confidence interval [CI] 1.01-1.17), OC (OR 1.41/mug/m3; 95% CI 1.12-1.78),
NO2 (OR 1.07/ppb; 95% CI 1.02-1.13), and ozone (OR 1.06/ppb; 95% CI 1.00-1.12).
The ORs associated with yearly within-community variability in air pollution
were larger than the effect of the between-community 4-year average concentrations.
In two pollutant models, the effects of yearly variation in OC and NO2 were
only modestly reduced by adjusting for other pollutants, except in a model
containing both OC and NO2; the effects of all other pollutants were reduced
after adjusting for OC or NO2. We conclude that OC and NO2 deserve greater
attention as potential causes of the chronic symptoms of bronchitis in children
with asthma and that previous cross-sectional studies may have underestimated
the risks associated with air pollution.
Centers Funded By: 